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CAS NUMBER: 9005-64-5
MOLECULAR FORMULA: C58H114O26F
MOLECULAR WEIGHT: 1.227,54 g/mol
Tween 20 is a polyoxyethylene sorbitol ester that belongs to the polysorbate family.
Tween 20 is a nonionic detergent having a molecular weight of 1,225 daltons, assuming 20 ethylene oxide units, sorbitol, and lauric acid as the primary fatty acid.
Tween 20 subunits are responsible for the hydrophilic nature of the surfactant, while the hydrocarbon chains provide the hydrophobic environment.
Tween 20 forms the backbone ring to which the ethylene oxide polymers are attached.
Tween 20 may not be stable to autoclaving, particularly with metal cations in buffer solutions.
Autoclaving is not recommended without testing for changes in properties.
Tween 20 is heat sensitive and will darken when exposed to elevated temperatures.
Tween 20s have been reported to be incompatible with alkalis, heavy metal salts, phenols, and tannic acid.
They may also reduce the activity of many preservatives.
Aqueous solutions of Tween 20 undergo autoxidation during storage, with changes being catalyzed by light, increased temperature, and copper sulfate.
Tween 20 is miscible in water (100mg/mL), yielding a clear, yellow solution.
Tween 20 is also miscible with alcohol, dioxane, and ethyl acetate.
Tween 20 is insoluble in liquid paraffin and fixed oils.
Tween 20 is a polyoxyethylene sorbitol ester that belongs to the polysorbate family.
Tween 20 is a nonionic detergent having a molecular weight of 1,225 daltons, assuming 20 ethylene oxide units, sorbitol, and lauric acid as the primary fatty acid.
Tween 20 subunits are responsible for the hydrophilic nature of the surfactant, while the hydrocarbon chains provide the hydrophobic environment.
Tween 20 forms the backbone ring to which the ethylene oxide polymers are attached.
Tween 20 is a nonionic detergent widely used in biochemical applications.
Tween 20 has been used as an emulsifying agent for the preparation of stable oil-in-water emulsions.
Tween 20 has been used in pre-extraction of membranes to remove peripheral proteins (used at 2% for extraction of membrane-bound proteins).
Tween 20 has been used as a blocking agent for membrane based immunoassays at a typical concentration of 0.05%.
Tween 20 can be used for lysing mammalian cells at a concentration of 0.005 to 0.5%.
Tween 20 is miscible in water (100mg/mL), yielding a clear, yellow solution.
Tween 20 is also miscible with alcohol, dioxane, and ethyl acetate.
Tween 20 is insoluble in liquid paraffin and fixed oils.
Tween 20 is a water-soluble yellowish liquid used as a non-toxic, nonionic surfactant/emulsifier and a dispersing agent that allows oil and water to mix without the use of alcohol.
Tween 20 is odor remover and stabilizer.
Tween 20 lubricates the skin and has a soothing effect.
Tween 20 is widely used in oil-in-water emulsions (lotions, conditioners, cream rinses, shampoos, liquid soaps, body polishes or scrubs, etc.), as well as body mist and linen sprays.
Tween 20 will be found as an ingredient in most body care products, cosmetics, and wet wipes currently on the market.
Tween 20s are often used in combination with other emulsifiers such as mono- and diglycerides or sorbitan monostearates for a variety of purposes, such as dispersing flavors and colors, solubilizing essential oils and vitamins, and improving volume and texture in baked goods.
Tween 20 when little foaming effect is desired in the finished product.
Tween 20 is a polysorbate type nonionic surfactant formed by ethoxylation of sorbitan prior to the addition of lauric acid.
Tween 20s stability and relative non-toxicity allow Tween 20 to be used as a detergent and emulsifier in a number of domestic, scientific and pharmacological applications.
As the name suggests, the ethoxylation process leaves the molecule with 20 repeat units of polyethylene glycol; in practice these are distributed in 4 different chains, resulting in a commercial product containing a number of chemical species.
Tween 20 is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.
Tween 20 is used by philatelists to remove stamps from envelopes and to remove residue from stamps without damaging the stamp itself.
Tween 20 is also used as a wetting agent in rubber balers in the elastomer industry.
Tween 20 was used as a shape-guiding agent to synthesize spheroidal magnetite nano-assemblies.
Tween 20s are stable to electrolytes and weak acids and bases; gradual saponification occurs with strong acids and bases.
Tween 20s are hygroscopic and should be inspected for water content and dried if necessary before use.
Also, in common with other polyoxyethylene surfactants, prolonged storage can lead to peroxide formation.
Derived mainly from natural materials, many of these versatile surfactants are water-soluble products used in the food, cosmetic and personal care industries as emulsifiers, solubilizers, wetting agents and dispersants.
These surfactants mainly consist of partial fatty acid esters of cyclic ethers derived from sorbitol polymerized with about 20 molecules of ethylene oxide per molecule of polysorbate.
