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THIABENDAZOLE = TIABENDAZOLE = THIABENDOLE
CAS Number: 148-79-8
EC Number: 205-725-8
MDL number: MFCD00005587
Molecular Formula: C10H7N3S
Thiabendazole is a benzimidazole derivative with anthelminthic property.
Thiabendazole (INN, BAN), also known as thiabendazole (AAN, USAN) or TBZ and the trade names Mintezol, Tresaderm, and Arbotect, is a preservative, an antifungal agent, and an antiparasitic agent.
Although the mechanism of action has not been fully elucidated, thiabendazole inhibits the helminth-specific mitochondrial enzyme fumarate reductase, thereby inhibiting the citric acid cycle, mitochondrial respiration and subsequent production of ATP, ultimately leading to helminth's death.
Thiabendazole may lead to inhibition of microtubule polymerization by binding to beta-tubulin and has an overt ovicidal effect with regard to some trichostrongylids.
Thiabendazole is an anthelmintic administered orally to treat creeping eruption and strongyloidiasis.
Thiabendazole appears as white or cream-colored odorless, tasteless powder.
Thiabendazole sublimes above 590°F.
Thiabendazole fluoresces in acidic solution.
Thiabendazole is an "antihelmintic," or anti-worm, medication. It prevents worms from growing or multiplying in the body.
Thiabendazole is an anthelmintic and fungicide, C10H7N3S, used to treat parasitic worm infections in humans and domestic animals and to control fungal diseases in fruits and vegetables.
Thiabendazole first introduced in 1962.
Thiabendazole is active against a variety of nematodes and is the drug of choice for strongyloidiasis.
Owing to the commercial importance of thiabendazole, the various synthetic routes are disclosed in the literature for preparing this pharmacologically and fungicidally active compound.
Thiabendazole was noted to exhibit moderate anti-inflammatory and analgesic activities, which led to the development of KB-1043.
Thiabendazole is approved in the EU under number E 233 as a food additive(preservative).
Thiabendazole (INN, BAN), also known as thiabendazole.
Thiabendazole is a white to off-white odorless powder with a molecular weight of 201.26, which is practically insoluble in water but readily soluble in dilute acid and alkali.
Thiabendazole's chemical name is 2-(4-thiazolyr)-1/-/-benzimidazole.
Thiabendazole is a fungicide and parasiticide.
Thiabendazole is vermicidal and vermifugal against Ascaris lumbricoides ("common roundworm"), Strongyloides stercoralis (threadworm), Necator americanus, Ancylostoma duodenale (hookworm), Trichuris trichiura (whipworm), Ancylostoma braziliense (dog and cat hookworm), Toxocara canis, Toxocara cati (ascarids) and Enterobius vermicularis (pinworm).
Thiabendazole (or tiabendazole) is a fungicide and parasiticide.
Thiabendazole is an anthelmintic.
Thiabendazole is a benzimidazole compound that acts as a fungicide and also against nematodes in Strongyloidiasis.
Thiabendazole is a benzimidazole compound that acts as a fungicide and is reported to have aneugenic effects.
Thiabendazole is abbreviated to "TBZ".
Was shown, that vascular disruption by TBZ results from reduced tubulin levels and hyper-active Rho signaling.
Thiabendazole (TBZ, trade names Mintezol, Tresaderm, and Arbotect) was first introduced in 1962.
A proposed route of biotransformation of thiabendazole is the CYP1A2-catalyzed hydroxylation to 5-hydroxythiabendazole, which is metabolized to glucuronide and sulfate conjugates.
Thiabendazole ( 2-( 4′thiazolyl) -benzimidazole) represents a new class of broad spectrum anthelmintics with a wide range of activity.
Thiabendazole is a potent inhibitor of cytochrome P450 1A2
Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property.
Thiabendazole is an antifungal agent and anthelmintic.
Thiabendazole belongs to the group of benzimidazoles.
Thiabendazole is a benzimidazole derivative with anthelminthic property.
Thiabendazole is an anthelmintic.
Thiabendazole is a benzimidazole carbamate based on a bicyclic ring structure in which a benzene ring is fused to the 4- and 5- positions of an imidazole ring.
USES and APPLICATIONS of THIABENDAZOLE:
-Thiabendazole is a broad spectrum anthelmintic agent used predominantly in treatment of intestinal pinworm and strongyloides infection, which recently has been replaced by better tolerated agents.
-Thiabendazole is formulated as a dust, flowable powder or wettable powder for use as a systemic fungicide and anthelmintic.
-Thiabendazole is used to treat infections caused by worms such as threadworm.
-Thiabendazole may also be used to treat pinworm (when it occurs with threadworm), hookworm, whipworm, roundworm, and trichinosis.
