PRODUCTS

TRIHEPTANOIN

EC / List no.: 210-647-2
CAS no.: 620-67-7
Mol. formula: C24H44O6

Triheptanoin, sold under the brand name Dojolvi, is a medication for the treatment of children and adults with molecularly confirmed long-chain fatty acid oxidation disorders (LC-FAOD).

The most common adverse reactions include abdominal pain, diarrhea, vomiting, and nausea.

Triheptanoin was approved for medical use in the United States in June 2020.

Triheptanoin is a triglyceride that is composed of three seven-carbon (C7:0) fatty acids.
These odd-carbon fatty acids are able to provide anaplerotic substrates for the TCA cycle.
Triheptanoin is used clinically in humans to treat inherited metabolic diseases, such as pyruvate carboxylase deficiency and carnitine palmitoyltransferase II deficiency.
It also appears to increase the efficacy of the ketogenic diet as a treatment for epilepsy.

Since triheptanoin is composed of odd-carbon fatty acids, it can produce ketone bodies with five carbon atoms, as opposed to even-carbon fatty acids which are metabolized to ketone bodies with four carbon atoms.
The five-carbon ketones produced from triheptanoin are beta-ketopentanoate and beta-hydroxypentanoate.
Each of these ketone bodies easily crosses the blood–brain barrier and enters the brain.

Medical uses
Dojolvi is indicated as a source of calories and fatty acids for the treatment of children and adults with molecularly confirmed long-chain fatty acid oxidation disorders (LC-FAOD).

History
Triheptanoin was designated an orphan drug by the U.S. Food and Drug Administration (FDA) in 2006, 2008, 2014, and 2015.
Triheptanoin was also designated an orphan drug by the European Medicines Agency (EMA).

Triheptanoin was approved for medical use in the United States in June 2020.

The FDA approved triheptanoin based on evidence from three clinical trials (Trial 1/NCT018863, Trial 2/NCT022141 and Trial 3/NCT01379625).
The trials enrolled children and adults with LC-FAOD.
Trials 1 and 2 were conducted at 11 sites in the United States and the United Kingdom, and Trial 3 was conducted at two sites in the United States.

Trial 1 and Trial 2 were used to evaluate the side effects of triheptanoin.
Both trials enrolled children and adults diagnosed with LC-FAOD.
In Trial 1, participants received triheptanoin for 78 weeks.
Trial 2 enrolled participants from other trials who were already treated with triheptanoin (including those from Trial 1) as well as participants who were never treated with triheptanoin before.
Trial 2 is still ongoing and is planned to last up to five years.

The benefit of triheptanoin was evaluated in Trial 3 which enrolled children and adults with LC-FAOD.
Half of the participants received triheptanoin and half received trioctanoin for four months.
Neither the participants nor the investigators knew which treatment was given until the end of the trial.
The benefit of triheptanoin in comparison to trioctanoin was assessed by measuring the changes in heart and muscle function.

Names
Triheptanoin is the international nonproprietary name.

Triheptanoin is triheptanoin is a medium chain triglyceride indicated to provide calories and fatty acids to treat long chain fatty acid oxidation disorders.

Triheptanoin is a source of heptanoate fatty acids, which can be metabolized without the enzymes of long chain fatty acid oxidation.
In clinical trials, patients with long chain fatty acid oxidation disorders (lc-FAODs) treated with triheptanoin are less likely to develop hypoglycemia, cardiomyopathy, rhabdomyolysis, and hepatomegaly.
Complications in lc-FAOD patients are reduced from approximately 60% to approximately 10% with the addition of triheptanoin.

triheptanoin is a triglyceride that acts as a surfactant and skinconditioning agent, it also helps increase product viscosity. often used in cleansers, face and neck products, moisturizers and lipsticks.

Triheptanoin is a triglyceride that is used for the treatment of inherited metabolic diseases, epilepsy, ventricular hypertrophy and myocardial glucose oxidation.

TRIHEPTANOIN is classified as :
Skin conditioning
Surfactant
Viscosity controlling
CAS Number   620-67-7
EINECS/ELINCS No:   210-647-2
COSING REF No:   80359
Chem/IUPAC Name:   Propane-1,2,3-triyl trisheptanoate

ProName: Glycerol triheptanoate
CasNo: 620-67-7
Molecular Formula: C24H44O6
Appearance: liquid
Application: It is an important raw material and in...
DeliveryTime: prompt
PackAge: according to the clients requirement
Port: Shanghai
Production Capacity: 1-100 Metric Ton/Month
Purity: 98%Storage: Store in dry, dark and ventilated plac...
Transportation: by sea or by airLimitNum: 1 Kilogram
Grade: Industrial Grade

Triheptanoin is a triglyceride that is used for the treatment of inherited metabolic diseases, epilepsy, ventricular hypertrophy and myocardial glucose oxidation.

Molecular weight:428.6

Appearance:Colorless liquid

Assay: 97%

Glyceryl Trioenanthate Usage

Used as a Pharmaceutical intermediate.

Triheptanoin (API, IND106011, UX007, Glycerol trienanthate) is a synthetic, medium-chain triglyceride consisting of three odd-chain 7-carbon (heptanoate) fatty acids on a glycerol backbone.
Triheptanoin is used for treatment of fatty acid oxidation disorders and GLUT1.

