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EC / List no.: 200-677-4
CAS no.: 68-11-1
Mol. formula: C2H4O2S
Thioglycolic acid (TGA) is the organic compound HSCH2CO2H.
Thioglycolic acid (TGA) is often called mercaptoacetic acid (MAA).
Thioglycolic acid (TGA) contains both a thiol (mercaptan) and carboxylic acid functional groups.
Thioglycolic acid (TGA) is a colorless liquid with a strongly unpleasant odor.
Thioglycolic acid (TGA) is miscible with polar organic solvents.
Thioglycolic acid (TGA) is used as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate.
Thioglycolic acid (TGA) is the precursor to ammonium thioglycolate that is used for permanents.
Thioglycolic acid (TGA) and its derivatives break the disulfide bonds in the cortex of hair.
One reforms these broken bonds in giving hair a "perm."
Alternatively and more commonly, the process leads to depilation as is done commonly in leather processing.
Thioglycolic acid (TGA) is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.
In fact thioglycolysis reactions used on condensed tannins to study their structure.
Organotin derivatives of thioglycolic acid isooctyl esters are widely used as stabilizers for PVC. These species have the formula R2Sn(SCH2CO2C8H17)2.
Applying Thioglycolic acid (TGA) can soften nails and then fix pincer nails in the correct position.
Sodium thioglycolate is a component of a special bacterial growth media : thioglycolate broth.
Thioglycolic acid (TGA) is also used in so-called "fallout remover" or "wheel cleaner" to remove iron oxide residue from rims.
Ferrous iron combines with thioglycolate to form red-violet ferric thioglycolate.
Production
Thioglycolic acid is prepared by reaction of sodium or potassium chloracetate with alkali metal hydrosulfide in aqueous medium.
Thioglycolic acid (TGA) can be also prepared via the Bunte salt obtained by reaction of sodium thiosulfate with chloroacetic acid:
ClCH2CO2H + Na2S2O3 → Na[O3S2CH2CO2H] + NaCl
Na[O3S2CH2CO2H] + H2O → HSCH2CO2H + NaHSO4
Reactions
Thioglycolic acid with a pKa of 3.83 is about 10 times stronger an acid than acetic acid (pKa 4.76):
HSCH2CO2H → HSCH2CO2− + H+
The second ionization has a pKa of 9.3:
HSCH2CO2− → −SCH2CO2− + H+
Thioglycolic acid is a reducing agent, especially at higher pH.
Thioglycolic acid (TGA) oxidizes to the corresponding disulfide (2-[(carboxymethyl)disulfanyl]acetic acid or dithiodiglycolic acid):
2 HSCH2CO2H + "O" → [SCH2CO2H]2 + H2O
With metal ions
Thioglycolic acid, usually as its dianion, forms complexes with metal ions.
Such complexes have been used for the detection of iron, molybdenum, silver, and tin.
Thioglycolic acid reacts with diethyl acetylmalonate to form acetylmercaptoacetic acid and diethyl malonate, the reducing agent in conversion of Fe(III) to Fe(II).
History
Scientist David R. Goddard, in the early 1930s, identified Thioglycolic acid (TGA) as a useful reagent for reducing the disulfide bonds in proteins, including keratin (hair protein), while studying why protease enzymes could not easily digest hair, nails, feathers, and such.
He realized that while the disulfide bonds, which stabilize proteins by cross-linking, were broken, the structures containing these proteins could be reshaped easily, and that they would retain this shape after the disulfide bonds were allowed to re-form.
Thioglycolic acid (TGA) was developed in the 1940s for use as a chemical depilatory.
Description
Thio glycolic acid (TGA) is the organic compound HSCH2CO2H .
Thioglycolic acid (TGA) contains both a thiol (mercaptan) and a carboxylic acid.
Thioglycolic acid (TGA) is a clear liquid with a strong unpleasant odor.
Thioglycolic acid (TGA) is readily oxidized by air to the corresponding disulfide [SCH2CO2H]2.
Thioglycolic acid (TGA) was developed in the 1940s for use as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate. Thioglycolic acid (TGA) is the precursor to ammonium thioglycolate that is used for permanents.
