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Thioglycolic acid (Mercaptoacetic acid) is employed to modify the properties of fibers during manufacturing, especially in synthetic fibers, where its ability to break down disulfide bonds is beneficial in improving texture and flexibility.
Thioglycolic acid (Mercaptoacetic acid) is sometimes used as a stabilizing agent in textile processing to prevent undesirable chemical reactions that may occur during dyeing or finishing.
Thioglycolic acid (Mercaptoacetic acid) is used in the production of specialty plastics and resins.
CAS Number: 68-11-1
Molecular Formula: C2H4O2S
Molecular Weight: 92.12
EINECS Number: 200-677-4
Synonyms: mercaptoacetic acid, thioglycolic acid, 68-11-1, Acetic acid, mercapto-, 2-Mercaptoacetic acid, 2-Thioglycolic acid, Sulfanylacetic acid, Thioglycollic acid, 2-sulfanylacetic acid, Thiovanic acid, Mercaptoessigsaeure, Glycolic acid, thio-, Acide thioglycolique, Glycolic acid, 2-thio-, USAF CB-35, Acetic acid, 2-mercapto-, mercapto acetic acid, mercapto-acetic acid, Mercaptoethanoic acid, Kyselina thioglykolova, Kyselina merkaptooctova, Thioglykolsaeure, alpha-Mercaptoacetic acid, Merkaptoessigsaeure, NSC 1894, .alpha.-Mercaptoacetic acid, NSC-1894, MFCD00004876, Thioglycolic Acid (~90%), CHEMBL116455, DTXSID8026141, CHEBI:30065, 7857H94KHM, thioglycolicacid, DTXCID406141, CAS-68-11-1, Acide thioglycolique [French], Kyselina thioglykolova [Czech], CCRIS 4873, Kyselina merkaptooctova [Czech], HSDB 2702, EINECS 200-677-4, UN1940, BRN 0506166, UNII-7857H94KHM, AI3-24151, mercaptoactic acid, 2-mercaptoaceticacid, Sulfanylacetic acid #, mercaptoacetic acid (thioglycolic acid), HSCH2COOH, HSCH2CO2H, WLN: SH1VQ, EC 200-677-4, Thioglycolic acid, >=97%, Thioglycolic acid, >=98%, Thioglycolic acid, >=99%, 4-03-00-00600 (Beilstein Handbook Reference), THIOGLYCOLIC ACID [MI], Thioglycolic acid, LR, ~80%, CWERGRDVMFNCDR-UHFFFAOYSA-, NSC1894, MERCAPTOACETIC ACID [HSDB], THIOGLYCOLIC ACID [WHO-DD], THIOGLYCOLLIC ACID [MART.], STR00166, Tox21_201717, Tox21_303306, BDBM50336509, STL264219, AKOS000118940, DB15429, Thioglycolic acid, for synthesis, 97%, UN 1940, NCGC00249103-01, NCGC00257153-01, NCGC00259266-01, NCI60_001579, 1ST000892, DB-002789, Thioglycolic acid [UN1940] [Corrosive], M0052, NS00003173, EN300-19250, C02086, E78850, Q414738, InChI=1/C2H4O2S/c3-2(4)1-5/h5H,1H2,(H,3,4), 2-MERCAPTOACETIC ACID;2-mercaptoacetate;2-Thioglycolic acid;2-thio-glycolicaci;2-thioglycolicacid;Aceticacid,mercapto-;Acide thioglycolique;acidethioglycolique
Thioglycolic acid (Mercaptoacetic acid) is employed to treat metal surfaces to prevent corrosion or enhance adhesion of coatings.
In addition to thiol-ene polymerization, it can also be used in the preparation of cross-linked networks and other specialized polymers.
Thioglycolic acid (Mercaptoacetic acid) is frequently used in biochemical research to modify proteins and peptides by introducing thiol groups.
This modification can influence protein folding, stability, and interactions with other molecules, which is useful in various biological assays.
