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THIAMINE MONONITRATE

CAS NUMBER: 532-43-4

EC NUMBER: 208-537-4

MOLECULAR FORMULA: C12H17N5O4S

MOLECULAR WEIGHT: 327.36

 

 

Thiamine mononitrate is a vitamin found in food and manufactured as a dietary supplement and medication.
Food sources of Thiamine mononitrate include whole grains, legumes, and some meats and fish.

Grain processing removes much of the thiamine content, so in many countries cereals and flours are enriched with thiamine.
Supplements and medications are available to treat and prevent thiamine deficiency and disorders that result from Thiamine mononitrate, including beriberi and Wernicke encephalopathy.

Other uses include the treatment of maple syrup urine disease and Leigh syndrome.
Thiamine mononitrates are typically taken by mouth, but may also be given by intravenous or intramuscular injection.

Thiamine mononitrate supplements are generally well tolerated.
Thiamine mononitrate is in the B complex family.

Thiamine mononitrate is an essential micronutrient, which cannot be made in the body.
Thiamine mononitrate is required for metabolism including that of glucose, amino acids, and lipids.

Thiamine mononitrate was discovered in 1897, was the first B vitamin to be isolated in 1926, and was first made in 1936.
Thiamine mononitrate is on the World Health Organization's List of Essential Medicines.

Thiamine mononitrate is available as a generic medication, and as an over-the-counter drug.
Thiamine mononitrate is a colorless organosulfur compound with an unpleasant sulfur odor. 

Thiamine mononitrates structure consists of an aminopyrimidine and a thiazolium ring linked by a methylene bridge. 
Thiamine mononitrate is substituted with methyl and hydroxyethyl side chains. 

Thiamine mononitrate is soluble in water, methanol, and glycerol and practically insoluble in less polar organic solvents. 
Thiamine mononitrate is a cation and is usually supplied as its chloride salt. 

The amino group can form additional salts with further acids. 
Thiamine mononitrate is stable at acidic pH, but is unstable in alkaline solutions.

Thiamine mononitrate is an enzyme cofactor used to catalyze benzoin condensations in vivo.
Thiamine mononitrate is unstable to heat and when exposed to ultraviolet light and gamma irradiation, but stable during frozen storage.

Thiamine mononitrate reacts strongly in Maillard-type reactions.
The first total synthesis of thiamine was reported in 1936.

Thiamine mononitrate is a synthetic stable nitrate salt form of Thiamine mononitrate that has been used for the preparation and assay of various multi-vitamin formulations and as an additive to foods to compensate for losses during processing.
Thiamine mononitrate is one of the 13 essential vitamins for the human body. 

Thiamine mononitrate is a water-soluble vitamin and belongs to the vitamin B family. 
Thiamine mononitrate was eventually designated the generic denomination vitamin B1. 

Thiamine mononitrates phosphate derivatives participate in many cellular processes. 
The best form is Thiamine mononitrate, a coenzyme for the catabolism of sugars and amino acids.

Thiamine mononitrate is vitamin B1. Thiamine is found in foods such as cereals, whole grains, meat, nuts, beans, and peas. 
Thiamine mononitrate is important in the breakdown of carbohydrates from foods into products needed by the body.

Thiamine mononitrate is used to treat or prevent vitamin B1 deficiency. 
Thiamine mononitrate taken by mouth (oral) is available without a prescription. 

Injectable Thiamine mononitratethiamine must be given by a healthcare professional.
Thiamine mononitrate may also be used for purposes not listed in this medication guide.

Thiamine mononitrate or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS. 
Thiamine mononitrate is soluble in water and insoluble in alcohol. 

Thiamine mononitrate decomposes if heated. 
Thiamine mononitrate was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. 

Thiamine mononitrate plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. 
Thiamine mononitrate plays an important role in helping the body convert carbohydrates and fat into energy. 

Thiamine mononitrate is essential for normal growth and development and helps to maintain proper functioning of the heart and the nervous and digestive systems. 
Thiamine mononitrate cannot be stored in the body; however, once absorbed, the vitamin is concentrated in muscle tissue.

Thiamine mononitrate is a vitamin, also called vitamin B1. 
Thiamine mononitrate is found in many foods including yeast, cereal grains, beans, nuts, and meat. 

Thiamine mononitrate is often used in combination with other B vitamins, and found in many vitamin B complex products. 
Thiamine mononitrate complexes generally include vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin/niacinamide), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), and folic acid. 