-Thiabendazole may also be used for purposes other than those listed in this medication guide.
-Tiabendazole (thiabendazole) is a benzimidazole compound used both as a broad-spectrum anthelmintic in various animal species and for the control of parasitic infestations in humans.
-Thiabendazole is used in the treatment of:
*Dracunculiasis
*Larva Migrans
*Strongyloidiasis
*Trichinellosis
-Thiabendazole 2-(4′-thiazolyl)-benzimidazole (TBZ) (I) is an important anthelmintic and fungicidal agent widely used in pharmaceutical, agriculture and food industry.
-Thiabendazole is used to treat infections caused by worms such as threadworm.
-Thiabendazole is a benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections.
-Thiabendazole is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning.
-Thiabendazole is used to suppress egg and/or larval production and may inhibit the subsequent development of those eggs or larvae which are passed in the feces.
-Thiabendazole is used primarily to control mold, blight, and other fungally caused diseases in fruits (e.g. oranges) and vegetables.
-Thiabendazole is able to control roundworms, hookworms, and other helminth species which attack wild animals, livestock and humans.
-Thiabendazole is applied to some bananas, including Chiquita brand bananas 'to ensure freshness'.
-Thiabendazole is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning.
-Thiabendazole is also used as a food additive, a preservative with E number E233.
-Thiabendazole is also used to treat ear infections in dogs and cats.
-Thiabendazole is able to control roundworms, hookworms, and other helminth species which attack wild animals, livestock and humans.
-Thiabendazole is used to treat infections caused by roundworms, hookworms, pinworms, whipworms, or threadworms.
-Thiabendazole is widely used in fruit, vegetable preservation, paper, leather, paint and other anti-corrosion and anti-mildew, human and animal intestinal insect repellent.
-Thiabendazole is used primarily to control mold, blight, and other fungally caused diseases in fruits (e.g. oranges) and vegetables.
-Thiabendazole is applied to some bananas.
-Thiabendazole is also a chelating agent, which means that Tiabendazole is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning.
-Thiabendazole is also used as a food additive, a preservative with E number E233.
-Thiabendazole is also used to treat ear infections in dogs and cats.
-Thiabendazole is a fungicide and parasiticide with potential anti-angiogenic (or vascular disrupting) action.
-Thiabendazole is a systemic benzimidazole with a preventative and curative fungicidal activity by contact, with a wide range of action.
-Thiabendazole is used on citrus fruit, and in combination with imazalil for citrus fruit, apples and pears.
-Thiabendazole is used to prevent storage decay as caused by Botrytis sp., Diaporthe citri (phomosis), Botryosphaeria rhodina (diplodia rot), Penicillium digitatum, Penicillium expansium, etc.
-Thiabendazole also acts on decay produced by Aspergillus sp., Fusarium sp., Gloeosporium sp.
-Thiabendazole is used primarily to control mold, blight, and other fungal diseases in fruits (e.g. oranges) and vegetables.
-Thiabendazole is also used as a prophylactic treatment for Dutch elm disease.
-Thiabendazole is applied to bananas to ensure freshness, and is a common ingredient in the waxes applied to the skins of citrus fruits.
-Use in treatment of aspergillosis has been reported.
-Thiabendazole is also used in anti-fungal wallboards as a mixture with azoxystrobin.
-As an antiparasitic, Thiabendazole is able to control roundworms (such as those causing strongyloidiasis), hookworms, and other helminth species which infect wild animals, livestock, and humans.
-In dogs and cats, Thiabendazole is used to treat ear infections.
-Thiabendazole is also a chelating agent, which means Tiabendazole is used medicinally to bind metals in cases of metal poisoning, such as lead, mercury, or antimony poisoning.
-Thiabendazole has also been shown to serve as a vascular disrupting agent to reduce newly established blood vessels.
Thiabendazole has been shown to effectively do this in certain cancer cells.
-Thiabendazole works by inhibition of the mitochondrial, helminth-specific enzyme, fumarate reductase, with possible interaction with endogenous quinone.
-A number of derivatives of Thiabendazole are also pharmaceutical drugs, including albendazole, cambendazole, fenbendazole, oxfendazole, mebendazole, and flubendazole.
-Thiabendazole is also used as a food additive, a preservative with E number E233 (INS number 233).
-Thiabendazole (tiabendazole) fungicidal and anti-parasite molecule.
Used as food preservative and antihelmintic drug.
-Thiabendazole is a fungicide and parasiticide and is indicated for the treatment of: strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, trichinosis: relief of symptoms and fever and a reduction of eosinophilia have followed the use of this drug during the invasion stage of the disease.
