TIONSIL 1258

TIONSIL 1258 typically has a fine particle size, which contributes to its high surface area and absorption capabilities.
TIONSIL 1258 is a potent activator of unique E3 ligase F-box/LRR-repeat protein 2 (FBXL2) that increases levels of FBXLs protein, thus promoting Aurora B degradation. 
TIONSIL 1258 induces mitotic arrest and apoptosis of tumorigenic cells. 

CAS Number: 1507370-40-2

Synonyms N,N′-Bis-(4-thiazol-2-yl-benzyl)-ethane-1,2-diamine,BC-1258,N,N'-bis[[4-(1,3-thiazol-2-yl)phenyl]methyl]ethane-1,2-diamine,1,2-Ethanediamine, N1,N2-bis[[4-(2-thiazolyl)phenyl]methyl]-,LRR,F-box,inhibit,repeat,BC-?1258,BC ?1258,FBXL2,Apoptosis,tumor,Inhibitor,BC?1258,N1,N2-Bis(4-(thiazol-2-yl)benzyl)ethane-1,2-diamine,LRR|||F-box|||BC1258|||inhibit|||repeat|||BC-1258|||BC-1258|||BC-?1258|||BC ?1258|||FBXL2|||Apoptosis|||BC-1258|||tumor|||Inhibitor|||BC?1258|||BC 1258,BC-1258, 10 mM in DMSO

TIONSIL 1258 has a high surface area, which makes it very effective as an adsorbent.
The material has a highly porous structure, which increases its ability to absorb various substances.
TIONSIL 1258 is an amorphous form of silica, meaning it does not have a crystalline structure, which makes it more effective in certain applications compared to crystalline silica.

Also TIONSIL 1258 inhibits tumor formation in athymic nude mice.
TIONSIL 1258 is a type of silica gel produced by Tianjin Tianshi Chemical Co., Ltd. 
It is primarily a high-purity, amorphous, and highly porous material that belongs to the class of silica-based adsorbents. 

TIONSIL 1258 is widely used in various applications due to its unique properties, such as its high surface area and the ability to absorb moisture or other substances.
TIONSIL 1258 is its high surface area, which significantly enhances its adsorption capacity. 
This makes it an excellent material for trapping small molecules, gases, and moisture, contributing to its widespread use in purification and separation processes.

The material has a highly porous and open structure, which allows it to absorb and retain moisture, gases, and other substances, depending on the application. 
The porosity increases the material’s effectiveness as an adsorbent and helps it maintain stability under various environmental conditions.
Unlike crystalline silica, which can pose risks such as respiratory issues when inhaled, TIONSIL 1258 is amorphous, meaning it does not have a rigid crystal structure. 

This gives it a more flexible range of applications, such as in catalyst support and dehumidification, without the same level of danger typically associated with crystalline silica.
TIONSIL 1258 is a high-purity, amorphous silica gel that is widely utilized in various industrial and scientific applications due to its unique properties, which include a high surface area, excellent porosity, and significant moisture-absorbing capabilities. 
Manufactured by Tianjin Tianshi Chemical Co., Ltd., this silica gel is primarily recognized for its ability to serve as an efficient adsorbent material, making it particularly valuable in processes such as chromatography, gas separation, and moisture control.

The silica gel is commonly employed as a desiccant in many industries, including pharmaceuticals, food, and electronics, where controlling moisture is critical. 
Its moisture-absorbing properties help in preventing damage to sensitive products by keeping the surrounding environment dry, thus extending the shelf life of products and preserving their integrity.

TIONSIL 1258 is used as a support for catalysts in various chemical reactions, where its high surface area and porous structure provide an ideal medium for holding the catalyst. 
This enhances the efficiency of the reaction by allowing the reactants to come into contact with the catalyst more effectively.
TIONSIL 1258 also serves as a carrier for pigments in paints and coatings. 

Its high surface area helps in evenly dispersing pigments, resulting in more stable formulations that maintain their color and appearance over time.
As a highly efficient dehydrating agent, TIONSIL 1258 is employed in chemical synthesis processes that require the removal of water from organic compounds. 
Its ability to absorb moisture makes it useful in a variety of chemical processes, especially when water is an undesired by-product.

storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear (warmed)
form: powder
color: white to beige
InChI: InChI=1S/C22H22N4S2/c1-5-19(21-25-11-13-27-21)6-2-17(1)15-23-9-10-24-16-18-3-7-20(8-4-18)22-26-12-14-28-22/h1-8,11-14,23-24H,9-10,15-16H2
InChIKey: FRTSLZJCGAFSET-UHFFFAOYSA-N

TIONSIL 1258, can pose a risk to the respiratory system. 
Prolonged exposure to silica dust may lead to irritation of the airways, coughing, and wheezing. 
Chronic inhalation of large amounts of silica dust can result in more serious conditions, such as silicosis, a form of lung disease. 

