TWEEN 65

Tween 65 is light yellow to yellow oily liquid. 
Tween 65 is easily soluble in water, soluble in ethanol, vegetable oil, ethyl acetate, methanol, toluene, insoluble in mineral oil. 
Tween 65 forms a gel at low temperature and recovers after being heated.

CAS Number: 9005-71-4

9005-71-4, 6-Chloro-1,5-dideuterio-7-methyl-2,3,4,9-tetrahydrofluorene-1-carboxamide;6-chloro-1,5-dideuterio-8-methyl-2,3,4,9-tetrahydrofluorene-1-carboxamide;6-chloro-1,5,8-trideuterio-7-methyl-2,3,4,9-tetrahydrofluorene-1-carboxamide;3,3-dideuterio-6-methyl-1,2,4,9-tetrahydrofluorene-1-carboxamide.

Tween 65 is a surface-active substance that is used as an emulsifier and wetting agent, for example in foods.
Tween 65 is an artificially produced surfactant that has an HLB value of 10.5 and is therefore suitable for producing water-in-oil emulsions . 
Tween 65 is biodegradable.

Tween 65 is a sorbitan fatty acid ester ethoxylate and is an effective emulsifier.
Tween 65 is an ethoxylated (20) sorbitan ester based on a natural fatty acid (stearic acid). 
This ethoxylate is highly effective at forming O/W emulsions, particularly when used in combination with its non-ethoxylated derivative, Span 65V.

Tween 65 ester widely used in personal care products.
Tween 65, also known as Polysorbate 65, is a nonionic surfactant that belongs to the class of compounds known as polyoxyethylene sorbitan fatty acid esters. 
Tween 65 is commonly used as an emulsifier, dispersing agent, and stabilizer in various industries including food, pharmaceuticals, cosmetics, and personal care products.

Tween 65 is a yellow-waxy solid. An oily liquid derived from PEG-ylated sorbitan (a derivative of sorbitol) esterified with fatty acids. 
Tween 65 is soluble in ethanol, isopropanol, and mineral oil. HLB value is 10.5.
Tween 65 emulsifier is also known as Polysorbate-65. 

Tween 65, the full name polyoxyethylene (20) sorbitan tristearate. 
Three stearic acids are in its molecule structure, while polysorbate-60 only has one.
Tween 65 is synthesized by esterification of sorbitan with fatty acids and subsequent ethoxylation of the resulting sorbitan ester. 

This process results in a Tween 65 with a hydrophilic polyoxyethylene chain and a lipophilic sorbitan fatty acid ester group, giving it surfactant properties.
Tween 65 is unnatural as it is made from the chemical synthesis of sorbitan fatty acid and ethylene oxide.
Tween 65 is an ethoxylated (20) sorbitan ester derived from stearic acid, a natural fatty acid. 

This highly effective ethoxylate is known for its ability to form O/W emulsions, particularly in combination with Span 65V, its non-ethoxylated derivative. 
Tween 65 is commonly used in vehicle care and waxes & polishes. Serving as an emulsifier and solubilizer.
Tween 65 is an ethoxylated sorbitan ester widely used in personal care products.

Tween 65 is a 100% bio-based ethoxylated sorbitan ester derived from a natural fatty acid (palmitic acid). 
This ethoxylate excels in creating oil-in-water (O/W) emulsions and is suitable for various applications such as hard surface cleaning, industrial and institutional cleaning, and waxes and polishes.
Tween 65 has been used in a study as a carbon source for the reductive dechlorination of hexachlorobenzene in a mixed, methanogenic culture.

Tween 65 is a polyoxyethylene sorbitan monooleate (polysorbate) surfactant that is used as a film-forming polymer and dispersing agent in solid preparations. 
Tween 65 has been shown to inhibit the proliferation of prostate cancer cells, which may be due to its ability to bind to anti-prostate specific antigen (anti-pcsk9) antibody causing the antibody to aggregate and form a particle. 
This process inhibits the interaction between the antibody and its target, preventing it from binding with PCSK9 protein. 