Thioglycolic acid (TGA) and its derivatives break the disulfide bonds in the cortex of hair.
One reforms these broken bonds in giving hair a "perm."
Alternatively and more commonly, the process leads to depilation as is done commonly in leather processing.
Thioglycolic acid (TGA) is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.
Thioglycolic acid (TGA) is also used in the making of tin stabilizers often used in certain polyvinyl chloride products (such as vinyl siding).
TGA, usually as its dianion, forms complexes with metal ions.
Such complexes have been used for the detection of iron, molybdenum, silver, and tin.
Thioglycolic acid is used as nucleophile in thioglycolysis reactions used on condensed tannins to study their structure.
Chemical Properties
Thioglycolic acid is a colorless liquid with a strong unpleasant odor like rotten eggs.
Chemical Properties
Also known as mercaptoacetic acid, HSCH2COOH is a colorless liquid with a strong unpleasant odor. Used as a reagent for metals such as iron, molybdenum, silver, and tin,and in bacteriology.
Uses
Thioglycolic Acid is an organic compound containing both a thiol and a carboxylic acid.
Thioglycolic Acid is a precursor to ammonium thioglycolate, a chemical used for permanents.
Thioglycolic Acid is used in organic synthesis as a nucleophile in thioglycolysis reactions and is used as a S transfer agent for sulfonyl chloride synthesis.
Sensitive reagent for iron, molybdenum, silver, tin.
With ferric iron a blue color appears, and when an alkali hydroxide is added to a solution contg ferrous salts and thioglycolic acid, a yellow precipitate forms.
Used in the manufacture of thioglycolates.
The ammonium and sodium salts are commonly used for cold waving and the calcium salt is a depilatory.
The sodium salt also is used in bacteriology in the preparation of thioglycolate media.
Mercaptoacetic acid is used as a reagent formetals analysis; in the manufacture of thioglycolates, pharmaceuticals, and permanentwave solutions; and as a vinyl stabilizer.
Carbonyl condensation catalyst
Used as a raw material in the manufacture of fine and specialty chemicals in the pharmaceutical and agricultural sectors.
Sensitive reagent for iron, molybdenum, silver, tin ... Used in the manufacture of thioglycolates.
The ammonium and sodium salts are commonly used for cold waving and the calcium salt is a depilatory.
The sodium salt is used in bacteriology in the prepn of thioglycolate media.
General Description
A colorless liquid with an unpleasant odor.
Density 1.325 g / cm3.
Used to make permanent wave solutions and depilatories.
Corrosive to metals and tissue.
Air & Water Reactions
Readily oxidized by air.
Water soluble.
Reactivity Profile
Mercaptoacetic acid is readily oxidized by air .
Reacts readily with other oxidizing agents as well in reactions that may generate toxic gases.
Incompatible with diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents.
Reactions with these materials may generate heat and toxic and flammable gases.
May react with acids to liberate hydrogen sulfide. Neutralizes bases in exothermic reactions.
Reacts with cyanides, sulfites, nitrites, thiosulfates to generate flammable and toxic gases and heat.
Reacts with carbonates and bicarbonates.
Application
Thioglycolic acid may be used as a sulfur source for the synthesis of metal sulfide nanostructures via hydrothermal process.
Thioglycolic acid appears as a colorless liquid with an unpleasant odor.
Density 1.325 g / cm3.
Used to make permanent wave solutions and depilatories.
Corrosive to metals and tissue.
Thioglycolic acid is a sulfur-containing carboxylic acid. Thioglycolic acid (TGA) is a conjugate acid of a thioglycolate(1-).
Thioglycolic acid is under investigation in clinical trial NCT03238105 (Treatment of Periorbicular Hyperchromia Comparing 10% Thioglycolic Acid Peeling Versus Pulsed Intense Light).
Industry Uses
Corrosion inhibitors and anti-scaling agents
Intermediates
PVC heat stabilizer
Solids separation agents
Consumer Uses
Building/construction materials not covered elsewhere
Methods of Manufacturing
Industrially, mercaptoacetic acid is produced from chloroacetic acid or its salts and sodium or potassium hydrogen sulfide.
