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Thioglycolic Acid 99%, cosmetic grade (TGA 99 cosm) by Bruno Bock acts as a restructuring and depilatory agent.
The reducing properties of the SH-group open the sulfur bridges in the keratin structure of the hair and thus weaken Thioglycolic Acid 99%.
After rinsing, the sulfur bridges are reconnected with an oxidizing chemical such as hydrogen-peroxide.
CAS: 68-11-1
MF: C2H4O2S
MW: 92.12
EINECS: 200-677-4
Synonyms
2-MERCAPTOACETIC ACID;2-mercaptoacetate;2-Thioglycolic acid;2-thio-glycolicaci;2-thioglycolicacid;Aceticacid,mercapto-;Acide thioglycolique;acidethioglycolique
If both steps are applied to hair tightly wrapped around hair rollers the hair fibers get its desired curled shape.
Thioglycolic Acid 99%, cosmetic grade (TGA 99 cosm) is used in production of permanent wave and depilatory formulations.
Thioglycolic Acid 99% is the organic compound HSCH2CO2H.
Thioglycolic Acid 99% contains both a thiol (mercaptan) and a carboxylic acid.
Thioglycolic Acid 99% is a clear liquid with a strong unpleasant odor.
Thioglycolic Acid 99% is readily oxidized by air to the corresponding disulfide [SCH2CO2H]2.
Thioglycolic Acid 99% was developed in the 1940s for use as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate.
Thioglycolic Acid 99% is the precursor to ammonium thioglycolate that is used for permanents.
Thioglycolic Acid 99% and its derivatives break the disulfide bonds in the cortex of hair.
One reforms these broken bonds in giving hair a "perm."
Alternatively and more commonly, the process leads to depilation as is done commonly in leather processing.
Thioglycolic Acid 99% is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.
Thioglycolic Acid 99% is also used in the making of tin stabilizers often used in certain polyvinyl chloride products (such as vinyl siding).
Thioglycolic Acid 99%, usually as its dianion, forms complexes with metal ions.
Such complexes have been used for the detection of iron, molybdenum, silver, and tin.
Thioglycolic Acid 99% is used as nucleophile in thioglycolysis reactions used on condensed tannins to study their structure.
Thioglycolic Acid 99% is a sulfur-containing carboxylic acid.
Thioglycolic Acid 99% is a conjugate acid of a thioglycolate(1-).
A colorless liquid with an unpleasant odor. Density 1.325 g / cm3.
Used to make permanent wave solutions and depilatories. Corrosive to metals and tissue.
The Thioglycolic Acid 99% also called Mercaptoacetic acid (MAA) (CAS 68-11-1) is a high-performance chemical containing mercaptan and carboxylic acid functionalities.
Thioglycolic Acid 99% is completely miscible in water and in general polar organic solvents.
Thioglycolic Acid 99% is a strong reducing agent especially at high pH and forms powerful complexes with metals that give it specific characteristics.
Thioglycolic Acid 99% is used in industries and applications as diverse as cosmetics, oil and gas, polymerization, fine chemistry, leather processing, cleaning, and metals receovery.
Thioglycolic Acid 99%, also known as Mercaptoacetic Acid.
Thioglycolic Acid 99% contains both a thiol and carboxylic acid functional groups.
Thioglycolic Acid 99% is a colorless liquid with a strongly unpleasant odor.
Thioglycolic Acid 99% is miscible with polar organic solvents.
Thioglycolic Acid 99% is colorless or slight yellow clarity liquid, with a physical properties as below:a melting point -16.5°C, boiling point 123 °C,(3.866KPa), opposite density (d420) 1.2-1.32, refractive index 1.5030, well mixed with water, alcohol and aether, with highly causticity.
Thioglycolic Acid 99% is widely used in cosmetics, pharmaceutical, rubber, pesticide, detergent and personal care industries.
Thioglycolic Acid 99%is an important intermediate or organic chemical material in the above related product manufacture process.
Thioglycolic Acid 99% is a colorless liquid with a strong unpleasant odor like rotten eggs.
Also known as mercaptoacetic acid, HSCH2COOH is a colorless liquid with a strong unpleasant odor.
Used as a reagent for metals such as iron, molybdenum, silver, and tin,and in bacteriology.
Thioglycolic Acid 99% is the organic compound HSCH2CO2H.
Thioglycolic Acid 99% is often called mercaptoacetic acid (MAA).
Thioglycolic Acid 99% contains both a thiol (mercaptan) and carboxylic acid functional groups.
Thioglycolic Acid 99% is a colorless liquid with a strongly unpleasant odor.
Thioglycolic Acid 99% is miscible with polar organic solvents.