The addition of propranolol hydrochloride has been shown to increase the effectiveness of Tween 65.
Tween 65 is a high-quality ingredient used in various applications. 
Tween 65 is known for its excellent emulsifying properties and is widely used in the pharmaceutical, cosmetics, and food industries.

Tween 65 used in skin care creams, lotions, hair care, color cosmetics, sprayable emulsions, cleaners as well as toners, eye care, feet, hands, nails, specific skin care treatments, sun protection, after-sun, baby care, male grooming and shaving.
Tween 65 is an amber oily viscous liquid that can be used as an emulsifier, stabilizer, wetting agent, diffusing agent, penetrant, etc.
Tween 65, also known as Polysorbate 65, is a nonionic surfactant commonly used in various industries. 

Tween 65 is particularly useful in the pharmaceutical and cosmetic industries as an emulsifier and solubilizer. 
Tween 65 helps to stabilize oil-in-water emulsions and improve the solubility of hydrophobic substances. 
Tween 65 has a wide range of applications including in creams, lotions, ointments, vaccines, and oral medications.

Tween 65 is known for its ability to stabilize oil-in-water emulsions. 
Tween 65 works by reducing the surface tension between oil and water phases, allowing them to mix more effectively and form stable emulsions. 
This property makes it valuable in various applications where emulsification is required, such as in food products like salad dressings, mayonnaise, and ice cream.

Tween 65 is often used as a solubilizing agent in pharmaceuticals and cosmetics. 
Tween 65 can improve the solubility of hydrophobic substances in aqueous solutions by forming micelles, which are small aggregates of surfactant molecules that encapsulate the hydrophobic compounds, allowing them to remain dispersed in the solution.
In addition to its emulsifying properties, Tween 65 also acts as a stabilizer in formulations. 

Tween 65 helps prevent the separation of ingredients, such as oil and water phases, and maintains the overall stability of the product over time. 
This is particularly important in products that may undergo temperature fluctuations or storage for extended periods.
Tween 65 is compatible with a wide range of other ingredients commonly used in food, pharmaceutical, cosmetic, and personal care formulations. 

Tween 65 can be used with various types of oils, fats, proteins, and other surfactants without causing compatibility issues or affecting the functionality of the final product.
Tween 65 is generally considered safe for use in food, pharmaceuticals, and cosmetics when used according to approved guidelines and within specified concentrations. 
However, like all chemical compounds, it should be handled and used with care to avoid potential hazards or adverse effects.

Tween 65 is regulated by various authorities, depending on its application. 
For example, in the United States, the Food and Drug Administration (FDA) regulates its use in food and pharmaceuticals. 
In the European Union, Tween 65 falls under the jurisdiction of the European Food Safety Authority (EFSA) and the European Medicines Agency (EMA) for similar purposes. 

Regulatory agencies evaluate its safety and set maximum allowable concentrations for use in different products.
Tween 65 can exhibit synergistic effects when used in combination with other emulsifiers and stabilizers. 
By combining it with other surfactants or polymers, manufacturers can enhance the emulsifying properties and stability of their formulations, allowing for greater control over product characteristics such as viscosity, texture, and shelf life.

In cosmetics and personal care products, Tween 65 is commonly used in creams, lotions, and emulsions to improve the texture and spreadability of formulations. 
Tween 65 can also help enhance the delivery of active ingredients, such as vitamins and botanical extracts, by solubilizing them and promoting their absorption into the skin.
Tween 65 is considered to be biodegradable under aerobic conditions, meaning it can be broken down by microorganisms in the environment over time. 

This property is important for minimizing its environmental impact when used in Tween 65 that are eventually disposed of in wastewater systems or landfills.
Tween 65 should be stored in a cool, dry place away from direct sunlight and moisture to maintain its stability and effectiveness. 
Tween 65 is important to follow proper handling procedures and use appropriate protective equipment when working with concentrated forms of Tween 65 to prevent skin or eye irritation.

