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CAS NO.: 5785-44-4
EC/LIST NO.: 212-391-7
The most commonly used calcium salt of citric acid is tricalcium dicitrate tetrahydrate, hereinafter referred to as tricalcium citrate.
In some countries such as USA, tricalcium citrate is simply denominated calcium citrate.
Tricalcium citrate is produced by complete neutralisation of citric acid with a high purity calcium source such as calcium hydroxide or calcium carbonate.
With its high calcium content of 21%, tricalcium citrate is the most economic calcium salt among the commonly used organic calcium salts.
Tricalcium citrate is supplied as a white, odourless, crystalline powder or fine powder.
Tricalcium citrate is slightly soluble in water and freely soluble in diluted hydrochloric acid.
In contrary to other salts, tricalcium citrate is better soluble at lower temperatures (so-called "inverse solubility").
Tricalcium citrate is practically insoluble in alcohol.
During heat treatment, Tricalcium citrate is less reactive than other calcium salts due to its inverse solubility.
With regard to its significantly better bioavailability, tricalcium citrate is preferred over inorganic calcium sources such as calcium carbonate or calcium phosphate.
Used for citric acid and to make other citrates and improve the baking of flour;
Tricalcium citrate is also used as nutrient content, food ingredient (sequestrant and astringent agent) and medicine;
Tricalcium citrate is a food additive that is included in Table 3, and as such may be used in the following foods under the conditions of good manufacturing practices (GMP) as outlined in the Preamble of the Codex GSFA.
Although not listed below, Tricalcium citrate could also be used in heat-treated butter milk of food category 01.1.1 and spices of food category 12.2.1.
Note that food categories listed in the Annex to Table 3 were excluded accordingly.
Tricalcium citrate is acceptable in foods conforming to the following commodity standards:
Tricalcium citrate (TCC) was characterized as a tableting excipient for direct compression (DC) and dry granulation (DG).
The most commonly used calcium salt of citric acid is tricalcium dicitrate tetrahydrate, hereinafter referred to as tricalcium citrate.
Produced by complete neutralization of citric acid with a high purity calcium source such as calcium hydroxide or calcium carbonate.
Used as a cleaning agent in dentifrices.
Tricalcium citrate (sometimes called tricalcium citrate) is found in the following products:3
Certain brands of calcium-fortified orange juice
Citracal
GNC Calcimate Plus 800
Solgar Calcium Citrate
TwinLab Calcium Citrate Caps
Tricalcium citrate are typically sold in the form of calcium carbonate or calcium citrate.
Tricalcium citrate is a calcium salt that's easier to absorb but less potent than calcium carbonate.
You may need to take more calcium citrate pills in order to achieve your desired dosage.
For anyone who takes heartburn medication or has digestive issues, Tricalcium citrate is often the better choice, since stomach acid isn't required for absorption.
Tricalcium citratee is safe for most people when not taken in excess of 2,500 milligrams per day.
Tricalcium citrate's available over the counter and typically recommended in multiple doses (of 500 milligrams or less) that add up to 1,200 to 1,500 milligrams a day.
Tricalcium citrate can be taken on a full or empty stomach at any time of the day.
Tricalcium citrate has the chemical formula of Na3C6H5O7.
Tricalcium citrate is sometimes referred to simply as "sodium citrate", though sodium citrate can refer to any of the three sodium salts of citric acid.
Tricalcium citrate possesses a saline, mildly tart flavor, and is a mild alkali.
Tricalcium citrate may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany).
Tricalcium citrate TB is a tricalcium citrate tetrahydrate designed to function as a direct compression excipient.
Tricalcium citrate combines exceptional compression characteristics, good flowability and good tolerability.
Properties of Tricalcium citrate TB
Tricalcium citrate with special crystal structure leading to exceptional flowability
Enables production of hard tablets even at low compression forces
Displays excellent disintegration properties
Calcium in citrate form with good tolerability and compatibility
One of the special salts produced by our partner Jungbunzlauer, Tricalcium Citrate is a fine white odorless powder with high calcium content (21%).
This ingredient has a neutral taste and high bio-availability.
Due to its superior technological and nutritional properties, Tricalcium Citrate can be used for mineral enrichment in food, beverages, nutraceutical and pharmaceutical products.
Tricalcium citrate TB is a tricalcium citrate tetrahydrate designed to function as filler or diluent.
Tricalcium citrate is suitable for usage in direct compression.
Tricalcium citrate combines exceptional compression characteristics, excellent flowability and good tolerability.
