PRODUCTS

TMG TETRAMETHYL GUANIDINE

TMG Tetramethyl Guanidine is employed as a polyurethane foam catalyst, as an accelerator for the syntheses of polysulfured rubber.
TMG Tetramethyl Guanidine is also used as a strong base in the photochemical (couplers) and in the pharmaceutical (steroids) industries.
TMG Tetramethyl Guanidine serves as an efficient and selective catalyst for the benzoylation of alcohols.

CAS Number: 80-70-6.
EC / EINECS number: 201-302-7.
Name (IUPAC): N,N,N′,N′-Tetramethylguanidine
Molecular formula: C₅H₁₃N₃.
Molecular weight: ≈ 115.18 g•mol⁻¹.

SYNONYMS:
1,1,3,3-Tetramethylguanidine, 80-70-6, N,N,N',N'-Tetramethylguanidine, Guanidine, N,N,N',N'-tetramethyl-, VEZ101E7ZU, NSC-148309, DTXSID2058835, RefChem:70941, DTXCID7048168, 201-302-7, Tetramethylguanidine, MFCD00008323, Guanidine, 1,1,3,3-tetramethyl-, N,N-1,1,3,3-TETRAMETHYLGUANIDINE, UNII-VEZ101E7ZU, CCRIS 6689, tetramethyguanidine, Tetramethlguanidine, EINECS 201-302-7, tetramethyl guanidine, tetramethyl-guanidine, NSC 148309, 1,1,3,3-TETRAMETHYL GUANIDINE, AI3-51030, (Me2N)2C=NH, 1,3,3-Tetramethylguanidine, n,n,n,n-tetramethylguanidine, SCHEMBL35686, N,N',N'-Tetramethylguanidine, Guanidine,1,3,3-tetramethyl-, SCHEMBL5579990, SCHEMBL5632126, 1, 1,3,3-tetramethylguanidine, 1,1,3,3 tetramethyl guanidine, 1,1,3,3,-tetramethylguanidine, 1,1,3,3-tetra-methylguanidine, 1,1,3,3-tetramethyl-guanidine, n,n,n',n'-tetramethyl-guanidine, Guanidine,N,N',N'-tetramethyl-, STR04857, BBL027708, NSC148309, STL146626, AKOS005169836, 1,1,3,3-Tetramethylguanidine, 99%, 1,1,3,3-TETRAMETHYLGUANIDINE [MI], CS-0015318, NS00019629, T0148, EN300-31847, 80T706, F011899, Q4545643, F0001-2088, InChI=1/C5H13N3/c1-7(2)5(6)8(3)4/h6H,1-4H, N,N,N',N'-Tetramethylguanidine, Lonza quality, >=99.0% (GC), Guanidine, 1,1,3,3-tetramethyl- (6CI,8CI), N,N,N',N'-Tetramethylguanidine, N1,N1,N3,N3-Tetramethylguanidine, NSC 148309, PC-CAT TMG, Tetramethylguanidine, TMG, 1,1,3,3-TETRAMETHYLGUANIDINE, TETRAMETHYL GUANIDINE, 1,1,3,3-Tetramethyl Guanidine (TMG), N,N’-Tetramethylguanidine, N,N-1,1,3,3-TETRAMETHYLGUANIDINE, Guanidine, N,N,N',N'-tetramethyl-, uanidine, TMG)1,1,3,3-TetraMeth, Metformin Impurity 69, N,N,N′,N′-Tetramethylguanidine, tetramethylguanidine, n,n,n',n'-tetramethylguanidine, guanidine, n,n,n',n'-tetramethyl, tetramethyl guanidine, unii-vez101e7zu, 1,1,3,3-tetramethyl guanidine, n,n-1,1,3,3-tetramethylguanidine, vez101e7zu, 1,1,3,3-tetramethyl-guanidine, n,n,n',n'-tetramethyl-guanidine, TMG, Tetramethylguanidine, 1,1,3,3-Tetramethylguanidine, N,N,N′,N′-Tetramethylguanidine, Guanidine, N,N,N′,N′-tetramethyl-, 1,1,3,3-TetraMethylguanidine, α,α-Bis(dimethylamino)methanimine, Metformin impurity 69, tetramethyl guanidine , tmg)1,1,3,3-tetrameth , n,n'-tetramethylguanidine , tmg , 1,1,3,3-tetramethylguayyniaine , tetramethylguanidine(tmg) , n,n,n',n'-tetramethyl-guanidin , 1,1,3,3-tetramethylguanidin , n,n,n,n-tetramethy1 guanidine , 1,1,3,3-tetramethylguanidine