Thioglycolic acid (Mercaptoacetic acid) is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.
Thioglycolic acid (Mercaptoacetic acid) is also used in the making of tin stabilizers often used in certain polyvinyl chloride products (such as vinyl siding).
Thioglycolic acid (Mercaptoacetic acid), usually as its dianion, forms complexes with metal ions. Such complexes have been used for the detection of iron, molybdenum, silver, and tin.
In some water treatment applications, TGA can be used to prevent scale formation and corrosion in pipes and machinery.
Its thiol group helps break down sulfur compounds and prevent the buildup of unwanted residues.
Thioglycolic acid (Mercaptoacetic acid) works by breaking down the disulfide bonds in hair proteins, which allows for reshaping.
Thioglycolic acid (Mercaptoacetic acid) is sometimes included in hair conditioners for its ability to smooth the cuticle layer of hair, helping it retain moisture and improve appearance.
Thioglycolic acid (Mercaptoacetic acid) is sometimes used in the rubber industry to improve the properties of rubber and elastomers, especially in enhancing flexibility and durability.
When exposed to certain catalysts, it can help crosslink polymer chains, improving the material’s mechanical properties such as tensile strength and thermal resistance.
Due to its ability to react with a variety of functional groups, Thioglycolic acid (Mercaptoacetic acid) is used in adhesive formulations where it enhances the bonding of different substrates, especially in situations where strong, flexible bonds are required.
Thioglycolic acid (Mercaptoacetic acid) and its derivatives break the disulfide bonds in the cortex of hair.
One reforms these broken bonds in giving hair a "perm."
Alternatively and more commonly, the process leads to depilation as is done commonly in leather processing.
Thioglycolic acid (Mercaptoacetic acid) is the organic compound HSCH2CO2H.
Thioglycolic acid (Mercaptoacetic acid) contains both a thiol (mercaptan) and a carboxylic acid.
Thioglycolic acid (Mercaptoacetic acid) is a clear liquid with a strong unpleasant odor.
Thioglycolic acid (Mercaptoacetic acid), HSCH2COOH is a colorless liquid with a strong unpleasant odor.
Used as a reagent for metals such as iron, molybdenum, silver, and tin,and in bacteriology.
Thioglycolic acid (Mercaptoacetic acid) has the reaction characteristics of both hydroxyl acid and sulfhydryl group, among which the most important reaction is with disulfide.
It is an intermediate for the production of methylene propionate, biotin, salicylic acid, sodium dithioglycosuccinate, and other medical products.
Thioglycolic acid (Mercaptoacetic acid) is a chemical compound primarily composed of thioglycolic acid, with a purity of 99%.
It is a colorless or pale yellow liquid with a strong odor, and it is an organosulfur compound.
Thioglycolic acid (Mercaptoacetic acid) is a type of mercaptoacetic acid that contains a thiol group (-SH) attached to an acetic acid structure.
Thioglycolic acid (Mercaptoacetic acid) is used as nucleophile in thioglycolysis reactions used on condensed tannins to study their structure.
Thioglycolic acid (Mercaptoacetic acid) is a colorless liquid with a strong unpleasant odor like rotten eggs.
Thioglycolic acid (Mercaptoacetic acid) is readily oxidized by air to the corresponding disulfide [SCH2CO2H]2.
Thioglycolic acid (Mercaptoacetic acid) was developed in the 1940s for use as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate.
Thioglycolic acid (Mercaptoacetic acid) is the precursor to ammonium thioglycolate that is used for permanents.
Thioglycolic acid (Mercaptoacetic acid) is a sulfur-containing carboxylic acid.
It is a conjugate acid of a thioglycolate(1-).
Thioglycolic acid (Mercaptoacetic acid) is one of the key ingredients in depilatory products such as creams and lotions used for hair removal.
Its ability to break down the disulfide bonds in keratin proteins helps dissolve hair and remove it from the skin.