Thiodiglycolic acid, dithiodiglycolic acid, and glycolic acid may be formed as side products.
The mercaptoacetic acid is isolated from the acidified reaction mixture by extraction with organic solvents (ethers, alcohols, or chlorinated hydrocarbons) and purified by distillation.
Both batch and continuous processes have been described in the patent literature as well as processes that operate under a partial pressure of hydrogen sulfide or carbon dioxide.
Prepd by the action of sodium sulfhydrate on sodium chloroacetate; by electrolysis of dithioglycollic acid (from sodium sulfide and sodium chloroacetate).
According to the Cosmetic, Toiletry, and Fragrance Association (CTFA), Thioglycolic Acid may be prepared via the reaction of sodium or potassium chloracetate with alkali metal hydrosulfide in aqueous medium.
The reaction mixture is acidified and purified by organic extraction and vacuum distillation.
Impurities
Cosmetic grade Thioglycolic Acid consists of Thioglycolic Acid (78% minimum), iron (0.02 ppm maximum), and monochloroacetic acid (0.05% maximum).
The following are listed in the CTFA Specification for Thioglycolic Acid:
dithiodiglycolic acid (2.0% maximum), sulfated ash (0.05% maximum), arsenic (3 ppm maximum), copper (1 ppm maximum), and lead (20 ppm maximum).
/Other sources/ reported that Thioglycolic Acid was pure at 99%.
Water content was <0.3% and dithiodiglycolic acid, thioglycolides, and monochloroacetic acid were reported as <0.4%, <0.3%, and <100 ppm, respectively.
General Manufacturing Information
Industry Processing Sectors
All other basic organic chemical manufacturing
Mining (except oil and gas) and support activities
Oil and gas drilling, extraction, and support activities
Plastic material and resin manufacturing
IDENTIFICATION AND USE:
Mecracaptoacetic acid is a clear, colorless liquid with a strong, unpleasant odor.
Thioglycolic acid (TGA) is used in the manufacture of pharmaceuticals, thioglycolates, permanent wave solutions, depilatories, and as a vinyl stabilizer.
Thioglycolic acid (TGA) is a sensitive reagent for iron, molybdenum, silver, tin.
Mercaptoacetic acid is also used as a hair waving agent.
In addition it is used in hydraulic fracturing mixtures to prevent precipitation of metal oxides (iron control).
About Thioglycolic acid (TGA)
Helpful information
Thioglycolic acid (TGA) is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.
Thioglycolic acid (TGA) is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Consumer Uses
Thioglycolic acid (TGA) is used in the following products: cosmetics and personal care products.
Other release to the environment of Thioglycolic acid (TGA) is likely to occur from: indoor use as processing aid.
Article service life
ECHA has no public registered data on the routes by which Thioglycolic acid (TGA) is most likely to be released to the environment. ECHA has no public registered data indicating whether or into which articles the substance might have been processed.
Widespread uses by professional workers
Thioglycolic acid (TGA) is used in the following products: laboratory chemicals and cosmetics and personal care products.
Thioglycolic acid (TGA) is used in the following areas: scientific research and development.
Other release to the environment of Thioglycolic acid (TGA) is likely to occur from: indoor use as reactive substance and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).
Formulation or re-packing
Thioglycolic acid (TGA) is used in the following products: leather treatment products and cosmetics and personal care products.
Thioglycolic acid (TGA) has an industrial use resulting in manufacture of another substance (use of intermediates).
Release to the environment of Thioglycolic acid (TGA) can occur from industrial use: formulation of mixtures.
Uses at industrial sites
Thioglycolic acid (TGA) is used in the following products: oil and gas exploration or production products.
Thioglycolic acid (TGA) has an industrial use resulting in manufacture of another substance (use of intermediates).
Thioglycolic acid (TGA) is used in the following areas: mining and scientific research and development.
Thioglycolic acid (TGA) is used for the manufacture of: chemicals.
Release to the environment of Thioglycolic acid (TGA) can occur from industrial use: of substances in closed systems with minimal release, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).