Flash point: 149 °C
storage temp.: Store at RT.
Hydrophilic-Lipophilic Balance (HLB): 10.5
FDA 21 CFR: 172.838; 172.836; 172.840; 172.842; 173.340
Substances Added to Food (formerly EAFUS): POLYSORBATE 65

Tween 65 is produced by reacting an anhydride of sorbitol (a so-called sorbitan - 1,4-sorbitan anhydride; for structural formula see sorbitan fatty acid ester ) with ethylene oxide and subsequent esterification with stearic acid .
Tween 65 is a fatty acid polyoxyethylene ester of sorbitan. 
Tween 65 is a yellow-waxy solid. 

Tween 65 is soluble in ethanol, isopropanol and mineral oil.
Tween 65 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Tween 65 is a 100% bio-based ethoxylated sorbitan ester based on a natural fatty acid (palmitic acid). 

This ethoxylate is highly effective at forming O/W emulsions. 
Tween 65 can be used in a wide range of applications.
Tween 65 has a specific HLB value, which indicates its balance between hydrophilic (water-attracting) and lipophilic (oil-attracting) properties. 

This HLB value influences its effectiveness as an emulsifier and determines its compatibility with different types of oils and water phases in emulsion systems. 
Formulators can select Tween 65 based on its HLB value to achieve the desired emulsion characteristics in their formulations.
In addition to its emulsifying and stabilizing properties, Tween 65 can also contribute to viscosity control in formulations. 

Depending on the concentration used and the specific application, Tween 65 can help adjust the thickness or flow properties of products such as creams, lotions, and sauces. 
This allows formulators to achieve the desired texture and rheology for their products.
The purity of Tween 65 is crucial for ensuring the quality and safety of products in which it is used. 

Manufacturers employ stringent purification processes to remove impurities and contaminants, ensuring that Tween 65 meets regulatory standards for purity and safety. 
Quality assurance measures, such as analytical testing and certification, are implemented to verify the quality and consistency of Tween 65 batches used in formulations.
Tween 65 is listed in various pharmacopoeias, such as the United States Pharmacopeia (USP) and the European Pharmacopoeia (Ph. Eur.), which provide standards for pharmaceutical ingredients and formulations. 

These pharmacopoeial monographs outline specifications for Tween 65, including purity criteria, identification tests, and analytical methods, to ensure its suitability for pharmaceutical applications and compliance with regulatory requirements.
Extensive toxicological studies have been conducted to assess the safety of Tween 65 for its intended uses in food, pharmaceuticals, cosmetics, and personal care products. 
These studies evaluate potential adverse effects, such as acute toxicity, irritation, sensitization, and genotoxicity, to determine acceptable exposure levels and establish safety guidelines for its use in consumer products.

Tween 65 is an ethoxylated (20) sorbitan ester based on a natural fatty acid (stearic acid). 
This ethoxylate is highly effective at forming O/W emulsions, particularly when used in combination with its non-ethoxylated derivative, Span 65V.
Tween 65 polysorbates are surfactants which are formed by reacting 100% bio-based ethylene oxide with 100% bio-based sorbitan esters (SPAN™ USDA BioPreferred Certified 100% bio-based). 

Tween 80 (polysorbat 80) is recommended by the European Pharmacopeia as surface-active additive for solubilisation of heavily wettable reagents (1 g/l).
Tween 65 is a hydrophilic and nonionic surfactant.
Tween 65 is safe and nontoxic to add it in food as emulsifier when properly used in accordance with GB2760-2011.

There are various items because of different fatty acids.
Tween 65 can dissolve or disperse in water,alcohol and other polar oragnic solvents,with the funciton of emulsification,solubilization and stabilization.
Tween 65, is a polysorbate surfactant manufactured through chemical synthesis from Sorbitol, available as Lemon colored oily liqiud. 

Tween 65 is widely used as emulsifier. 
Tween 65 is affirmed by US FDA as GRAS(generally recognized as safe) and widely accepted as safe food additive in many countries with E number E433. 
As a professional supplier and manufacturer of food additives, Foodchem International Corporation has been supplying food grade Tween to customers all over the world for over 10 years.

Tween 65 can act as a foaming agent in certain formulations, contributing to the formation of stable foams. 
This property is particularly useful in products such as whipped toppings, mousses, and foaming bath products where a desirable foam structure is desired.
Tween 65 exhibits good stability and compatibility across a wide range of pH levels, making it suitable for use in acidic, neutral, and alkaline formulations. 