Thioglycolic Acid 99% Chemical Properties
Melting point: −16 °C(lit.)
Boiling point: 96 °C5 mm Hg(lit.)
Density: 1.326 g/mL at 20 °C(lit.)
Vapor density: 3.2 (vs air)
Vapor pressure: 0.4 mm Hg ( 25 °C)
Refractive index: n20/D 1.505(lit.)
Fp: 126 °C
Storage temp.: Store at +2°C to +8°C.
Solubility: Chloroform (Sparingly), Methanol (Sparingly)
Form: Liquid
pka: 3.68(at 25℃)
Color: clear clear, colorless
Odor: strong unpleasant odor
PH: 1 (H2O, 20℃)
Water Solubility: soluble
Sensitive: Air Sensitive
Merck: 14,9336
BRN: 506166
Exposure limits: TLV-TWA 1 ppm (～3.8 mg/m3) (ACGIH).
Stability: Air Sensitive
InChIKey: CWERGRDVMFNCDR-UHFFFAOYSA-N
LogP: 0.090
CAS DataBase Reference: 68-11-1(CAS DataBase Reference)
NIST Chemistry Reference: Thioglycolic Acid 99%(68-11-1)
EPA Substance Registry System: Thioglycolic Acid 99% (68-11-1)
Thioglycolic Acid 99% is a colorless liquid with a strong unpleasant odor like rotten eggs.
Also known as Thioglycolic Acid 99%, HSCH2COOH is a colorless liquid with a strong unpleasant odor.
Used as a reagent for metals such as iron, molybdenum, silver, and tin,and in bacteriology.
Uses
Thioglycolic Acid 99% is an organic compound containing both a thiol and a carboxylic acid. Thioglycolic Acid 99% is a precursor to ammonium thioglycolate, a chemical used for permanents.
Thioglycolic Acid 99% is used in organic synthesis as a nucleophile in thioglycolysis reactions and is used as a S transfer agent for sulfonyl chloride synthesis.
Sensitive reagent for iron, molybdenum, silver, tin.
With ferric iron a blue color appears, and when an alkali hydroxide is added to a solution contg ferrous salts and Thioglycolic Acid 99%, a yellow precipitate forms.
Used in the manufacture of thioglycolates.
The ammonium and sodium salts are commonly used for cold waving and the calcium salt is a depilatory.
The sodium salt also is used in bacteriology in the preparation of thioglycolate media.
Mercaptoacetic acid is used as a reagent formetals analysis; in the manufacture of thioglycolates, pharmaceuticals, and permanentwave solutions; and as a vinyl stabilizer.
Thioglycolic Acid 99% is an intermediate in the production of thiomethoprol (caputril), biotin, thiozinc acid, sodium dithiosuccinate and other pharmaceuticals, and is also an intermediate in the synthesis of cysteine, hormonal agent, and industrial disinfectant.
And an important raw material for the synthesis of sulfuric acid.
Thioglycolic Acid 99% is used as antioxidant and stabilizer in pharmaceuticals to enhance the stability of the main drug and prolong the validity period of pharmaceutical preparations.
Ammonium and sodium salts of Thioglycolic Acid 99% are mainly used as curling agents, calcium salts can be used as depilatory agents, polymerization initiators, accelerators and chain transfer agents, and can be used for hair removal before cosmetic surgery and animal experiments.
Thioglycolic Acid 99% is used to make epoxy resin, catalyst of bisphenol A, and it can also be used as the basic raw material for synthesizing PVC transparent plastic and organic antimony and organic tin heat stabilizer.
Thioglycolic Acid 99% is a sensitive reagent for the determination of iron, molybdenum, aluminum, tin, etc., and is an inhibitor of copper sulfide and iron sulfide minerals in beneficiation.
In the petrochemical industry and the railway sector, Thioglycolic Acid 99% is used for cleaning and derusting of equipment and rails.
Thioglycolic Acid 99% can be used as a crystallization nucleating agent in polypropylene processing and molding, as a modifier for coatings and fibers, as a blanket quickening agent, as a stabilizer raw material for polyvinyl chloride and rubber, as a cold perm agent, and as a pharmaceutical intermediate.
Thioglycolic Acid 99% is used as a color developer for the photometric determination of molybdenum, rhenium and iron, and as a compounding masking agent.
Thioglycolic Acid 99% is a very good activator and catalyst for epoxy resin and bisphenol A production.
Thioglycolic Acid 99% is also the the main material of cosmetics such as cold wave lotion and depilatory.
Thioglycolic Acid 99% can also be used as restraining agent for copper sulfide, chemical mineral processing reagent, acid reagent.
Thioglycolic Acid 99% may also wok as an important organic reagent for metallic ion such as iron, molybdenum, silver and tin, etc.