Manufacture
Release to the environment of Thioglycolic acid (TGA) can occur from industrial use: manufacturing of the substance.
General Information
Thioglycolic acid is a colorless liquid with a strong, typical mercaptan disagreeable odor (although olfactory fatigue may occur) which is used in cosmetic formulations including permanent wave solutions and depilatories, in pharmaceutical manufacture, and as a stabilizer for vinyl plastics.
A recent use is as a capping or stabilizing agent for Cd/Te quantum microdots (QDs).
Thioglycolic acid (TGA) is a member of the thioglycolate chemical class.
Other names for thioglycolic acid include:
Mercaptoacetic acid
Thiovanic sacid
Thioglycollic acid
Acetomercaptan
Mercaptoacetate
2-Mercaptoacetic acid
2-Thioglycolic acid
Thioglycolic Acid
The Thioglycolic acid (TGA) also called Mercaptoacetic acid (MAA) (CAS 68-11-1) is a high-performance chemical containing mercaptan and carboxylic acid functionalities.
Thioglycolic acid is completely miscible in water and in general polar organic solvents.
Thioglycolic acid is a strong reducing agent especially at high pH and forms powerful complexes with metals that give it specific characteristics.
Thioglycolic acid is used in industries and applications as diverse as cosmetics, oil and gas, polymerization, fine chemistry, leather processing, cleaning, and metals receovery.
The Thioglycolic acid (TGA) is:
A polar and dual functional (-SH & -COOH) mercaptan
Fully water soluble
Colorless and liquid
A strong reducing agent especially at high pH
A powerful complexing/chelating agent
A good nucleophilic agent
A wide range of Industrial applications
Cosmetics
The salts of thioglycolic acid and also some of its esters are used in the formulation of perms and for the preparation of depilatory creams.
In these applications, the main salts are ammonium thioglycolate and potassium thioglycolate.
In some areas, glycerol monothioglycolate is also used.
Oil & Gas
Thioglycolic acid (TGA) is used in several areas of the Oil & Gas industry:
As a reducing and chelating agent to limit Fe3+ precipitation during well drilling or stimulation.
For the oil refining, thioglycolic acid mercaptides act as passivating agents during the catalytic cracking of hydrocarbons to limit the contamination of metal catalysts (Ni, V, etc.)
Thioglycolic acid is also used as an additive in corrosion inhibiting formulations to protect the equipment.
Corrosion inhibitors are injected either continuously into the fluid stream or into a producing well.
Polymerization
Thioglycolic acid (TGA) is a very effective chain transfer agent for emulsion polymerizations in aqueous media, in particular for acrylic acid and acrylates.
The total miscibility of Thioglycolic acid (TGA) with water is a benefit in this application.
Fine chemicals
Thioglycolic acid is used as reagent for the preparation of different chemicals such as pesticides, herbicide, or for some polythiols and thio-esters.
Leather processing
Alkaline sodium thioglycolate is used for the removal of hair during the beamhouse step in the industry of the leather hides’ treatment. Thioglycolic acid (TGA) allows the manufacturers to obtain a more resource-efficient and less polluting process as compared to the more toxic and harmful sodium hydrosulfide. Compound (NaSH). Indeed, it minimizes the wastewater treatment and reduces the risk of hydrogen sulfide generation therefore improving the working conditions and safety.
Cleaning formulations
Due to their ability to complex with metals, thioglycolic acid and thioglycolic acid salts are excellent additives in cleaning solutions, in particular for automotive applications including automotive wheel rim cleaners.
Mining & Metal treatment
Thioglycolic acid (TGA) and its derivatives are also used as depressant agents in flotation processes for separating valuable metals from ores in mining operations.
Thioglycolic acid (TGA) derivatives are a safer alternative to the more traditional sodium sulfhydrate (NaSH), particularly in mining environments.
Thioglycolic acid (TGA) is also an additive for coating formulations for metal surface cleaning and protection from corrosion and other damages.
