PRODUCTS

TETRASODIUM EDTA

Synonyms : Edetate sodium; Sodium edetate; 64-02-8; Ethylenediaminetetraacetic acid tetrasodium salt; EDTA tetrasodium; Sequestrene; EDTA tetrasodium salt; EDTA sodium; Sodium EDTA; Tetrasodium edetate; EDTA, tetrasodium; Aquamollin

Tetrasodium EDTA is the salt resulting from the neutralization of ethylenediaminetetraacetic acid with four equivalents of sodium hydroxide. It is a white solid that is highly soluble in water.

Synonyms:

Edetate sodium; Sodium edetate; 64-02-8; Ethylenediaminetetraacetic acid tetrasodium salt; EDTA tetrasodium; Sequestrene; EDTA tetrasodium salt; EDTA sodium; Sodium EDTA; Tetrasodium edetate ; EDTA, tetrasodium; Aquamollin; Complexone; Irgalon; Komplexon; Nullapon; Queste; Tetracemin; Tetrine; Tyclarosol; Versene 100; Versene 220; Calsol; Distol; Ergon; Kalex; Na4EDTA; Versene powder; Natrii edetas; Versene beads; Versene flake; TETRASODIUM EDTA; Aquamoline BC; Metaquest C; Nervanaid B; Sequestrene ST; Nullapon B; Kutrilon CS; Natrium aedeticum; Syntron B; Nullapon BFC; Cheelox BF; Clewat T; Conigon BC; Sequestrene 30A; Celon E; Celon H; Ergon B; Questex 4; Tetrasodium ethylenediaminetetraacetate; Celon IS; Endrate tetrasodium; Sequestrene Na 4; Distol 8; Nervanaid B liquid; Nervanaid-B liquid; Tetrasodium salt of EDTA; Hamp-ene Na4; Warkeelate S-42; Nullapon BFC Xonc; Chemcolox 200; Versene 67; Versene FE 3; Nullapon BF-12; Nullapon BF-78; Perma kleer 100; Perma-kleer 100; Warkeelate PS-42; Edathanil tetrasodium; Syntes 12A; Nullapon BFC Liquid; Cheelox BF-12; Perma-kleer tetra cp; Sodium (edetate de); Perma kleer tetra CP; Chelon 100; Caswell No. 846; Hamp-ene 100; Tetracemate tetrasodium; Tetrasodium salt EDTA; Trilon B; Chemcolox 240 powder; Edetate Sodium [USAN]; Nullapon BFC Xonc Beads; Perma kleer 50 crystals; Versene powder tetra sodium; Edetic acid tetrasodium salt; UNII-MP1J8420LU; CCRIS 6797; SODIUM ETHYLENEDIAMINETETRAACETATE; HSDB 5003; EINECS 200-573-9; Tetrasodium ethylenediaminetetracetate; Sodium ethylenediaminetetraacetic acid; EPA Pesticide Chemical Code 039107; Tetrasodium(ethylenedinitrilo)tetraacetate; AI3-17182; MP1J8420LU; Ethylene diamine tetraacetic acid sodium salt; Tetranatrium ethylendiamintetraacetat [Czech]; Sodium salt of ethylenediaminetetraacetic acid; Ethylenebis(iminodiacetic acid) tetrasodium salt; Ethylenediaminetetraacetic acid, tetrasodium salt; Tetrasodium salt of EDTA solution; Tetrasodium salt of ethylenediaminetetracetic acid; N,N'-Ethylenediaminediacetic acid tetrasodium salt; (Ethylenedinitrilo)tetraacetic acid tetrasodium salt; Tetrasodium ethylenediamine-N,N,N',N'-tetraacetate; 67401-50-7; Tetrasodium ethylene diamine tetraacetate; Tetrasodium(ethylenedinitrilo)tetraacetate; Edetate sodium (USAN); N,N'-1,2-Ethanediylbis(N-(carboxymethyl)glycine) tetrasodium salt; Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, sodium salt (1:4); Glycine, N,N'-1,2-ethanediylbis(N-carboxymethyl-, tetrasodium salt; Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, tetrasodium salt; N,N'-1,2-Ethanediylbis(N-(carboxymethyl)glycine), tetrasodium salt; Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:4); Ethylenediaminetetraacetic acid tetrasodium salt hydrate; Tetranatrium ethylendiamintetraacetat; EDTA 4Na; Tetrasodium ethylenediaminetetraacetate hydrate; EC 200-573-9; C10H12N2Na4O8; EDTA tetrasodium 64-02-8; edta Teterasodyum; TETRA SODIUM EDTA