Thioglycolic acid (Mercaptoacetic acid) is also used in nail care products, particularly for breaking down keratin in nails, allowing for the creation of artificial nails and other nail treatments.
Due to its thiol group (-SH), thioglycolic acid is used as a powerful reducing agent in chemical reactions.
It can also facilitate the formation of disulfide bonds, which are important in various types of chemical and biochemical processes.
Thioglycolic acid (Mercaptoacetic acid) is used in the thiolation of drugs and active pharmaceutical ingredients, introducing a thiol group into the molecular structure, which can enhance the biological activity or modify the pharmacokinetics of the compound.
Thioglycolic acid (Mercaptoacetic acid) is utilized in the production of thiol-ene polymers through free-radical polymerization.
Thioglycolic acid (Mercaptoacetic acid) serves as a chain transfer agent, influencing the polymerization process to form specific types of materials.
Thioglycolic acid (Mercaptoacetic acid) is often used in leather treatment processes. It acts as a reducing agent in the tanning and finishing of leather, helping improve the softness and texture of leather products.
Thioglycolic acid (Mercaptoacetic acid) is a useful reagent in laboratories for processes involving the reduction of disulfide bonds in proteins, assisting in denaturation or refolding experiments.
Thioglycolic acid (Mercaptoacetic acid) is not considered highly persistent in the environment, but its release into water sources should be avoided, as it can be harmful to aquatic organisms.
Due to its corrosive nature, it can cause severe irritation or burns to the skin and eyes.
Appropriate personal protective equipment (PPE) like gloves, goggles, and lab coats should be worn when handling thioglycolic acid.
Breathing in vapors or ingesting Thioglycolic acid (Mercaptoacetic acid) can lead to respiratory distress, nausea, and other toxic effects.
Adequate ventilation should be maintained in workplaces using Thioglycolic acid (Mercaptoacetic acid), and ingestion should be avoided at all costs.
If exposure occurs, seek medical attention immediately.
The acid dissociation constant (pKa) of thioglycolic acid is around 3.9. This gives it a relatively strong acidic nature.
In some conditions, especially when exposed to air, Thioglycolic acid (Mercaptoacetic acid) may undergo slight discoloration.
This can sometimes affect the appearance of products that contain it, though the chemical properties remain largely unchanged.
Thioglycolic acid (Mercaptoacetic acid) is a key ingredient in products designed for perming and straightening eyebrows and eyelashes.
Thioglycolic acid (Mercaptoacetic acid) has a relatively low vapor pressure, which means it is less likely to evaporate into the air at ambient temperatures, but care should still be taken in poorly ventilated areas.
Thioglycolic acid (Mercaptoacetic acid) is stable under normal conditions but may decompose under extreme conditions (high temperature or in the presence of strong oxidizers).
Thioglycolic acid (Mercaptoacetic acid) is essential to dispose of waste containing thioglycolic acid according to local environmental regulations to minimize its environmental footprint.
Melting point: −16 °C(lit.)
Boiling point: 96 °C5 mm Hg(lit.)
Density: 1.326 g/mL at 20 °C(lit.)
vapor density: 3.2 (vs air)
vapor pressure: 0.4 mm Hg ( 25 °C)
refractive index: n20/D 1.505(lit.)
Flash point: 126 °C
storage temp.: Store at +2°C to +8°C.
solubility: Chloroform (Sparingly), Methanol (Sparingly)
form: Liquid
pka: 3.68(at 25℃)
color: clear clear, colorless
Odor: strong unpleasant odor
PH: 1 (H2O, 20℃)
Water Solubility: soluble
Sensitive: Air Sensitive
Merck: 14,9336
BRN: 506166
Exposure limits TLV-TWA 1 ppm (～3.8 mg/m3) (ACGIH).
Stability: Air Sensitive
InChIKey: CWERGRDVMFNCDR-UHFFFAOYSA-N
LogP: 0.090
Thioglycolic acid (Mercaptoacetic acid) should be kept in a cool, dry place, preferably in an area with adequate ventilation.
