PRODUCTS

THIODIPROPIONIC ACID

THIODIPROPIONIC ACID = 3,3'-THIOBISPROPANOIC ACID = THIODIHYDRACRYLIC ACID = TDPA

CAS Number: 111-17-1
EC Number: 203-841-3
MDL number: MFCD00002781
Linear Formula: S(CH2CH2COOH)2

Thiodipropionic acid (3,3'-Thiobispropanoic acid) is a dicarboxylic acid.
Thiodipropionic acid is a white crystalline solid having a slight characteristic odour.
Thiodipropionic acid is a carboxylic acid also known as Bis(2-carboxyethyl) sulfide.
Thiodipropionic Acid is a dicarboxylic acid that contains a sulfur group.

Dilauryl Thiodipropionate, Dicetyl Thiodipropionate, Dimyristyl Thiodipropionate, Distearyl Thiodipropionate and Ditridecyl Thiodipropionate are diester derivatives of Thiodipropionic Acid with similar functions.
This means that there is one carbon chain (with a chain length of 12 to 18 carbons) attached to each oxygen of the carboxyl groups.

Among these ingredients, Thiodipropionic Acid and Dilauryl Thiodipropionate are most common in cosmetics and personal care products including eye and face makeup products, and skin care preparations.
Thiodipropionic Acid or Thiodipropanoic acid is a dicarboxylic acid with the condensed structural formula S(CH2CH2COOH)2.
Thiodipropionic Acid is also a thioether , bis(2-carboxyethyl) sulfide.

Thiodipropionic acid derived from the processing of phosphate rocks, Thiodipropionic acid is used as a food additive , E388 as an antioxidant .
Thiodipropionic Acid (TDPA) is a high purity, free flowing white powder without caking tendency.
The water solution of Thiodipropionic Acid is colorless and the transparency is very high.
Classification: Dicarboxylic acids and derivatives

USES and APPLICATIONS of THIODIPROPIONIC ACID:
-Thiodipropionic acid is an organic disulfide that can be used as a ligand for the synthesis of cadminum and zinc coordination polymers with luminescent properties.
-Thiodipropionic acid for synthesis.
-Cosmetic Uses: skin conditioning

-Thiodipropionic acid was used as a reactant to synthesize bis(phenylacetamidothiadiazolyl)ethyl sulfide analogs as glutaminase inhibitors and antitumor agents.
-Thiodipropionic acid can also be used as precursor substrate for synthesis of 3-mercaptopropionic acid (M257070) containing polythioesters.

-Acid-based synthetic antioxidant.
-In theory, and when stably packaged, Thiodipropionic acid should exert an antioxidant effect when applied topically.
-Antioxidant for soap products and polymers of ethylene.
-In plasticizers and lubricants.
-Proposed for edible fats, oils, other foods.

-Thiodipropionic acid is used as an antioxidant in cosmetic and food products.
-Why is Thiodipropionic acid used in cosmetics and personal care products?
Thiodipropionic acid and Thiodipropionic acid's derivatives prevent or slow the deterioration of cosmetic and personal care products by inhibiting reactions that occur through contact with oxygen in the air.
-Thiodipropionic acid reduces the oxidation of soybean oil , olive oil and palm oil , and also prevents the breakdown of vitamin E in these oils.

-Thiodipropionic acid is a halal , kosher and vegetarian antioxidant.
-Antioxidant in food packaging, soaps, plasticizers, lubricants, fats, and oils.
-Thiodipropionic acid is an antioxidant used to prevent fats and oils from going rancid.
Thiodipropionic acid has the same functionality as bha, bht, and propyl gallate.

-Thiodipropionic acid is used as an antioxidant for fats and other foodstuffs.
-Thiodipropionic acid is used as iThiodipropionic acid is, after neutralization to make alkaline metal salt and after esterfication to make esters.
-Thiodipropionic acid’s an antioxidant, and used in the production of thioesters antioxidant.

