Quick Search
TRIGLYCIDYL ISOCYANURATE= TGIC
CAS: 2451-62-9
European Community (EC) Number: 219-514-3
IUPAC Name: 1,3,5-tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione
Molecular Formula: C12H15N3O6
DESCRIPTION:
Tris(2,3-epoxypropyl)isocyanurate is a white crystalline solid.
Occupational contact dermatitis can occur in people producing this chemical, in those producing the powder coat paint and in sprayers.
TGIC is an epoxy compound used as a cross-linker in the manufacture of materials such as laminated sheets, printed circuits, electrical insulations, inks, adhesives and lining materials.
Further research may identify additional product or industrial usages of this chemical.
Commercial (technical) grade TGIC is a mixture of two optical stereoisomers, alpha and beta, which have different physicochemical properties.
There are two main technical grades of TGIC.
These are Araldite PT 810 (also known as TK 10622), and TEPIC.
Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities.
Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via p53 activation. Triglycidyl isocyanurate induces cell apoptosis.
Triglycidyl isocyanurate can be used for cancer research.
The TGIC is a kind of heterocyclic epoxy compound, is also named Triglycidyl Isocyanurate.
TGIC has very good heat resistance, weathering resistance, adhesion and excellent high temperature performance.
TGIC is mainly used for containing carboxyl polyester, carboxyl acrylic resin powder coating of the curing agent.
The TGIC is always used as curing agent.
High purity of TGIC can be used in the manufacture of electrical insulating laminated board, adhesive, plastic stabilizer, etc. (TGIC) is added to powders as a cross-linking agent to enhance durability and finish.
TGIC is known to increase the sensitivity of the skin and respiratory tract, is toxic by ingestion and inhalation and may cause serious eye damage.
Triglycidal Isocyanurate (TGIC) is an odorless white powder or granules.
TGIC is insoluble in water and has the potential to be explosive.
Triglycidal Isocyanurate is widely used as a cross-linking agent or curing agent in powder coating industry.
TGIC is used also in the printed circuit board industry, electrical insulation and as a stabilizer in plastic industry.
TGIC is an excellent curing agent for powder coatings.
TGIC is combined with adequate polyester resins, which provides powder coatings with high performance.
With stable quality, our TGIC has good weather resistance.
Through its free functional epoxide groups, it functions very well when combined with resins containing carboxyl groups like saturated polyesters.
TGIC curing agent can be used in the production of electrical insulation materials, printed circuits, tools, adhesives, stabilizers for plastic materials, laminated sheeting.
Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity.
TGIC inhibits growth of human non-small cell lung cancer cells by activating p53.
Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication.
Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.
Triglycidyl isocyanurate (TGIC) is a reactive chemical that has been used as a model system to study the reaction mechanism of thermal expansion.
TGIC is soluble in organic solvents and reacts with water to form a free radical, which then reacts with an organic molecule.
This reaction solution can be used as an analytical method for the determination of methyl ethyl ketones.
The high resistance of TGIC to thermal aging makes it suitable for use in polyester manufacturing, metal hydroxides, and wastewater treatment.
TGIC also has biological properties such as its ability to inhibit mitochondrial membrane potential and prevent cell death through apoptosis.
TGIC has also been shown to have nitrogen atoms that react with water vapor at high temperatures, which may lead to the production of nitrates that could be toxic to bacteria or plants.
CAS: 2451-62-9
European Community (EC) Number: 219-514-3
IUPAC Name: 1,3,5-tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione
Molecular Formula: C12H15N3O6
APPLICATION OF TRIGLYCIDYL ISOCYANURATE:
Applications:
• Curing agent for polyester powder coating
• Used to manufacture electrical insulation materials, laminate sheeting
• Stabilizer for plastic materials
Industrial Application:
1,3,5-triglycidyl isocyanurate (TGIC) is a white powder or granular solid and is normally sold under the trade name ARALDITE PT810R or TEPIC G R.
As a tri-functional epoxy monomer, TGIC is used in large scale as curing agent for powder coatings or for cross-linking elastomers.
Rosin acids of natural origin may also be cured with TGIC for versatile applications.
TGIC has also been used for pharmaceutical purposes, in membranes, for curing intelligent gels or liquid crystal elastomers.
Especially, this curing agent has been widely used in dry powder coating for over 40 years.
USES OF TRIGLYCIDYL ISOCYANURATE:
1,3,5-triglycidyl isocyanurate be used for curing agent of polyester and acrylic resin carboxyl-containing powder coating, manufacturing an electrical insulating laminates, adhesives, plastics stabilizers.