Tween 20 is a lauric acid with an approximate hydrophilic-lipophilic balance of 16.7.
This product can be used as a solvent in oil-in-water emulsifications and as a moisturizer in skin care products.
In addition, polysorbate-20 is often used as an indirect additive for food emulsification.
Sorbitol is a white, sweet, hygroscopic, crystalline sugar alcohol with six carbons.
Tween 20 occurs naturally in a variety of fruits and berries.
Tween 20 is prepared synthetically by high pressure catalytic hydrogenation of glucose sugar derived from corn starch.
Depending on the form, it melts at 93-98 C.
Tween 20 is used in sweeteners, food additives, toothpaste, tobacco, toiletries and cosmetics.
Used for vitamin C fermentation.
Tween 20 is used as an adjuvant and intravenous osmotic diuretic in pharmaceutical fields.
Tween 20 is also used in the manufacture of polyurethanes and polyethers for surfactants.
The term sorbitan describes the anhydrous form of sorbitol, whose fatty acids are lipophilic while the sorbitol body is hydrophilic.
This bifunctionality in a single molecule provides essential properties useful as emulsifiers, wetting agents and viscosity modifiers in cleaners, detergents, polymer additives and the textile industry.
Tween 20 esters are more lipophilic (or hydrophobic) surfactants that exhibit low HLB (Hydrophilic-Lipophilic Balance) values; Having an affinity for lipids (or water-insoluble), tending to coalesce, or having the ability to dissolve.
While ethoxylated sorbitan esters are hydrophilic exhibiting high HLB values; have an affinity for water; easily absorbed or dissolved in water.
The fatty acid type and mole number of ethylene oxide provide various HLB values for suitable applications.
Tween 20 is derived from coconut oil.
Tween 20 is a non-toxic, nonionic surfactant/emulsifier and a water-soluble yellowish liquid used as a dispersing agent which allows oil and water to mix without the use of alcohol.
Tween 20 is a fragrance solubilizer and stabilizer; it lubricates and has a soothing effect on the skin.
This skin- safe ingredient is used extensively in oil-in-water emulsions and also for body mists and linen sprays.
Will be found as an ingredient in the majority of body toiletries, cosmetics and wipes now in the market.
Tween 20s are generally used in combination with other emulsifiers such as mono- and diglycerides or sorbitan monostearates for various purposes such as to disperse flavors and colors, to make essential oils and vitamins soluble and to improve volume and texture in baked goods.
Use Tween 20 when very little foaming action (or none at all) is desired in the finished product.
Tween 20 is a highly hydrophilic surfactant and approved as a food additives.
Tween 20 is a usuful emulsifier, dispersant and solubilizer for aroma chemiclas and oils
Tween 20 is a nonionic, solubilizer, o/w emulsifier, antistat and fiber lubricant used in textile industry, wetting agent, viscosity modifier, suspending agent used in food, cosmetics, drugs, textile and metal working industries, solubilizer for perfumes and flavours, insecticides, herbicides, paints and inks, pharmaceuticals.
Tween 20 is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan before the addition of lauric acid.
Tween 20s stability and relative nontoxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.
As the name implies Tween 20 process leaves the molecule with 20 repeat units of polyethylene glycol; in practice these are distributed across 4 different chains, leading to a commercial product containing a range of chemical species.
Tween 20 is a white, sweetish, hygroscopic, crystalline sugar alcohol of six-carbon.
Tween 20 is found naturally in various berries and fruits.
Tween 20 is prepared synthetically by high-pressure catalytic hydrogenation of glucose sugar derived from cornstarch.
Tween 20 melts at 93 to 98 C depending on the form.
Tween 20 is used as a a sweetening agent, food additive, toothpaste, tobacco, toiletries and in cosmetics.
Tween 20 is used for vitamin-C fermentation.
Tween 20 is used as a excipient and intravenous osmotic diuretic in pharmaceutical fields.
Tween 20 is also used in the manufacture of polyethers for polyurethanes and surfactants.
The term sorbitan describes the anhydride form of sorbitol, whose fatty acids are lipophilic whereas sorbitol body is hydrophilic.
This bifunctionality in one molecule provides the basic properties useful in cleaners, detergents, polymer additives, and textile industry as emulsifiers, wetting agents, and viscosity modifiers.
Tween 20s are rather lipophilic (or hydrophobic) surfactants exhibiting low HLB values; having an affinity for, tending to combine with, or capable of dissolving in lipids (or water-insoluble).
While, the ethoxylated sorbitan esters are hydrophilics exhibiting high HLB values; having an affinity for water; readily absorbing or dissolving in water.
The type of fatty acid and the mole number of ethylene oxide provides diverse HLB values for proper applications.
Tween 20s are synthesized by the addition, via polymerization, of ethylene oxide to sorbitan fatty acid esters.
These nonionic hydrophilic emulsifiers are very effective antistaling agents and, thus, are used in a wide variety of bakery products.
