Quick Search
Tetrasodium Glutamate is used in the formulation of natural cosmetics.
Tetrasodium Glutamate is used in makeup, hair care, skin care and sun care.
Tetrasodium glutamate can be used as a dietary ingredient to promote the production of volatile fatty acids.
CAS Number: 51981-21-6
EC Number: 257-573-7
MDL Number: MFCD01862262
Molecular Formula: C10H14N2Na4O8
Molecular Weight: 382.19 g/mol
SYNONYMS:
C9H13NO8Na4, L-Glutamic acid, N,N-Bis(Carboxymethyl)-, Tetrasodium Salt, L-glutamic acid N,N-diacetic acid, tetrasodium salt, GLDA-Na 4, Tetrasodium glutamate diacetate, Tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate, L-Glutamic acid, N,N-bis(carboxymethyl)-, sodium salt (1:4), 51981-21-6, tetrasodium glutamate diacetate, GLDA, UNII-5EHL50I4MY, 5EHL50I4MY, Tetrasodium N,N-Bis(carboxymethyl)-L-glutamate, Tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate, EINECS 257-573-7, L-Glutamic acid, N,N-bis(carboxymethyl)-, sodium salt (1:4), EC 257-573-7, N,N-Bis(carboxymethyl)-L-glutamic Acid Tetrasodium Salt, tetrasodium, (2S)-2-[bis(carboxylatomethyl)amino]pentanedioate, N,N-Bis(carboxymethyl)-L-glutamic acid tetrasodium salt (ca. 40% in Water), L-Glutamic acid, N,N-bis(carboxymethyl)-, tetrasodium salt, Sodium (S)-2-(bis(carboxylatomethyl)amino)pentanedioate, DISSOLVINE GL, CHELEST CMG-40, C9H13NO8.4Na, DTXSID2052158, C9-H13-N-O8.4Na, UZVUJVFQFNHRSY-OUTKXMMCSA-J, MFCD01862262, B2135, TETRASODIUM GLUTAMATE DIACETATE [INCI], GLUTAMIC ACID N,N-DIACETIC ACID SODIUM SALT, Q25393000, N,N-BIS(CARBOXYMETHYL)GLUTAMIC ACID TETRASODIUM SALT, L-GLUTAMIC ACID-N,N-DI(ACETIC ACID) TETRASODIUM SALT, N,N-BIS-(CARBOXYMETHYL)-L-GLUTAMIC ACID TETRASODIUMN SALT, tetrasodium mono((S)-2-(bis(carboxymethyl)amino)-4-carboxybutanoate), CHELEST CMG-40, DISSOLVINE GL, GLUTAMIC ACID N,N-DIACETIC ACID SODIUM SALT, L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, SODIUM SALT (1:4), L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, TETRASODIUM SALT, L-GLUTAMIC ACID-N,N-DI(ACETIC ACID) TETRASODIUM SALT, N,N-BIS(CARBOXYMETHYL)GLUTAMIC ACID TETRASODIUM SALT, TETRASODIUM GLUTAMATE DIACETATE, TETRASODIUM GLUTAMATE DIACETATE [INCI], TETRASODIUM N,N-BIS(CARBOXYMETHYL)-L-GLUTAMATE, L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, TETRASODIUM SALT, N,N-BIS(CARBOXYMETHYL)- TETRASODIUM SALT L-GLUTAMIC ACID, TETRASODIUM GLUTAMATE DIACETATE, TETRASODIUM N,N-BIS(CARBOXYLATOMETHYL)-L-GLUTAMATE, TETRASODIUM SALT L-GLUTAMIC ACID, N,N-BIS(CARBOXYMETHYL)-, L-Glutamic acid, N,N-bis(carboxymethyl)-, tetrasodium salt, Glutamic acid diacetate tetrasodium salt, Tetrasodium glutamate diacetate, Tetrasodium N,N-bis(carboxymethyl)-L-glutamate, N,N-Bis(carboxymethyl)glutamate tetrasodium salt, Tetrasodium N,N-dicarboxymethyl-L-glutamate, L-Glutamic acid-N,N-di(acetic acid) tetrasodium salt, GLDA-4Na, Tetrasodium dicarboxymethyl glutamate, tetrasodium glutamate, SCHEMBL330961, L-glutamic acid, N,N-bis(carboxymethyl)-, sodium salt (1:4), tetrasodium (2S)-2-[bis(carboxylatomethyl)amino]pentanedioate, tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate, tetrasodium N,N-bis(carboxylatomethyl)-laevo-glutamate, tetrasodium, 2-[bis(carboxylatomethyl)amino]pentanedioate, GLDA, TETRASODIUM GLUTAMATE DIACETATE, tetrasodium N,N-bis(carboxylatomethyl)-L-glutamate, Glda. Na4, (ca. 40% in Water), Chelating agent GLDA, Chelating Agent GLDA-4Na, 6-dioxo-3-piperidinyl)-5-fluoro-, L-glutamic acid N,N-diacetic aci, TETRASODIUM DICARBOXYMETHYL GLUTAMATE
Tetrasodium Glutamate is a high purity, versatile and readily biodegradable chelating agent based upon L-glutamic acid, a natural and renewable raw material.