This versatility allows it to be incorporated into products with different pH requirements without compromising its emulsifying or stabilizing properties.
In pharmaceutical and personal care applications, Tween 65 is known for its biocompatibility, meaning it is generally well-tolerated by the skin and mucous membranes. 
This makes it suitable for use in topical medications, ointments, and dermatological formulations where skin irritation or sensitization must be minimized.

When formulating products containing Tween 65, it's essential to consider packaging compatibility to ensure that the material used for packaging is resistant to interactions with the surfactant. 
Certain plastics or elastomers may be susceptible to degradation or leaching when in contact with Tween 65, potentially affecting the stability or safety of the product.
Manufacturers of products containing Tween 65 must adhere to strict quality control measures to ensure the consistency and purity of their formulations. 

This includes rigorous testing of raw materials, in-process testing during production, and final product testing to verify compliance with regulatory standards and specifications.
Tween 65 is widely used and versatile, there are alternative emulsifiers and surfactants available for different applications. 
Depending on specific formulation requirements or regulatory considerations, formulators may opt for alternatives such as other polysorbates, lecithin, or glycerol esters of fatty acids.

Uses Of Tween 65:
Tween 65 is an emulsifier manufactured by reacting stearic acid with sorbitol to yield a product which is then reacted with ethylene oxide. 
Tween 65 is a nonionic surfaceactive agent which is dispersible in fat, oil, and water. 
Tween 65 is also termed polysorbate 65. 

Tween 65 is used in frozen desserts, cakes, and coffee whiteners. 
Tween 65 is frequently used with sorbitan monostearates or monoand diglycerides. 
Tween 65 is approved in the EU as a food additive under number E 436 for certain foods in quantities of up to five grams per kilogram or in shortenings up to ten grams per kilogram. 

The permitted daily dose is 10 milligrams per kilogram of body weight for all polysorbates combined.
Tween 65 has been used in a study as a carbon source for the reductive dechlorination of hexachlorobenzene in a mixed, methanogenic culture. 
Tween 65 has also been used in a study to investigate its ability to stimulate growth of the hypocotyl of Amaranthus caudatus L. 

Tween 65 is used as an emulsifier in medicine, food, textiles, and cosmetics. 
Tween 65 is also used as a stabilizer and wetting agent etc.
Tween 65 series products are widely used as emulsifiers in food, cosmetics and other industries.

The emulsifier for various emulsifiers can be prepared when used with the disk.As a food additive, it is widely used in cake oil, bread improver and various kinds of drinks.
As a cosmetic additive, various oils can be emulsified steadily.High HLB value graphics and text are also used as flavoring solvent and mild detergent.
Tween 65 has special emulsifying properties to mineral oil and is also used in other industries.

Such as textile auxiliaries, paint auxiliaries.
Tween 65 has excellent emulsification, dispersion, wetting and other properties. 
In the food industry, it is used as an emulsifier or dispersant for ice cream, bread, cakes, candy, and the like. 

Also widely used in advanced cosmetics, textile, pharmaceutical industry as a solubilizer, also widely used in textiles, paints, emulsion explosives, pesticides, printing, petroleum and other industries as emulsifiers, stabilizers, lubricants, softeners, antistatic agents .
In food applications, Tween 65 is often used to stabilize emulsions, prevent crystallization in certain products, and improve the texture and mouthfeel of food formulations. 
In pharmaceuticals, Tween 65 can be found in oral and topical medications as a solubilizer and emulsifying agent. 

Additionally, Tween 65 is used in cosmetics and personal care products such as creams, lotions, and shampoos to improve the consistency and stability of formulations.
Tween 65 is used to stabilize oil-in-water emulsions in products such as salad dressings, sauces, and mayonnaise.
Tween 65 helps improve the texture and moisture retention in baked goods like cakes, cookies, and bread.

Tween 65 is used in ice cream and frozen desserts to prevent the formation of ice crystals and improve smoothness.
Tween 65 is used in chocolates and confectionery to ensure uniform dispersion of ingredients and prevent blooming.
Tween 65 is used as a solubilizing agent in oral suspensions and solutions to enhance the dissolution and bioavailability of poorly soluble drugs.