These emulsifiers are much more widely known as the polysorbates, e.g., polysorbate 20, 60, and 80.
Tween 20 utilize lauric, stearate, and oleate, respectively, for the fatty acid portion of the molecule.
Tween 20 is a monostearate, whereas polysorbate 65 is a tristearate.
Tween 20 is a polyoxyethylene sorbitol ester that belongs to the polysorbate family.
Tween 20 is a nonionic detergent having a molecular weight of 1,225 daltons, assuming 20 ethylene oxide units, sorbitol, and lauric acid as the primary fatty acid.
The ethylene oxide subunits are responsible for the hydrophilic nature of the surfactant, while the hydrocarbon chains provide the hydrophobic environment.
Tween 20 forms the backbone ring to which the ethylene oxide polymers are attached.
Tween 20 is a nonionic detergent widely used in biochemical applications.
Tween 20 has been used as an emulsifying agent for the preparation of stable oil-in-water emulsions.
Tween 20 has been used in pre-extraction of membranes to remove peripheral proteins (used at 2% for extraction of membrane-bound proteins).
Tween 20 has been used as a blocking agent for membrane based immunoassays at a typical concentration of 0.05%.
Tween 20 can be used for lysing mammalian cells at a concentration of 0.005 to 0.5%.
Tween 20 is a non-ionic surfactant commonly used as a blocking and washing agent in western blotting and other immuno-staining assays.
Tween 20 is typically included in blocking buffers and washing buffers at a concentration of 0.05-0.1% to reduce non-specific antibody binding.
Tween 20 (Polyethylene glycol sorbitan monolaurate) is a non-ionic detergent that is routinely used in biochemical and life science research.
G-Biosciences provides research grade Tween 20 in 0.5L and 1L packages or a highly purified and sterile Tween 20 for critical protein research.
Tween 20 is provided in glass amber vials, sealed under inert gas and certified low levels of harmful aldehydes and peroxides.
Non-ionic detergent for solubilizing membrane proteins during isolation of membrane-protein complexes.
Ultra low concentrations of contaminating peroxides, aldehydes, salts and carbonyl compounds.
USES:
TWEEN 20 has been used as a component of:
-washing buffer and blocking buffer in Western blotting
-blocking buffer in immunohistochemistry
-washing buffer in ELISA (enzyme linked immunosorbent assay)
-reaction mixture in PCR (polymerase chain reaction)
USAGES:
-Bath, shower & soaps
-Antiperspirants & deodorants
-After sun
-Body care
-Eye contour care
-Face / neck skin care
-Facial cleansers
-Hair conditioners - rinse off
-Lip care
-Nail care & colour
-Shampoos
-Shaving / hair removal
-Styling
-Sun protection
-Tanning
APPLICATION:
Tween 20 is widely used in biochemical applications. It has been used:
-As an emulsifying agent for the preparation of stable oil-in-water emulsions
-In pre-extraction of membranes to remove peripheral proteins (used at 2% for extraction of membrane-bound proteins)
-As a blocking agent for membrane based immunoassays at a typical concentration of 0.05%
-For lysing mammalian cells at a concentration of 0.005 to 0.5%
-Along with PBS in the dilution of antibodies in immunohistochemistry technique
-For washing cells in FISH (Fluorescence in situ hybridization) technique
PROPERTIES:
-Quality Level:300
-grade: for molecular biology
-description: non-ionic
-assay: ≥40.0% (GC)
-form: viscous liquid
-mol wt: ~1228, ~1228
-composition: lauric acid, ≥40% (balance primarily myristic, palmitic, and stearic acids)
-refractive index: n20/D 1.468 (lit.)
-CMC: 60 mg/L
-density: 1.095 g/mL at 25 °C (lit.)
PHYSICAL AND CHEMICAL PROPERTIES:
-Boiling point: >100 °C
-Density: 1.1 g/cm3 (25 °C)
-Flash point 275 °C
-Melting Point: 98.9 °C
-pH value: 6 - 8 (50 g/l, H₂O, 20 °C)
-Vapor pressure: <1.4 hPa (20 °C)
-Solubility: <0.2 mg/l soluble
FUNCTIONS:
-Dispersing agents
-Solubilisers
-Emulsifiers
-Surfactants / detergents
STORAGE:
Store at room temperature.
SYNONYM:
Polyoxyethylene (20) sorbitan monolaurate
Polyoxyethylenesorbitan monolaurate
2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
Polysorbate (INN)
Sorbimacrogol laurate 300
2-{2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate
2-(2-(3,4-Bis(2-hydroxyethoxy)tetrahydrofuran-2-yl)-2-(2-hydroxyethoxy)ethoxy)ethyl dodecanoate
2-[2-[3,4-bis(2-hydroxyethoxy)tetrahydrofuran-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
Alkest TW 20
Polysorbate 20 (NF)
Polysorbate 40 (NF)
Polysorbate 60 (NF)
Tween(R) 20
tween (R) 20