TMG Tetramethyl Guanidine is essential for the preparation of alkyl nitriles from alkyl halides and 3'-alkylthymidines from 3'-nitrothymidines.
TMG Tetramethyl Guanidine serves as an efficient and selective catalyst for the benzoylation of alcohols.
TMG Tetramethyl Guanidine replaces the expensive bases 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) and 1,5-Diazabicyclo[4.3.0]non-5-ene (DBN) in organic synthesis.

TMG Tetramethyl Guanidine is an organic compound with the formula HNC(N(CH3)2)2.
TMG Tetramethyl Guanidine is a strong base, as judged by the high pKa of its conjugate acid.

TMG Tetramethyl Guanidine was originally prepared from tetramethylthiourea via S-methylation and amination, but alternative methods start from cyanogen iodide.
TMG Tetramethyl Guanidine is a small, colorless to pale-yellow liquid organic base with a guanidine core substituted with four methyl groups.

TMG Tetramethyl Guanidine is an unusually strong, non-nucleophilic base (the conjugate-acid pK_a in water/related scales is very high), widely used in organic synthesis and polymer chemistry where strong basicity without nucleophilicity is required.
TMG Tetramethyl Guanidine is commercially available as the neat base and as salts (e.g., the hydrochloride).

TMG Tetramethyl Guanidine is an organic compound characterized by its guanidine structure, featuring four methyl groups attached to the nitrogen atoms.
TMG Tetramethyl Guanidine is a colorless to pale yellow liquid with a strong, amine-like odor.

TMG Tetramethyl Guanidine is known for its high basicity, making it an effective non-nucleophilic base in various organic reactions, particularly in the synthesis of pharmaceuticals and agrochemicals.
TMG Tetramethyl Guanidine is a chemical compound from the group of guanidines.

TMG Tetramethyl Guanidine is a highly versatile compound recognized for its unique properties as a strong organic base and a nucleophilic catalyst.
Tetramethylguanidine is an organic compound with the formula HNC(N(CH3)2)2.

This colourless liquid, TMG Tetramethyl Guanidine, is a strong base, as judged by the high pKa of its conjugate acid.
TMG Tetramethyl Guanidine was originally prepared from tetramethylthiourea via S-methylation and amination, but alternative methods start from cyanogen iodide.

TMG Tetramethyl Guanidine, also known as TMG, is a versatile organic compound commonly used in chemical synthesis as a strong, non-nucleophilic base.
Its unique structure and properties make TMG Tetramethyl Guanidine a valuable reagent in various reactions, particularly in organic transformations where high basicity and steric hindrance are required.

USES and APPLICATIONS of TMG TETRAMETHYL GUANIDINE:
Organic synthesis: TMG Tetramethyl Guanidine is widely used as a strong, non-nucleophilic base for deprotonations, alkylations, condensations, and other base-promoted transformations (often a less expensive substitute for DBU/DBN in some reactions).
Polyurethane production: TMG Tetramethyl Guanidine is used as a catalyst for polyurethane foam formation (promotes isocyanate reactions).

Polymer chemistry and specialty catalysis: TMG Tetramethyl Guanidine is sued base catalyst for various polymerizations and functional group transformations (e.g., in the synthesis of nitriles, benzoylation reactions).
Pharmaceutical / fine chemical synthesis: TMG Tetramethyl Guanidine is employed in selective catalytic steps (acylations, benzoylations), steroid / heterocycle synthesis where strong base strength but low nucleophilicity is needed.

TMG Tetramethyl Guanidine is employed as a polyurethane foam catalyst, as an accelerator for the syntheses of polysulfured rubber.
TMG Tetramethyl Guanidine is also used as a strong base in the photochemical (couplers) and in the pharmaceutical (steroids) industries.
TMG Tetramethyl Guanidine is essential for the preparation of alkyl nitriles from alkyl halides and 3′-alkylthymidines from 3′-nitrothymidines.