Triglycidyl isocyanurate is used as cross-linker in heat-cured polyester paints, such as laminated sheetings, printed circuits, tools, inks, adhesives, lining materials etc.
TGIC is widely used as a cross-linking agent or curing agent in powder coating industry.
TGIC is used also in the printed circuit board industry, electrical insulation and as a stabilizer in plastic industry.
Typical applications of polyester TGIC powder coatings are where sharp edges and corners exist such as on automotive wheels, air conditioners, lawn furniture, and air conditioner cabinets.
1,3,5-Triglycidyl isocyanurate is widely used as a cross-linking agent or curing agent in powder coating industry.
TGIC is also used in the printed circuit board industry, electrical insulation and as a stabilizer in plastic industry.
TGIC is produced from epichlorohydrin and isocyanuric acid using sodium hydrate and methanol.
No production of TGIC occurs in Denmark.
TGIC has been used as a curing agent for polyester resins in weather-resistant powder coatings in Europe for about 20 years.
In Denmark TGIC has an extended use in powder coatings.
A powder coating contains up to 10 % TGIC.
It is sprayed directly onto metal objects by an electrostatic process.
Powder coated objects include office and garden steel furniture, car parts, metal fencing, window and door frames, shelving, electrical equipment, and domestic appliances such as refrigerators, washing machines and ovens.
TGIC is also used in electrical insulation materials, resin moulding systems, laminated sheetings, printed circuits, tools, inks, adhesives, lining materials, stabilisers for plastics and amine captures
The alpha isomer of TGIC was used as an experimental anti-tumour agent under the names of Teroxirone, alpha-TGT, and Henkels compound.
Clinical use of the alpha isomer was not pursued.
CAS: 2451-62-9
European Community (EC) Number: 219-514-3
IUPAC Name: 1,3,5-tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione
Molecular Formula: C12H15N3O6
Chemical and Physical Properties of TRIGLYCIDYL ISOCYANURATE:
Molecular Weight: 297.26
XLogP3-AA: -1.5
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 6
Rotatable Bond Count: 6
Exact Mass: 297.09608521
Monoisotopic Mass: 297.09608521
Topological Polar Surface Area: 98.5 Ų
Heavy Atom Count: 21
Formal Charge: 0
Complexity: 416
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 3
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Odor: No odor at room temperature
Melting point: 95-98°C
Boiling point: 438.78°C (rough estimate)
Density: 1,42 g/cm3
refractive index. 1.5290 (estimate)
pka: -2.44±0.20(Predicted)
Water Solubility: <0.1 g/100 mL at 20 ºC
CAS DataBase Reference: 2451-62-9(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances: TRIGLYCIDYL ISOCYANURATE
EWG's Food Scores: 3-4
NCI Drug Dictionary: teroxirone
EPA Substance Registry System: Triglycidyl isocyanurate (2451-62-9)
Air & Water Reactions: Insoluble in water.
Appearance: White to Almost white powder to crystal
Purity(GC): min. 98.0 %
Purity(Epoxy Equivalent): min. 98.0 %
Melting Point: 108 °C
Solubility in water: Practically insoluble
Degree of solubility in water: 9 g/l 25 °C
Solubility (soluble in): Dimethylformamide
CAS: 2451-62-9
European Community (EC) Number: 219-514-3
IUPAC Name: 1,3,5-tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione
Molecular Formula: C12H15N3O6
SAFETY INFORMATION ABOUT TRIGLYCIDYL ISOCYANURATE:
First aid Measures:
Eyes Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Skin Wash off with soap and plenty of water.
Consult a physician.
Ingestion Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
Inhalation If breathed in, move person into fresh air.
If not breathing give artificial respiration
Consult a physician.
Fire Fighting Measures
General Information
Wear self contained breathing apparatus for fire fighting if necessary.
Extinguishing Media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Accidental Release Measures:
General Information
Use proper personal protective equipment
Spills/Leaks Pick up and arrange disposal without creating dust.
Keep in suitable, closed containers for disposal.
Handling and Storage
Handling Avoid exposure - obtain special instructions before use.
Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
Normal measures for preventive fire protection.
Storage:
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Store at 2-8ºC
Storage :
Powder:
• -20°C 3 years
• 4°C 2 years
In solvent:
• -80°C 6 months
• -20°C 1 month
POTENTIAL HEALTH EFFECTS:
Eye: Causes serious eye irritation.
Skin: May be harmful if absorbed through skin.
May cause skin irritation.
Ingestion: Toxic if swallowed.
