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THIOGLYCOLIC ACID (MERCAPTOACETIC ACID)

Thioglycolic acid (Mercaptoacetic acid) is a colorless liquid with a strong unpleasant odor like rotten eggs.
Thioglycolic acid (Mercaptoacetic acid) is a sulfur-containing carboxylic acid. 
Thioglycolic acid (Mercaptoacetic acid) is a conjugate acid of a thioglycolate(1-).

CAS Number: 68-11-1
Molecular Formula: C2H4O2S
Molecular Weight: 92.12
EINECS Number: 200-677-4

Synonyms: mercaptoacetic acid, thioglycolic acid, 68-11-1, Acetic acid, mercapto-, 2-Mercaptoacetic acid, 2-Thioglycolic acid, Sulfanylacetic acid, Thioglycollic acid, 2-sulfanylacetic acid, Thiovanic acid, Mercaptoessigsaeure, Glycolic acid, thio-, Acide thioglycolique, Glycolic acid, 2-thio-, USAF CB-35, Acetic acid, 2-mercapto-, mercapto acetic acid, mercapto-acetic acid, Mercaptoethanoic acid, Kyselina thioglykolova, Kyselina merkaptooctova, Thioglykolsaeure, alpha-Mercaptoacetic acid, Merkaptoessigsaeure, NSC 1894, .alpha.-Mercaptoacetic acid, NSC-1894, MFCD00004876, Thioglycolic Acid (~90%), CHEMBL116455, DTXSID8026141, CHEBI:30065, 7857H94KHM, thioglycolicacid, DTXCID406141, CAS-68-11-1, Acide thioglycolique [French], Kyselina thioglykolova [Czech], CCRIS 4873, Kyselina merkaptooctova [Czech], HSDB 2702, EINECS 200-677-4, UN1940, BRN 0506166, UNII-7857H94KHM, AI3-24151, mercaptoactic acid, 2-mercaptoaceticacid, Sulfanylacetic acid #, Thioglycolic acid (Mercaptoacetic acid), HSCH2COOH, HSCH2CO2H, WLN: SH1VQ, EC 200-677-4, Thioglycolic acid, >=97%, Thioglycolic acid, >=98%, Thioglycolic acid, >=99%, 4-03-00-00600 (Beilstein Handbook Reference), THIOGLYCOLIC ACID [MI], Thioglycolic acid, LR, ~80%, CWERGRDVMFNCDR-UHFFFAOYSA-, NSC1894, MERCAPTOACETIC ACID [HSDB], THIOGLYCOLIC ACID [WHO-DD], THIOGLYCOLLIC ACID [MART.], STR00166, Tox21_201717, Tox21_303306, BDBM50336509, STL264219, AKOS000118940, DB15429, Thioglycolic acid, for synthesis, 97%, UN 1940, NCGC00249103-01, NCGC00257153-01, NCGC00259266-01, NCI60_001579, 1ST000892, DB-002789, Thioglycolic acid [UN1940] [Corrosive], M0052, NS00003173, EN300-19250, C02086, E78850, Q414738, InChI=1/C2H4O2S/c3-2(4)1-5/h5H,1H2,(H,3,4), 2-MERCAPTOACETIC ACID;2-mercaptoacetate;2-Thioglycolic acid;2-thio-glycolicaci;2-thioglycolicacid;Aceticacid,mercapto-;Acide thioglycolique;acidethioglycolique

Thioglycolic acid (Mercaptoacetic acid) is used as nucleophile in thioglycolysis reactions used on condensed tannins to study their structure.
Also known as Thioglycolic acid (Mercaptoacetic acid), HSCH2COOH is a colorless liquid with a strong unpleasant odor. 
Thioglycolic acid (Mercaptoacetic acid) is used as a reagent for metals such as iron, molybdenum, silver, and tin,and in bacteriology.

Thioglycolic acid (Mercaptoacetic acid) is prepared from Sodium sulfide plus Sodium monochloride acetate to yield Dithioglycollic acid. 
Electrolysis of the latter acid yields the title material.
Thioglycolic acid (Mercaptoacetic acid) is readily oxidized by air. 

Reacts readily with other oxidizing agents as well in reactions that may generate toxic gases. 
Incompatible with diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. 
Reactions with these materials may generate heat and toxic and flammable gases. 