TMG Tetramethyl Guanidine serves as an efficient and selective catalyst for the benzoylation of alcohols.
TMG Tetramethyl Guanidine replaces the expensive bases 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) and 1,5-Diazabicyclo[4.3.0]non-5-ene (DBN) in organic synthesis.

TMG Tetramethyl Guanidine is used as polyurethane foam catalyst, as accelerator for the syntheses of polysulfured rubber, as a strong base in the photochemical (e.g. couplers) and in the pharmaceutical (e.g. steroids) industries.
Uses of TMG Tetramethyl Guanidine: Base employed in the preparation of alkyl nitriles from alkyl halides and 3′-alkylthymidines from 3′-nitrothymidines.

TMG Tetramethyl Guanidine is used as a strong, non-nucleophilic base for alkylations in organic synthesis.
TMG Tetramethyl Guanidine is an efficient and selective catalyst for the benzoylation of alcohols.
TMG Tetramethyl Guanidine is employed as a polyurethane foam catalyst, as an accelerator for the syntheses of polysulfured rubber.

TMG Tetramethyl Guanidine is also used as a strong base in the photochemical (couplers) and in the pharmaceutical (steroids) industries.
TMG Tetramethyl Guanidine is essential for the preparation of alkyl nitriles from alkyl halides and 3'-alkylthymidines from 3'-nitrothymidines.

TMG Tetramethyl Guanidine use in Chemical Manufacturing,Polymer Industry,Plastics Industry,Rubber Industry,Textile Industry,Construction and Building Materials Industry.
TMG Tetramethyl Guanidine is widely utilized as a strong organic base in pharmaceutical manufacturing.

TMG Tetramethyl Guanidine serves as a catalyst and reagent in various chemical reactions, played crucial roles in the synthesis of APIs, and shows excellent solubility in organic solvents.
TMG Tetramethyl Guanidine is mainly used as a catalyst for polyurethane foam, and also used for the dyeing of nylon, wool and other proteins.

TMG Tetramethyl Guanidine is used in organic synthesis, 1,1,3,3-tetramethylguanidine is used as a strong, non-nucleophilic base.
TMG Tetramethyl Guanidine is an efficient and selective catalyst for the benzoylation of alcohols.
TMG Tetramethyl Guanidine is widely used in the synthesis of pharmaceutical and chemical raw materials.

TMG Tetramethyl Guanidine is mainly used in the production of cephalosporins in medicine.
TMG Tetramethyl Guanidine is mainly used as a catalyst for polyurethane foam, and also used for the dyeing of nylon, wool and other proteins.
Removal of oxidant: TMG Tetramethyl Guanidine can be used as an oxidant removal agent, which can consume the active oxidant in the excess hydrogen peroxide, benzoyl peroxide and other oxidants, and reduce its oxidation reaction to the substance.

Dye intermediates: TMG Tetramethyl Guanidine has good reactivity and nucleophilicity, and can be used to synthesize dyes and dye intermediates.
TMG Tetramethyl Guanidine can be used as a reagent to synthesize dyes and participate in the substitution reaction of nitrogen atoms in dye molecules.

Super base: Due to the strong alkali of TMG Tetramethyl Guanidine, it can be used as a super base in some fields.
For example, TMG Tetramethyl Guanidine can be used to accelerate the formation of carbonates, the synthesis of polyamides, and the cyclization of polymers.

Electronic materials: chemical TMG Tetramethyl Guanidine has excellent polymerization performance and high melting point, which can be used for polymer synthesis in the field of electronic materials.
In addition, TMG Tetramethyl Guanidine has a number of other applications, such as synthetic drugs, as an ingredient in antibacterial agents and flame retardants.

TMG Tetramethyl Guanidine is an important chemical raw material, which is used in the synthesis of headhold series antimicrobials in the pharmaceutical industry.
TMG Tetramethyl Guanidine is a strong organic base catalyst, which has a wide range of industrial applications, mainly used in the synthesis of new antibiotics cephalosporin cosolvent;

TMG Tetramethyl Guanidine can also be used as a catalyst for polyurethane foam.
TMG Tetramethyl Guanidine can also be used for the dyeing of nylon, wool and other proteins to improve their durability.
TMG Tetramethyl Guanidine is soluble in water and many organic solvents, which enhances its utility in diverse chemical processes.