Tricalcium citrate TB is produced in a unique production process, which creates the special crystalline structure responsible for its outstanding characteristics.
This makes it the ideal choice for a direct compression excipient.
Download this free whitepaper to find out more including Tricalcium citrate TB's properties, manufacturing, particle size distribution, and compression behaviour.
Tricalcium Citrate has high calcium content of 21%, and is the most commonly used calcium salt of citric acid.
Tricalcium citrate is odorless, crystalline powder and is slightly soluble in water and freely soluble in diluted hydrochloric acid.
Has low reactivity compared to other calcium salts.
Highly bioavailable calcium source in foods, beverages and pharmaceuticals.
Used as a Sequestering and stabilizing agent in food, firming agent for fruits and vegetables.
Tricalcium citrate Tetrahydrate is calcium salt of citric acid, it is a white, odourless, crystalline powder or fine powder.
Tricalcium citrate is slightly soluble in water and freely soluble in diluted hydrochloric acid.
The main function is to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.
Tricalcium citrate, also referred to as tricalcium dicitrate tetrahydrate, is produced by neutralizing citric acid with a high quality calcium source such as calcium carbonate or calcium hydroxide.
Tricalcium citrate is the most commonly used calcium salt of citric acid.
Globally, development of efficient and advanced technology, rising awareness for health, nutrition and food safety, flourishing agriculture industry, growth in end user industries such as, food & beverage and healthcare and advantageous properties of tricalcium citrate such as, better compressibility, and low reactivity compared to other calcium salts are the prime growth drivers of the tricalcium citrate market.
In addition, increase in adoption of tricalcium citrate for application in new industrial verticals, and emerging economies such as China, India and others, will create new opportunities for the tricalcium citrate market.
However, volatile prices and availability of raw materials, availability of substitute compounds, and higher cost of tricalcium citrate as compared to conventional calcium salts are the key restraints for the tricalcium citrate market.
Tricalcium citrate anhydrous is also named tricalcium citrate anhydrous.
Tricalcium citrate is a tribasic salt of citric acid.
Tricalcium citrate is manufactured from tricalcium citrate tetrahydrate.
Water molecules of the tetrahydrate crystals are removed by a patented process without destroying the original crystal matrix.
Tricalcium citrate occurs as colorless crystalline powder.
Tricalcium citrate is insoluble in water and practically soluble in acid.
Tricalcium citrate anhydrous is used as chelating agent,buffering agent,tissue coagulator,calcium fortifier and emulsifying salt.
The absorption effect is more superior than inorganic calcium when it’s used as food calcium enhancer.
And Tricalcium citrate can be made chewable tablet,granule,capsule and oral liquid in pharmaceutical because it can be easier absorbed by the body than the calcium carbonate.
CAS number : 5785-44-4
EC number : 212-391-7
Grade : DAC,USP,E 333,FCC
Hill Formula : C₁₂H₁₀Ca₃O₁₄ * 4 H₂O
Molar Mass : 570.51 g/mol
HS Code : 2918 15 00
pH value : 5 - 6 (25 g/l, H₂O, 20 °C) (slurry)
Bulk density : 350 kg/m3
Solubility : 0.85 g/l
Storage class : 10 - 13 Other liquids and solids
WGK : WGK 1 slightly hazardous to water
Disposal : 3
Relatively unreactive organic reagents should be collected in container.
If halogenated, they should be collected in container.
For solid residues use container .
Assay (complexometric; calculated on dried substance) : 98.0 - 100.5 %
Identity (wet chemistry) :passes test
Appearance :white to almost white, fine powder
Appearance of solution :(50 g/l, hydrochloric acid 0.8 mol/l) not more turbid than 18 NTU and not more intense in color than reference solution BY₆
Substances insoluble in hydrochloric acid :≤ 0.2 %
pH (25 g/l, after boiling in water) :5.0 - 6.0
Carbonate (as CO₂): passes test
Fluoride (F) :≤ 30 ppm
Al (Aluminium) :≤ 30 ppm
As (Arsenic) :≤ 1 ppm
As (Arsenic) (ICP) :≤ 1 ppm
Cd (Cadmium)* :≤ 0.2 ppm
Fe (Iron) :≤ 100 ppm
Fe (Iron) (ICP) :≤ 100 ppm
Mn (Manganese) :≤ 50 ppm
Ni (Nickel)* :≤ 2 ppm
Hg (Mercury) :≤ 1 ppm
Pb (Lead) :≤ 1 ppm
Pb (Lead) (ICP) :≤ 1 ppm
Oxalates (as C₂H₂O₄, calc. on dried substance) :≤ 100 ppm
Readily carbonisable substance :passes test
Residual solvents (ICH Q3C) :excluded by manufacturing process
Loss on drying (150 °C, 4 h) :11.5 - 13.3 %
Total aerobic microbial count (TAMC) :≤ 1000 CFU/g
Total combined yeasts/moulds count (TYMC) :≤ 100 CFU/g
Tricalcium citrate meets the requirements of the US Pharmacopeia (USP), the Food Chemicals Codex (FCC), and the Commission Regulation (EU) No.
