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TETRAPEPTIDE-14
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Tetrapeptide-14 is said to soothe skin and reduce redness.
Tetrapeptide-14 reduces the production of a pro-inflammatory signaling molecule called interleukin-6 and thus prevents inflammation.
In combination with herbal extracts of green tea, boswellia and honey, it is sold under the brand name Granactive AR-1423.
The use of a 5% drug for four weeks reduces redness from rosacea by 50%.
Peptides are linkage products of some (oligopeptides, e.g. 6 = hexapeptide) or many amino acids (then referred to as polypeptides or proteins).
Tetrapeptide-14 functions in skincare and cosmetics as a/an moisturizing ingredient.
Tetrapeptide-14 is a specific peptide sequence that can be used in cosmetic treatments to relieve redness associated with rosacea or moderate sun exposure.
Tetrapeptide-14 is a specific peptide sequence that can be used in cosmetic treatments to alleviate the redness associated with rosacea or mild sun exposure.
According to the company, this ingredient combines a redness diminishing peptide with the antioxidant properties of tea, the calming properties of Boswellia serrata, and the soothing quality of honey.
Tetrapeptide-14, a specific peptide sequence designed by the company's supply partner Helix Biomedix, acts by down regulating interleukin-6 (IL-6) to prevent inflammation, which in turn reduces MMP-1 damage with the net effect of a bright and even skin appearance.
The ingredient was screened in a leave-on cosmetic treatment at 5% on several subjects with excessive facial redness and, when used with tetrapeptide-14 and botanicals, reportedly diminished the redness by 50% in 4 weeks.
A tetrapeptide is a peptide, classified as an oligopeptide, since it only consists of four amino acids joined by peptide bonds.
Many tetrapeptides are pharmacologically active, often showing affinity and specificity for a variety of receptors in protein-protein signaling.
Present in nature are both linear and cyclic tetrapeptides (CTPs), the latter of which mimics protein reverse turns which are often present on the surface of proteins and druggable targets.
Tetrapeptides may be cyclized by a fourth peptide bond or other covalent bonds.
The tetrapeptide Phe-Met-Phe-Arg-NH2 (FMFRamide), discovered in the ganglia of the clam Macrocallista was the first member of the extended family of the FMRFamide-related peptides (FaRPs, also named RFamide peptides).
They are known as molluscan cardioexcitatory peptides but also as neurotransmitters and neuromodulators in the central nervous system
Biochemical and molecular approaches showed that the sequences vary among members of the RFamide family in the N-terminal region
Other RFamide peptides have been described:
the Fusinus ferrugineus and Aplysia californica FRFamide family (see reference in the Achatina fulica cardioexcitatory peptide the Lymnaea stagnalis cardioexcitatory peptide (LyCEP, ), and the recent Lymnaea stagnalis family of LFRFamide peptides which is up-regulated during parasitization.
The tetrapeptide N-terminal portion of Tetrapeptide-14 (NAsp-Ala-His-Lys-) binds Cu, Ni, and Co ions with high affinity, whereas Au, Ag, and Hg ions bind to cysteine-34.
Tetrapeptide-14 is also the major Zn binding protein in plasma, although there is some debate as to the nature and location of its binding site.
Free or loosely bound, redox-active transition metal ions are extremely prooxidant, having the potential to cause extensive tissue damage.
In biological terms the two most important such metals are iron and copper.
Tetrapeptide-14 can limit copper (and other metals)-mediated oxidative damage via its high-affinity copper-binding site thus directing the damage toward itself
Is a u nique delivery matrix which combines a redness diminishing peptide with the anti-oxidant properties of tea, the calming properties of boswellia serrata and the soothing quality of honey.
Tetrapeptide-14, a specific peptide sequence that can be used in cosmetic treatments to alleviate the redness associated with rosacea or mild sun exposure.
Tetrapeptide-14 acts by down regulating interleukin-6 (IL-6) to prevent inflammation, which in turn reduces MMP-1 damage with the net effect of a bright and even skin appearance.
Puffy Eye Study A 6 week, 4 subjects study demonstrates tetrapeptide-14 dramatic reduction of puffiness under the eye.
The photo on the left displays tetrapeptide-14 ability to noticeably reduce puffiness in 2 weeks.
A mean value of 42.86% puffiness reduction was observed during the 6 week study.
Tetrapeptide-14 is a unique delivery matrix that combines a red and inflammatory reducing peptide with the anti-oxidant properties of tea, the calming properties of boswellia serrata and the calming quality of honey.
IUPAC NAME :
H-Gly-Glu-Pro-Gly-OH
SYNONYMS:
tetrapeptide-4
UNII-S9N5X165MO
S9N5X165MO
Q27289090
