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TRIETHYLENETETRAMINE (TETA)

CAS NUMBER: 112-24-3

EC NUMBER: 203-950-6

MOLECULAR FORMULA: (NH2CH2CH2NHCH2)2

MOLECULAR WEIGHT: 146.23

IUPAC NAME: N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine

Triethylenetetramine (TETA), also called trientine (INN), is an organic compound with the formula [CH2NHCH2CH2NH2]2. 
This oily liquid is colorless but, like many amines, older samples assume a yellowish color due to impurities resulting from air-oxidation. 

Triethylenetetramine (TETA) is soluble in polar solvents.
Triethylenetetramine (TETA) is a colorless to light-yellow liquid containing linear, branched and cyclic molecules. 

Triethylenetetramine (TETA) is mainly used in the manufacture of fuel oil additives, lubricating oil additives and epoxy curing agents. 
Triethylenetetramine (TETA) is also used in the production of asphalt additives. 

The branched isomer tris(2-aminoethyl)amine and piperazine derivatives may also be present in commercial samples of TETA.
Triethylenetetramine (TETA) is an organic compound. 

Triethylenetetramine (TETA) belongs to the class of ethyleneamines. 
Triethylenetetramine (TETA) is a very useful chemical compound that is industrially produced by heating ethylenediamine or ethanolamine/ammonia mixtures over an oxide catalyst. 

Triethylenetetramine (TETA) is then separated by distillation and sublimation. 
Triethylenetetramine (TETA)'s chemical formula is C6H18N4.

USES:
The reactivity and uses of Triethylenetetramine (TETA) are similar to those for the related polyamines ethylenediamine and diethylenetriamine. 
Triethylenetetramine (TETA) is primarily used as a crosslinker ("hardener") in epoxy curing

Medical Uses:
The hydrochloride salt of Triethylenetetramine (TETA), referred to as trientine hydrochloride, is a chelating agent that is used to bind and remove copper in the body to treat Wilson's disease, particularly in those who are intolerant to penicillamine.
Some recommend trientine as first-line treatment, but experience with penicillamine is more extensive

Production:
Triethylenetetramine (TETA) is prepared by heating ethylenediamine or ethanolamine/ammonia mixtures over an oxide catalyst. 
This process gives a variety of amines, especially ethylene amines which are separated by distillation and sublimation.

Triethylenetetramine (TETA) appears as a yellowish liquid. 
Triethylenetetramine (TETA) is less dense than water. Combustible, though may be difficult to ignite. 

Triethylenetetramine (TETA) is corrosive to metals and tissue. 
Triethylenetetramine (TETA)'s vapors heavier than air. Toxic oxides of nitrogen produced during combustion.

Triethylenetetramine (TETA) is used in detergents and in the synthesis of dyes, pharmaceuticals and other chemicals.
Triethylenetetramine (TETA) is a highly selective divalent Cu(II) chelator and orphan drug that revereses copper overload in tissues. 

Triethylenetetramine (TETA)'s salt form, trientine (triethylenetetramine dihydrochloride or 2,2,2-tetramine) was introduced in 1969 as an alternative to D-penicillamine. 
Triethylenetetramine (TETA) consists of a polyamine-like structure different from D-penicillamine, as it lack sulfhydryl groups. 

Triethylenetetramine (TETA) was previously approved by FDA in 1985 as second-line pharmacotherapy for Wilson's disease. 
Although penicillamine treatment is believed to be more extensive, Triethylenetetramine (TETA) therapy has been shown to be an effective initial therapy, even with patients with decompensated liver disease at the outset, and prolonged TETA treatment is not associated with adverse effects as expected in penicillamine treatment. 

Triethylenetetramine (TETA)'s clinical applications on cancer, diabetes mellitus, Alzheimer's disease and vascular demetia are being studied.
Triethylenetetramine (TETA) is an oral copper chelating agent used to treat Wilson disease. 
Triethylenetetramine (TETA) has not been associated with worsening of serum enzyme elevations during therapy or with cases of clinically apparent liver injury with jaundice.

Triethylenetetramine (TETA) has similar activity and uses to ethylenediamine and diethylenetriamine. 
Triethylenetetramine (TETA) finds use as a crosslinker (hardener) in epoxy curing, as an intermediate in the synthesis of cellulose chemicals and paper auxillaries, and in lube oil and fuel additives.

Chemical Appearance:
Triethylenetetramine (TETA) is an oily liquid. 
Triethylenetetramine (TETA) is colourless. 