However, some products do not contain all of these ingredients and some may include others, such as biotin, para-aminobenzoic acid (PABA), choline bitartrate, and inositol.
Thiamine mononitrate is required by our bodies to properly use carbohydrates. 

Thiamine mononitrate also helps maintain proper nerve function.
Thiamine mononitrate belongs to the class of organic compounds known as thiamines. 

Thiamine mononitrates are compounds containing a thiamine moiety, which is structurally characterized by a 3-[(4-Amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-5-yl backbone.
Thiamine mononitrate is a very strong basic compound (based on its pKa).

Thiamine mononitrate is one of themost unstable vitamins: Thiamine mononitrate is highly affected by heat,light, alkaline pH, the presence of some food ingredients, radiation, inorganic bases, and processing treatments. 
The susceptibility of thiamine to these conditions makes Thiamine mononitrates delivery in processed, shelf-stable foods and dietary supplements challenging.

When Thiamine mononitrate degrades, off-flavors develop due to formation of sulfur-containing degradation products, thereby affecting not only vitamin label claims but also product acceptability as degradation proceeds. 
Therefore, understanding factors that affect the stability of thiamine in foods and dietary supplements is important for shelf-life, nutritional labeling, and food quality considerations

Thiamine Mononitrate, USP is the mononitrate salt form of a material also known as vitamin B1. 
All Spectrum Chemical USP grade products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP).

Thiamine mononitrate is vitamin B1. Thiamine is found in foods such as cereals, whole grains, meat, nuts, beans, and peas. 
Thiamine mononitrate is important in the breakdown of carbohydrates from foods into products needed by the body. 

Thiamine mononitrate is used to treat or prevent vitamin B1 deficiency.
Thiamine mononitrate (C12H17N5O4S, CAS Reg. No. 532-43-4) is the mononitrate salt of thiamine. 

Thiamine mononitrate occurs as white crystals or a white crystalline powder and is prepared from thiamine hydrochloride by dissolving the hydrochloride salt in alkaline solution followed by precipitation of the nitrate half-salt with a stoichiometric amount of nitric acid.
Thiamine mononitrate, the salt formed from one mole of thiamine base and one mole of nitric acid, occurs as an anhydrous crystalline solid of low hygroscopicity, differing in this respect from thiamine hydrochloride. 

The stability of thiamine mononitrate was investigated in sterile solutions, compressed tablets, multivitamin capsules and dry-filled capsules. 
Assay data are given to show that thiamine mononitrate is more stable than thiamine hydrochloride in these preparations. 

The use of thiamine mononitrate in B complex capsules eliminated the need for an acidic stabilizer, the presence of which accelerated the decomposition of the pantothenic acid component.
Thiamine mononitrate, also known as thiamin or vitamin B0. 

Thiamine mononitrate is found in many foods including yeast, cereal grains, beans, nuts, and meat. 
Thiamine mononitrate is often used in combination with other B vitamins, and found in many vitamin B complex products. 

Thiamine mononitrate complexes generally include vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin/niacinamide), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), and folic acid.
Thiamine mononitrate is a synthetic stable nitrate salt form of vitamin B1. 

Thiamine mononitrate is also known as vitamin B1 nitrate and has the molecular formula C12H17N5O4S. 
The molar weight is 327.36 g/mol.

Thiamine mononitrate can be manufactured from thiamine hydrochloride. 
Thiamine mononitrate is produced by removing chloride ion and mixing with nitric acid. 

Then, Thiamine mononitrate ion combines with the thiamine molecule. 
Thiamine mononitrate is more stable than Thiamine hydrochloride.

Thiamine mononitrate can be used in multivitamin formulations and as a food and feed additive.
Thiamine mononitrate provides thiamine (Vitamin B1), an essential dietary nutrient. 

Thiamine mononitrate intake is necessary for the metabolic function of mitochondrial Adenosine triphosphate (ATP) synthesis as well as metabolism of carbohydrates, fat and protein.
Thiamine mononitrate helps the body generate energy from nutrients. 

Also known as Thiamine mononitrate, Thiamine mononitrate is necessary for the growth, development and function of cells.
Most people get enough Thiamine mononitrate from the food they eat. 

Foods rich in thiamin include yeast, legumes, pork, brown rice, as well as fortified foods, such as breakfast cereals. 
However, heating foods containing thiamin can reduce thiamin content. 