Tetrasodium Glutamate is also known as GLDA chelate.
Tetrasodium Glutamate is a biodegradable chelating agent.
Tetrasodium Glutamate is water-soluble.
Tetrasodium Glutamate is a yellowish liquid, ammonia odor.
Tetrasodium Glutamate is a plant-based chelating agent.
Tetrasodium Glutamate is the counterpart of EDTA but unlike EDTA, it is extracted from the seed of an Indian plant, Cassia Angustifolia.
Cassia Angustifolia (angustifolia = narrow leaf) is native to the Arabias and Somalia and is cultivated in many locations in India.
Tetrasodium Glutamate is an advanced chelating agent and water softener derived from natural glutamic acid, an amino acid.
This biodegradable ingredient, Tetrasodium Glutamate, represents the next generation of environmentally responsible chelating agents, serving as a safer, greener alternative to traditional chelators like EDTA (ethylenediaminetetraacetic acid).
Tetrasodium glutamate is a safe synthetic chelating agent with natural origins.
Tetrasodium Glutamate is a biodegradable, eco-friendly chelating agent ideal for natural and clean beauty products.
Derived from renewable fermented sugar, it offers a non-toxic, GMO-free alternative to EDTA, ensuring safer formulations.
Tetrasodium Glutamate is gentle on the skin and eyes, making it perfect for organic skincare, haircare, and personal care products.
Tetrasodium Glutamate enhances soap scum control across a wide pH range while maintaining a low environmental impact.
With the smallest ecological footprint among potent complexing agents (ISO standards), Tetrasodium Glutamate supports sustainable, green beauty formulations without compromising performance.Tetrasodium glutamate is a biodegradable chelating agent with the activity of removing polyvalent metal ions from waste activated sludge.
Tetrasodium Glutamate is a 'chelating agent'.
Tetrasodium Glutamate usually appears as an odorless white powder that is soluble in water, and is used as a multi-purpose, clear, liquid chelating agent and preservative booster.
Tetrasodium Glutamate has a molecular weight of 351.13 and its molecular formula is C9H9NNa4O8.
Tetrasodium Glutamate Diacetate is a 'chelating agent'.
Tetrasodium Glutamate usually appears as an odourless white powder that is soluble in water and is used as a multi-purpose, clear, liquid chelating agent and preservative booster.
Tetrasodium Glutamate Diacetate inactivates metallic ions (charged particles) in product formulations, acting as a chelating agent.
Free-roaming iron and copper ions in formulations can lead to rapid oxidation.
Using a chelating agent helps to slow this process, allowing for the creation of products with improved stability and appearance.
Tetrasodium Glutamate Diacetate is often found in sunscreen, facial cleanser, shampoo, makeup, lotion, cleansing wipes, bar soap, and other cleaning products.
Tetrasodium Glutamate is a high purity, versatile and readily biodegradable chelating agent based upon L-glutamic acid, a natural and renewable raw material.
Tetrasodium Glutamate is excellent chelating effectiveness controlling metal catalyzed decomposition.
Tetrasodium Glutamate reduces water hardness and prevents precipitations.
Tetrasodium Glutamate boosts performance of preservatives improving shelf life.
Tetrasodium Glutamate stabilizes the pH value and is effective in wide pH range.
Tetrasodium Glutamate does not sensitize human skin.
Tetrasodium Glutamate is completely biodegradable as compared to phosphates and phosphonates.
Tetrasodium Glutamate is efffective alternative to EDTA.
Tetrasodium glutamate (commonly called tetrasodium glutamate diacetate) is a chelating agent derived from the amino acid L-glutamic acid.
By chelating these ions, Tetrasodium Glutamate improves product stability, prevents oxidation, and enhances preservative performance.