The container should be labeled with proper hazard warnings.
Thioglycolic acid (Mercaptoacetic acid) should not be stored with strong oxidizers, bases, or alkaline materials, as these could cause unwanted reactions.
Avoid contact with materials like copper and brass, as they may corrode when exposed to thioglycolic acid.
In case of a spill, personal protective equipment (PPE) should be worn. The area should be ventilated, and the spill should be neutralized with a suitable absorbent material, such as sand or an inert absorbent, before disposal.
Thioglycolic acid (Mercaptoacetic acid) is not highly toxic in the concentrations used in most applications, prolonged or repeated exposure can lead to chronic health effects.
Toxicity varies depending on the route of exposure (skin contact, ingestion, inhalation).
Immediately wash the affected area with plenty of water and soap. Remove contaminated clothing. If irritation persists, seek medical attention.
Rinse immediately with water for at least 15 minutes, keeping eyelids open. Seek medical attention without delay.
If symptoms like coughing, shortness of breath, or dizziness persist, seek medical attention.
Do not induce vomiting. Rinse the mouth with water and seek medical attention immediately.
Thioglycolic acid (Mercaptoacetic acid) serves diverse functions in the world of personal care and cosmetics.
It is a key ingredient in depilatory creams, where its ability to break down hair proteins facilitates hair removal.
Its inclusion ensures an efficient and convenient method for temporary hair removal, commonly used on areas like legs and arms
In skincare, Thioglycolic acid (Mercaptoacetic acid) is employed as a peeling agent.
Thioglycolic acid (Mercaptoacetic acid)s exfoliating properties help remove dead skin cells, promoting smoother skin texture.
However, due to its potency, it must be used cautiously to avoid skin irritation or adverse reactions
Thioglycolic acid (Mercaptoacetic acid) is used in permanent wave solutions, thioglycolic acid alters the protein structure of hair, allowing it to take on a new shape.
This chemical process, known as a "perm," is popular for creating long-lasting curls or waves in hair
Thioglycolic acid (Mercaptoacetic acid) is synthesized through the reaction of chloroacetic acid with hydrogen sulfide.
This process involves the substitution of a chlorine atom in chloroacetic acid with a sulfhydryl (thiol) group from hydrogen sulfide, resulting in the formation of thioglycolic acid.
Purification steps are then carried out to obtain the final product.
In Thioglycolic acid (Mercaptoacetic acid)s raw form, it appears as a colorless liquid.
Thioglycolic acid (Mercaptoacetic acid) is an important chemical compound with diverse applications, and its wide usage across various industries necessitates a deeper understanding of its properties, safety, and handling.
Thioglycolic acid (Mercaptoacetic acid) is prepared from Sodium sulfide plus Sodium monochloride acetate to yield Dithioglycollic acid.
Electrolysis of the latter acid yields the title material.
Thioglycolic acid (Mercaptoacetic acid) a colorless liquid with an unpleasant odor.
Thioglycolic acid (Mercaptoacetic acid) can act as an antioxidant in some pharmaceutical formulations, where it helps to prevent oxidation of sensitive ingredients.
It is sometimes used in diagnostic tests and assays to modify proteins and other biological molecules, introducing thiol groups that can facilitate further study or interactions with other assay components.
Mercaptoacetic acid is readily oxidized by air.
Reacts readily with other oxidizing agents as well in reactions that may generate toxic gases.
Incompatible with diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents.
Reactions with these materials may generate heat and toxic and flammable gases.
May react with acids to liberate hydrogen sulfide.
Neutralizes bases in exothermic reactions.
Reacts with cyanides, sulfites, nitrites, thiosulfates to generate flammable and toxic gases and heat.
Thioglycolic acid (Mercaptoacetic acid) is readily oxidized by air.
Reacts readily with other oxidizing agents as well in reactions that may generate toxic gases.
Incompatible with diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents.
Reactions with these materials may generate heat and toxic and flammable gases. May react with acids to liberate hydrogen sulfide.