May react with acids to liberate hydrogen sulfide. Neutralizes bases in exothermic reactions. 
Reacts with cyanides, sulfites, nitrites, thiosulfates to generate flammable and toxic gases and heat. 
Thioglycolic acid (Mercaptoacetic acid) is the organic compound HSCH2CO2H. 

Thioglycolic acid (Mercaptoacetic acid) is often called mercaptoacetic acid (MAA). 
It contains both a thiol (mercaptan) and carboxylic acid functional groups. 

It is a colorless liquid with a strongly unpleasant odor.
Thioglycolic acid (Mercaptoacetic acid) is miscible with polar organic solvents.
Thioglycolic acid (Mercaptoacetic acid) is a chemical compound that contains a thiol (–SH) group attached to an acetic acid molecule. 

Thioglycolic acid (Mercaptoacetic acid) is a clear liquid with a strong unpleasant odor. 
Thioglycolic acid (Mercaptoacetic acid) is readily oxidized by air to the corresponding disulfide [SCH2CO2H]2.
Thioglycolic acid (Mercaptoacetic acid) was developed in the 1940s for use as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate. 

Thioglycolic acid (Mercaptoacetic acid) is the precursor to ammonium thioglycolate that is used for permanents. 
Thioglycolic acid (Mercaptoacetic acid) and its derivatives break the disulfide bonds in the cortex of hair. 
One reforms these broken bonds in giving hair a "perm." Alternatively and more commonly, the process leads to depilation as is done commonly in leather processing. 

Thioglycolic acid (Mercaptoacetic acid) is widely used in various industrial and cosmetic applications due to its properties as a reducing agent and its ability to break down disulfide bonds in proteins.
Thioglycolic acid (Mercaptoacetic acid) contains both a thiol (mercaptan) and carboxylic acid functional groups.

Thioglycolic acid (Mercaptoacetic acid) is a colorless liquid with a strongly unpleasant odor.
Thioglycolic acid (Mercaptoacetic acid) is miscible with polar organic solvents.
Thioglycolic acid (Mercaptoacetic acid) is used as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate.

Thioglycolic acid (Mercaptoacetic acid) is the precursor to ammonium thioglycolate that is used for permanents.
Thioglycolic acid (Mercaptoacetic acid) and its derivatives break the disulde bonds in the cortex of hair.
One reforms these broken bonds in giving hair a "perm."

Alternatively and more commonly, the process leads to depilation as is done commonly in leather processing.
Thioglycolic acid (Mercaptoacetic acid) is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.
In fact Thioglycolic acid (Mercaptoacetic acid) reactions used on condensed tannins to study their structure.

Organotin derivatives of thioglycolic acid isooctyl esters are widely used as stabilizers for PVC. 
Thioglycolic acid (Mercaptoacetic acid) can soften nails and then x pincer nails in the correct position.
Thioglycolic acid (Mercaptoacetic acid) is a component of a special bacterial growth media : thioglycolate broth.

Thioglycolic acid (Mercaptoacetic acid) is also used in so-called "fallout remover" or "wheel cleaner" to remove iron oxide residue from rims.
Ferrous iron combines with thioglycolate to form red-violet ferric thioglycolate.
Commonly used in depilatory products to break down the disulfide bonds in keratin, facilitating the removal of hair.

Thioglycolic acid (Mercaptoacetic acid) is used in hair perming solutions to break and reform the disulfide bonds of hair, giving it a permanent wave or curl.
Employed as a reducing agent in various chemical reactions, such as in the production of rubber and as an intermediate in the synthesis of other chemicals.
It can be used in certain formulations for treating skin conditions due to its ability to break down keratin.

It is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.
Thioglycolic acid (Mercaptoacetic acid) is also used in the making of tin stabilizers often used in certain polyvinyl chloride products (such as vinyl siding).
Thioglycolic acid (Mercaptoacetic acid), usually as its dianion, forms complexes with metal ions. 

Such complexes have been used for the detection of iron, molybdenum, silver, and tin.
Thioglycolic acid (Mercaptoacetic acid) that is serves as a stabilizer, reducing agent, and ligand.

Thioglycolic acid (Mercaptoacetic acid) is the organic compound HSCH2CO2H . 
Thioglycolic acid (Mercaptoacetic acid) contains both a thiol (mercaptan) and a carboxylic acid. 

