PRODUCTS

TRIPOTASSIUM CITRATE MONOHYDRATE

CAS Number: 6100-05-6
EC Number: 612-062-1
Molecular formula: C6H5K3O7 • H2O
IUPAC Name: Tripotassium; 2-hydroxypropane-1,2,3-tricarboxylate; hydrate

DESCRIPTION:
TRIPOTASSIUM CITRATE MONOHYDRATE is a hydrate that is the monohydrate form of potassium citrate.
TRIPOTASSIUM CITRATE MONOHYDRATE has a role as a diuretic.
TRIPOTASSIUM CITRATE MONOHYDRATE contains a potassium citrate (anhydrous).
Potassium Citrate is the potassium salt form of citrate with alkalinizing property.
Following absorption, potassium citrate causes increased plasma bicarbonate concentration, thereby raising blood and urinary pH.
A simultaneous decrease in calcium ion activity occurs as a result of increasing calcium complex formation with dissociated anions.
Levels of urinary citrate are increased due to modification of the renal handling of citrate.
By promoting excretion of free bicarbonate ion and by increasing urinary pH in addition to an increased ionization of uric acid to more soluble urate ions, this agent exerts the alkalizing and anti-urolithic effect.
A powder that dissolves in water, which is administered orally, and is used as a diuretic, expectorant, systemic alkalizer, and electrolyte replenisher.
TRIPOTASSIUM CITRATE MONOHYDRATE is a white, hygroscopic crystalline powder.
TRIPOTASSIUM CITRATE MONOHYDRATE is odorless with a saline taste.
TRIPOTASSIUM CITRATE MONOHYDRATE contains 38.3% potassium by mass.
In the monohydrate form it is highly hygroscopic and deliquescent.
TRIPOTASSIUM CITRATE MONOHYDRATE is used to treat a kidney stone condition called renal tubular acidosis.
TRIPOTASSIUM CITRATE MONOHYDRATE is indicated also for the management of Hypocitraturic calcium oxalate nephrolithiasis.
TRIPOTASSIUM CITRATE MONOHYDRATE, also known as potassium citrate, is a white, granular powder with an odorless but cooling, salty taste.
TRIPOTASSIUM CITRATE MONOHYDRATE is a non-toxic, slightly alkaline salt with low reactivity.
Contrary to other potassium salts, TRIPOTASSIUM CITRATE MONOHYDRATE is less bitter and thus can be used at higher concentration levels.
TRIPOTASSIUM CITRATE MONOHYDRATE can be used for mineral enrichment in food, beverages, nutraceutical and pharmaceutical products, due to its superior technological and nutritional properties.

CAS Number: 6100-05-6
EC Number: 612-062-1
Molecular formula: C6H5K3O7 • H2O
IUPAC Name: Tripotassium; 2-hydroxypropane-1,2,3-tricarboxylate; hydrate

USES OF TRIPOTASSIUM CITRATE M:ONOHYDRATE
Tripotassium citrate hydrate is used in food and beverage industries.
TRIPOTASSIUM CITRATE MONOHYDRATE finds application as buffering, sequestering or emulsifying agent.
TRIPOTASSIUM CITRATE MONOHYDRATE is also used as a potassium source in pharmaceuticals and an active ingredient to treat urinary duct stones.
TRIPOTASSIUM CITRATE MONOHYDRATE is added to oral care products to reduce the teeth sensitivity.
Tripotassium citrate monohydrate (TPC) is the common tribasic potassium salt of citric acid, also known as potassium citrate.
Potassium citrate (TPC) is used in foods, beverages, personal care and technical applications as buffering, sequestering or emulsifying agent.
Potassium citrate (TPC) usually replaces trisodium citrate whenever a low sodium content is desired.
Potassium citrate (also known as tripotassium citrate) is a potassium salt of citric acid.
Tripotassium Citrate Monohydrate is used in manufacturing method of printed circuit board for autonomous vehicle to perform recognition, judgment, determination and execution.
Citric acid is a weak organic acid that is known as a commodity chemical, as more than a million tonnes are produced every year by mycological fermentation on an industrial scale using crude sugar solutions, such as molasses and strains of Aspergillus niger.
Citric acid is widely distributed in plants and in animal tissues and fluids and exist in greater than grace amounts in variety of fruits and vegetables, most notably in citrus fruits such as lemon and limes.
Citric acid is mainly used as an acidifier, flavoring agent and chelating agent.