Neutralizes bases in exothermic reactions. Reacts with cyanides, sulfites, nitrites, thiosulfates to generate flammable and toxic gases and heat.
Thioglycolic acid (Mercaptoacetic acid) reacts with carbonates and bicarbonates.
Thioglycolic acid (Mercaptoacetic acid), cosmetic grade (TGA 99 cosm) by Bruno Bock acts as a restructuring and depilatory agent.
The reducing properties of the SH-group open the sulfur bridges in the keratin structure of the hair and thus weaken it.
After rinsing, the sulfur bridges are reconnected with an oxidizing chemical such as hydrogen-peroxide.
If both steps are applied to hair tightly wrapped around hair rollers the hair fibers get its desired curled shape.
Thioglycolic acid (Mercaptoacetic acid), cosmetic grade (TGA 99 cosm) is used in production of permanent wave and depilatory formulations.
Thioglycolic acid (Mercaptoacetic acid) can cause severe burns or irritation upon contact with skin or eyes.
Inhalation or ingestion can also lead to significant harm. Safety protocols such as using gloves, safety goggles, and protective clothing are essential when working with Thioglycolic acid (Mercaptoacetic acid).
Always wear splash-proof goggles when handling TGA to prevent eye damage.
Protective gloves (preferably nitrile or rubber) should be used to avoid direct skin contact.
Ensure good ventilation when working with TGA to avoid inhalation of vapors. Work in a fume hood when necessary, particularly when working with high concentrations.
The vapors of thioglycolic acid can cause respiratory irritation.
If inhaled, it may cause coughing, difficulty breathing, or other respiratory issues.
In case of exposure, move to fresh air immediately and seek medical attention if symptoms persist.
Thioglycolic acid (Mercaptoacetic acid) may be harmful to aquatic life, with long-lasting effects.
Thioglycolic acid (Mercaptoacetic acid) should not be released into the environment, especially water bodies. Proper disposal methods must be followed to prevent contamination.
Waste containing Thioglycolic acid (Mercaptoacetic acid) should be treated as hazardous and disposed of according to local regulations.
Avoid mixing it with incompatible substances like strong oxidizers.
Thioglycolic acid (Mercaptoacetic acid) should be stored in tightly sealed containers, away from direct sunlight and moisture.
Uses:
Thioglycolic acid (Mercaptoacetic acid) is used in formulations for both hair perms and relaxers.
Similar to its use in hair treatments, TGA is used in eyebrow and eyelash perming products to alter the structure of the hair for desired shapes and curls.
Thioglycolic acid (Mercaptoacetic acid) is occasionally included in skin care products as a reducing agent and skin softener, particularly in treatments designed to break down keratin bonds in calloused or hardened skin.
Thioglycolic acid (Mercaptoacetic acid) is used in the rubber industry to improve the properties of rubbers and elastomers, enhancing flexibility and durability.
Thioglycolic acid (Mercaptoacetic acid) is used in water treatment chemicals, often to help control scale formation, remove contaminants, or prevent corrosion in pipes and machinery.
In the production of specialty plastics, Thioglycolic acid (Mercaptoacetic acid) can act as a crosslinking agent, helping to improve the strength, flexibility, and chemical resistance of polymers and resins.
Thioglycolic acid (Mercaptoacetic acid) is used in textile processing to modify synthetic fibers, particularly to enhance the texture and flexibility of the fibers.
It may be included in textile processing to modify the interaction of fibers with dyes and to improve the overall quality of finished fabrics.
Thioglycolic acid (Mercaptoacetic acid) is sometimes used in metal treatment to prevent corrosion and improve the bonding of metals with other materials.
It works as a reducing agent in certain metal coating processes.
Thioglycolic acid (Mercaptoacetic acid) is used in laboratories for the synthesis of other chemicals, as its thiol group can readily react with other functional groups, enabling it to be a useful reagent in organic chemistry.