TETRASODIUM EDTA

Tetrasodium EDTA

Tetrasodium EDTA
Tetrasodium EDTA.svg
Identifiers
CAS Number
64-02-8 (anhydrous)
13235-36-4 (tetrahydrate)
3D model (JSmol)
Interactive image
ChemSpider
5914
ECHA InfoCard   100.000.522
EC Number
200-573-9
PubChem CID
6144
UNII
MP1J8420LU (anhydrous) check
L13NHD21X6 (tetrahydrate) check
CompTox Dashboard (EPA)
DTXSID3026350 Edit this at Wikidata
InChI[show]
SMILES[show]
Properties
Chemical formula   C10H12N2Na4O8
Molar mass   380.171 g·mol−1
Appearance   White solid
Hazards
GHS pictograms   GHS05: CorrosiveGHS07: Harmful
GHS Signal word   Danger
GHS hazard statements   H302, H318
GHS precautionary statements   P264, P270, P280, P301+312, P305+351+338, P310, P330, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Tetrasodium EDTA is the salt resulting from the neutralization of ethylenediaminetetraacetic acid with four equivalents of sodium hydroxide (or an equivalent sodium base). It is a white solid that is highly soluble in water. Commercial samples are often hydrated, e.g. Na4EDTA.4H2O. The properties of solutions produced from the anhydrous and hydrated forms are the same, provided they are at the same pH.

Tetrasodium EDTA is used as a source of the chelating agent EDTA4-. A 1% aqueous solution has a pH of approximately 11.3. When dissolved in neutral water, it converts partially to H2EDTA2-. Ethylenediaminetetraacetic acid is produced commercially via the intermediacy of tetrasodium EDTA.

Tetrasodium EDTA

What Is Tetrasodium EDTA?
EDTA (ethylenediamine tetraacetic acid) and its salts, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA and Trisodium EDTA, and the related ingredients HEDTA (hydroxyethyl ethylenediamine triacetic acid) and its trisodium salt, Trisodium HEDTA, are crystalline powders often sold as aqueous solutions.

In cosmetics and personal care products, these ingredients are widely used and can be found in moisturizers, skin care and cleansing products, personal cleanliness products, bath soaps, shampoos and conditioners, hair dyes, hair bleaches, and many other product types.

Why is Tetrasodium EDTA used in cosmetics and personal care products?
Disodium EDTA and the related ingredients bind to metal ions which inactivates them. The binding of metal ions helps prevent the deterioration of cosmetics and personal care products. It also helps to maintain clarity, protect fragrance compounds, and prevent rancidity.

Scientific Facts of Tetrasodium EDTA:
EDTA, also known as edetic acid, and its salts were developed to counteract the effects of hard water and heavy metal ions in the manufacture of textiles. These metal chelators are widely used in cosmetics and personal care products, in food, and in medicines.

Tetrasodium EDTA form complexes with calcium, magnesium, and iron, which allows for better foaming and cleaning performance of cosmetics and personal care products. By binding with metal ions, these ingredients prevent the metals from being deposited onto the hair, scalp and skin.

Properties of Tetrasodium EDTA
Related Categories   Chelation/Complexation Compounds, Chemical Synthesis, EDTA Derivatives, Synthetic Reagents
Quality Level     200
assay     ≥97.0% (KT)
Description
Application of Tetrasodium EDTA
EDTA is an inhibitor of metalloproteases, at effective concentrations of 1-10 mM. EDTA acts as a chelator of the zinc ion in the active site of metalloproteases, and can also inhibit other metal ion-dependent proteases such as calcium-dependent cysteine proteases. For use as an anticoagulant, disodium or tripotassium salts of EDTA are most commonly used. The optimal concentration is 1.5 mg per ml of blood.

Preparation Note of Tetrasodium EDTA
Soluble in water at room temperature up to 1.45 M. The pH of this solution will be approximately 10 to 11 and will be rather viscous.