TMG Tetramethyl Guanidine is also recognized for its ability to stabilize carbanions and facilitate deprotonation reactions.
However, TMG Tetramethyl Guanidine should be handled with care due to its potential irritant properties and the need for proper safety measures during use.

In terms of stability, TMG Tetramethyl Guanidine is relatively stable under normal conditions but can decompose under extreme temperatures or in the presence of strong acids.
Overall, its unique properties make TMG Tetramethyl Guanidine a valuable reagent in synthetic organic chemistry.

In pharmaceutical industry, TMG Tetramethyl Guanidine is employed for synthesis of antibiotics, it can dissolve antibiotic medical intermediates, such as 7-ADCA, 7-ACA, 6-APA.
TMG Tetramethyl Guanidine also serves as the catalyst for polyurethane foamed plastic.

TMG Tetramethyl Guanidine is used as dye leveling agent for nylon, wool and other proteins.
TMG Tetramethyl Guanidine is used to synthesize alkyl nitriles from alkyl halides and 3′-alkylthymidines from 3′-nitrothymidines.
TMG Tetramethyl Guanidine is also used as a catalyst for polyurethane foam, as a vulcanization accelerator for rubber, and as a strong base in photochemical reactions and steroid syntheses in the pharmaceutical industry.

TMG Tetramethyl Guanidine is also suitable as a catalyst for transesterifications.
TMG Tetramethyl Guanidine is used as polyurethane foam catalyst, as accelerator for the syntheses of polysulfured rubber, as a strong base in the photochemical (eg couplers) and in the pharmaceutical (eg steroids) industries.

TMG Tetramethyl Guanidine is widely utilized in various applications, including organic synthesis, polymer production, and as a catalyst in chemical reactions.
Its ability to facilitate reactions involving electrophiles makes TMG Tetramethyl Guanidine particularly valuable in the synthesis of pharmaceuticals and agrochemicals.

Researchers appreciate TMG Tetramethyl Guanidine's effectiveness in promoting reactions that require a strong base, such as deprotonation and nucleophilic substitution, enhancing reaction rates and yields.
In addition to its role in organic synthesis, TMG Tetramethyl Guanidine is also employed in the production of specialty polymers and resins, where it acts as a curing agent.

Its stability and solubility in various solvents make TMG Tetramethyl Guanidine an ideal choice for formulations in both laboratory and industrial settings.
TMG Tetramethyl Guanidine's low toxicity and ease of handling further contribute to its appeal, making it a preferred option for researchers and industry professionals seeking reliable and efficient chemical solutions.

TMG Tetramethyl Guanidine is an efficient and selective catalyst for the benzoylation of alcohols.
TMG Tetramethyl Guanidine, as a crucial guanidine compound, has been successfully commercialized.

In industrial production, the preparation of TMG Tetramethyl Guanidine is primarily achieved through the following process: firstly, reacting dimethylamine aqueous solution, sodium cyanide, and chlorine to produce dimethylaminonitrile, then reacting with dimethylamine hydrochloride to form tetramethylguanidine hydrochloride, and finally neutralizing with a strong alkaline solution, followed by purification to obtain TMG.

TMG Tetramethyl Guanidine serves as a cosolvent in the synthesis of cephalosporin antibiotics and a catalyst widely used in the synthesis of polyurethane, as well as being utilized in the dyeing of nylon, wool, and other proteins.
Meanwhile, TMG Tetramethyl Guanidine, as an organic strong base, also plays an essential role in organic synthesis chemistry.

TMG Tetramethyl Guanidine is mainly used as a strong, non-nucleophilic base for alkylations, often as a substitute for the more expensive DBU and DBN.
Since TMG Tetramethyl Guanidine is highly water-soluble, it is easily removed from mixtures in organic solvents.