Related market & applications
Chemical And Plastic Industry
Polymer Manufacturing
Detergency & Cleaning Chemicals
Chemicals Manufacturing
Coatings & Inks
Textile & Leather Coating
Health, Hygiene & Beauty
Beauty, Perfumes, & Cosmetics
Metallurgy & Mining
Mining
Oil & Gas
Upstream
Thioglycolic acid and its salts may be used in:
(a) Hair products:
— general use, max concentration allowed 8% (pH 7 to 9.5)
— professional use, max concentration allowed 11% (pH 7 to 9.5)
(b) Depilatories, max concentration allowed 5% (pH 7 to 12.7)
(c) Hair rinse-off products, max concentration allowed 2% (pH up to 9.5)
Homogeneity and Stability
Stable at room temperature in closed containers under normal storage and handling
conditions.
Thioglycolic acid (TGA) oxidizes when exposed to air.
According to information submitted by the industry (ICADA 2012) the stability of thioglycolic acid in a gel preparation, containing circa 8.8% (range 8.7% to 8.9%) thioglycolic acid, over seven months at alternating temperatures (20°C / 40°C) in different bottles was evaluated.
In the polyolefin bottle, the content of the active ingredient declined to 82.8% of the initial value.
In the glass bottle the thioglycolic acid was able to resist the thermal stress (the final measured content was 97.8% of the t0-value).
When the original product was stored at room temperature over one year, the content of the active ingredient declined to 94.9% of the initial value.
Thus, this marketed product appeared to be stable with respect to thioglycolic acid content when stored in a glass bottle.
Physical Description
Colorless liquid with a strong, disagreeable odor characteristic of mercaptans.
[Note: Olfactory fatigue may occur after short exposures.]
Why is it used in cosmetics and personal care products?
Thioglycolic Acid and it salts and esters modify hair fibers to facilitate changes to the structure of the fibers, such as with permanent waves or with hair straightening.
They are also used to chemically break down hair fibers so that unwanted hair can be removed by simply wiping it from the skin.
Scientific Facts:
Thioglycolic Acid and its salts and esters break disufide bonds in the cortex of the hair.
After washing, the hair is treated with a mild solution of hydrogen peroxide, which causes new bonds to form, giving hair the rigid structure necessary for permanent waves.
What Is Thioglycolic Acid?
Thioglycolic Acid is an organic compound that contains a thiol group (-SH) and carboxylic acid.
Thioglycolic Acid is a colorless liquid.
Applications
Reagent that protects tryptophan in amino acid analysis.
Mercaptoacetic acid is used as a protecting agent for tryptophan in amino acid analysis and an acidity indicator.
Thioglycolic acid (TGA) finds application as an intermediate in the chemical reactions such as addition, elimination and cyclization.
Thioglycolic acid (TGA) acts as a precursor to ammonium thioglycolate, sodium thioglycolate and calcium thioglycolate.
Its organotin derivatives are used as stabilizers for polyvinyl chloride (PVC).
In organic synthesis, it acts as a nucleophile in thioglycolysis reactions and sulfur transfer agent for sulfonyl chloride synthesis.
Further, it is used in leather processing.
Solubility
Miscible with water, ethanol, ethers, ketones, esters, chlorinated hydrocarbons, benzene and aromatic hydrocarbons.
Slightly miscible with chloroform.
Thioglycolic acid is an organic acid used in the preparation of thioglycolate media.
Thioglycolic acid (TGA) is used as a sulfur transfer agent for sulfonyl chloride synthesis, as well as, a nucleophile in thioglycolysis reactions.
Physical State :Liquid
Storage :Store at -20° C
Melting Point :-16° C(lit.)
Boiling Point :96° C (lit.) at 5 mmHg
Density :1.33 g/mL at 20° C (lit.)
Refractive Index :n20/D 1.505
General Description
A colorless liquid with an unpleasant odor.
Density 1.325 g / cm3.
Used to make permanent wave solutions and depilatories.
Corrosive to metals and tissue.
The interaction of thioglycolic acid (HSCH2COOH) with the Au(111) surface is investigated, and it is found that at the low coverage the molecule lies down on the substrate.
If the mercaptan-hydrogen atom is eliminated, the resulting SCH2COOH molecule is randomly oriented on the surface.