CAS Number: 6100-05-6
EC Number: 612-062-1
Molecular formula: C6H5K3O7 • H2O
IUPAC Name: Tripotassium; 2-hydroxypropane-1,2,3-tricarboxylate; hydrate

PHYSICAL AND CHEMICAL PROPERTIES OF TRIPOTASSIUM CITRATE MONOHYDRATE:

Density:   1.98 g/cm3 (20 °C)
Melting Point:   >180 °C Elimination of water of crystallisation
pH value:   8.0 - 9.5 (H₂O)
Bulk density:   950 kg/m3
Solubility:   640 g/l
Storage:   Store at +15°C to +25°C.
Molecular Weight:   324.41
Hydrogen Bond Donor Count:   2
Hydrogen Bond Acceptor Count:   8
Rotatable Bond Count:   2
Exact Mass:   323.9052116
Monoisotopic Mass:   323.9052116
Topological Polar Surface Area:   142 Å²
Heavy Atom Count:   17
Formal Charge:   0
Complexity:   211
Isotope Atom Count:   0
Defined Atom Stereocenter Count:   0
Undefined Atom Stereocenter Count:   0
Defined Bond Stereocenter Count:   0
Undefined Bond Stereocenter Count:   0
Covalently-Bonded Unit Count:   5
Compound Is Canonicalized:   Yes
Physical Description: Pellets Large Crystals
White odorless solid; White powder or granules
Water Solubility: 39.4 mg/mL
logP:   -0.7
logP:   -1.3
logS:   -0.89
pKa (Strongest Acidic):   3.05
pKa (Strongest Basic):   -4.2
Physiological Charge:   -3
Hydrogen Acceptor Count:   7
Hydrogen Donor Count:   1
Polar Surface Area:   140.62 Å2
Rotatable Bond Count:   5
Refractivity:   68.14 m3•mol-1
Polarizability:   14.23 Å3
Number of Rings:   0
Bioavailability:   1
Rule of Five:   Yes
Ghose Filter:   No
Veber's Rule:   No
MDDR-like Rule:   No

Specifications:
Assay (perchloric acid titration, calculated on dried substance):   99.0 - 100.5 %
Assay (perchloric acid titration after drying):   99.0 - 100.5 %
Identity:   passes test
Appearance of solution:   passes test
Alkalinity:   passes test
Acidity or alkalinity:   passes test
pH-value (5 %; water):   7.5 - 9.0
Chloride (Cl):   ≤ 0.0050 %
Sulfate (SO₄):   ≤ 0.0150 %
Heavy metals (as Pb):   ≤ 0.0005 %
As (Arsenic):   ≤ 0.0001 %
Hg (Mercury):   ≤ 0.0001 %
Na (Sodium):   ≤ 0.3 %
Pb (Lead):   ≤ 0.0001 %
Oxalate (C₂O₄):   ≤ 0.009 %
Tartrate (C₄H₄O₆):   passes test
Residual solvents (ICH Q3C):   excluded by manufacturing process
Readily carbonisable substance:   passes test
Loss on drying (180 °C)   :4.0 - 6.0 %
Water:   4.0 - 7.0 %

Shelf Life and Storage:
It is recommended that product held for more than 5 years be reevaluated for fitness of use. Tripotassium Citrate Monohydrate is very hydroscopic and should be stored under conditions of low temperature and low humidity in airtight containers.