-Thiabendazole may inhibit the helminthspecific enzyme fumarate reductase.
-It was shown that thiabendazole reversibly disassembles newly established blood vessels, marking it as vascular disrupting agent (VDA) and thus as a potential complementary therapeutic for use in combination with current anti-angiogenic therapies.
-Was confirmed, that thiabendazole slowed tumor growth and decreased vascular density in preclinical fibrosarcoma xenografts and thus, it could lead directly to the identification of a potential new therapeutic application for an inexpensive drug that is already approved for clinical use in humans.
-Tiabendazole (INN, BAN), thiabendazole (AAN, USAN), TBZ (and the trade names Mintezol, Tresaderm, and Arbotect) is a fungicide and parasiticide.
-Thiabendazole is used primarily to control mold, blight, and other fungal diseases in fruits (e.g. oranges) and vegetables.
Thiabendazole is also used as a prophylactic treatment for Dutch elm disease.
-Use in treatment of aspergillosis has been reported.
-As an antiparasitic, Thiabendazole is able to control roundworms (such as those causing strongyloidiasis), hookworms, and other helminth species which attack wild animals, livestock and humans.
-Tiabendazole has been shown to effectively do this in certain cancer cells.
-Medicinally, thiabendazole is also a chelating agent, which means Thiabendazole is used medicinally to bind metals in cases of metal poisoning, such as lead, mercury, or antimony poisoning.
-In dogs and cats, thiabendazole is used to treat ear infections.
-Thiabendazole is also used as a food additive, a preservative with E number E233 (INS number 233).
-Thiabendazole is applied to bananas to ensure freshness, and is a common ingredient in the waxes applied to the skins of citrus fruits.
-Thiabendazole (TBZ) is a broad-spectrum antihelminthic and is used to treat parasitic infections in humans.
-Thiabendazole is used as an agricultural fungicide and as a food preservative.
-Thiabendazole has been used as a heavy metal chelating detoxification agent.
-Thiabendazole is used clinically to treat threadworm, cutaneous larva migrans, visceral larva migrans, and trichinosis.
-Thiabendazole inhibits anaerobic respiration at the level of mitochondrial helminth-specific enzyme.
-Thiabendazole acts as a quinol-fumarate reductase (QFR) inhibitor in ,C. jejuni and H. pylori, blocking quinol oxidation to quinone.
-Thiabendazole suppresses egg and larval production and may inhibit the subsequent development of eggs and larvae which are passed in feces.
-Mintezol (thiabendazole) is an anthelmintic, or anti-worm, medication used to treat infections caused by worms such as threadworm.
-Thiabendazole may also be used to treat pinworm (when it occurs with threadworm), hookworm, whipworm, roundworm, and trichinosis.
-Thiabendazole, which is structurally related to albendazole and mebendazole, is used primarily for the treatment of several nematodes of cattle, horses, and sheep.
-Thiabendazole (TBZ) is a substance which has been receiving multiple important applications in several domains, from medicine and pharmaceutical sciences, to agriculture and food industry.
-Thiabendazole has been considered the mainstay of treatment for strongyloidiasis for decades, with a clinical efficacy of ∼90% in the immunocompetent host.
-Thiabendazole inhibits the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property, used as an anthelmintic and fungicide agent.
-Tiabendazole (INN, BAN), also known as thiabendazole (AAN, USAN) or TBZ, is a preservative, an antifungal agent, and an antiparasitic agent.
-Tiabendazole is a white compound used as an antifungal agent and as an anthelmintic.
-Thiabendazole (TBZ) is a broad-spectrum anthelmintic that is effective against gastrointestinal nematodes in ruminants and lungworms in sheep.
-Thiabendazole is effective against fungi and parasites.
-Thiabendazole is in agriculture as a plant protection product and in veterinary medicine.
-Thiabendazole is a broad spectrum antihelmintic agent used primarily in treatment of intestinal pinworm and strongyloides infection.
-Thiabendazole is used to treat infections caused by roundworms, hookworms, pinworms, whipworms, or threadworms.
-Thiabendazole (TBZ) is a broad-spectrum antihelminthic and is used to treat parasitic infections in humans.
-Thiabendazole is used as an agricultural fungicide and as a food preservative.
-Thiabendazole has been used as a heavy metal chelating detoxification agent.
-Thiabendazole is used clinically to treat threadworm, cutaneous larva migrans, visceral larva migrans, and trichinosis.
-Thiabendazole slows tumor growth.
-Thiabendazole is active against most intestinal nematodes that infect humans.
-Thiabendazole is effective against a broad spectrum of infectious agents.