If the carboxylic acid group in the HSCH2COOH molecule is deprotonated instead, the HSCH2COO− molecule lies down on the surface.
However, when the mercaptan-hydrogen atom in the HSCH2COO− molecule is removed, the resulting SCH2COO− molecule rises up to a certain level on the substrate.
The calculated Raman vibrational spectra decipher which compounds and atomic displacements contribute to the corresponding frequencies.
We thus propose a consistent mechanism for the deposition of thioglycolic acid on the Au(111) surface.
Thioglycolic acid is an organic thioacid used as an agent for chemical peels in the approach to periocular constitutional hyperchromia in hemosiderin deposits, such as ochre dermatitis of the legs, with reports of its use in post-inflamatory hyperchromia, showing promise as a therapeutic adjuvant for the treatment of these dermatoses.
How is it used?
Thioglycolic acid is used in cosmetics* such as hair products, depilatories and eyelash waving products.
Thioglycolic acid (TGA) functions as an antioxidant, reducing (changes the chemical nature of another substance by adding hydrogen or removing oxygen), hair waving or straightening agent (modifies the chemical structure of the hair, allowing it to be set in the style required).
The substance is generally only for use for professional.
THIOGLYCOLIC ACID is classified as :
Antioxidant
Depilatory
Hair waving or straightening
Reducing
Category
Antioxidants
Depilatory Agents
Restructuring / Replenishing Agents
Smoothing Agents
Application/Recommended for
Hair care (Shampoos, Conditioners & Styling)
Toiletries (Shower & Bath, Oral care...)
Thioglycolic acid (TGA) is the organic compound HSCH2CO2H.
Thioglycolic acid (TGA) contains both a thiol (mercaptan) and a carboxylic acid.
Thioglycolic acid (TGA) is a clear liquid with a strong unpleasant odor.
Thioglycolic acid (TGA) is readily oxidized by air to the corresponding disulfide [SCH2CO2H]2.
Thioglycolic acid (TGA) was developed in the 1940s for use as a chemical depilatory and is still used as such, especially in the calcium thioglycolate salt form.
Thioglycolic acid (TGA) is the precursor to ammonium thioglycolate that is used for permanents.
Thioglycolic acid (TGA) and its derivatives break the disulfide bonds in the cortex of hair.
One reforms these broken bond in giving hair a "perm." Alternatively and more commonly, the process leads to depilation as is done commonly in leather processing
Thioglycolic acid (TGA) is also used in the making of polyvinyl chloride.
TGA, usually as its dianion, forms complexes with metal ions.
Such complexes have been used for the detection of iron, molybdenum, silver, and tin.
Thioglycolic acid (TGA) is used as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate.
Thioglycolic acid (TGA) is the precursor to ammonium thioglycolate that is used for permanents.
Thioglycolic acid (TGA) and its derivatives break the disulfide bonds in the cortex of hair.
Use: Thioglycolic acid forms powerful complexes with metals that gives it specific characteristics sought after for the assisted recovery of ore as well as for cleaning and corrosion inhibition.
Use: TGA's unique reducing properties make it an ideal candidate for a wide variety of chemical reactions including addition, elimination, or cyclization reactions.
TGA's thiol group (-SH) will react in the presence of bases, acids, ketone groups or organic halogens.
In the presence of alcohols or amines, the carboxylic group will react preferentially.
Thioglycolic acid modifies the hair fibers to facilitate their restructuring: it is used, for example, in hair restructuring products.
Thioglycolic acid (TGA) is also used to chemically decompose unwanted hair so that it can then be removed by simply wiping it off.
Thioglycolic acid (TGA) is its potassium salt which is the most used today.
Thioglycolic acid (CAS: 68-11-1) is a chemical compound very present in the cosmetic industry, particularly in depilatory creams and cold perms.
This molecule has also found its use in the petrochemical, agrochemical and pharmaceutical industries.
The organotin derivatives of thioglycolic acid esters (CAS: 68-11-1) are for example used as stabilizers for PVC.
However, this acid is corrosive and toxic by inhalation, ingestion and skin contact.