However, like many amines, its older samples have the appearance of a yellow-coloured liquid because of impurities resulting from air oxidation. 
Triethylenetetramine (TETA) is a slightly viscous liquid. 
Triethylenetetramine (TETA) is soluble in polar solvents. 

Triethylenetetramine (TETA) is slightly less dense than water. 
Triethylenetetramine (TETA) is combustible but difficult to ignite. 

Triethylenetetramine (TETA) is corrosive to metals and tissue. 
Triethylenetetramine (TETA)'s vapours are heavier than air. 

Triethylenetetramine (TETA) has a fishy or ammoniacal odour. 
Triethylenetetramine (TETA) is soluble in water.


Chemical Applications and Strengths:
Triethylenetetramine (TETA) or Triethylene Tetramine is an extremely useful chemical compound and therefore, has many industrial applications. 
Triethylenetetramine (TETA)'s main applications and strengths are:

*Triethylenetetramine (TETA) is most commonly used as a crosslinker or hardener in epoxy curing.
*Triethylenetetramine (TETA)'s hydrochloride salt which is known as trientine hydrochloride is a chelating agent. 
This salt is used to bind and remove copper in the body to treat Wilson’s disease. 
Triethylenetetramine (TETA) therapy is an effective starting therapy.

*Triethylenetetramine (TETA) is used in the manufacturing of cleaning products such as detergents.
*In the pharmaceutical industries, Triethylenetetramine (TETA) is used for the production of pharmaceuticals.

*Triethylenetetramine (TETA) is consumed for the production of many chemicals in the chemical industries
*In medicine Triethylenetetramine (TETA) is used as a replacement of D-penicillamine.

*Triethylenetetramine (TETA) is utilised for the casting and surface treatment of metals.
*Triethylenetetramine (TETA) is effective in the production of water softeners.

*Triethylenetetramine (TETA) is employed in products used in the process of collection, purification, and distribution of water.
*Triethylenetetramine (TETA) is expended as a raw material in various products and industries such as cosmetics, chemical manufacturing, metal production and many more.

*Triethylenetetramine (TETA) acts as a modifier for numerous purposes.
*Triethylenetetramine (TETA) performs essential functions in the extraction of gases.

*Triethylenetetramine (TETA) is crucial in the extraction of crude oil, crude petroleum, refined oil products, fuel oils, and drilling oils etc.
*Triethylenetetramine (TETA) is put to use as a solvent in cleaning products such as paint and graffiti removers.

*Triethylenetetramine (TETA) is essential for the surface treatment of metals as a corrosion inhibitor, polishing agent, rust preventer, and water repellent etc.
*Triethylenetetramine (TETA) is a significant component in the production of pesticides.
*Triethylenetetramine (TETA) is also used for making preservatives used in cosmetics, film, wood, and foods etc.

Triethylenetetramine (TETA) is a chemical substance that occurs in the form of an oily, dense yellowish liquid. 
Triethylenetetramine (TETA) has the molecular formula C6H18N4 and is widely used to manufacture corrosion inhibitor fluids.

Triethylenetetramine (TETA) is used as a corrosion inhibitor for metallic surfaces that are used in aqueous media applications.
Triethylenetetramine (TETA) is an oily liquid, with yellowish hue due to impurities. 

Triethylenetetramine (TETA) melts at 12 °C and boils at 280 °C. 
Triethylenetetramine (TETA)'s formula is H2N-CH2CH2-NH-CH2CH2-NH-CH2CH2-NH2. 

Triethylenetetramine (TETA) is soluble in water, producing an alkaline solution, as well as other polar solvents.
Triethylenetetramine (TETA) has similar reactivity and uses as ethylenediamine and diethylenetriamine, with applications in epoxy curing.

Triethylenetetramine (TETA) is a copper chelating agent used for the management of Wilson's disease in cases where penicillamine therapy is clinically inappropriate.
Triethylenetetramine (TETA), also known as trientine, is a potent and selective copper (II)-selective chelator.

Triethylenetetramine (TETA) by Huntsman is triethylenetetramine. 
Triethylenetetramine (TETA) acts as a curing agent for epoxy resins. 

Triethylenetetramine (TETA) also functions as a corrosion inhibitor, surfactant and mineral processing aid. 
Triethylenetetramine (TETA) is compatible with polyamides. 
Triethylenetetramine (TETA) can be used in composites. 