INCI name: TRIHEPTANOIN
EINECS/ELINCS number: 210-647-2
Bio-compatible (COSMOS Reference)
Its functions (INCI)
Skin conditioning : Keeps the skin in good condition
Surfactant : Reduces the surface tension of cosmetics and contributes to the even distribution of the product when it is used
Viscosity controlling : Increases or decreases the viscosity of cosmetics
Skin conditioning - occlusive : Retarding the evaporation of water from the skin surface.
Occlusives are generally lipids which tend to remain on the skin surface and thus increase the water content of skin.

About Triheptanoin
Helpful information
Triheptanoin is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.

Triheptanoin is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Consumer Uses
Triheptanoin is used in the following products: washing & cleaning products, plant protection products, lubricants and greases, adhesives and sealants, polishes and waxes, fertilisers and coating products. Other release to the environment of Triheptanoin is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

Article service life
Other release to the environment of Triheptanoin is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).
Triheptanoin can be found in complex articles, with no release intended: vehicles.
Triheptanoin can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones).
Triheptanoin is intended to be released from scented: clothes.
Widespread uses by professional workers
Triheptanoin is used in the following products: washing & cleaning products, polishes and waxes and plant protection products.
ECHA has no public registered data on the types of manufacture using Triheptanoin. Other release to the environment of Triheptanoin is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
Formulation or re-packing
Triheptanoin is used in the following products: polymers, lubricants and greases and textile treatment products and dyes.
Release to the environment of Triheptanoin can occur from industrial use: formulation of mixtures and formulation in materials.
Uses at industrial sites
Triheptanoin is used in the following products: washing & cleaning products, metal surface treatment products, polymers, textile treatment products and dyes, pH regulators and water treatment products and leather treatment products.
ECHA has no public registered data on the types of manufacture using Triheptanoin. Release to the environment of Triheptanoin can occur from industrial use: in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.
Manufacture
Release to the environment of Triheptanoin can occur from industrial use: manufacturing of the substance.

IUPAC NAMES:
1,3-bis(heptanoyloxy)propan-2-yl heptanoate
2,3-di(heptanoyloxy)propyl heptanoate
propane-1,2,3-triyl triheptanoate
Propane-1,2,3-triyl trisheptanoate
Propane-1,2,3-triyl trisheptanoate
Triheptanoin

SYNONYMS:
glyceroltriheptanoate
Glycerol-triheptanoate-
Glyceroltriheptanoate,1,2,3-propanetriylester
GLYCERINETRIHEPTANOATE
triheptylin
trioenanthoin
GLYCERYL TRIHEPTANOATE
GLYCEROL TRIOENANTHATE
TRIHEPTANOIN
TRIOENANTHIN
1,2,3-Trienanthoylglycerol
propane-1,2,3-triyl trisheptanoate
glycerol trienanthate
Propan-1,2,3-triyltrisheptanoat
TRIHEPTANION
glyceryl trioenanthate
1,2,3-Propanetriol trisheptanoate
1,2,3-Propanetriyl=triheptanoate
1-O,2-O,3-O-Triheptanoyl-L-glycerol
Triheptanoic acid 1,2,3-propanetriyl ester
1,3-di(heptanoyloxy)propan-2-yl heptanoate
enanthic acid [2-enanthyloxy-1-(enanthyloxymethyl)ethyl] ester
Heptanoic acid 1,1',1''-(1,2,3-propanetriyl) ester
Glycerol trienanthate >=94%
Camicinal Hydrochloride
Propane-1,2,3-triyl triheptanoate
heptanoicacid,1,2,3-propanetriylester
trienanthoin
tri-heptanoi
triheptanicglyceride
1,2,3-Trihptanoyl-rac-glycerol
1,2,3-Trihetanoyl Glycerol
Triheptanoin
620-67-7
Propane-1,2,3-triyl triheptanoate
GLYCERYL TRIHEPTANOATE
UX007
Propane-1,2,3-triyl trisheptanoate
2,3-di(heptanoyloxy)propyl heptanoate
UNII-2P6O7CFW5K
UX-007
2P6O7CFW5K
3-02-00-00769 (Beilstein Handbook Reference)
Triheptanoin (USAN)
Triheptanoin [USAN]
Trienanthoin
Triheptylin
Trioenanthoin
Glycerol triheptanoate
1,2,3-propanetriyl triheptanoate
Triheptanoic glyceride
Dermofeel TC 7
glyceroltriheptanoate
BRN 1807724
Lanol 37T
EINECS 210-647-2
Trienantin
Dojolvi
Dojolvi (TN)
Glyceryl trienanthate
Heptanoin, tri- (6CI,7CI,8CI)
EC 210-647-2
SCHEMBL525618
Glycerol trienanthate, >=94%
CHEMBL4297585
GTPL11431
DTXSID40862306
Glycerol trienanthate, Triheptanoin
ZINC4521897
IND106011
MFCD00042910
UX 007
1R,2S-(-)-Norephedrinehydrochloride
DB11677
IND 106011
IND-106011
IND106011; UX007
LS-15081
FT-0757070
D11465
A868568
Heptanoic acid, 1,2,3-propanetriyl ester (9CI)
Q414576
W-109093
Heptanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester