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Thioglycolic Acid (TGA) is a highly reactive organosulfur compound widely used in chemical synthesis, cosmetics, and industrial applications.
Thioglycolic Acid (TGA) is valued for its strong reducing and chelating properties, making it a key ingredient in formulations for depilatory creams, hair treatments, and metal cleaning solutions.
This versatile chemical serves as a critical intermediate in the manufacture of pharmaceuticals, agrochemicals, and polymers.
CAS Number: 68-11-1
EC Number: 200-677-4
Molecular Formula: HSCH2COOH
Molecular Weight: 92.11 g/mol
Synonyms: Thioglycolic Acid, TGA, Mercaptoacetic Acid, Acetyl Mercaptan, Thiomonochloroacetic Acid, Hydroxyethanethioic Acid, TGA Reagent, Thioglycolic Acid Industrial Grade, Thioglycolic Acid Cosmetic Grade, Mercaptoacetic Acid Reducing Agent, TGA for Hair Treatments, Thioglycolic Acid Chelating Agent, Mercaptoacetic Acid Cleaner, TGA Depilatory Ingredient, TGA Polymer Intermediate, Mercaptoacetic Acid Stabilizer, Thioglycolic Acid Analytical Reagent, TGA Corrosion Inhibitor, Thioglycolic Acid pH Adjuster
APPLICATIONS
Thioglycolic Acid (TGA) is extensively used in depilatory creams and hair removal products for its ability to break down keratin.
Thioglycolic Acid (TGA) is employed in hair perming solutions to alter disulfide bonds in the hair structure.
Thioglycolic Acid (TGA) is included in cleaning formulations for metals, removing rust, scale, and oxide layers effectively.
Thioglycolic Acid (TGA) is a preferred component in the synthesis of PVC heat stabilizers, improving thermal stability.
Thioglycolic Acid (TGA) is utilized as a chelating agent in chemical formulations to control metal ions in solutions.
Thioglycolic Acid (TGA) is found in industrial water treatment formulations, preventing scale formation and corrosion.
Thioglycolic Acid (TGA) is applied in the manufacture of pharmaceuticals, serving as a precursor for active pharmaceutical ingredients.
Thioglycolic Acid (TGA) is used in agrochemical production as an intermediate for herbicides and pesticides.
Thioglycolic Acid (TGA) is employed in polymer chemistry for crosslinking and chain modification of resins.
Thioglycolic Acid (TGA) is a key reagent in analytical chemistry for the detection and quantification of metal ions.
Thioglycolic Acid (TGA) is used in the creation of specialty lubricants, offering anti-corrosion properties.
Thioglycolic Acid (TGA) is included in cosmetics as a pH adjuster and stabilizer in formulations.
Thioglycolic Acid (TGA) is applied in the electroplating industry as a brightener and leveling agent.
Thioglycolic Acid (TGA) is incorporated into personal care products, such as exfoliants, for controlled keratolytic activity.
Thioglycolic Acid (TGA) is used in leather tanning to remove hair and prepare hides for further processing.
Thioglycolic Acid (TGA) is found in specialty adhesives, enhancing adhesion properties to difficult substrates.
Thioglycolic Acid (TGA) is employed in the synthesis of thiol-containing compounds, including biologically active molecules.
Thioglycolic Acid (TGA) is utilized in the production of coatings and paints to improve film formation and durability.
Thioglycolic Acid (TGA) is a key additive in oil and gas drilling fluids, acting as a corrosion inhibitor.
Thioglycolic Acid (TGA) is used in textile processing to remove unwanted metal deposits and improve fabric brightness.
Thioglycolic Acid (TGA) is applied in specialty chemical formulations for electronics, ensuring high purity and performance.
DESCRIPTION
Thioglycolic Acid (TGA) is a clear, colorless to light-yellow liquid with a pungent odor, known for its strong reducing and chelating properties.
This compound exhibits excellent solubility in water, alcohols, and other polar solvents, making it versatile for various applications.
Thioglycolic Acid (TGA) is highly reactive due to its thiol (-SH) group, enabling efficient interaction with metals and proteins.
Thioglycolic Acid (TGA) is a critical component in depilatory products, altering disulfide bonds in keratin for effective hair removal.
In industrial applications, Thioglycolic Acid (TGA) acts as a stabilizer, chelator, and corrosion inhibitor in diverse formulations.
Thioglycolic Acid (TGA) is biodegradable, aligning with sustainability goals for environmentally friendly chemical processes.
This compound’s ability to control pH and metal ion activity enhances its value in analytical and industrial chemistry.
Thioglycolic Acid (TGA) is compatible with a range of resins and polymers, enabling its use in adhesives, coatings, and composites.
Its dual functionality as a carboxylic acid and thiol group compound allows Thioglycolic Acid (TGA) to perform unique chemical transformations.
PROPERTIES
Chemical Formula: HSCH2COOH
Molecular Weight: 92.11 g/mol
Common Name: Thioglycolic Acid (TGA)
Appearance: Clear, colorless to light-yellow liquid
Density: Approx. 1.33 g/cm³ at 20°C
Melting Point: -16°C
Boiling Point: Approx. 96°C (at 10 mmHg)
Flash Point: Approx. 80°C (closed cup)
Solubility: Highly soluble in water and polar organic solvents
Reactivity: Reactive with oxidizing agents; avoid excessive heat
Chemical Stability: Stable under recommended storage conditions
Storage Temperature: Store at 5–25°C in a dry, ventilated area
Vapor Pressure: Approx. 0.1 mmHg at 20°C
pH (1% Solution): Acidic
FIRST AID
Inhalation:
If vapors or fumes of Thioglycolic Acid (TGA) are inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.
Skin Contact:
Wash the affected area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Remove contaminated clothing and wash before reuse.
Eye Contact:
Flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.
Ingestion:
If Thioglycolic Acid (TGA) is ingested, rinse the mouth thoroughly with water.
Do not induce vomiting unless instructed by medical personnel.
Seek immediate medical attention if discomfort persists.
If the person is conscious, give small sips of water to drink.
Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.
HANDLING AND STORAGE
Handling:
Personal Protection:
Wear appropriate personal protective equipment (PPE), such as gloves, safety goggles, and protective clothing, when handling Thioglycolic Acid (TGA).
Use in a well-ventilated area to minimize exposure to vapors.
Ventilation:
Ensure proper ventilation during handling to prevent the accumulation of vapors.
Use local exhaust systems if necessary.
Avoidance:
Avoid direct contact with eyes, skin, and clothing.
Do not eat, drink, or smoke while handling.
Wash hands thoroughly after handling.
Spill and Leak Procedures:
Contain spills to prevent further release.
Absorb with inert material (e.g., sand, vermiculite) and collect for disposal.
Dispose of waste according to local regulations.
Storage:
Store in a cool, dry, well-ventilated area away from heat sources and incompatible materials.
Keep containers tightly closed when not in use.
Protect from freezing and contamination.
Handling Cautions:
Avoid exposure to oxidizing agents and excessive heat.
Ensure storage containers are compatible with the material.