Triethylenetetramine (TETA) is used as a polymer and resin modifier. 
Triethylenetetramine (TETA) is used as an amine hardener in epoxy resin

Triethylenetetramine (TETA) is used in synthesis of detergents, softeners, and dyestuffs
Triethylenetetramine (TETA)is manufactured by reacting ethylene dichloride and ammonia under controlled conditions.
Triethylenetetramine (TETA) is a strong base


PHYSICAL PROPERTIES: 

-Molecular Weight: 146.23

-XLogP3-AA: -2.5    

-Exact Mass: 146.153146591    

-Monoisotopic Mass: 146.153146591    

-Topological Polar Surface Area: 76.1 Ų

-Physical Description: Viscous, colourless to yellow liquid with an ammonia-like odor

-Color: Yellowish

-Form: Viscous liquid

-Boiling Point: 266.5 °C

-Melting Point: 12.0 °C

-Flash Point: 135 °C

-Solubility: 32.63 M

-Density: 0.982

-Vapor Density: 5.04

-Vapor Pressure: 0.000412

-LogP: -1.4/-1.66

-Autoignition Temperature: 640 °F

-Viscosity: 27.24 mm²/s

-Chemical Classes: Nitrogen Compounds -> Amines, Aliphatic


Triethylenetetramine (TETA) is an organic compound with the formula [CH2NHCH2CH2NH2]2. 
Triethylenetetramine (TETA) is soluble in polar solvents.
Triethylenetetramine (TETA) is a colorless to light-yellow liquid containing linear, branched and cyclic molecules. 

Triethylenetetramine (TETA) is mainly used in the manufacture of fuel oil additives, lubricating oil additives and epoxy curing agents. 
Triethylenetetramine (TETA) is also used in the production of asphalt additives. 

Triethylenetetramine (TETA) is an organic compound. 
Triethylenetetramine (TETA) belongs to the class of ethyleneamines. 
Triethylenetetramine (TETA) is a very useful chemical compound that is industrially produced by heating ethylenediamine or ethanolamine/ammonia mixtures over an oxide catalyst. 


CHEMICAL PROPERTIES: 

-Hydrogen Bond Donor Count: 4    

-Hydrogen Bond Acceptor Count: 4    

-Rotatable Bond Count: 7    

-Heavy Atom Count: 10    

-Formal Charge: 0    

-Complexity: 49.7    

-Isotope Atom Count: 0    

-Defined Atom Stereocenter Count: 0    

-Undefined Atom Stereocenter Count: 0    

-Defined Bond Stereocenter Count: 0    

-Undefined Bond Stereocenter Count: 0    

-Covalently-Bonded Unit Count: 1    

-Compound Is Canonicalized: Yes


Triethylenetetramine (TETA)'s chemical formula is C6H18N4.
Triethylenetetramine (TETA) appears as a yellowish liquid. 
Triethylenetetramine (TETA) is less dense than water. 

Triethylenetetramine (TETA)'s vapors heavier than air. Toxic oxides of nitrogen produced during combustion.
Triethylenetetramine (TETA) is used in detergents and in the synthesis of dyes, pharmaceuticals and other chemicals.

Triethylenetetramine (TETA)'s salt form, trientine (triethylenetetramine dihydrochloride or 2,2,2-tetramine) was introduced in 1969 as an alternative to D-penicillamine. 
Triethylenetetramine (TETA) is an oily liquid. 

Triethylenetetramine (TETA) is colourless. 
Triethylenetetramine (TETA) is soluble in polar solvents. 

Triethylenetetramine (TETA) is slightly less dense than water. 
Triethylenetetramine (TETA) is corrosive to metals and tissue. 
Triethylenetetramine (TETA)'s vapours are heavier than air. 

Triethylenetetramine (TETA) has a fishy or ammoniacal odour. 
Triethylenetetramine (TETA) is soluble in water.

Triethylenetetramine (TETA) is used in the manufacturing of cleaning products such as detergents.
Triethylenetetramine (TETA) is used for the production of pharmaceuticals.

Triethylenetetramine (TETA) is consumed for the production of many chemicals in the chemical industriesTriethylenetetramine (TETA) is used as a replacement of D-penicillamine.
Triethylenetetramine (TETA) is effective in the production of water softeners.
Triethylenetetramine (TETA) is employed in products used in the process of collection, purification, and distribution of water.

Triethylenetetramine (TETA) acts as a modifier for numerous purposes.
Triethylenetetramine (TETA) is essential for the surface treatment of metals as a corrosion inhibitor, polishing agent, rust preventer, and water repellent etc.