Thioglycolic Acid 99% is the organic compound HSCH2CO2H.
Thioglycolic Acid 99% is often called mercaptoacetic acid (MAA).
Thioglycolic Acid 99% contains both a thiol (mercaptan) and carboxylic acid functional groups.
Thioglycolic Acid 99% is a colorless liquid with a strongly unpleasant odor.
Thioglycolic Acid 99% is miscible with polar organic solvents.
Thioglycolic Acid 99% is used as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate.
Thioglycolic Acid 99% is the precursor to ammonium thioglycolate, which is used for permanents.
Thioglycolic Acid 99% and its derivatives break the disulfide bonds in the cortex of hair.
One reforms these broken bonds in giving hair a "perm".
Alternatively and more commonly, the process leads to depilation, as is done commonly in leather processing.
Thioglycolic Acid 99% is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.
Thioglycolysis reactions are used on condensed tannins to study their structure.
Thioglycolic Acid 99% has also been used to soften nails, either to reshape pincer nails into the correct position or to help the topical antifungal agent terbinafine penetrate the nail.
Organotin derivatives of Thioglycolic Acid 99% isooctyl esters are widely used as stabilizers for PVC.
These species have the formula R2Sn(SCH2CO2C8H17)2.
Thioglycolic Acid 99% is a component of thioglycolate broth, a special bacterial growth media.
Thioglycolic Acid 99% is also used in so-called "fallout remover" or "wheel cleaner" to remove iron oxide residue from wheels.
Ferrous iron combines with thioglycolate to form red-violet ferric thioglycolate.
Preparation
Thioglycolic Acid 99% is prepared from Sodium sulfide plus Sodium monochloride acetate to yield Dithioglycollic acid.
Electrolysis of the latter acid yields the title material.
Reactivity Profile
Thioglycolic Acid 99% is readily oxidized by air.
Reacts readily with other oxidizing agents as well in reactions that may generate toxic gases.
Incompatible with diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents.
Reactions with these materials may generate heat and toxic and flammable gases.
May react with acids to liberate hydrogen sulfide.
Neutralizes bases in exothermic reactions.
Reacts with cyanides, sulfites, nitrites, thiosulfates to generate flammable and toxic gases and heat.
Reacts with carbonates and bicarbonates.
Health Hazard
Thioglycolic Acid 99% is a highly toxic and ablistering compound.
Even a 10% solutionwas lethal to most experimental animals by dermal absorption.
The oral LD50 value ofundiluted acid is less than 50 mg/kg (Patty1963).
The lethal dose in rabbits by skinabsorption is 300 mg/kg.
The acute toxicsymptoms in test animals include weakness, respiratory distress, convulsions, irritation ofthe gastrointestinal tract, and liver damage.
Thioglycolic Acid 99% is a severe irritant.
Contact with eyes can cause conjunctivalinflammation and corneal opacity.
Skin contact can result in burns and necrosis.
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes.
Avoid any skin contact.
Effects of contact or inhalation may be delayed.
Fire may produce irritating, corrosive and/or toxic gases.
Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Mercaptoacetic acid is readily oxidized by air.
Reacts readily with other oxidizing agents as well in reactions that may generate toxic gases.
Incompatible with diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents.
Reactions with these materials may generate heat and toxic and flammable gases.
May react with acids to liberate hydrogen sulfide.
Neutralizes bases in exothermic reactions.
Reacts with cyanides, sulfites, nitrites, thiosulfates to generate flammable and toxic gases and heat.
Reacts with carbonates and bicarbonates.
Production
Thioglycolic Acid 99% is prepared by reaction of sodium or potassium chloroacetate with alkali metal hydrosulfide in aqueous medium.
Thioglycolic Acid 99% can be also prepared via the Bunte salt obtained by reaction of sodium thiosulfate with chloroacetic acid:
ClCH2CO2H + Na2S2O3 → Na[O3S2CH2CO2H] + NaCl
Na[O3S2CH2CO2H] + H2O → HSCH2CO2H + NaHSO4
Reactions
Thioglycolic Acid 99% with a pKa of 3.83 is an acid about 8.5 times stronger than acetic acid (pKa 4.76):
HSCH2CO2H → HSCH2CO2− + H+
The second ionization has a pKa of 9.3:
HSCH2CO2− → −SCH2CO2− + H+
Thioglycolic Acid 99% is a reducing agent, especially at higher pH.
Thioglycolic Acid 99% oxidizes to the corresponding disulfide (2-[(carboxymethyl)disulfanyl]acetic acid or dithiodiglycolic acid):
2 HSCH2CO2H + "O" → [SCH2CO2H]2 + H2O