Molecular Weight of Tetrasodium EDTA:   380.17 g/mol
Hydrogen Bond Donor Count of Tetrasodium EDTA:   0
Hydrogen Bond Acceptor Count of Tetrasodium EDTA:   10
Rotatable Bond Count of Tetrasodium EDTA:   7
Exact Mass of Tetrasodium EDTA:   380.018442 g/mol
Monoisotopic Mass of Tetrasodium EDTA:   380.018442 g/mol
Topological Polar Surface Area of Tetrasodium EDTA:   167 Å²
Heavy Atom Count of Tetrasodium EDTA:   24
Formal Charge of Tetrasodium EDTA:   0
Complexity of Tetrasodium EDTA:   293
Isotope Atom Count of Tetrasodium EDTA:   0
Defined Atom Stereocenter Count of Tetrasodium EDTA:   0
Undefined Atom Stereocenter Count of Tetrasodium EDTA:   0
Defined Bond Stereocenter Count of Tetrasodium EDTA:   0
Undefined Bond Stereocenter Count of Tetrasodium EDTA:   0
Covalently-Bonded Unit Count of Tetrasodium EDTA:   5
Compound of Tetrasodium EDTA Is Canonicalized   Yes

What is Tetrasodium EDTA?

Tetrasodium ETDA (which stands for ethylenediaminetetraacetic acid) is a water-soluble ingredient used as a “chelator,” which means it binds to certain mineral ions to inactivate them. Through this action, it can prevent the deterioration of cosmetic and personal care products, as it stops the growth of mold and other microorganisms. Tetrasodium EDTA also helps maintain clarity, protect fragrance compounds, and prevent rancidity. One of its main uses it to help personal care products work better in hard water.

Laboratory technicians use the three ingredients mentioned above to synthesize EDTA, and then tetrasodium EDTA is derived from that. You’ll find it in moisturizers, skin care and cleansing products, personal cleanliness products, bath soaps, shampoos and conditioners, hair dyes, hair bleaches, and many other products. It’s also cleared for use in packaged foods, vitamins, and baby food.
Is It Safe?

The Cosmetic Ingredient Review Expert Panel evaluated the scientific data and concluded that disodium ETDA and related ingredients (including tetrasodium EDTA) were safe as used in cosmetic ingredients and personal care products. The panel also said the ingredient was not well absorbed in the skin. They did note, however, that since the ingredients are penetration enhancers, formulators should be careful when combining these preservatives with other ingredients that may be hazardous if absorbed.

The Cosmetic Safety Database rates the hazard of the ingredient at a low “2,” with a low overall health hazard, and EDTA has not been found to cause cancer in laboratory animals.

In addition to the formaldehyde thing, however—which makes me uncomfortable—this ingredient may also contain dangerous levels of dioxane, a by-product of manufacturing that is also carcinogenic. There have been some case reports of sensitive individuals developing eczema after using cream with tetrasodium EDTA, and it’s known to be a potent eye irritant. It can also be slow to degrade, making it a poor choice for environmental health.

To avoid this ingredient, watch for these on the label:

Edetate sodium
Tetrasodium edetate
Tetrasodium salt
TEA-EDTA

TETRASODIUM EDTA

Tetrasodium EDTA

Preparation Note of Tetrasodium EDTA
Soluble in water at room temperature up to 1.45 M. The pH of this solution will be approximately 10 to 11 and will be rather viscous.

What is Tetrasodium EDTA?
Tetrasodium ETDA (which stands for ethylenediaminetetraacetic acid) is a water-soluble ingredient used as a “chelator,” which means it binds to certain mineral ions to inactivate them. Through this action, it can prevent the deterioration of cosmetic and personal care products, as it stops the growth of mold and other microorganisms. Tetrasodium EDTA also helps maintain clarity, protect fragrance compounds, and prevent rancidity. One of its main uses it to help personal care products work better in hard water.

The Cosmetic Safety Database rates the hazard of the ingredient at a low “2,” with a low overall health hazard, and EDTA has not been found to cause cancer in laboratory animals.

To avoid this ingredient, watch for these on the label:

Edetate sodium
Tetrasodium edetate
Tetrasodium salt
TEA-EDTA