Thiamine mononitrate can also be taken as a supplement, typically orally.
Thiamine mononitrate, or vitamin B1, is a water-soluble vitamin found naturally in some foods, added to foods, and sold as a supplement. 

Thiamine mononitrate plays a vital role in the growth and function of various cells.
Only small amounts are stored in the liver, so a daily intake of thiamin-rich foods is needed.

Thiamine mononitrate is a synthetic stable nitrate salt form of the water-soluble Vitamin B1. 
Thiamine mononitrate is a white crystalline powder.

Thiamine mononitrate, often referred to as vitamin B1, is an essential human nutrient involved in a variety of cellular processes, such as the synthesis of amino acids or the use of sugars as energy. 
Though the compound is required by the biology of all animals on Earth, it is only generated in primitive organisms such as bacteria and plant life, so human beings must obtain it through their food or nutritional supplements. 

When thiamine mononitrate is added as a supplement to foods such as breakfast cereals, it is often referred to in a broader context as a B-vitamin complex. 
Thiamine mononitrate is commonly referred to as vitamin B1. 

Thiamine mononitrate form of vitamin B is known as ‘aneurin’ in Europe and the UK. 
Thiamine mononitrate is the nitrate salt form of thiamine and it is present in various multivitamins. 

The chemical formula that describes this element is C12H17N5O4S. 
Thiamine mononitrates molecular weight is 327.36. 

Thiamine mononitrate comes in the form of white-yellowish, water soluble, crystal powder.
Thiamine mononitrate may be better known to you as B1 or simply thiamine. 

One of many B-complex vitamins, thiamine mononitrate was the first to be identified.
Our bodies cannot produce thiamine mononitrate. 

Thiamine mononitrate must come from a balanced diet or from supplements. 
Thiamine mononitrate is widely available in pill form but can also be found as an injection.

Thiamine mononitrate helps to breakdown food for energy. 
Thiamine mononitrate is essential for brain development and supports the immune system. 

Thiamine mononitrate can also help reduce cell damage from stress.
Thiamine mononitrate is the thiamine salt formed from one mole of thiamine base and one mole of nitric acid. 

Thiamine mononitrate occurs as an anhydrous crystalline solid of low hygroscopicity. Thiamin (vitamin B1) is a member of the vitamin B complex. Attributing to low hydroscopicity, thiamine nitrate works as a more stable form of thiamine in pharmaceutical preparations.
Thiamine mononitrate is preferred to be used for the preparation of multivitamins and as a food fortification in dry blends and dry products such as in wheat flour.

 

 

 

USES OF THIAMINE MONONITRATE:


Thiamine mononitrate can protect the nervous system and promote gastrointestinal motility and increase appetite.    
Thiamine mononitrate mainly plays the role of sugar and sugar (starch) in the process of digestion in the food, and finally produces energy; at the same time, it is necessary for muscle coordination and maintenance of nerve conduction.

Thiamine mononitrate also has a moderate diuretic effect.     
Thiamine Mononitrate is a medicine that is used for the treatment of Thiamine deficiency, Beriberi and other conditions.

Thiamine mononitrate is a water soluble vitamin found in many foods including yeast, cereal grains, nuts and meat. 
Thiamine mononitrates are often found in the grain bran. People take thiamine for thiamine deficiency conditions including beriberi, neuritis(nerves inflammation) etc. 

Thiamine mononitrate also functions to provide the body with adequate positive mental energy and assist with memory related problems.
Thiamine mononitrate is one of the two forms of vitamin B1, the other one being thiamine hydrochloride. 

Thiamine mononitrate is a synthetic stable nitrate salt form of vitamin B1. 
Thiamine mononitrate is in the form of white crystals or crystalline powder, little soluble in water. 