TMG Tetramethyl Guanidine is also used as a base-catalyst in the production of polyurethane.
TMG Tetramethyl Guanidine is used Alkylating Agents, Flame Retardants, Pharmaceutical & Fine Chemicals, Plastic, Resin & Rubber, Polyurethane foams, Accelerators, Catalysts, Solvents

In organic synthesis, TMG Tetramethyl Guanidine is frequently employed as a base catalyst in reactions such as deprotonation, elimination, and condensation.
Due to its strong basicity and lack of nucleophilicity, TMG Tetramethyl Guanidine is an ideal choice for promoting reactions that involve sensitive functional groups or require precise control over selectivity.

TMG Tetramethyl Guanidine's bulky structure helps to prevent unwanted side reactions by hindering unwanted interactions with neighboring functional groups or substrates.
Additionally, TMG Tetramethyl Guanidine is often used in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals where the precise manipulation of reaction conditions is crucial to achieving high yields and selectivity.

TMG Tetramethyl Guanidine's application extends to various organic transformations including the formation of carbon-carbon bonds, the activation of electrophiles, and the deprotection of functional groups.
Overall, TMG Tetramethyl Guanidine plays a significant role in modern organic synthesis by providing chemists with a powerful tool to facilitate complex reactions with enhanced control and efficiency.

-Catalyst uses of TMG Tetramethyl Guanidine:
TMG Tetramethyl Guanidine, as an alkaline compound, is commonly used as an intermediate of catalyst or base catalyst.
TMG Tetramethyl Guanidine can be used to promote various organic reactions, such as oxidation reactions, esterification reactions and vinylation reactions.

CHEMICAL PROPERTIES of TMG TETRAMETHYL GUANIDINE:
TMG Tetramethyl Guanidine is a stable, unusually strong base, pKa 13.6 (25 ℃), with a free imino group.
TMG Tetramethyl Guanidine is a colorless to light-yellow liquid, miscible with water and common organic solvents: 0.92 g/cm3 (25℃), bp 160℃, vapor pressure 0.03 kPa (25℃).

BENEFITS / WHY CHEMISTS USE TMG TETRAMETHYL GUANIDINE:
Very strong basicity combined with low nucleophilicity — TMG Tetramethyl Guanidine allows clean deprotonations without competing SN2 or nucleophilic side reactions.
Water miscibility — easier to remove from some reaction mixtures and to handle in certain aqueous biphasic conditions.
Versatile catalyst in industrial processes such as polyurethane foam manufacture where efficient base catalysis is required.

RELATED COMPOUNDS of TMG TETRAMETHYL GUANIDINE:
*Tetramethylurea
*Noxytiolin
*Metformin
*Buformin
*Allantoic acid
*Carmustine

SYNTHESIS of TMG TETRAMETHYL GUANIDINE:
Prepared from cyanogen chloride and dimethylamine in a 1 : 2 molar ratio, TMG Tetramethyl Guanidine is used as a polyurethane foam catalyst, in the preparation of pigments for color photography, and in steroid synthesis.

PURIFICATION METHODS of TMG TETRAMETHYL GUANIDINE:
Reflux it over granulated BaO, then fractionally distil TMG Tetramethyl Guanidine.
Protect TMG Tetramethyl Guanidine from CO2.

CHARACTERISTICS of TMG TETRAMETHYL GUANIDINE:
TMG Tetramethyl Guanidine is a colorless liquid with an amine-like odor and is miscible with water.
TMG Tetramethyl Guanidine's aqueous solution is strongly alkaline.

SOLUBILITY of TMG TETRAMETHYL GUANIDINE:
TMG Tetramethyl Guanidine is miscible with water.

NOTES of TMG TETRAMETHYL GUANIDINE:
TMG Tetramethyl Guanidine is air sensitive.
TMG Tetramethyl Guanidine is incompatible with strong oxidizing agents, mineral and organic acids, carbon dioxide.
Keep TMG Tetramethyl Guanidine away from sources of ignition.