Therefore, adequate ventilation and protective equipment, such as dust masks, should be used when handling this material in powder form.
While TIONSIL 1258 is not typically harmful upon brief contact, prolonged skin exposure can lead to irritation. 
Similarly, if the material comes into contact with the eyes, it may cause redness, discomfort, and watering. 

Protective gloves and safety goggles should be worn to minimize the risk of irritation during handling.
Although TIONSIL 1258 is biodegradable, it is important to handle and dispose of the material according to local environmental regulations. 
Large quantities of silica can contribute to environmental pollution if disposed of improperly, potentially affecting water or soil quality.

While TIONSIL 1258 is not highly flammable, it is an organic material, and like most such substances, it can catch fire under certain conditions, especially if exposed to open flames or high heat. 
In case of fire, appropriate fire suppression methods, such as using a fire extinguisher suitable for chemical fires, should be followed.
TIONSIL 1258 contributes to its high surface area and allows for efficient adsorption, making it especially useful in applications that require fast and effective absorption, such as in desiccants for packaging or in laboratory applications.

Due to its high surface area and porous structure, TIONSIL 1258 is widely used as an adsorbent in chromatography. 
Its ability to adsorb a wide range of molecules makes it particularly effective in separating different compounds in chemical processes, making it a staple in analytical laboratories.
TIONSIL 1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator that stabilized and increased levels of FBXL2 protein that promoted Aurora B degradation, resulting in tetraploidy, mitotic arrest and apoptosis of tumorigenic cells, and profoundly inhibiting tumor formation in athymic nude mice. 

TIONSIL 1258 is sufficient to stabilize and upregulate FBXL2 levels, and, when administered in vivo, prematurely depletes Aurora B by SCFFBXL2-induced ubiquitination and degradation, leading to cell death and inhibiting growth of human leukemic cells in a xenograft model.
TIONSIL 1258 may pose respiratory hazards if its dust is inhaled. 

It could irritate the respiratory tract and lead to conditions like silicosis if exposure is prolonged and not controlled.
Contact with the eyes or prolonged skin exposure may lead to irritation. 
Wearing appropriate personal protective equipment (PPE) such as gloves and goggles is recommended during handling.

Uses Of TIONSIL 1258:
TIONSIL 1258 is often used as an adsorbent in applications like chromatography and gas separation. 
Its porous structure helps in trapping moisture or other small molecules from gases or liquids.
TIONSIL 1258 is used in desiccant applications, where its moisture-absorbing properties are valuable in preventing damage to products from humidity or moisture.

TIONSIL 1258 can be used as a support material for catalysts in various chemical reactions. 
Its large surface area allows it to support the catalyst and enhance the reaction efficiency.
In some industries, it is used as a carrier for pigments, enhancing the dispersion and stability of the pigment in formulations.

Due to its moisture-absorbing nature, TIONSIL 1258 can be used to remove water from organic compounds, making it useful in chemical synthesis processes.
TIONSIL 1258 is extensively used as an adsorbent in chromatography, where it plays a crucial role in separating and purifying different chemical compounds. 
Its high surface area and porous structure allow it to effectively interact with molecules, making it ideal for applications where precise separation and analysis are required, such as in research laboratories, pharmaceutical production, and environmental testing.

This silica gel is widely employed as a desiccant to control humidity in various packaging and storage environments. 
By absorbing moisture from the air, TIONSIL 1258 helps protect sensitive products, such as electronics, pharmaceuticals, and food items, from moisture-related damage, thereby extending their shelf life and ensuring their integrity throughout the supply chain. 
Its ability to maintain low humidity levels is crucial in preventing the degradation of products that are sensitive to water.

In chemical processes, TIONSIL 1258 is used as a support material for catalysts, particularly in reactions that require high surface area for better catalytic efficiency. 
The porous nature of TIONSIL 1258 allows for greater interaction between the catalyst and reactants, leading to more efficient reactions. 
This application is commonly found in petrochemical refining, pharmaceutical synthesis, and other industries that rely on catalytic processes.

TIONSIL 1258 serves as a carrier for pigments in coatings and paints. 
Its fine particle size and high surface area allow it to evenly disperse pigments, resulting in more stable and uniform paint formulations. 
This helps enhance the quality and appearance of finished products, ensuring that the pigments maintain their color and intensity over time, even under harsh environmental conditions.

TIONSIL 1258 is often used as a dehydrating agent in chemical synthesis, particularly when water removal is essential in the preparation of certain compounds. 
Its excellent moisture-absorbing properties make it highly effective in eliminating water from organic compounds, which is particularly important in processes such as the production of pharmaceuticals, fine chemicals, and specialty materials.
As a highly effective moisture absorber, TIONSIL 1258 is used in packaging materials to prevent the growth of mold, mildew, and bacteria, which can thrive in damp environments.