Melting point: −16 °C(lit.)
Boiling point: 96 °C5 mm Hg(lit.)
Density: 1.326 g/mL at 20 °C(lit.)
vapor density: 3.2 (vs air)
vapor pressure: 0.4 mm Hg ( 25 °C)
refractive index: n20/D 1.505(lit.)
Flash point: 126 °C
storage temp.: Store at +2°C to +8°C.
solubility: Chloroform (Sparingly), Methanol (Sparingly)
form: Liquid
pka: 3.68(at 25℃)
color: clear clear, colorless
Odor: strong unpleasant odor
PH: 1 (H2O, 20℃)
Water Solubility: soluble
Sensitive: Air Sensitive
Merck: 14,9336
BRN: 506166
Exposure limits    TLV-TWA 1 ppm (~3.8 mg/m3) (ACGIH).
Stability: Air Sensitive
InChIKey: CWERGRDVMFNCDR-UHFFFAOYSA-N
LogP: 0.090

Thioglycolic acid (Mercaptoacetic acid) contains both a thiol (mercaptan) and a carboxylic acid.
Thioglycolic acid (Mercaptoacetic acid) is a clear liquid with a strong unpleasant odor.
Thioglycolic acid (Mercaptoacetic acid) is readily oxidized by air to the corresponding disulde [SCH2CO2H]2.

Thioglycolic acid (TGA) was developed in the 1940s for use as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate. 
Thioglycolic acid (Mercaptoacetic acid) is the precursor to ammonium thioglycolate that is used for permanents.
Thioglycolic acid (Mercaptoacetic acid) and its derivatives break the disulde bonds in the cortex of hair.

One reforms these broken bonds in giving hair a "perm."
Alternatively and more commonly, the process leads to depilation as is done commonly in leather processing.
Thioglycolic acid (Mercaptoacetic acid) is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.

Thioglycolic acid (Mercaptoacetic acid) is also used in the making of tin stabilizers often used in certain polyvinyl chloride products (such as vinyl siding).
Thioglycolic acid (Mercaptoacetic acid), usually as its dianion, forms complexes with metal ions.
Such complexes have been used for the detection of iron, molybdenum, silver, and tin.

Thioglycolic acid (Mercaptoacetic acid) is used as nucleophile in thioglycolysis reactions used on condensed tannins to study their structure.
Thioglycolic acid (Mercaptoacetic acid) is a colorless liquid with a strong unpleasant odor like rotten eggs.
Also known as Thioglycolic acid (Mercaptoacetic acid), HSCH2COOH is a colorless liquid with a strong unpleasant odor. Used as a reagent for metals such as iron, molybdenum, silver, and tin,and in bacteriology.

Thioglycolic acid (Mercaptoacetic acid) is prepared by reaction of sodium or potassium chloroacetate with alkali metal hydrosulfide in aqueous medium.
Used as a reagent in the determination of various metals and in the analysis of organic compounds.
Can be used to modify proteins or in the production of various biomolecules by cleaving disulfide bonds.

Thioglycolic acid (Mercaptoacetic acid) is corrosive to the skin and eyes and can cause burns if not handled properly.
Inhalation or ingestion of thioglycolic acid can lead to poisoning, causing symptoms such as headaches, dizziness, or nausea.
Thioglycolic acid (Mercaptoacetic acid) is flammable, and appropriate storage and handling are required to prevent fire hazards.

Thioglycolic acid (Mercaptoacetic acid) is used to make thioglycolates; in sensitivity tests for iron; in formulations of permanent wave solutions and depilatories; in pharmaceutical manufacture; as a stabilizer in vinyl plastics.
Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. 
Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur). 

Air, strong oxidizers; bases, active metals, for example, sodium potassium, magnesium, and calcium. Readily oxidized by air. 
Thermal decomposition causes release of hydrogen sulfide. May attack various metals.
Thioglycolic acid (Mercaptoacetic acid) is the organic compound HSCH2CO2H .

Uses:
Thioglycolic acid (Mercaptoacetic acid) is used as a color developer for the photometric determination of molybdenum, rhenium and iron, and as a compounding masking agent.
Thioglycolic acid (Mercaptoacetic acid) is an organic compound containing both a thiol and a carboxylic acid.
Thioglycolic acid (Mercaptoacetic acid) is a precursor to ammonium thioglycolate, a chemical used for permanents.