Triethylenetetramine (TETA) is a significant component in the production of pesticides.
Triethylenetetramine (TETA) is also used for making preservatives used in cosmetics, film, wood, and foods etc.

Triethylenetetramine (TETA) is a chemical substance that occurs in the form of an oily, dense yellowish liquid. 
Triethylenetetramine (TETA) has the molecular formula C6H18N4 and is widely used to manufacture corrosion inhibitor fluids.

Triethylenetetramine (TETA) is used as a corrosion inhibitor for metallic surfaces that are used in aqueous media applications.
Triethylenetetramine (TETA) is an oily liquid, with yellowish hue due to impurities. 
Triethylenetetramine (TETA) melts at 12 °C and boils at 280 °C. 

Triethylenetetramine (TETA) is a copper chelating agent
Triethylenetetramine (TETA) acts as a curing agent for epoxy resins. 

Triethylenetetramine (TETA) also functions as a corrosion inhibitor, surfactant and mineral processing aid. 
Triethylenetetramine (TETA) is compatible with polyamides. 

Triethylenetetramine (TETA) can be used in composites. 
Triethylenetetramine (TETA) is used as a polymer and resin modifier. 
Triethylenetetramine (TETA) is used as an amine hardener in epoxy resin

Triethylenetetramine (TETA) is used in synthesis of detergents, softeners, and dyestuffs
Triethylenetetramine (TETA) is a strong base
Triethylenetetramine (TETA) is soluble in water


SYNONYMS: 

TRIETHYLENETETRAMINE
trientine
112-24-3
Trien
TETA
Tecza
Triethylene tetramine
1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-
Araldite hardener HY 951
DEH 24
Araldite HY 951
1,4,7,10-Tetraazadecane
1,8-Diamino-3,6-diazaoctane
N,N'-Bis(2-aminoethyl)-1,2-ethanediamine
Syprine
3,6-Diazaoctane-1,8-diamine
N,N'-Bis(2-aminoethyl)ethylenediamine
HY 951
triethylenetetraamine
2,2,2-tetramine
triethylene tetraamine
N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine
Ethylenediamine, N,N'-bis(2-aminoethyl)-
N,N'-bis(2-aminoethyl)ethane-1,2-diamine
(2-aminoethyl)({2-[(2-aminoethyl)amino]ethyl})amine
1,2-Ethanediamine, N1,N2-bis(2-aminoethyl)-
N1,N1'-(Ethane-1,2-diyl)diethane-1,2-diamine
Trientinum
Trientina
Trientinum 
Trientina 
EINECS 203-950-6
triene
Trientene
N,N-Bis(2-aminoethyl)-1,2-diaminoethane
AI3-24384
Trethylenetetramine
1,6-diazaoctane
EPH 925
Trientine
3,8-diamine
1,7,10-Tetraazadecane
3,6-Diazaoctanethylenediamin
N,N'-Di(2-aminoethyl)ethylenediamine
Triethylenetetramine, >=97.0% (T)
DB06824
Ethylenediamine,N'-bis(2-aminoethyl)-
Ethanediamine, N,N'-bis(2-aminoethyl)-
N,N'-Bis(2-aminoethyl)-1,2-diaminoethane
Triethylenetetramine
Triethylenetetramine
N,N''-Bis-(2-amino-ethyl)-ethane-1,2-diamine
N,N''-BIS(2-AMINOETHYL)-1,2-ETHANEDIAMINE
Ethanediamine, N,N'-bis(2-aminoethyl)-
Ethylenediamine, N,N'-bis(2-aminoethyl)-
N,N'-Bis(2-aminoethyl)-1,2-diaminoethane
N,N-Bis(2-aminoethyl)-1,2-diaminoethane
N,N'-Bis(2-aminoethyl)ethylenediamine
N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine
N'-[2-(2-azanylethylamino)ethyl]ethane-1,2-diamine
N1,N1'-(Ethane-1,2-diyl)bis(ethane-1,2-diamine)
N1,N1'-(Ethane-1,2-diyl)diethane-1,2-diamine
2-aminoethyl-[2-(2-aminoethylamino)ethyl]amine
3,6-Diazaoctane-1,8-diamine
3,6-diazaoctanediethylenediamine
3,6-Diazaoctanethylenediamin
(2-aminoethyl)({2-[(2-aminoethyl)amino]ethyl})amine
(2-aminoethyl){2-[(2-aminoethyl)amino]ethyl}amine
1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-
1,2-Ethanediamine, N1,N2-bis(2-aminoethyl)-
1,4,7,10-Tetraazadecane

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