Thioglycolic acid (Mercaptoacetic acid) can act as an antioxidant in certain pharmaceutical formulations, helping to prevent the oxidation of sensitive ingredients.
In biochemical research, thioglycolic acid is sometimes used to modify proteins, particularly to introduce thiol groups that can be used for further chemical reactions or assays.
Thioglycolic acid (Mercaptoacetic acid) is included in formulations for adhesives and sealants, where it helps improve the bond between different surfaces, especially in materials that require strong, flexible adhesives.
Thioglycolic acid (Mercaptoacetic acid) is an organic compound containing both a thiol and a carboxylic acid.
Thioglycolic acid (Mercaptoacetic acid) is a precursor to ammonium thioglycolate, a chemical used for permanents.
Thioglycolic acid (Mercaptoacetic acid) is used in organic synthesis as a nucleophile in thioglycolysis reactions and is used as a S transfer agent for sulfonyl chloride synthesis.
Sensitive reagent for iron, molybdenum, silver, tin. With ferric iron a blue color appears, and when an alkali hydroxide is added to a solution contg ferrous salts and thioglycolic acid, a yellow precipitate forms.
Thioglycolic acid (Mercaptoacetic acid) is used in the manufacture of thioglycolates.
The ammonium and sodium salts are commonly used for cold waving and the calcium salt is a depilatory.
The sodium salt also is used in bacteriology in the preparation of thioglycolate media.
Thioglycolic acid (Mercaptoacetic acid) is used as a reagent formetals analysis; in the manufacture of thioglycolates, pharmaceuticals, and permanentwave solutions; and as a vinyl stabilizer.
Thioglycolic acid (Mercaptoacetic acid) is an intermediate in the production of thiomethoprol (caputril), biotin, thiozinc acid, sodium dithiosuccinate and other pharmaceuticals, and is also an intermediate in the synthesis of cysteine, hormonal agent, and industrial disinfectant.
And an important raw material for the synthesis of sulfuric acid.
Thioglycolic acid (Mercaptoacetic acid) is used as antioxidant and stabilizer in pharmaceuticals to enhance the stability of the main drug and prolong the validity period of pharmaceutical preparations.
Ammonium and sodium salts of thioglycolic acid are mainly used as curling agents, calcium salts can be used as depilatory agents, polymerization initiators, accelerators and chain transfer agents, and can be used for hair removal before cosmetic surgery and animal experiments.
Thioglycolic acid (Mercaptoacetic acid) is used to make epoxy resin, catalyst of bisphenol A, and it can also be used as the basic raw material for synthesizing PVC transparent plastic and organic antimony and organic tin heat stabilizer.
Thioglycolic acid (Mercaptoacetic acid) is a sensitive reagent for the determination of iron, molybdenum, aluminum, tin, etc., and is an inhibitor of copper sulfide and iron sulfide minerals in beneficiation.
In the petrochemical industry and the railway sector, it is used for cleaning and derusting of equipment and rails.
It can be used as a crystallization nucleating agent in polypropylene processing and molding, as a modifier for coatings and fibers, as a blanket quickening agent, as a stabilizer raw material for polyvinyl chloride and rubber, as a cold perm agent, and as a pharmaceutical intermediate.
Thioglycolic acid (Mercaptoacetic acid) is used as a color developer for the photometric determination of molybdenum, rhenium and iron, and as a compounding masking agent.
A sulfur source and stabilizing agent to synthesize nanocrystalline metal sulfides via hydrothermal reaction.
Thioglycolic acid (Mercaptoacetic acid) also controls the morphology and particle sizes of nanocrystalline metal sulfides during the process.
An effective agglomeration suppressant for the agglomeration of sulfurized mineral pyrite.
A reactant to prepare 2,3-disubstituted-thiazolidin-4-one derivatives by one-pot cyclo-condensation reaction with various aldehydes and amines using supported protic acid catalyst.
A capping or stabilizing agent to synthesize CdTe quantum dots with controllable photoluminescence wavelengths.