Tetrasodium Glutamate is considered a biodegradable and environmentally friendly alternative to traditional chelating agents such as EDTA or NTA.
USES and APPLICATIONS of TETRASODIUM GLUTAMATE:
Tetrasodium Glutamate preserves cosmetic quality.
Tetrasodium Glutamate is a plant-based preservative widely used in cosmetics for its ability to extend product longevity.
Listed in the INCI as Tetrasodium Glutamate , this chelating agent protects cosmetic formulations from contaminants, enhancing the stability and effectiveness of other ingredients.
Tetrasodium Glutamate prevents the deterioration of cosmetic products, keeping them fresh and safe.
Ideal for creams, serums, and haircare products, Tetrasodium Glutamate is well-tolerated by the skin and appreciated for its low environmental impact, offering a sustainable choice for skin and hair care.
Agricultural Applications of Tetrasodium Glutamate: Fertilizers & Crop Protection: Tetrasodium Glutamate is used in fertilizers and crop protection products to manage micronutrients and improve the availability of essential metals for plants.
Application of Tetrasodium Glutamate: Cosmetics: creams, lotions, shampoos, conditioners, makeup, sunscreens, hair dyes, powders, wipes.
Tetrasodium Glutamate is used in amounts up to 1% to boost the effectiveness of preservatives, allowing for the use of lower amounts than is typical without compromising effectiveness.
Tetrasodium Glutamate acts as a chelating and sequestering agent.
Tetrasodium Glutamate is used in the formulation of natural cosmetics.
Tetrasodium Glutamate is also available in powder form.
Tetrasodium Glutamate is used in makeup, hair care, skin care and sun care.
Tetrasodium glutamate can be used as a dietary ingredient to promote the production of volatile fatty acids.
Tetrasodium Glutamate is a cationic surfactant that has been used in the production of personal care products and industrial cleaners.
Tetrasodium Glutamate is soluble in water and can be used as a post-treatment to reduce the redox potential of hydrochloric acid.
Tetrasodium Glutamate is widely used in cleaning products, cosmetics, detergents, and industrial formulations to bind metal ions such as calcium, magnesium, iron, and copper.
-Stabilizers
Tetrasodium glutamate is a chemical compound often used in cosmetics due to its ability to stabilize the formula and improve the effectiveness of ingredients.
Tetrasodium Glutamate is a chelating agent, acting as a “molecular magnet” that binds metal ions and protects products from unwanted oxidation.
Tetrasodium Glutamate is of synthetic origin and is obtained through a strictly controlled chemical process to ensure its purity and safety.
Tetrasodium glutamate diacetate is also known as a strong alternative to EDTA, but its environmental impact is milder, making it a popular choice for sustainable cosmetic products.
In addition, Tetrasodium Glutamate helps extend the shelf life of products and improves the penetration of active ingredients into the skin, while maintaining their stability.
Applications of Tetrasodium Glutamate: All kinds of cosmetic products like creams, lotions, shampoos, conditioners, makeup products, sunscreen products, hair colorings, powders, personal care wipes.
Tetrasodium Glutamate is a synthetic chelating agent.
Often proposed as an alternative to EDTA, its method of manufacture remains problematic for the environment: Tetrasodium Glutamate uses cyanomethylation with highly toxic ingredients such as hydrogen cyanide and formaldehyde.
For this reason, Tetrasodium Glutamate is accompanied by an orange flower on our application, which is exploded since the ingredient is biodegradable (high solubility over a wide PH range).
-Food Industry Applications of Tetrasodium Glutamate:
*Flavor Enhancement
GLDA-Na4 helps enhance the overall taste of food.
By binding metal ions that could alter flavors, it keeps food tasting fresh and balanced.
*Preservation Function:
Tetrasodium Glutamate extends shelf life by preventing oxidation and spoilage, maintaining food quality and freshness.
*Stability Improvement:
By stabilizing food formulations, Tetrasodium Glutamate ensures consistent quality throughout the product’s life cycle.
-Industrial Applications of Tetrasodium Glutamate:
*Textiles – Dyeing & Finishing
Tetrasodium Glutamate improves color consistency and enhances fabric quality by preventing metal ion interference during the dyeing process.
*Pulp & Paper – Pulp Bleaching:
Tetrasodium Glutamate enhances the brightness of paper and reduces the negative effects of metal ions during the bleaching process.
