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CAS Number: 139-33-3 (Disodium EDTA dihydrate) or 6381-92-6 (Disodium EDTA dihydrate, common form)
EC Number: 205-358-3
Molecular Formula: C₁₀H₁₄N₂Na₂O₈·2H₂O (disodium EDTA dihydrate)
Molecular Weight: 372.24 g/mol
Synonyms:
Trilon B; EDTA disodium salt; Ethylenediaminetetraacetic acid disodium salt; Disodium EDTA; Disodium dihydrogen ethylenediaminetetraacetate; Edetate disodium; (Ethylenedinitrilo)tetraacetic acid disodium salt; EDTA Na₂; Komplexon III
Note: While some sources refer to Trilon B as the tetrasodium salt (Na₄EDTA) , the most common and widely recognized Trilon B product is the disodium salt of EDTA. The product described as Trilon B Powder with >99% purity, white powder, and pH 4-5 in 1% solution corresponds to disodium EDTA .
Chemical Identity and Properties:
Trilon B (disodium EDTA) is a white, crystalline, odorless powder that serves as a powerful chelating agent. It is the disodium salt of ethylenediaminetetraacetic acid (EDTA), a hexadentate ligand that forms stable, water-soluble complexes with metal ions through its two amine groups and four carboxylate groups. The compound is highly soluble in water and slightly soluble in alcohol .
Physical Properties:
Appearance: White, crystalline powder
Odor: Odorless
Purity: Greater than 99%
pH (1% aqueous solution): 4.0 – 5.0
Solubility: Highly soluble in water (forms clear solution); slightly soluble in alcohol
Form: Powder
Packaging Type: Drum
Manufacturing Process:
Trilon B is synthesized through the reaction of ethylenediaminetetraacetic acid (EDTA) with sodium hydroxide to produce the disodium salt. The reaction yields a product that is more soluble and easier to handle than the free acid form of EDTA. The product is then crystallized, dried, and milled to the desired particle size .
Mechanism of Action:
Trilon B functions as a chelating agent by forming stable, water-soluble complexes with metal ions:
Coordination: The EDTA molecule wraps around metal ions, forming six coordinate bonds (two from nitrogen atoms, four from oxygen atoms)
Stability: Forms complexes with a 1:1 metal-to-EDTA ratio, regardless of the metal's charge
Selectivity: Forms the most stable complexes with transition metals and heavy metals (Fe³⁺, Cu²⁺, Pb²⁺, Zn²⁺) and also effectively chelates alkaline earth metals (Ca²⁺, Mg²⁺)
Applications:
1. Detergents and Cleaners:
Laundry detergents: Sequestering hard water ions (calcium, magnesium) to enhance surfactant effectiveness; prevents soap scum formation
Dishwashing liquids: Improves cleaning performance in hard water conditions
Industrial cleaners: Boosts detergency by removing metal ions that interfere with cleaning processes
2. Water Treatment:
Chelates calcium and magnesium ions to prevent scale formation in boilers, cooling towers, and piping systems
Removes heavy metals from industrial wastewater
Stabilizes hydrogen peroxide and other oxidizing agents
3. Textile Industry:
Used in dyeing processes to remove metal ions that can interfere with color development and fabric quality
Prevents metal-catalyzed degradation of fibers
Stripping agent for removing metal-complex dyes
4. Cosmetics and Personal Care:
Stabilizer: Prevents degradation of active ingredients caused by trace metal ions
Preservative booster: Enhances efficacy of preservatives by chelating metals that support microbial growth
Used in shampoos, conditioners, lotions, creams, and soaps
5. Laboratory Applications:
Biochemistry: Chelation of metal ions in enzyme reactions to study metal-dependent enzymes
Molecular biology: Used in buffer preparations (e.g., TE buffer) to protect DNA and RNA from metal-catalyzed degradation
Protein purification: Removes metal ions that may interfere with purification processes
Analytical chemistry: Standard titrant for determination of metal ions (complexometric titration)
6. Food Industry:
Food additive E385: Approved as a food additive in many countries
Prevents oxidation and maintains color and texture of processed foods by sequestering metal ions
Used in salad dressings, canned foods, carbonated beverages, and pickled vegetables
7. Pharmaceuticals:
Heavy metal chelation: Used in formulations to treat heavy metal poisoning (lead, mercury, etc.)
Stabilizer: Prevents metal-catalyzed degradation in pharmaceutical formulations
Preservative: Enhances antimicrobial efficacy in ophthalmic and topical preparations
8. Photography:
Used in photographic processing solutions to prevent precipitation of metal ions
9. Agriculture:
Chelating agent in micronutrient fertilizers (iron, zinc, copper, manganese) to improve plant availability
SAFETY INFORMATION ABOUT TRION B POWDER
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:
If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.
In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.
If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.
Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.
Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.
Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials
Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.
Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.
Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product