Thioglycolic acid (Mercaptoacetic acid) is used in organic synthesis as a nucleophile in thioglycolysis reactions and is used as a S transfer agent for sulfonyl chloride synthesis.
Sensitive reagent for iron, molybdenum, silver, tin.
With ferric iron a blue color appears, and when an alkali hydroxide is added to a solution contg ferrous salts and thioglycolic acid, a yellow precipitate forms.

Used in the manufacture of thioglycolates.
The ammonium and sodium salts are commonly used for cold waving and the calcium salt is a depilatory.
The sodium salt also is used in bacteriology in the preparation of thioglycolate media.

Thioglycolic acid (Mercaptoacetic acid) is used in the following products: laboratory chemicals and cosmetics and personal care products.
Thioglycolic acid (Mercaptoacetic acid) is used in the following areas: scientic research and development.
Other release to the environment of Thioglycolic acid (Mercaptoacetic acid) is likely to occur from: indoor use as reactive substance and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).

Thioglycolic acid (Mercaptoacetic acid) is used in the following products: leather treatment products and cosmetics and personal care products.
Thioglycolic acid (Mercaptoacetic acid) has an industrial use resulting in manufacture of another substance (use of intermediates).
Release to the environment of Thioglycolic acid (Mercaptoacetic acid) can occur from industrial use: formulation of mixtures.

Thioglycolic acid (Mercaptoacetic acid) is used in the following products: oil and gas exploration or production products.
Thioglycolic acid (Mercaptoacetic acid) has an industrial use resulting in manufacture of another substance (use of intermediates).
Thioglycolic acid (Mercaptoacetic acid) is used in the following areas: mining and scientic research and development.

Thioglycolic acid (Mercaptoacetic acid) is used for the manufacture of: chemicals.
Release to the environment of Thioglycolic acid (Mercaptoacetic acid) can occur from industrial use: of substances in closed systems with minimal release, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).
Thioglycolic acid (Mercaptoacetic acid) is used as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate. 

Thioglycolic acid (Mercaptoacetic acid) is the precursor to ammonium thioglycolate, which is used for permanents. 
Thioglycolic acid (Mercaptoacetic acid) and its derivatives break the disulfide bonds in the cortex of hair. 
One reforms these broken bonds in giving hair a "perm". 

Alternatively and more commonly, the process leads to depilation, as is done commonly in leather processing. 
Thioglycolic acid (Mercaptoacetic acid) is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.
Thioglycolysis reactions are used on condensed tannins to study their structure.

Thioglycolic acid (Mercaptoacetic acid) has also been used to soften nails, either to reshape pincer nails into the correct position or to help topical antifungals penetrate the nail.
Organotin derivatives of Thioglycolic acid (Mercaptoacetic acid)s are widely used as stabilizers for PVC. 
Thioglycolic acid (Mercaptoacetic acid) is a component of thioglycolate broth, a special bacterial growth media. 

Thioglycolic acid (Mercaptoacetic acid) is also used in so-called "fallout remover" or "wheel cleaner" to remove iron oxide residue from wheels.
Ferrous iron combines with thioglycolate to form red-violet ferric thioglycolate.
Thioglycolic acid (Mercaptoacetic acid) may be used as a sulfur source for the synthesis of metal sulfide nanostructures via hydrothermal process.

Used in depilatory products, as it breaks down the disulfide bonds in keratin, allowing for hair removal.
Common in perming solutions, where it helps to break and reform the disulfide bonds in hair, enabling the creation of permanent curls or waves.
Thioglycolic acid (Mercaptoacetic acid) sometimes found in skincare products designed to treat keratinized skin conditions, as it can aid in exfoliation by breaking down keratin.

Thioglycolic acid (Mercaptoacetic acid) is used as a reducing agent in chemical syntheses, especially in the production of certain polymers and rubber.
It serves as an intermediate in the synthesis of various chemicals, including some pharmaceutical and agricultural chemicals.
Sometimes included in formulations designed to treat conditions affecting the skin, particularly where keratin breakdown is needed (e.g., treating scars, warts).

Thioglycolic acid (Mercaptoacetic acid) utilized in some topical products for treating certain types of skin growths or conditions involving keratinized tissue.
It is used in the biotech industry to break disulfide bonds in proteins, aiding in protein modification and purification.
Thioglycolic acid (Mercaptoacetic acid) is used to cleave disulfide bonds in certain enzymes, helping with their deactivation or modification for various biochemical applications.