-Thiodipropionic acid can be used in ubricating oil and rubber.
-Thiodipropionic acid can be used in combination with phenollic antioxidant to produce synergistic effect.
-Thiodipropionic acid was used as a reactant to synthesize bis(phenylacetamidothiadiazolyl)ethyl sulfide analogs as glutaminase.

PHYSICAL and CHEMICAL PROPERTIES of THIODIPROPIONIC ACID:
Molecular Weight: 178.21
Appearance Form: powder
Color: beige
Odor: No data available
Odor Threshold: No data available
pH: No data available
Melting point/range: 131 - 134 °C - lit.

Initial boiling point and boiling range: No data available
Flash point: 128 °C - closed cup
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Molecular Weight: 178.21

XLogP3-AA: -0.1
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 5
Rotatable Bond Count: 6
Exact Mass: 178.02997997
Monoisotopic Mass: 178.02997997
Topological Polar Surface Area: 99.9 Å²

Heavy Atom Count: 11
Formal Charge: 0
Complexity: 130
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Solubility:
Water: 1 g is soluble in about 30 ml
Acetone: Freely soluble
Ethanol: Freely soluble

FIRST AID MEASURES of THIODIPROPIONIC ACID:
-General advice:
Consult a physician.

-If inhaled:
If breathed in, move person into fresh air.
Consult a physician.

-In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.

-In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

-If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

ACCIDENTAL RELEASE MEASURES of THIODIPROPIONIC ACID:
-Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
Ensure adequate ventilation.

-Environmental precautions:
Do not let product enter drains.

-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.

FIRE FIGHTING MEASURES of THIODIPROPIONIC ACID:
-Extinguishing media:
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

-Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.

EXPOSURE CONTROLS/PERSONAL PROTECTION of THIODIPROPIONIC ACID:
-Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

-Eye/face protection:
Safety glasses

-Skin protection:
Handle with gloves.
Wash and dry hands.

-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of THIODIPROPIONIC ACID:
-Precautions for safe handling:
Normal measures for preventive fire protection.

-Conditions for safe storage, including any incompatibilities:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.

STABILITY and REACTIVITY of THIODIPROPIONIC ACID:
-Reactivity: No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions: No data available
-Conditions to avoid: No data available

SYNONYMS:
Bis(2-carboxyethyl) sulfide
Propanoic acid, 3,3'-thiobis-
Propionic acid, 3,3'-thiodi-
β,β'-Thiodipropionic acid
Diethyl sulfide 2,2'-dicarboxylic acid
Thiodihydracrylic acid
Tyox A
TDPA
NSC 8166
4-Thiaheptanedioic acid
Kyselina β,β'-thiodipropionova
Sulfide, bis(2-carboxyethyl)
Kyselina 3,3-thiodipropionova
3,3'-Thiobis-propanoic acid
3,3'-Thiodipropionic acid
3,3'-Thiodipropanoic acid
3,3'-Thiodi-propionic Acid
3,3'-Thiobis(propanoic acid)
3,3'-Thiodi(propionic acid)
Bis(2-carboxyethyl) Sulfide
Diethyl Sulfide 2,2'-Dicarboxylic AciD
Tyox A
b,b-thiodipropionic acid
thiodihydracrylic acid
diethyl sulfide 2,2¢-dicarboxylic acid
3,3'-Thiodi(propionic acid)
Bis(2-carboxyethyl) sulfide
Propanoic acid, 3,3'-thiobis-
Thiahydracrylic acid
3-(2-carboxyethylsulfanyl)propanoic acid
3-(2-carboxyethylthio)propanoic acid
3-(2-carboxyethylthio)propionic acid
3-[(2-carboxyethyl)sulfanyl]propanoic acid
Propionic acid, 3,3'-thiodi-
4-Thiaheptanedioic acid
Bis(2-carboxyethyl) sulfide
Diethyl sulfide 2,2'-dicarboxylic acid
Kyselina 3,3-thiodipropionova
Kyselina beta,beta'-thiodipropionova
TDPA
Thiahydracrylic acid
Thiodihydracrylic acid
Thiodipropionic acid
Tyox A
3-(2-carboxyethylsulfanyl)propanoic acid