Thioglycolic acid is the organic compound HSCH2CO2H.
Thioglycolic acid (TGA) contains both a thiol and a carboxylic acid.
Thioglycolic acid (TGA) is a clear liquid with a strong unpleasant odor.
Thioglycolic acid (TGA) is readily oxidized by air to the corresponding disulfide [SCH2CO2H]2.
Thioglycolic acid (TGA) was developed in the 1940s for use as a chemical depilatory and is still used as such, especially in salt forms, including calcium thioglycolate and sodium thioglycolate.
Thioglycolic acid (TGA) is the precursor to ammonium thioglycolate that is used for permanents.
Thioglycolic acid (TGA) and its derivatives break the disulfide bonds in the cortex of hair.
One reforms these broken bonds in giving hair a "perm." Alternatively and more commonly, the process leads to depilation as is done commonly in leather processing.
Thioglycolic acid (TGA) is also used as an acidity indicator, manufacturing of thioglycolates, and in bacteriology for preparation of thioglycolate media.
Thioglycolic acid (TGA) is also used in the making of tin stabilizers often used in certain polyvinyl chloride products.
TGA, usually as its dianion, forms complexes with metal ions.
Such complexes have been used for the detection of iron, molybdenum, silver, and tin.
Thioglycolic acid is used as nucleophile in thioglycolysis reactions used on condensed tannins to study their structure.
Uses
Chemical intermediate for thioglycolates (eg, calcium thioglycolate), ingredient of depilatories, permanent hair wave solutions and biological media for microorganism growth, reagent for detection of iron and other metal ions, chelating agent.
IUPAC names
2-Sulfanylacetic acid
2-sulfanylacetic acid
Mercaptoacetic acid
mercaptoacetic acid
sulfanylacetic acid
Thioglycolic acid
thioglycolic acid
thioglycolic acid
Thioglycolic acid TGA, mercaptoacetic acid
THIOGLYKOLSAEURE
SYNONYMS:
2-MERCAPTOACETIC ACID
2-mercaptoacetate
2-Thioglycolic acid
2-thio-glycolicaci
2-thioglycolicacid
Aceticacid,mercapto-
Acide thioglycolique
acidethioglycolique
acidethioglycolique(french)
alpha-Mercaptoacetic acid
thioglycolic
thio-glycolicaci
Thiovanic acid
thiovanicacid
USAF cb-35
usafcb-35
Thiovanie acid
THIOGLYCOLIC ACID
THIOGLYCOLLIC ACID
Thioglyeollic acid
TGA
TRIGLYCOLIC ACID
Thioglycolic acid solution,Mercaptoacetic acid
THIOGLYCOLIC ACID REAGENT, (Mercaptoacetic Acid)
MERCAPTOACETIC ACID
THIOGLYCOLIC ACID GR FOR ANALYSIS
Mercaptoacetic acid, 98% 250ML
Thioglycolic acid (TGA)
Acetic acid,2-Mercapto-
Thioglycolic acid >=99%
Thioglycolic acid >=98%
Benzene Ramification
Mercaptoacetic acid TGA
ic acid soL
Thiog
Hydrophobic base acetic acid
alpha-mercaptoaceticacid
Glycolic acid, 2-thio-
Glycolic acid, thio-
glycolicacid,2-thio-
Kyselina merkaptooctova
Kyselina thioglykolova
kyselinamerkaptooctova
kyselinathioglykolova
Mercaptoacetate
mercaptoacetic
mercapto-aceticaci
Sulfanylacetic acid
Thioglycolate
thioglycolic acid free acid
Thioglycolic acid solution
Thioglypollic Acid
THIOGLYCOLIC ACID 80 % EXTRA PURE
THIOGLYCOLIC ACID 80%, A PRODUCT FROM EL F ATOCHEM (TGA80%)
MERCAPTOESSIGSAEURE 99+%, EIN PRODUKT VO
THIOGLYCOLIC ACID SOLUTION, 80% IN WATER
MERCAPTOACETIC ACID, 99+% (TGA99) (WORLD
MERCAPTOACETIC ACID, SOLUTION EXTRA PURE 80+%