Thioglycolic acid (Mercaptoacetic acid) is used in the following products: laboratory chemicals and cosmetics and personal care products.
Thioglycolic acid (Mercaptoacetic acid) is used in the following areas: scientific research and development.
Other release to the environment of Thioglycolic acid (Mercaptoacetic acid) is likely to occur from: indoor use as reactive substance and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).
Thioglycolic acid (Mercaptoacetic acid) is used in the following products: leather treatment products and cosmetics and personal care products.
Thioglycolic acid (Mercaptoacetic acid) has an industrial use resulting in manufacture of another substance (use of intermediates).
Release to the environment of Thioglycolic acid (Mercaptoacetic acid) can occur from industrial use: formulation of mixtures.
Thioglycolic acid (Mercaptoacetic acid) is used in the following products: oil and gas exploration or production products.
Thioglycolic acid (Mercaptoacetic acid) has an industrial use resulting in manufacture of another substance (use of intermediates).
Thioglycolic acid (Mercaptoacetic acid) is used in the following areas: mining and scientific research and development.
Thioglycolic acid (Mercaptoacetic acid) is used for the manufacture of: chemicals.
Release to the environment of Thioglycolic acid (Mercaptoacetic acid) can occur from industrial use: of substances in closed systems with minimal release, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).
Thioglycolic acid (Mercaptoacetic acid) is commonly used in depilatories (hair removal products) due to its ability to break down keratin, the protein that makes up hair.
It serves as a precursor in the production of thiol-containing compounds and in the synthesis of other chemicals.
Thioglycolic acid (Mercaptoacetic acid) is used in textile finishing, leather processing, and as a reducing agent in the chemical processing of fibers and leather.
Thioglycolic acid (Mercaptoacetic acid) is used in the preparation of certain types of polymers, such as thiol-ene polymers, by acting as a chain transfer agent in free-radical polymerization.
Thioglycolic acid (Mercaptoacetic acid) is also used in the preparation of certain pharmaceuticals, especially in processes requiring the introduction of a thiol group.
Thioglycolic acid (Mercaptoacetic acid) is commonly used in hair perming and hair straightening products because it helps break the disulfide bonds in the hair, allowing it to be reshaped.
Safety Profile:
Combustible material: may burn but does not ignite readily.
When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards.
Contact with metals may evolve flammable hydrogen gas.
Thioglycolic acid (Mercaptoacetic acid) containers may explode when heated.
Thioglycolic acid (Mercaptoacetic acid) may be transported in a molten form.
Thioglycolic acid (Mercaptoacetic acid) can cause severe skin and eye irritation.
Thioglycolic acid (Mercaptoacetic acid) is corrosive to tissues.
Prolonged exposure or high concentrations can lead to toxicity and health issues.
Although not highly flammable, it can present fire hazards due to its volatility and chemical reactivity under certain conditions
While depilatory creams and perm solutions containing diluted thioglycolic acid are generally considered safe when used as directed, prolonged or excessive exposure may lead to adverse effects.
Thioglycolic acid (Mercaptoacetic acid) is crucial to perform patch tests before application, and individuals with sensitive skin or respiratory conditions should exercise caution or consult a healthcare professional before using products containing thioglycolic acid.
Poison by ingestion, skin contact, intraperitoneal, and intravenous routes.
Moderately toxic by subcutaneous route.
A corrosive irritant to skin, eyes, and mucous membranes.
Thioglycolic acid (Mercaptoacetic acid) when heated to decomposition it emits toxic fumes of SOx.
Thioglycolic acid (Mercaptoacetic acid) is a highly toxic and ablistering compound.
Even a 10% solutionwas lethal to most experimental animals by dermal absorption.
The oral LD50 value ofundiluted acid is less than 50 mg/kg (Patty1963).
The lethal dose in rabbits by skinabsorption is 300 mg/kg.
The acute toxicsymptoms in test animals include weakness,respiratory distress, convulsions, irritation ofthe gastrointestinal tract, and liver damage.