*Water Treatment – Scale Prevention
Tetrasodium Glutamate reduces scaling and improves water quality by binding metal ions that can cause scaling and blockages in pipes.
-Pharmaceutical & Cosmetics Applications of Tetrasodium Glutamate:
*Pharmaceuticals
Tetrasodium Glutamate stabilizes active pharmaceutical ingredients, ensuring the effectiveness and extending the shelf life of medications.
*Cosmetics
In cosmetics, Tetrasodium Glutamate prevents ingredient degradation, improving product stability and extending the shelf life of creams, lotions, and other personal care products.
-Household & Industrial Cleaners uses of Tetrasodium Glutamate:
*Dishwashing Liquids
Tetrasodium Glutamate improves the performance of dishwashing liquids by softening water and helping to break down grease and grime more effectively.
*Laundry Detergents
Tetrasodium Glutamate stabilizes laundry detergent formulations, ensuring consistent cleaning performance even in hard water conditions.
*Hard Surface Cleaners
Tetrasodium Glutamate helps to remove stubborn residues and prevent the redeposition of dirt and soils, ensuring thorough cleaning.
-Personal Care Products uses of Tetrasodium Glutamate:
*Shampoos & Conditioners
Tetrasodium Glutamate enhances the stability of shampoo and conditioner formulas, improving their performance and effectiveness over time.
*Skincare Products
Tetrasodium Glutamate prevents the breakdown of active ingredients, ensuring consistent quality and extending the shelf life of skincare products.
-Use of Tetrasodium Glutamate:
Typical use level 0.1-0.5%.
Add Tetrasodium Glutamate at the end of formulation process or to water phase of emulsions.
Tetrasodium Glutamate is used for external use only.
-Uses and Applications of Tetrasodium Glutamate:
*Cleaning and Detergents:
Water-softening agent in household and industrial cleaners.
Chelating agent in laundry detergents.
Tetrasodium Glutamate prevents mineral deposits and soap scum.
*Cosmetics and Personal Care:
Tetrasodium Glutamate is used in shampoos, soaps, and skincare products.
Tetrasodium Glutamate enhances preservative effectiveness.
Tetrasodium Glutamate improves formulation stability.
*Industrial Applications:
Tetrasodium Glutamate is used in industrial cleaning formulations.
Metal ion sequestration in process water.
Stabilizer in chemical formulations.
*Food and Packaging Industry:
Occasionally used in food-contact cleaning agents.
*Environmental Applications:
Replacement for EDTA in environmentally friendly products.
PURPOSE AND BENEFITS of TETRASODIUM GLUTAMATE:
Tetrasodium Glutamate is characterized by its ability not only to protect cosmetic formulas from degradation but also to enhance their effectiveness.
Tetrasodium Glutamate's uniqueness lies in its ability to neutralize the subtle yet harmful effects of metal ions, which can disrupt product quality.
This means that your favorite creams, serums, or shampoos remain effective and stable until their expiration date.
Tetrasodium glutamate also helps ingredients work synergistically, creating a harmonious effect on the skin or hair.
Another equally important property is that this compound helps maintain the health of the skin and hair by reducing the damage caused by environmental factors.
Unlike some other chelating agents, Tetrasodium Glutamate is friendlier not only to your skin but also to the environment.
This is an important advantage in modern products that aim to combine effectiveness with a responsible approach to the environment.
Tetrasodium Glutamate's use allows for the creation of formulas that not only perform their function well but are also ethical and conscious.
Furthermore, Tetrasodium Glutamate provides the ability to create transparent, lightweight textures that do not feel heavy or greasy.
This is especially relevant in modern cosmetic products that focus on consumer comfort and the pleasure of daily use.
Tetrasodium glutamate helps maintain the aesthetics of products while ensuring their quality and effectiveness.
Tetrasodium Glutamate's use represents a new generation of cosmetics where science merges with responsibility.
Tetrasodium Glutamate not only enhances product functions but also paves the way for innovative approaches to formulation.
Manufacturers who choose Tetrasodium Glutamate prove that it is possible to create beauty products that are effective, safe, and harmoniously exist in our world.
WHAT IS TETRASODIUM GLUTAMATE USED FOR?
Tetrasodium Glutamate Diacetate inactivates metallic ions (charged particles) in product formulations, hence acting as is a chelating agent.
Free roaming iron and copper ions in formulations can lead to rapid oxidation.
Using a chelating agent helps to slow this process, allowing for the creation of products with improved stability and appearance.
