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CAS NUMBER: 101-20-2
EC NUMBER: 202-924-1
MOLECULAR FORMULA: Cl2C6H3NHCONHC6H4Cl
MOLECULAR WEIGHT: 315.58
Triclocarban is an antibacterial chemical once common in, but now phased out of, personal care products like soaps and lotions.
Triclocarban was originally developed for the medical field.
Although the mode of action is unknown, Triclocarban can be effective in fighting infections by targeting the growth of bacteria such as Staphylococcus aureus.
Additional research seeks to understand its potential for causing antibacterial resistance and its effects on organismal and environmental health.
Triclocarban is a triclosan analogue with an antibacterial property.
Triclocarban exerts its effect by inhibiting the activity of enoyl-(acyl-carrier protein) (ACP) reductase, widely distributed in bacteria, fungi and plants.
Triclocarban reductase catalyses the last step in each cycle of fatty acid elongation in the type II fatty acid synthase systems.
As a result, this agent interrupts cell membrane synthesis and leads to bacterial growth inhibition.
Triclocarban appears as fine white plates or white powder.
Triclocarban is a member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.
Triclocarban has a role as a disinfectant, an antiseptic drug, an antimicrobial agent, an environmental contaminant and a xenobiotic.
Triclocarban is a dichlorobenzene, a member of monochlorobenzenes and a member of phenylureas.
Triclocarban is an antimicrobial active ingredient used globally in a wide range of personal cleansing products including deodorant soaps, deodorants, detergents, cleansing lotions, and wipes.
Triclocarban is also used globally as an antimicrobial active ingredient in bar soaps.
Triclocarban is a limited spectrum antibacterial agent, meaning that it is not effective against all microbes.
There is a specific set of organisms for which Triclocarban effectively prevents or controls growth.
Triclocarban, with the chemical formula C13H9Cl3N2O is an antibacterial agent that is particularly effective against Gram-positive bacteria such as Staphylococcus aureus.
Triclocarban is a bacteriostatic compound that has been found in antibacterial soaps and other personal care products.
In 2017, the US FDA prohibited the marketing of over-the-counter (OTC) consumer antiseptic wash products containing triclocarban due to negative health effects such as bacterial resistance or hormonal effects.
Triclocarban is a chemical used as a disinfectant and antibacterial agent in deodorant soaps and body washes, and as a preservative in some personal care products.
In the U.S., Triclocarban is primarily found in antibacterial deodorant bar soaps at concentrations up to 1.5 percent.
Triclocarban, a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants.
Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes.
Triclocarban is an antimicrobial used to control bacterial and fungal growth.
Triclocarban's used in soaps, body washes, detergents, wipes, etc.
The likely environmental sources are from human use in care products, where they are then washed down the drain and enter wastewater treatment plants.
Triclocarban could then leave the treatment plant in the effluent into surface water, or bound in sludge where it could be land applied.
Triclocarban has been detected in surface waters and sediment.
Triclocarban is a substituted carbanilide.
Triclocarban is a triclosan analogue with an antibmicrobial property.
Triclocarban has been used in a wide range of personal cleansing products including deodorant and bar soaps, deodorants, detergents, cleansing lotions, and wipes.
USES OF TRICLOCARBAN:
Triclocarban has been used as an antimicrobial and antifungal compound since the 1960s.
Triclocarban was commonly found in personal care products as an antimicrobial in soaps, lotions, deodorants, toothpaste, and plastic.
As of 2005 about 80% of all antimicrobial bar soap sold in the United States contained triclocarban.
In 2011 United States consumers were spending nearly 1 billion dollars annually on products containing triclocarban and triclosan.
In December 2013, the Food and Drug Administration (FDA) required all companies to prove within the next year, that triclocarban is not harmful to consumers.
Companies like Johnson & Johnson, Procter & Gamble, Colgate-Palmolive, and Avon began phasing out antibacterial ingredients due to health concerns.
By 2016 usage of triclocarban in soaps had declined to 40%, and that September the FDA banned triclocarban, triclosan and 17 other common antibacterial chemicals by September 2017, for their failure to be proven safe, or more effective than plain soap and water.
The most widespread use of Triclocarban is in antimicrobial bar soaps.
Triclocarban is also commonly used as an active ingredient in deodorant products such as sprays, roll-ons and sticks, shampoos and shaving creams and in some over-the-counter preparations like antiseptic foaming solution for topical application on the skin.
Additionally, Triclocarban is used in cleansing preparations in hospitals where a high risk exists for the transmission of infection.
-the antibacterial tableware detergent,
-the wound disinfectant,
-the fabric antibacterial reorganization medicinal preparation,
-the medical disinfectant,
-the fiber textile and the products which can eliminates the dermatophytosis and the underarm odor,
-in order to sterilize, kill germs and deodorizes.
APPLICATIONS OF TRICLOCARBAN:
-Creams, lotions & gels
-Decorative cosmetics/Make-up
-Hair care (Shampoos, Conditioners & Styling)
-Perfumes & fragrances
-Skin care (Facial care, Facial cleansing, Body care, Baby care)
-soap,
-shampoo,
-bodywash,
-facewash,
-laundry powder,
-the wound paste,
-the cosmetology cosmetics,
-shaving cream,
-the toothpaste,
-the mouth wash,
BENEFITS OF TRICLOCARBAN:
Triclocarban is used in consumer antimicrobial products designed to reduce the number of harmful bacteria on the skin better than the use of plain soap.
The use of Triclocarban helps to stop the transmission of germs to other people or to objects.
FUNCTION OF TRICLOCARBAN:
-Deodorant: Reduces or masks unpleasant body odor
-Preservative: Triclocarban prevents the growth of microorganisms in cosmetic products.
-Antimicrobial: Helps slow the growth of microorganisms on the skin and counteracts the growth of microbes.
-cosmetic biocide,
-deodorant agent,
-preservative,
-deodorant
SPECIFICATIONS OF TRICLOCARBAN:
-Appearance: White Powder
-Purity %: 99.0 Min.
-Dichlorocarbanilide%: 1.0 Max.
-Tetrachlorocarbanilide%: 0.5 Max.
-Triaryl Biuret%: 0.5 Max.
-Chloroaniline: 475PPM Max.
-Loss on drying %: 0.15Max.
-Melting Point ºC: 250-255
-Particle size-median, um 7Max.
CHEMICAL STRUCTURE AND PROPERTIES OF TRICLOCARBAN:
Triclocarban, 3-(4-chlorophenyl)-1-(3,4-dichlorophenyl)urea, is a white powder that is insoluble in water.
While triclocarban has two chlorinated phenyl rings, Triclocarban is structurally similar to carbanilide compounds often found in pesticides (such as diuron) and some drugs.
Triclocarban of ring structures is often associated with hydrophobicity, persistence in the environment, and bioaccumulation in fatty tissues of living organisms.
For this reason, chlorine is also a common component of persistent organic pollutants.
Triclocarban is incompatible with strong oxidizing reagents and strong bases, reaction with which could result in safety concerns such as explosion, gas, and heat.
STORAGE OF TRICLOCARBAN:
-Polyethylene or polypropylene container.
-Check all containers are clearly labelled and free from leaks.
SYNONYM:
101-20-2
1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea
3,4,4'-TRICHLOROCARBANILIDE
Solubacter
Cutisan
Procutene
Genoface
Trilocarban
Cusiter
N-(4-Chlorophenyl)-N'-(3,4-dichlorophenyl)urea
Trichlorocarbanilide
3,4,4'-Trichlorodiphenylurea
Triclocarbanum
Urea, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)-
TCC
3,4,4'-trichloro carbanilide