Thiamine mononitrate has been used for the preparation and assay of various multi-vitamin formulations. 
Thiamine mononitrate is used for food fortification, as the mononitrate is more stable than thiamine hydrochloride and does not absorb water from natural humidity, being non-hygroscopic.
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The complete list of uses and indications for Thiamine Mononitrate is as follows:

-Thiamine deficiency
-Beriberi

 

 


USAGE AREAS OF THIAMINE MONONITRATE:


-Nutritional Supplements 

-Sport Nutrition 

-Protein Shake 

-Pharmaceutical field 

-Medical Usage 

 

 

BENEFITS OF THIAMINE MONONITRATE:

 

-Alcohol or other substance abusers by accelerating metabolism

-Those with poor nutritional dietary intake

-Age greater than 55 years old

-Women who are breastfeeding or pregnant

-Recent surgery patients

-Those with liver disease, overactive thyroid, or prolonged diarrhea

 

 

PROPERTIES OF THIAMINE MONONITRATE:


-Quality Level: 200

-assay: ?98% (HPLC)

-form: powder

-application(s): HPLC: suitable

-color: white to off-white

-Melting point: 374-392 °C

-storage temp.: 2-8°C

-SMILES string: [O-][N+]([O-])=O.CC1=NC=C(C[N+]2=CSC(CCO)=C2C)C(N)=N1

-InChI: 1S/C12H17N4OS.NO3/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;2-1(3)4/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);/q+1;-1

-InChI key: UIERGBJEBXXIGO-UHFFFAOYSA-: 

 

 

PHYSICAL AND CHEMICAL PROPERTIES OF THIAMINE MONONITRATE:

 

-appearance: White crystalline or crystalline powder

-solubility: Soluble in water and slightly soluble in alcohol and chloroform

-melting point: 196 - 200 ºC

-PH: 6.5 - 7.1

-odor: wh. cryst. or cryst. powd., sl. char. odor

-molecular weight: 327.36

-pratically insoluble: roscopic

-slightly soluble: in alcohol, chloroform

 

 

FUNCTION OF THIAMINE MONONITRATE: 

Thiamine mononitrates phosphate derivatives are involved in many cellular processes. 
The best-characterized form is Thiamine mononitrate, a coenzyme in the catabolism of sugars and amino acids. 

In yeast, Thiamine mononitrate is also required in the first step of alcoholic fermentation. 
All organisms use thiamine, but Thiamine mononitrate is made only in bacteria, fungi, and plants. 

Thiamine is usually considered as the transport form of the vitamin. 
Five natural thiamine phosphate derivatives are known: thiamine monophosphate (ThMP), thiamine diphosphate (ThDP), also sometimes called thiamine pyrophosphate (TPP), thiamine triphosphate (ThTP), the most recently discovered adenosine thiamine triphosphate (AThTP), and adenosine thiamine diphosphate (AThDP). 
While the coenzyme role of Thiamine mononitrate is well-known and extensively characterized, the non-coenzyme action of thiamine and derivatives may be realized through binding to a number of recently identified proteins which do not use the catalytic action of thiamine diphosphate.

 

 

APPEARANCE OF THIAMINE MONONITRATE:

White crystalline or crystalline powder

 

 

SOLUBILITY OF THIAMINE MONONITRATE:

White crystalline or crystalline powder

 

 

STORAGE OF THIAMINE MONONITRATE:

Store long-term in a cool, dry place

 

SYNONYM:

thiamine nitrate
532-43-4
THIAMINE MONONITRATE
Vitamin B1 nitrate
Vitamin B1 mononitrate
UNII-8K0I04919X
Thiamine mononitrate [USP]
MFCD00036330
2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol;nitrate
8K0I04919X
Aneurine mononitrate
Thiaminenitrate
Aneurine nitrate
Thiamine mononitrate (USP)
3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium nitrate
Betabion mononitrate
C12H17N5O4S
Thiamine nitrate (salt)
Vitamin B(sub 1) nitrate
Mononitrato de tiamina
EINECS 208-537-4
Thiamin nitrate
Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, nitrate (1:1)
Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-, nitrate (1:1)
Vitanon (TN)
Thiamine nitrate, 95%
Thiamine Mononitrate,(S)
Thiamine nitrate (JP17)
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium nitrate
3-(4-Amino-2-methylpyrimidyl-5-methyl)-4-methyl-5,beta-hydroxyethylthiazolium nitrate
DSSTox_CID_18762
DSSTox_RID_79391
DSSTox_GSID_38762
SCHEMBL60971
Thiamine nitrate, AldrichCPR
Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, nitrate (salt)

 

 

IUPAC NAME:

2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol nitrate
3 - (4-ammino-2-methylpyrimidyl-5-metil)-4-metil-5, b-hydroxyethylthiazolium nitrate
3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium nitrate
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium nitrate
Thiamine nitrate
thiamine nitrate
Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-, nitrate (1:1)

 

 

 

 

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