This also improves the effectiveness of preservative ingredients, allowing us to use a lower percentage of these, for safer shelf-stable products.
Tetrasodium Glutamate Diacetate is often found in sunscreen, facial cleanser, shampoo, makeup, lotion, cleansing wipes, bar soap, and other cleaning products.
ORIGIN of TETRASODIUM GLUTAMATE:
Tetrasodium Glutamate Diacetate is an organic salt synthesized from glutamic acid (an amino acid abundant in nature).
WHAT DOES TETRASODIUM GLUTAMATE DO IN A FORMULATION?
CHELATING
SAFETY PROFILE of TETRASODIUM GLUTAMATE:
The safety of Tetrasodium Glutamate Diacetate was assessed by the Expert Panel for Cosmetic Ingredient Safety (formerly called the Cosmetic Ingredient Review Expert Panel) in 2021.
The Expert Panel concluded that it was safe as used in the present practices of use and concentration in cosmetics and personal care products.
The Expert Panel noted Tetrasodium Glutamate Diacetate is slowly absorbed through the gastrointestinal tract and skin absorption is likely to be even slower.
The Expert Panel also noted the lack of carcinogenicity (cancer-causing potential) data and that it may contain a salt of nitrilotriacetic acid, a category 2B carcinogen according to the International Agency for Research on Cancer (IARC).
However, the concern was mitigated by multiple genotoxicity studies (both in vitro and in vivo), which did not indicate adverse genetic activity at the low concentrations of this ingredient in leave-on products.
ALTERNATIVES of TETRASODIUM GLUTAMATE:
*TRISODIUM ETHYLENEDIAMINE DISUCCINATE
*EDTA
WHY DO SO MANY INDUSTRIES USE TETRASODIUM GLUTAMATE?
*Eco-Friendly Choice:
With tightening regulations on environmental impact, Tetrasodium Glutamate is a smart move.
Tetrasodium Glutamate biodegrades quickly, reducing wastewater concerns and helping manufacturers meet eco-label requirements.
*Strong Metal Binding:
Tetrasodium Glutamate efficiently binds troublesome metal ions that could otherwise reduce cleaning effectiveness or cause discoloration in formulations.
*Versatility:
Tetrasodium Glutamate performs well across a wide pH range, making it suitable for acidic and alkaline formulations alike.
*Safer Profile:
Compared to harsher chelators, Tetrasodium Glutamate offers a safer handling profile, which is great news for plant operations and worker safety compliance.
HISTORICAL DEVELOPMENT AND DISCOVERY of TETRASODIUM GLUTAMATE:
The history of Tetrasodium Glutamate is tied to finding better, eco-friendly chelating agents.
As environmental concerns grew, the need for biodegradable alternatives to old chelating agents like EDTA increased.
Tetrasodium Glutamate became a big deal because it’s biodegradable and works well.
Tetrasodium Glutamate's creation was driven by the need for green ingredients in food, cosmetics, and pharmaceuticals.
WHAT EXACTLY IS TETRASODIUM GLUTAMATE?
To keep it simple, Tetrasodium Glutamate is a highly effective, biodegradable chelating agent, widely used across food, cosmetics, cleaning formulations, and industrial applications.
As a synthetic compound derived from glutamic acid — a naturally occurring amino acid — Tetrasodium Glutamate excels at binding and neutralizing metal ions such as calcium, magnesium, and iron.
This not only prevents undesirable reactions but Tetrasodium Glutamate also helps maintain the stability, freshness, and overall quality of the final product.
FUNCTIONS (INCI) of TETRASODIUM GLUTAMATE:
*Chelating :
Tetrasodium Glutamate reacts and forms complexes with metal ions that could affect the stability and / or appearance of cosmetic products.
TETRASODIUM GLUTAMATE ISPRESENT IN:
Tetrasodium Glutamate is present in 3.11% of cosmetics.
*Solid shampoo (18.35%).
*Solid cleanser (17.27%).
*Liquid soap (15.74%).
*Exfoliating solid soap (15.38%).
*Solid soap (12.85%).
FUNCTION(S) of TETRASODIUM GLUTAMATE IN COSMETIC PRODUCTS
*CHELATING
Tetrasodium Glutamate binds metal ions which could negatively affect the stability and / or appearance of cosmetics
WHAT DOES TETRASODIUM GLUTAMATE DO?
Tetrasodium Glutamate binds with metal ions such as calcium, magnesium, and iron that are commonly found in tap water.