PHYSICAL and CHEMICAL PROPERTIES of THIABENDAZOLE:
Molecular Formula: C10H6N2S2
Molar Mass: 218.298
Density: 1.415g/cm3
Melting Point: 298-301℃
Boling Point: 396.5°C at 760 mmHg
Flash Point: 192.5°C
Solubility: 0.005 g/100 mL
Vapor Presure: 3.89E-06mmHg at 25°C
Refractive Index: 1.731
water-soluble: 0.005g/100 mL
Appearance Form: powder
Odour: No data available
Odour: Threshold No data available
pH: No data available
Evaporation rate: No data available
Flammability (solid,gas): No data available
Upper/lower flammability or explosive limits: No data available
Relative density: No data available
XLogP3: 2.5
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 1
Exact Mass: 201.03606841
Monoisotopic Mass: 201.03606841
Topological Polar Surface Area: 69.8 Ų
Heavy Atom Count: 14
FIRST AID MEASURES of THIABENDAZOLE:
-General advice:
Consult a physician.
-If inhaled:
If breathed in, move person into fresh air.
Consult a physician.
-In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
-In case of eye contact:
Rinse out with plenty of water.
Remove contact lenses.
-If swallowed:
Rinse mouth with water.
Consult a physician.
ACCIDENTAL RELEASE MEASURES of THIABENDAZOLE:
-Advice for non-emergency personnel:
Use personal protective equipment.
-Environmental precautions
Do not let product enter drains.
-Methods and materials for containment and cleaning up
Cover drains.
Collect, bind, and pump off spills.
Take up dry.
Clean up affected area.
FIRE FIGHTING MEASURES of THIABENDAZOLE:
-Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
EXPOSURE CONTROLS/PERSONAL PROTECTION of THIABENDAZOLE:
-Eye/face protection:
Safety glasses.
-Skin Protection:
Use gloves.
-Respiratory protection:
Respiratory protection is not required.
-Control of environmental exposure:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
HANDLING and STORAGE of THIABENDAZOLE:
-Conditions for safe storage, including any incompatibilities:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Tightly closed.
Dry.
STABILITY and REACTIVITY of THIABENDAZOLE:
Reactivity: Not available.
Chemical stability: Stable under recommended temperatures and pressures.
SYNONYMS:
thiabendazole
Tiabendazole
Mintezol
2-(4-Thiazolyl)benzimidazole
1H-Benzimidazole, 2-(4-thiazolyl)
2-(1,3-Thiazol-4-yl)-1H-benzimidazol
2-(1,3-Thiazol-4-yl)-1H-benzimidazole
2-(4-Thiazoly)benzimidazole
2-(4-Thiazolyl)-1H-benzimidazole
2-(4-Thiazolyl)benzimidazole
thiabenzole
thibendole
thibenzol
thibenzole
tiabendazol
tiabendazole
bovizole
equizole
mintesol
minzolum
omnizole
Equizole
Mertec
Mertect
Mertect 160
Metasol TK 100
Mintesol
Mintezol
Minzolum
MK 360
Omnizole
Tebuzate
Tecto
Tecto 10P
Tecto 40F
Tecto 60
Testo
1H-Benzimidazole, 2-(4-thiazolyl)-
Benzimidazole, 2-(4-thiazolyl)-
Equizole
Mertect
Mertect 160
Metasol TK 100
Mintesol
Mintezol
Minzolu
MK 360
Omnizole
Tebuzate
Thibenzole 200
Tiabenda
Triasox
2-(Thiazol-4-yl)benzimidazole
2-(4-Thiazolyl)benzimidazole
2-(4'-Thiazolyl)benzimidazole
Apl-Luster; Bovizole
E-Z-Ex; Eprofil
Lombristo
Mycozol
Nemapan
Polival
Thiaben
Thibenzole ATT
Top form wormer
2-Thiazole-4-ylbenzimidazole
Arbotect
4-(2-Benzimidazolyl)thiazole
Bioguard
RPH
Storite
Tbdz
Tecto rph
Thiabenzazole
2-(4-Thiazolyl)-1H-benzimidazole
Tobaz
Tiabendazole
Equivet TZ
Tiabendazol
Tibimix 20
Thibendole
Thiabendole
Sistesan
Sanaizol 100
Chemviron TK 100
Tecto B
5-(4-Thiazolyl)benzimidazole
Ormogal; Cropasal
Drawipas; g 491
Hokustar HP
Mertect 340F
Mertect LSP
2-(1,3-Thiazol-4-yl)benzimidazole
Hymush;
Nemacin
Thiprazole
2-(4-Thiazolyl)-1H-benzoimidazole
4-(1H-Benzimidazol-2-yl)thiazole
Pitrizet
Metasol TK 25
Statin
2-(4-Thiazolyl)-1H-benzimidazole (thiabendazole)