Tween 65 is used in creams, lotions, and ointments as an emulsifier and stabilizer to improve the spreadability and consistency of formulations.
Tween 65 is utilized in injectable formulations to solubilize hydrophobic drugs and facilitate their delivery.
Tween 65 is used in moisturizers, creams, and lotions to improve texture, stability, and absorption of active ingredients into the skin.

Tween 65 is used in shampoos, conditioners, and hair styling products to enhance formulation stability and aid in the dispersion of oils and other ingredients.
Tween 65 is utilized in sunscreens and sun care products to ensure uniform distribution of UV filters and improve product efficacy.
Tween 65 can be used as a dispersing agent in paint formulations to ensure uniform distribution of pigments and additives.

Tween 65 is employed as an emulsifier in metalworking fluids to facilitate the dispersion of lubricants and improve cooling and cutting performance.
Tween 65 is used in polymer processing as an emulsifier and processing aid to improve the dispersion of additives and modifiers.
Tween 65 finds use as an emulsifier in textile processing for dyeing and finishing operations.

Tween 65 is used in personal lubricants and intimate care products to provide smoothness and enhance formulation stability.
Tween 65 is commonly used in food products to create stable emulsions, particularly in dairy products like ice cream, salad dressings, and whipped toppings.
Tween 65 helps in improving the texture and crumb structure of baked goods like bread, cakes, and cookies.

Tween 65 is used in chocolate confectionery to prevent fat bloom and improve texture.
Found in various processed foods to maintain uniformity and stability in the formulation.
Tween 65 is utilized as a solubilizer to improve the bioavailability of poorly soluble drugs in oral suspensions and liquid formulations.

Tween 65's used in creams, lotions, and ointments to aid in the dispersion of active pharmaceutical ingredients (APIs) and improve their absorption into the skin.
Tween 65 can be found in injectable formulations to solubilize lipophilic drugs for intravenous administration.
Included in moisturizers, creams, and serums to enhance texture and improve the spreadability of formulations.

Tween 65 is used in shampoos, conditioners, and hair styling products to stabilize emulsions and improve product consistency.
Found in foundations, mascaras, and lipsticks to aid in the dispersion of pigments and improve product performance.
Tween 65 can act as a dispersing agent in paint formulations to ensure uniform distribution of pigments and additives.

Tween 65 is used to stabilize emulsions in metalworking fluids, such as cutting oils and coolants, to improve lubrication and cooling properties.
Employed as an emulsifier in textile dyeing and finishing processes to enhance dye dispersion and color uniformity.
Tween 65 may be utilized in the formulation of pesticides, herbicides, and fertilizers to improve dispersibility and stability.

Found in photographic developers and emulsions to aid in the dispersion of light-sensitive compounds.
Tween 65 can be used as a surfactant in various laboratory applications, such as cell culture media and diagnostic assays.

Safety Profile Of Tween 65:
When heated to decomposition Tween 65 emits acrid smoke and irritating fumes.
Concentrated solutions of Tween 65 can cause irritation to the eyes and skin upon direct contact. 
Prolonged or repeated exposure may exacerbate irritation, leading to redness, itching, or dermatitis. 

Tween 65's essential to use appropriate personal protective equipment, such as gloves and goggles, when handling concentrated solutions of Tween 65 to minimize the risk of irritation.
Inhalation of aerosolized Tween 65 particles may cause respiratory irritation, coughing, or difficulty breathing, particularly in individuals with pre-existing respiratory conditions or sensitivities. 
Adequate ventilation should be maintained in areas where Tween 65 is handled in aerosolized form to minimize inhalation exposure.

Tween 65 is generally considered safe for its intended uses in food, pharmaceuticals, cosmetics, and personal care products when used according to approved guidelines and within specified concentrations, ingestion of large quantities may cause gastrointestinal discomfort or other adverse effects.
Tween 65's essential to store Tween 65-containing products securely and out of reach of children to prevent accidental ingestion.