These minerals can interfere with the cleaning power of detergents by reducing the effectiveness of surfactants—the cleaning agents that lift dirt and oil from fabrics.
By neutralizing these minerals, Tetrasodium Glutamate allows our detergent to perform at its best, even in hard water conditions.
Additionally, Tetrasodium Glutamate prevents mineral deposits from forming on fabrics and in washing machines, ensuring cleaner laundry and longer machine life.
STRUCTURAL AND MOLECULAR CHARACTERISTICS of TETRASODIUM GLUTAMATE:
Tetrasodium Glutamate is derived from L-glutamic acid, a naturally occurring amino acid.
Tetrasodium Glutamate contains multiple carboxylate groups that coordinate with metal ions.
Tetrasodium Glutamate forms stable chelate complexes through multidentate binding.
Tetrasodium Glutamate contains one stereocenter derived from glutamic acid.
High polar surface area due to multiple carboxylate groups, leading to strong water solubility.
HOW IS TETRASODIUM GLUTAMATE MADE?
Tetrasodium Glutamate is synthesized from glutamic acid (a naturally occurring amino acid) through a chemical reaction with formaldehyde and sodium cyanide, followed by hydrolysis and neutralization.
The manufacturing process has been optimized to create a chelating agent that is both highly effective and readily biodegradable.
Modern production methods ensure minimal environmental impact while delivering superior water-softening performance.
WHY WE USE TETRASODIUM GLUTAMATE:
*Enhanced Cleaning Power:
By softening water and preventing mineral buildup, Tetrasodium Glutamate helps our detergent deliver superior cleaning results, leaving your fabrics spotless and fresh.
*Eco-Friendly Choice:
Tetrasodium Glutamate is readily biodegradable (over 60% in 28 days), making it a more sustainable alternative to traditional chelating agents like EDTA.
It breaks down quickly in the environment, minimizing its ecological footprint.
*Protects Fabrics and Machines:
Mineral deposits can dull fabrics and cause buildup in washing machines over time.
Tetrasodium Glutamate helps prevent this, keeping both your clothes and your washer in peak condition.
*Preserves Detergent Efficacy:
Tetrasodium Glutamate stabilizes the detergent formula by preventing metal ions from degrading other ingredients, ensuring a consistent, high-performance clean every time.
WHAT DOES TETRASODIUM GLUTAMATE DO IN A FORMULATION?
*Chelating
ALTERNATIVES OF TETRASODIUM GLUTAMATE:
*TRISODIUM ETHYLENEDIAMINE DISUCCINATE
*EDTA
TETRASODIUM GLUTAMATE IS OFTEN FOUND IN:
*Sunscreen
*Facial cleanser
*Shampoo
*Makeup
*Lotion
*Detergents
*Cleansing wipes
*Bar soap
*Body oil
*Food products
*Bath soak
*Bath products
BENEFITS AND FUNCTIONAL ADVANTAGES of TETRASODIUM GLUTAMATE:
Strong chelating capability for metal ions.
Biodegradable and environmentally safer than EDTA.
Tetrasodium Glutamate improves preservative efficiency in formulations.
Tetrasodium Glutamate enhances stability of cosmetic and cleaning products.
Effective over a wide pH range.
Derived from renewable raw materials such as glutamic acid.
MOLECULAR COMPOSITION of TETRASODIUM GLUTAMATE:
Tetrasodium Glutamate has a complex molecular structure based on glutamic acid.
Its formula is C10H14N2Na4O8.
This formula shows Tetrasodium Glutamate has sodium ions and carboxylate groups.
These elements help Tetrasodium Glutamate bind metal ions effectively.
Tetrasodium Glutamate's molecular composition is vital for binding metal ions.
This makes Tetrasodium Glutamate useful in many industries.
The four sodium ions also make Tetrasodium Glutamate very soluble in water, which is handy for use in solutions.
PHYSICAL PROPERTIES of TETRASODIUM GLUTAMATE:
Tetrasodium Glutamate is usually a white or off-white powder.
Tetrasodium Glutamate dissolves well in water.
These physical properties make Tetrasodium Glutamate easy to mix into various products, like food and industrial solutions.
Appearance: White or off-white powder
Solubility: Highly soluble in water
Stability: Stable under normal storage conditions
WHAT IS A CHELATOR OR SEQUESTRANT, TETRASODIUM GLUTAMATE?
Tetrasodium Glutamate is a substance consisting of molecules possessing two or more atoms that can bind to the same metal atom to form stable complexes.