CAS Number: 6100-05-6
EC Number: 612-062-1
Molecular formula: C6H5K3O7 • H2O
IUPAC Name: Tripotassium; 2-hydroxypropane-1,2,3-tricarboxylate; hydrate

SAFETY INFORMATION ABOUT TRIPOTASSIUM CITRATE MONOHYDRATE:
HAZARD IDENTIFICATION:
ACUTE HEALTH EFFECTS:
SWALLOWED:
Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-existing organ (e.g. liver, kidney) damage is evident.
Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health).
Gastrointestinal tract discomfort may produce nausea and vomiting.
In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.
Considered an unlikely route of entry in commercial/industrial environments.
Use as a food additive indicates good tolerance of small amounts, but excessive amounts or overuse may bring irritant and / or harmful effects.
EYE:
Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).
SKIN
The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models).
Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.
INHALED:
The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified using animal models).
Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be used in an occupational setting.
Not normally a hazard due to non-volatile nature of product.
CHRONIC HEALTH EFFECTS:
Primary route of exposure is usually by inhalation of generated dust.
As with any chemical product, contact with unprotected bare skin; inhalation of vapor, mist or dust in work place atmosphere; or ingestion in any form, should be avoided by observing good occupational work practice

FIRST AID MEASURES
SWALLOWED:
Rinse mouth out with plenty of water.
If poisoning occurs, contact a doctor or Poisons Information Center.
EYE:
If this product comes in contact with the eyes:
Wash out immediately with fresh running water. Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper and lower lids.
If pain persists or recurs seek medical attention.
Removal of contact lenses after an eye injury should only be undertaken by skilled personnel.
SKIN:
If skin or hair contact occurs:
Flush skin and hair with running water (and soap if available).
Seek medical attention in event of irritation.
INHALED
If dust is inhaled, remove from contaminated area.
Encourage patient to blow nose to ensure clear passage of breathing.
If irritation or discomfort persists seek medical attention or
If fumes or combustion products are inhaled remove from contaminated area.
Other measures are usually unnecessary.

FIRE FIGHTING MEASURES:
EXTINGUISHING MEDIA:
Water spray or fog.
Foam.
Dry chemical powder.
BCF (where regulations permit).
Carbon dioxide.

FIRE FIGHTING:
Alert Emergency Responders and tell them location and nature of hazard.
Wear breathing apparatus plus protective gloves.
Prevent, by any means available, spillage from entering drains or water course.
Use water delivered as a fine spray to control fire and cool adjacent area.
DO NOT approach containers suspected to be hot.
Cool fire exposed containers with water spray from a protected location.
If safe to do so, remove containers from path of fire.
Equipment should be thoroughly decontaminated after use.
GENERAL FIRE HAZARDS/HAZARDOUS COMBUSTIBLE PRODUCTS
Combustible.
Slight fire hazard when exposed to heat or flame.
Heating may cause expansion or decomposition leading to violent rupture of containers.
On combustion, may emit toxic fumes of carbon monoxide (CO).
May emit acrid smoke.
Mists containing combustible materials may be explosive.
Other combustion products include: carbon dioxide (CO2).
FIRE INCOMPATIBILITY:
Avoid contamination with strong oxidizing agents as ignition may result.
Avoid creating dust - may present dust explosion hazard.
Dry dust can be electrostatically charged by turbulence, pneumatic transport, pouring, in exhaust ducts and during transport.
Build-up of electrostatic charge may be prevented by grounding.

PERSONAL PROTECTION:
Glasses:
Chemical goggles.
Gloves:
Respirator:
Particulate

ACCIDENTAL RELEASE MEASURES
MINOR SPILLS:
Clean up all spills immediately.
Avoid contact with skin and eyes.
Wear protective clothing, gloves, safety glasses and dust respirator.
Use dry clean up procedures and avoid generating dust.
Sweep up or vacuum up (consider explosion-proof machines designed to be grounded during storage and use).
Place in clean drum then flush area with water.
MAJOR SPILLS:
Avoid smoking, naked lights or ignition sources.
Clear area of personnel and move upwind.
Alert Emergency Responders and tell them location and nature of hazard.
Control personal contact by using protective equipment and dust respirator.
Prevent spillage from entering drains, sewers or water courses.
Recover product wherever possible.
Avoid generating dust.
Sweep / shovel up.
If required, wet with water to prevent dusting.
Put residues in labelled plastic bags or other containers for disposal.
Wash area down with large quantity of water and prevent runoff into drains.
If contamination of drains or waterways occurs, advise emergency services