PERSONAL PROTECTIVE EQUIPMENT
Eyes: Wear appropriate chemical splash goggles.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: Where risk assessment shows air-purifying respirators are appropriate use a dust mask type N95 (US) or type P1 (EN 143) respirator.
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N99 (US) or type P2 (EN 143) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU)
CAS: 2451-62-9
European Community (EC) Number: 219-514-3
IUPAC Name: 1,3,5-tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione
Molecular Formula: C12H15N3O6
Synonyms of TRIGLYCIDYL ISOCYANURATE
MeSH Entry Terms
1,3,5-triglycidyl isocyanurate
1,3,5-triglycidyl-s-triazinetrione
alpha-1,3,5-triglycidyl-s-triazinetrione
alpha-TGT
NSC 296934
NSC-296934
Tepic
teroxirone
TGIC
triglycidyl isocyanurate
Depositor-Supplied Synonyms
Triglycidyl isocyanurate
2451-62-9
1,3,5-Triglycidyl isocyanurate
Teroxirone
1,3,5-tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione
TGIC
Triglycidylisocyanurate
Tris(2,3-epoxypropyl) isocyanurate
Glycidyl isocyanurate
Tri(epoxypropyl)isocyanurate
Tris(2,3-epoxypropyl)isocyanurate
Tris(epoxypropyl) isocyanurate
1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(oxiranylmethyl)-
XB 2615
Triglycidyl Isocyanurate (TGIC)
Tris(2-epoxypropyl) isocyanurate
1,3,5-Triglycidylisocyanuric acid
N,N',N''-Triglycidyl isocyanurate
MLS002703049
TGT
DTXSID4026262
s-Triazine-2,4,6(1H,3H,5H)-trione, tris(2,3-epoxypropyl)-
Isocyanuric Acid Triglycidyl Ester
s-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(2,3-epoxypropyl)-
NSC-296934
NSC296934
NCGC00091182-01
DSSTox_CID_6262
Isocyanuric Acid Tris(2,3-epoxypropyl) Ester
NSC 296964
BRN 0765833
DSSTox_RID_78079
DSSTox_GSID_26262
1,5-Triglycidyl isocyanurate
1,5-Triglycidylisocyanuric acid
Araldite PT 810
Henkel's compound
ALPHATGI
1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(2-oxiranylmethyl)-
1,3,5-Triglycidyl-s-triazinetrione
Tris(epoxypropyl)isocyanurate
SMR001223822
CAS-2451-62-9
NSC 296934
CCRIS 6112
HSDB 7188
EINECS 219-514-3
1,3,5-TRIGLYCIDYLISOCYANURATE
s-Triazine-2,6(1H,3H,5H)-trione, 1,3,5-tris(2,3-epoxypropyl)-
1,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(oxiranylmethyl)-
1,3,5-Tris(oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione
GATGI
EC 219-514-3
SCHEMBL4932
Isocyanuricacidtriglycidylester
28825-96-9
MLS006011655
CHEMBL453863
.alpha.-triglycidyl isocyanurate
BDBM442751
Tox21_111097
Tox21_201660
Tox21_300119
MFCD00080670
NSC296964
s2427
Triglycidyl Isocyanurate (Teroxirone)
AKOS000269627
AKOS016039416
CS-W012150
HY-W011434
MCULE-5172595440
NSC-296964
NCGC00091182-02
NCGC00091182-03
NCGC00091182-04
NCGC00091182-05
NCGC00091182-06
NCGC00091182-07
NCGC00254066-01
NCGC00259209-01
AC-18356
AS-12208
NCI60_002484
DB-046472
FT-0627405
I0428
F20307
Tris(2,3-epoxypropyl) Isocyanurate Isocyanurate
A817349
Q2453240
Triglycidyl Isocyanurate (Electronic Grade, Type 1)
Triglycidyl Isocyanurate (Electronic Grade, Type 2)
W-107310
F0777-0193
Triglycidyl Isocyanurate (Powder Coating Grade, Type 7)
Triglycidyl Isocyanurate (Powder Coating Grade, Type 8)
1,3,5-Triglycidyl isocyanurate(Columns or Chunks or pellets)
1,3,5-Tris(2-oxiranylmethyl)-1,3,5-triazinane-2,4,6-trione
1,3,5-Tris(2-oxiranylmethyl)-1,3,5-triazinane-2,4,6-trione #
1,3,5-Triazine-2,4,6(1H,3H,5H)-trione,1,3,5-tris(2-oxiranylmethyl)-, homopolymer
1,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(oxiranylmethyl)-, (.alpha.)-
1,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(oxiranylmethyl)-, (.beta.)-