231/2012 always in their latest versions.
The following granulation types are available:
Micronised Powder
Powder
Granular
Tricalcium citrate is supplied in polyethylene lined paper bags.
Net quantity is 10, 15, 20 or 25 kg, depending on the individual bulk density of the desired granulation.
Tricalcium Citrate (TCC) is produced by complete neutralization of citric acid with a calcium source.
With its high calcium content of 21 %, TCC is the most economic calcium salt among the commonly used organic calcium salts.
Due to its functional properties, high bioavailability and health benefits, TCC is widely used as a calcium source in foodstuffs, nutrional supplements, dietary products and pharmaceutical applications.
Some calcium phosphates derive from phosphate rocks, calcium from plant sources, and ammonia.
These can be considered vegan.
Most of the time, however, calcium phosphates are made from ground animal bones.
Calcium phosphate aids in cell functioning and plays a vital role in many different body processes, including bone growth and energy production.
Tricalcium phosphate is effective as a nutritional supplement because Tricalcium citrate is readily absorbed in the body.
However, there is little evidence to show Tricalcium citrate is more effective than other calcium supplements, in particular, those containing citrate and carbonateTrusted Source.
Tricalcium citrate also has many other uses.
Tricalcium citrate is found in many household items, including baby powder, toothpaste, and antacids.
A variety of industries use Tricalcium citrate.
For example, the biomedical sector uses Tricalcium citrate to make cement or composite to repair bones
Tricalcium citrate is an essential mineral that supports multiple systems throughout the body.
You need to maintain adequate calcium levels in order for your heart, nervous system, and muscles to function properly.
When you don't get enough calcium from outside sources, such as food or supplements, your body dips into the calcium bank stored in your bones to keep blood levels up.
Over time, pulling calcium from your bones weakens them and increases the risk of fracture.
Beyond bones, additional possible benefits of calcium supplementation include improvements in blood pressure and weight loss.
Here's what the research says.
Blood pressure: Although the underlying mechanism is unclear, calcium has been associated with reducing blood pressure in multiple studies.
However, there are rising concerns that excessive calcium through supplements may harden arteries and pose cardiovascular risks.
Weight loss: When people are placed on low-calorie diets, studies show that adding calcium and vitamin D supplements improves their rate of fat loss while preserving muscle and bone mass.
As with many dietary supplements, taking more calcium than we need probably does more harm than good.
Instead of blindly adding calcium citrate, only purchase a supplement if you know you aren't getting enough from food and beverages.
Tricalcium citrate tetrahydrate may be used as raw material in the preparation of nanoparticle with the nominal composition Ca0.8 Ba0.2 Ti03 :Pr3+, via sol-gel process.
Tricalcium citrate may be employed as carbon source in a simple and effective carbonization method to prepare porous carbon without any activation process.
Tricalcium citrate is suitable for use in the preparation of bovine serum albumin (BSA) nanoparticles.
IUPAC NAME :
2-hydroxy-1,2,3-propane- tricarboxylic acid calcium salt (2:3)
2-hydroxypropane-1,2,3-tricarboxylate
calcium citrates
tri-Calcio di-Citrato 4-hidrato
Tricalcium 2-hydroxypropane-1,2,3-tricarboxylate
SYNONYMS:
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, calcium salt, hydrate (2:3:2)
Calcium 2-hydroxy-1,2,3-propanetricarboxylate hydrate (3:2:4)
Calcium 2-hydroxypropane-1,2,3-tricarboxylate hydrate (3:2:4)
Calcium Citrate (Tricalcium citrate):1,2,3-Propanetricarboxylicacid, 2-hydroxy-, calcium salt (2:3), tetrahydrate
Calcium-2-hydroxy-1,2,3-propantricarboxylathydrat (3:2:4)
Citrate de calcium, hydrate (2:3:4)
212-391-7
2-hydroxypropane-1,2,3-tricarboxylate
5785-44-4
Calcium 2-hydroxypropane-1,2,3-tricarboxylate tetrahydrate