- HANDLING AND STORAGE
PROCEDURE FOR HANDLING
Limit all unnecessary personal contact.
Wear protective clothing when risk of exposure occurs.
Use in a well-ventilated area.
Avoid contact with incompatible materials.
When handling, DO NOT eat, drink or smoke.
Keep containers securely sealed when not in use.
Avoid physical damage to containers.
Always wash hands with soap and water after handling.
Work clothes should be laundered separately.
Use good occupational work practice.
Observe manufacturer's storing and handling recommendations.
Atmosphere should be regularly checked against established exposure standards to ensure safe working conditions are maintained.
RECOMMENDED STORAGE METHODS:
Multiply paper bag with sealed plastic liner or heavy gauge plastic bag.
NOTE: Bags should be stacked, blocked, interlocked, and limited in
height so that they are stable and secure against sliding or collapse.
Check that all containers are clearly labelled and free from leaks.
Packing as recommended by manufacturer.
STORAGE REQUIREMENTS:
Store in original containers.
Keep containers securely sealed.
No smoking, naked lights or ignition sources.
Store in a cool, dry, well-ventilated area.
Store away from incompatible materials and foodstuff containers.
Protect containers against physical damage and check regularly for leaks.
Observe manufacturer's storing and handling recommendations.

CAS Number: 6100-05-6
EC Number: 612-062-1
Molecular formula: C6H5K3O7 • H2O
IUPAC Name: Tripotassium; 2-hydroxypropane-1,2,3-tricarboxylate; hydrate

Synonyms of TRIPOTASSIUM CITRATE MONOHYDRATE:
MeSH Entry Terms:
Anhydrous, Potassium Citrate

Citrate, Potassium

Potassium Citrate

Potassium Citrate Anhydrous

Depositor-Supplied Synonyms:
Potassium citrate monohydrate

6100-05-6

Tripotassium citrate monohydrate

Potassium citrate tribasic monohydrate

Kalii citras

UROCIT-K

UNII-EE90ONI6FF

MFCD00150442

EE90ONI6FF

Potassium citrate (monohydrate)

tri-potassium citrate monohydrate

Potassium citrate (USP)

Potassium citrate [USP]

Hydroxycitric acid (tripotassium hydrate)

Potassium 2-hydroxypropane-1,2,3-tricarboxylate hydrate

Citric acid tripotassium salt

CCRIS 6543

K-cit-v

Urocit-K (TN)

potassium citrate.H2O

Citric acid, tripotassium salt, monohydrate

C6H7K3O8

CHEMBL3989822

DTXSID8042501

CHEBI:64746

Tripotassium 2-hydroxy-1,2,3-propanetricarboxylate monohydrate

Citric acid potassium salt monohydrate

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt, monohydrate

NSC 760107

X3586

D05578

Q27133400

Potassium citrate tribasic monohydrate, puriss., 99.5%

Potassium citrate tribasic monohydrate, cell culture tested

Potassium citrate tribasic solution, BioUltra, 1 M in H2O

Potassium citrate tribasic monohydrate, >=98% (GC/titration)

Potassium citrate tribasic monohydrate, purum p.a., >=99.0% (NT)

Potassium citrate tribasic monohydrate, SAJ special grade, >=99.0%

Potassium citrate tribasic monohydrate, tested according to Ph.Eur.

tripotassium 2-hydroxypropane-1,2,3-tricarboxylate--water (1/1)

Potassium citrate tribasic monohydrate, meets USP testing specifications

Potassium citrate tribasic monohydrate, Vetec(TM) reagent grade, 98%

Potassium citrate, United States Pharmacopeia (USP) Reference Standard

Potassium citrate tribasic monohydrate, meets analytical specification of Ph. Eur., BP, FCC, E332, 99-100.5% (calc with ref. to anhyd. subst.)