MARKETS CASE of TMG TETRAMETHYL GUANIDINE:
Coatings, Adhesives, Sealants & Elastomers, Chemical & Materials Manufacturing, Construction & Building Materials, Personal Care & Pharmaceutical

PHYSICAL and CHEMICAL PROPERTIES of TMG TETRAMETHYL GUANIDINE:
Chemical Formula: C₅H₁₃N₃
Molar Mass: 115.180 g/mol
Appearance: Colourless liquid
Density: 918 mg/mL
Melting Point: −30 °C (−22 °F; 243 K)
Boiling Point: 160–162 °C (320–324 °F; 433–435 K)
Solubility in Water: Miscible
Vapor Pressure: 30 Pa (20 °C)
Acidity (pKa): 13.0 ± 1.0
Refractive Index (nD): 1.469

Molecular Weight: 115.18 g/mol
XLogP3: 0.4
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 2
Exact Mass: 115.110947427 Da
Monoisotopic Mass: 115.110947427 Da
Topological Polar Surface Area: 30.3 Å²
Heavy Atom Count: 8

Formal Charge: 0
Complexity: 75.7
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
CBNumber: CB0355799

Molecular Formula: C₅H₁₃N₃
Molecular Weight: 115.18
MDL Number: MFCD00008323
MOL File: 80-70-6.mol
Melting Point: -30 °C
Boiling Point: 162–163 °C (lit.)
Density: 0.916 g/mL at 20 °C (lit.)
Vapor Pressure: 0.2 mmHg (20 °C)
Refractive Index: n20/D 1.469

Flash Point: 140 °F
Storage Temperature: Store below +30 °C
Solubility: Acetonitrile (slightly), DMSO (slightly), Methanol (slightly)
pKa: 15.20 ± 0.70 (Predicted)
Form: Liquid
Color: APHA ≤ 150
pH: 12.7 (10 g/L, H₂O, 25 °C)
Relative Polarity: 5.5
Odor: Mild ammoniacal odor

Explosive Limit: 1.0–7.5% (V)
Water Solubility: Miscible
Sensitive: Air sensitive
BRN: 969608
Dielectric Constant: 23.1
Stability: Stable; combustible; incompatible with strong oxidizing agents, mineral/organic acids, CO₂; air-sensitive
InChIKey: KYVBNYUBXIEUFW-UHFFFAOYSA-N
LogP: -0.49 at 20 °C
CAS Database Reference: 80-70-6
FDA UNII: VEZ101E7ZU

NIST Chemistry Reference: N,N,N',N'-Tetramethylguanidine (80-70-6)
EPA Substance Registry System: Guanidine, N,N,N',N'-tetramethyl- (80-70-6)
UNSPSC Code: 12352129
NACRES: NA.22
Linear Formula: (CH₃)₂NC(=NH)N(CH₃)₂
CAS Number: 80-70-6
Molecular Weight: 115.18
Beilstein: 969608
EC Number: 201-302-7
MDL Number: MFCD00008323

UNSPSC Code (Alt): 12352116
PubChem Substance ID: 24854327
NACRES (Alt): NA.22
Physical State: Liquid
Color: Light yellow
Odor: Amine-like
Melting Point/Freezing Point: < -80 °C at 1.013 hPa (OECD TG 102)
Initial Boiling Point and Boiling Range: 52–54 °C at 15 hPa (lit.)

Flammability (solid, gas): No data available
Upper Explosion Limit: 7.5% (V)
Lower Explosion Limit: 1.0% (V)
Flash Point: 50 °C (closed cup, DIN 51755 Part 1)
Autoignition Temperature: No data available
Decomposition Temperature: No data available
pH: 12.7 at 10 g/L at 25 °C
Viscosity (Kinematic): No data available
Viscosity (Dynamic): 1.40 mPa•s at 20 °C

Water Solubility: 1,000 g/L at 20.3 °C (OECD TG 105, completely miscible)
Partition Coefficient (log Pow): -0.49 at 20 °C (OECD TG 107)
Vapor Pressure: 2.9 hPa at 20 °C (OECD TG 104)
Density: 0.918 g/cm³ at 25 °C (lit.)
Relative Density: No data available
Relative Vapor Density: No data available
Particle Characteristics: No data available

Explosive Properties: Not classified as explosive
Oxidizing Properties: None
Surface Tension: 71.5 mN/m at 1 g/L at 20.3 °C (OECD TG 115)
Relative Vapor Density (additional): 4.04
Molecular Formula: C5H13N3
Molecular Weight: 115.18 g/mol
Physical State (20 °C): Liquid
Storage Temperature: Room temperature (< 15 °C recommended)
Store Under Inert Gas: Yes
Conditions to Avoid: Air sensitive, hygroscopic