In cosmetics they are often used to reduce or prevent reactions catalyzed by trace or impurity metals in formulations.
They also enhance the effect of the preservative in some cases and generally give stability to the formulation.
Tetrasodium Glutamate is a high-purity, versatile and readily biodegradable chelator based on L-glutamic acid, a natural and renewable raw material.
Tetrasodium Glutamate is in liquid form with a transparent coloration.
Tetrasodium Glutamate is bio-compatible and bio-degradable.
Since Tetrasodium Glutamate is not easily absorbed by the skin, it does not irritate or sensitize it.
DIFFERENCES BETWEEN TETRASODIUM GLUTAMATE AND EDTA:
Demonizing EDTA would be a mistake, but it must be said that some substances commonly used in cosmetics can, as of today, be replaced with more eco-friendly alternatives.
This is the case with EDTA, which has always been used as a chelator, especially in rinse-off products such as shampoos or detergents, because it also has an inherent cleansing action.
Studies, however, show that its metal sequestering action is, especially with regard to the marine ecosystem, very polluting because it allows greater dispersion of heavy metals into sea water, especially when used in everyday detergents.
In skincare cosmetics, the use of EDTAs definitely has a lower environmental impact especially because of their leave-on nature (they do not rinse off).
However, using more eco-friendly alternatives here as well, such as Tetrasodium Glutamate, is meant to be a support for future generations not to underestimate any aspect related to the environment.
Finally, it should be kept in mind that Tetrasodium Glutamate is not a skin sensitizer and is therefore less aggressive on the skin as well.
This is why Gen-Hyal chooses not to use EDTA in any of its products, preferring instead more green solutions.
FUNCTIONAL PROPERTIES of TETRASODIUM GLUTAMATE:
*Chelating Ability:
Strong chelator of metal ions (Ca²⁺, Mg²⁺, Fe³⁺, Cu²⁺)
*Cosmetic Functions:
Chelating agent
*Stability:
Stable under normal conditions; hygroscopic
PHYSICAL and CHEMICAL PROPERTIES of TETRASODIUM GLUTAMATE:
Molecular Weight: 382.19 g/mol
Molecular Formula: C10H14N2Na4O8
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 10
Rotatable Bond Count: 4
Exact Mass: 382.03409254 g/mol
Monoisotopic Mass: 382.03409254 g/mol
Topological Polar Surface Area: 213Ų
Heavy Atom Count: 24
Formal Charge: 0
Complexity: 134
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 2
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 6
Compound Is Canonicalized: Yes
Chemical Name: Tetrasodium Glutamate Diacetate (TSGDA)
IUPAC Name: Tetrasodium 2-[bis(carboxylatomethyl)amino]pentanedioate
CAS Number: 51981-21-6
EC (EINECS) Number: 257-573-7
MDL Number: MFCD01862262
FDA UNII: 5EHL50I4MY
Nikkaji Web: J1.167.940D
MOL File: 51981-21-6.mol
Molecular Formula: C₉H₉NO₈Na₄
Molecular Weight: ~351.13 g/mol
Chemical Type: Amino acid–based chelating agent
Structure: Derived from glutamic acid with two carboxymethyl groups forming a tetra-sodium salt
Appearance: Colorless to light yellow liquid or crystalline powder
Physical State: Solid or aqueous solution (commonly 40–50%)
Color: Light orange to yellow or greenish solution
Odor: Odorless
Hygroscopicity: Hygroscopic
Density: ~1.20–1.46 g/cm³ at 20 °C
Boiling Point: ~105–110 °C (for solution)
Flash Point: 0 °C (32 °F, TCC, estimated)
Viscosity: 75–275 mPa·s at 25 °C
pH: 11–12 (1% aqueous solution)
Vapor Pressure: ~80 Pa at 20 °C
Solubility:
Highly soluble in water (~650 g/L at 21 °C)
Slightly soluble in ethanol and methanol
Chemical Properties & Applications:
Chelating Ability: Strong chelator; binds metal ions (Ca²⁺, Mg²⁺, Fe³⁺, Cu²⁺)
Complex Formation: Forms stable metal complexes in aqueous solution
Ionization: Highly ionized in water
Thermal Stability: Maintains chelating efficiency at elevated temperatures