This makes it particularly valuable for products that need to remain dry, such as food, medical devices, and electronics, ensuring that they are kept in optimal conditions during transportation and storage.
TIONSIL 1258 is also used in environmental applications such as water purification, where its high adsorption capacity can help remove pollutants and contaminants from water.
By trapping harmful substances, it contributes to cleaner water sources and can be part of filtration systems aimed at improving water quality for industrial, agricultural, or municipal use.

TIONSIL 1258 is sometimes used in the pharmaceutical and personal care industries, where its absorbent properties help in the formulation of creams, lotions, and gels. 
Its ability to absorb excess moisture and provide a smooth texture makes it an ideal ingredient for products that need to maintain a consistent viscosity and stability. 
Additionally, it helps with the controlled release of active ingredients in drug formulations and topical applications, ensuring that products perform effectively and consistently.

In the rubber and plastics industries, TIONSIL 1258 is used as a reinforcing agent and processing aid. 
It improves the durability, flexibility, and strength of the materials by enhancing their mechanical properties. 
This makes it a valuable additive in the production of high-performance rubber products, such as seals, gaskets, and tires, as well as plastic components used in automotive, construction, and electronics applications.

Soil Remediation: Due to its excellent adsorption characteristics, TIONSIL 1258 is utilized in environmental remediation efforts, particularly in soil contamination clean-up projects. 
The material can help absorb and remove heavy metals, hydrocarbons, and other pollutants from contaminated soil, aiding in the restoration of soil quality. 
This is especially important for remediating industrial sites, landfills, and areas impacted by oil spills or chemical leaks.

In food packaging and preservation, TIONSIL 1258 is employed to absorb excess moisture in food products, such as dried foods, snacks, and spices. 
By maintaining low moisture levels, it helps preserve the freshness, texture, and shelf life of these products. 
This application is crucial for preventing spoilage and mold growth in food items, ensuring they remain safe and edible for longer periods.

TIONSIL 1258 can also be found in the cosmetic and fragrance industry, where it serves as a carrier for scents and other ingredients. 
Its ability to bind with aromatic compounds ensures that fragrances are evenly distributed in products like perfumes, deodorants, and body sprays. 
Furthermore, its moisture-absorbing capabilities help maintain the stability and longevity of these products, ensuring they retain their quality over time.

TIONSIL 1258 is sometimes used in the textile industry as a treatment for fabrics. 
It can improve the texture, moisture resistance, and durability of textiles, making them more suitable for specific uses, such as waterproof clothing, outdoor gear, and upholstery. 
TIONSIL 1258 may also be used in fabric finishing processes to create fabrics with enhanced performance characteristics.

In addition to its applications in soil and water purification, TIONSIL 1258 can be used in the cleanup of oil spills, particularly in aquatic environments. 
The material’s high adsorption capacity allows it to efficiently soak up oils and hydrocarbons, making it a valuable component in the development of materials designed for cleaning up spills in oceans, rivers, and lakes.

Beyond its role in pigment dispersion, TIONSIL 1258 can be used as an additive in paints and coatings to enhance properties such as durability, scratch resistance, and weatherability. 
TIONSIL 1258 helps create smoother and more consistent finishes, which is especially valuable in automotive paints, industrial coatings, and protective coatings for infrastructure and machinery.

Safety Profile Of TIONSIL 1258:
To ensure safe handling and minimize the potential hazards associated with TIONSIL 1258, it is important to:
Work in well-ventilated areas to avoid inhalation of silica dust.
Wear appropriate protective equipment, including gloves, goggles, and respiratory protection, especially when handling the material in powder form.

Store TIONSIL 1258 in cool, dry conditions, away from sources of heat or open flames, and in accordance with the manufacturer’s storage guidelines.
Dispose of the material following local safety and environmental regulations to avoid contamination.
Inhalation of fine silica dust, such as that from TIONSIL 1258, can cause irritation to the respiratory system. 

Long-term or repeated exposure to airborne silica dust can lead to more serious conditions such as silicosis, a chronic lung disease that results from the accumulation of silica particles in the lungs. 
TIONSIL 1258 is important to use proper respiratory protection when working with TIONSIL 1258 in its powdered form or in processes that generate airborne dust.
Direct contact with TIONSIL 1258 dust or particles may cause irritation to the eyes. 

The fine particles can irritate the conjunctiva and cause discomfort, redness, or watering of the eyes. 
Wearing protective eyewear is recommended when handling the material in bulk or during activities that may generate dust.
Prolonged or repeated contact with TIONSIL 1258 in its powder form can cause mild skin irritation, especially if the material is not handled properly. 

The particles may cause dryness or redness of the skin in sensitive individuals. 
Although it is generally not considered highly toxic, it is recommended to wear gloves and protective clothing to minimize contact and reduce the risk of irritation.