CAS Number: 80-70-6
Reaxys Registry Number: 969608
PubChem Substance ID: 87576150
SDBS ID: 10085
MDL Number: MFCD00008323
Formula: C5H13N3
InChI: InChI=1S/C5H13N3/c1-7(2)5(6)8(3)4/h6H,1-4H3
InChI Key: KYVBNYUBXIEUFW-UHFFFAOYSA-N

SMILES: C(N(C)C)(N(C)C)=N
Boiling Point (lit.): 160–162 °C
Infrared Spectrum: Authentic
Refractive Index: 1.4670–1.4690
Physical State: Liquid
Storage: Store at room temperature
Melting Point: <-30° C
Boiling Point: 162-163° C (lit.)
Density: 0.916 g/cm3 at 20° C

Fieser: 01,1145; 04,489; 12,477
Merck Index: 15,9375
Solubility Information: Solubility in water: miscible. Other solubilities: miscible
SMILES: CN(C)C(=N)N(C)C
Molecular Weight (g/mol): 115.18
Viscosity: 0.002 Pas (20°C)
Percent Purity: 99%
Chemical Name or Material: 1,1,3,3-Tetramethylguanidine

InChI Key: KYVBNYUBXIEUFW-UHFFFAOYSA-N
IUPAC Name: 1,1,3,3-tetramethylguanidine
PubChem CID: 66460
Formula Weight: 115.18
Physical Form: Liquid
Melting Point: -30.0°C
Density: 0.9100g/mL
Flash Point: 50°C
Assay Percent Range: 98.5% min. (GC)
Molecular Formula: C5H13N3
Linear Formula: (CH3)2NC(=NH)N(CH3)2

Beilstein: 04,I,335
Specific Gravity: 0.91
Name (IUPAC): N,N,N′,N′-Tetramethylguanidine
Common abbreviation: TMG
CAS Number: 80-70-6.
EC / EINECS number: 201-302-7.
Molecular formula: C₅H₁₃N₃.
Molecular weight: ≈ 115.18 g•mol⁻¹.
(Identifiers from ECHA and standard chemical databases.)
Linear Formula: (CH3)2NC(=NH)N(CH3)2

CAS Number: 80-70-6
Molecular Weight: 115.18
Beilstein: 969608
EC Number: 201-302-7
MDL number: MFCD00008323
UNSPSC Code: 12352100
PubChem Substance ID: 329761375
NACRES: NA.22
Appearance: Colorless transparent liquid
Odor: Slight smell

Density: 0.918
Boiling point: 160-162°C
Melting point: -30 °C
Flash point: 140 °F
Vapor pressure: 0.2 mm Hg ( 20 °C)
Refractive index: 1.4692
Quality standard: Content ≥99% ; Moisture ≤0.2%
Solubility: Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
Solubility in water: miscible

log P: -0.49 at 20°C
Sensibility: Air Sensitive
Stability: Stable.
Incompatible with strong oxidizing agents, mineral and organic acids, carbon dioxide.
Air-sensitive.
Quality standard: Content ≥99% Moisture ≤0.2%
package: 180kg/barrel (galvanized drum or plastic drum) ; 25kg/barrel (plastic drum)
Storage condition: Store below +30°C.
CAS: 80-70-6

EINECS: 201-302-7
InChI: InChI=1/C5H13N3/c1-7(2)5(6)8(3)4/h6H,1-4H3
InChIKey: KYVBNYUBXIEUFW-UHFFFAOYSA-N
Molecular Formula: C5H13N3
Molar Mass: 115.18
Density: 0.916 g/mL at 20 °C (lit.)
Melting Point: -30 °C
Boling Point: 162-163 °C (lit.)
Flash Point: 140°F
Water Solubility: miscible
Vapor Presure: 0.2 mm Hg ( 20 °C)
Appearance: Liquid

Color: APHA: ≤150
BRN: 969608
PH: 12.7 (10g/l, H2O, 25℃)
Storage Condition: Store below +30°C.
Stability: Stable.
Incompatible with strong oxidizing agents, mineral and organic acids, carbon dioxide. Air-sensitive.
Sensitive: Air Sensitive
Explosive Limit: 1.0-7.5%(V)
Refractive Index: n20/D 1.469
Physical and Chemical Properties: Colorless transparent liquid.