Thioglycolic acid (Mercaptoacetic acid) can be used in analytical chemistry for determining the presence of metals or in creating metal-thiol complexes for analysis.
Employed in the synthesis and modification of organic compounds in research laboratories.

Thioglycolic acid (Mercaptoacetic acid) can be used in the synthesis of certain agricultural chemicals, including pesticides or herbicides.
Sometimes utilized in the rubber industry to modify the properties of rubber, particularly in vulcanization processes.
Thioglycolic acid (Mercaptoacetic acid), ingestion or skin contact with material may cause severe injury or death. 

Thioglycolic acid (Mercaptoacetic acid) contact with molten substance may cause severe burns to skin and eyes. 
Avoid any skin contact. Effects of contact or inhalation may be delayed. 
Fire may produce irritating, corrosive and/or toxic gases. 

Thioglycolic acid (Mercaptoacetic acid) runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Thioglycolic acid (Mercaptoacetic acid) is a highly toxic and ablistering compound. 
Even a 10% solutionwas lethal to most experimental animals by dermal absorption. 

The acute toxicsymptoms in test animals include weakness,respiratory distress, convulsions, irritation ofthe gastrointestinal tract, and liver damage.
Thioglycolic acid (Mercaptoacetic acid) is a severe irritant.
Contact with eyes can cause conjunctivalinflammation and corneal opacity. 

Thioglycolic acid (Mercaptoacetic acid) is used as a reagent formetals analysis; in the manufacture of thioglycolates, pharmaceuticals, and permanentwave solutions; and as a vinyl stabilizer.
Thioglycolic acid (Mercaptoacetic acid) is an organic compound containing both a thiol and a carboxylic acid. 
Thioglycolic acid (Mercaptoacetic acid) is a precursor to ammonium thioglycolate, a chemical used for permanents. 

Thioglycolic acid (Mercaptoacetic acid) is used in organic synthesis as a nucleophile in thioglycolysis reactions and is used as a S transfer agent for sulfonyl chloride synthesis.
Sensitive reagent for iron, molybdenum, silver, tin. 
With ferric iron a blue color appears, and when an alkali hydroxide is added to a solution contg ferrous salts and thioglycolic acid, a yellow precipitate forms. 

Thioglycolic acid (Mercaptoacetic acid) is used in the manufacture of thioglycolates. 
The ammonium and sodium salts are commonly used for cold waving and the calcium salt is a depilatory. 
The sodium salt also is used in bacteriology in the preparation of thioglycolate media.

Thioglycolic acid (Mercaptoacetic acid) is an intermediate in the production of thiomethoprol (caputril), biotin, thiozinc acid, sodium dithiosuccinate and other pharmaceuticals, and is also an intermediate in the synthesis of cysteine, hormonal agent, and industrial disinfectant. 
And an important raw material for the synthesis of sulfuric acid.
Thioglycolic acid (Mercaptoacetic acid) is used as antioxidant and stabilizer in pharmaceuticals to enhance the stability of the main drug and prolong the validity period of pharmaceutical preparations. 

Ammonium and sodium salts of thioglycolic acid are mainly used as curling agents, calcium salts can be used as depilatory agents, polymerization initiators, accelerators and chain transfer agents, and can be used for hair removal before cosmetic surgery and animal experiments. 
Thioglycolic acid (Mercaptoacetic acid) is used to make epoxy resin, catalyst of bisphenol A, and it can also be used as the basic raw material for synthesizing PVC transparent plastic and organic antimony and organic tin heat stabilizer.

Thioglycolic acid (Mercaptoacetic acid) is a sensitive reagent for the determination of iron, molybdenum, aluminum, tin, etc., and is an inhibitor of copper sulfide and iron sulfide minerals in beneficiation. 
In the petrochemical industry and the railway sector, it is used for cleaning and derusting of equipment and rails. 
Thioglycolic acid (Mercaptoacetic acid) can be used as a crystallization nucleating agent in polypropylene processing and molding, as a modifier for coatings and fibers, as a blanket quickening agent, as a stabilizer raw material for polyvinyl chloride and rubber, as a cold perm agent, and as a pharmaceutical intermediate. 

Safety Profile:
Thioglycolic acid (Mercaptoacetic acid) when heated to decomposition it emits toxic fumes of SOx.
Poison by ingestion, skin contact, intraperitoneal, and intravenous routes. 
Thioglycolic acid (Mercaptoacetic acid) a corrosive irritant to skin, eyes, and mucous membranes. 


 

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