Compatibility: Compatible with surfactants, detergents, and preservatives
Biodegradability: Readily biodegradable
Stability: Stable under normal conditions and over wide pH range
Assay / Purity: 95–100%
Food Chemicals Codex Listed: No
Chemical Name: Tetrasodium Glutamate Diacetate (TSGDA)
IUPAC Name: Tetrasodium 2-[bis(carboxylatomethyl)amino]pentanedioate
CAS Number: 51981-21-6
EC (EINECS) Number: 257-573-7
MDL Number: MFCD01862262
FDA UNII: 5EHL50I4MY
Nikkaji Web: J1.167.940D
MOL File: 51981-21-6.mol
Molecular Formula: C₉H₉NO₈Na₄
Molecular Weight: ~351.13 g/mol
Chemical Type: Amino acid–based chelating agent
Structure: Derived from glutamic acid with two carboxymethyl groups forming a tetra-sodium salt
Appearance: Colorless to light yellow liquid or crystalline powder
Physical State: Solid or aqueous solution (commonly 40–50%)
Color: Light orange to yellow or greenish solution
Odor: Odorless
Hygroscopicity: Hygroscopic
Density: ~1.20–1.46 g/cm³ at 20 °C
Boiling Point: ~105–110 °C (for solution)
Viscosity: 75–275 mPa·s at 25 °C
pH: 11–12 (1% aqueous solution)
Vapor Pressure: ~80 Pa at 20 °C
Solubility:
Highly soluble in water (~650 g/L at 21 °C)
Slightly soluble in ethanol and methanol
Chemical Properties & Applications:
Chelating Ability: Strong chelator; binds metal ions (Ca²⁺, Mg²⁺, Fe³⁺, Cu²⁺)
Complex Formation: Forms stable metal complexes in aqueous solution
Ionization: Highly ionized in water
Thermal Stability: Maintains chelating efficiency at elevated temperatures
Compatibility: Compatible with surfactants, detergents, and preservatives
Biodegradability: Readily biodegradable
Stability: Stable under normal conditions and over wide pH range
Assay / Purity: 95–100%
Food Chemicals Codex Listed: No
Flash Point: 0 °C (32 °F, TCC, estimated)
Chemical Name: Tetrasodium Glutamate Diacetate (TSGDA)
IUPAC Name: Tetrasodium 2-[bis(carboxylatomethyl)amino]pentanedioate
CAS Number: 51981-21-6
EC (EINECS) Number: 257-573-7
FDA UNII: 5EHL50I4MY
CAS DataBase Reference: 51981-21-6
EPA Substance Registry System: L-Glutamic acid, N,N-bis(carboxymethyl)-, sodium salt (1:4)
EWG Food Score: 1
Molecular Formula: C₉H₉NO₈Na₄
Molecular Weight: ~351.13 g/mol
InChI: InChI=1/C9H13NO8.Na.H/c11-6(12)2-1-5(9(17)18)10(3-7(13)14)4-8(15)16;;/h5H,1-4H2,(H,11,12)(H,13,14)(H,15,16)(H,17,18);;/t5-;;/s3
InChIKey: VWDYINKBFDHFPJ-WHWWGIJDNA-N
SMILES: N(CC(=O)O)(CC(=O)O)C@H
CCC(=O)O.[NaH]
Appearance: Colourless solution; light orange to yellow to green
Physical State: Liquid or solid crystalline powder
Odor: Odorless
Hygroscopicity: Hygroscopic
Density / Specific Gravity: 1.466 g/cm³ (20 °C); 1.15–1.45 g/cm³ reported
Boiling Point: 105–110 °C (solution)
Vapor Pressure: ~80 Pa at 20 °C
pH: 11–12 (1% aqueous solution)
Viscosity: 75–275 mPa·s at 25 °C
Water Solubility: Highly soluble; ~650 g/L at 21 °C
Solubility in Organic Solvents: Slightly soluble in methanol and ethanol
Storage Temperature: Refrigerator recommended
FIRST AID MEASURES of TETRASODIUM GLUTAMATE:
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Rresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available
ACCIDENTAL RELEASE MEASURES of TETRASODIUM GLUTAMATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up dry.
Dispose of properly.
FIRE FIGHTING MEASURES of TETRASODIUM GLUTAMATE:
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
EXPOSURE CONTROLS/PERSONAL PROTECTION of TETRASODIUM GLUTAMATE:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use Safety glasses.
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
protective clothing
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of TETRASODIUM GLUTAMATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
Store in cool, dry place.
Store in a well-ventilated place.
STABILITY and REACTIVITY of TETRASODIUM GLUTAMATE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Incompatible materials:
No data available