Product: 1,1,3,3-Tetramethylguanidine
CAS: 80-70-6
Formula: C5H13N3
Boiling Point: 160 c
Odor: mild ammoniacal odor
Refractive Index: 1.4692
Molecular weight: 115.17
Color: colorless liquid
Flash Point: 60 c
Specific gravity: 0.918
Solubility: water forming alkaline solns.

CAS number: 80-70-6
Characteristics
Molar mass: 115.18 g• mol −1
State of matter: liquid
density: 0.92 g•cm −3
Melting point: <−30 °C
boiling point: 162 °C
Vapor pressure: 0.26 hPa (25 °C)
solubility: miscible with water

Refractive index: 1.469 (20 °C)
CAS Number: 80-70-6
Purity: ≥ 99% (GC)
Molecular Formula: C5H13N3
Molecular Weight: 115.18
MDL Number: MFCD00008323
PubChem ID: 66460
Density: 0.92 g/mL (Lit.)
Appearance: Clear, colorless to light yellow liquid

Conditions: Store at 0 - 8 °C
Molecular Formula: C5H13N3
Molecular Weight: 115.1768
InChI: InChI=1/C5H13N3/c1-7(2)5(6)8(3)4/h6H,1-4H3
EINECS: 201-302-7
Density: 0.9g/cm3
Melting point: -30℃
Boiling point: 163.2°C at 760 mmHg
Refractive index: 1.455
Flash point: 60°C
Water solubility: miscible

Vapour Pressur: 2.09mmHg at 25°C
Molecular Weight:: 115.18
Molecular Formula:: C5H13N3
Canonical SMILES:: CN(C)C(=N)N(C)C
InChI:: InChI=1S/C5H13N3/c1-7(2)5(6)8(3)4/h6H,1-4H3
InChI Key:: KYVBNYUBXIEUFW-UHFFFAOYSA-N
Boiling Point:: 162-163°C
Melting Point:: -30°C
Flash Point:: 60°C
Purity:: ≥95%

Density:: 0.916 g/mL at 20°C
Solubility:: Soluble in Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
Appearance:: Clear Colorless to Pale Yellow Oily Liquid
Storage:: Store at 2-8°C
MDL:: MFCD00008323
LogP:: 0.14410
Refractive Index:: 1.467-1.469
Density: 0.9100g/mL
Color: Colorless to Yellow
Melting Point: -30.0°C

Boiling Point: 160.0°C to 162.0°C
Flash Point: 50°C
Assay Percent Range: 98.5% min. (GC)
Infrared Spectrum: Authentic
Linear Formula: (CH3)2NC(=NH)N(CH3)2
Beilstein: 04,I,335
Fieser: 01,1145; 04,489; 12,477
Merck Index: 15,9375
Refractive Index: 1.4670 to 1.4690
Solubility Information: Solubility in water: miscible.
Other solubilities: miscible

Specific Gravity: 0.91
Formula Weight: 115.18
Physical Form: Liquid
Viscosity: 0.002 Pas (20°C)
Water: 0.5% Max. (K.F.)
Chemical Name or Material: 1,1,3,3-Tetramethylguanidine
Basicity / reactivity: TMG is an exceptionally strong, largely non-nucleophilic base — useful for deprotonations, promoting condensations, and catalyzing reactions where nucleophilic attack by the base would be undesirable.
Stability / sensitivity: The neat base is stable under typical handling but is air-sensitive toward CO₂ (absorbs CO₂/acidic gases); it should be stored under inert atmosphere or tightly sealed to avoid uptake of CO₂ and moisture.
It is incompatible with strong oxidizers and strong acids (which protonate it).
Thermal behaviour: Relatively low volatility at ambient conditions, but will boil at elevated temperature; decomposition products on heating may include nitrogen oxides / irritant fumes typical for nitrogenous organics — follow SDS guidance.

FIRST AID MEASURES of TMG TETRAMETHYL GUANIDINE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of TMG TETRAMETHYL GUANIDINE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of TMG TETRAMETHYL GUANIDINE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of TMG TETRAMETHYL GUANIDINE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of TMG TETRAMETHYL GUANIDINE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of TMG TETRAMETHYL GUANIDINE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available