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TYLOSE H 300 P2

 


TYLOSE H 300 P2 is a synthetic, nonionic hydroxyethyl derivative of starch used as a plasma expander when prepared in an isotonic solution. Upon intravenous administration, hydroxyethyl starch colloid increases blood volume and thus improves circulation. This agent is almost exclusively excreted by the kidneys and is potentially nephrotoxic.


CAS NO:9004-62-0
EC NO:618-387-5


IUPAC NAMES:
2-Hydroxyethyl cellulose
2-hydroxyethyl cellulose
4-(2-aminopropyl) phenolhydrobromide
4-(2-aminopropyl)phenol hydrobromide
5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol
cellulose
Cellulose, 2-hydroxyethyl ether
Cellulose-2-hydroxyethylether
ethyl cellulose
HYDROXY ETHYL CELLULOSE
Hydroxy Ethyl Cellulose
Hydroxy ethyl cellulose
hydroxy ethyl cellulose
HYDROXYETHYL CELLULOSE
Hydroxyethyl Cellulose
Hydroxyethyl cellulose
hydroxyethyl ether; hydroxyethylcellulose
Hydroxyethylcellulose
hydroxyethylcelluse
NATROSOL
 hydroxyethyl ether; hydroxyethylcellulose


SYNONYMS:
        2-hydroxyethylcelluloseether;ah15;aw15(polysaccharide);aw15[polysaccharide];bl15;cellosize;The blood coHydroxyethyl cellulose etherngeals the appearance board;5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol
cellosize
 cellosize QP
 cellulose 2-hydroxyethyl ether
 cellulose ether
 cellulose ethylene oxide-grafted
 cellulose hydroxyethyl ether
 cellulose hydroxyethylate
 cellulose, 2-hydroxyethyl ether
 etharamnosan-1 (Vevy)
 etharamnosan-2 (Vevy)


TYLOSE H 300 P2


Tylose H 300 P2 is a water-soluble, non-ionic, highly etherified hydroxyethyl cellulose powder. Tylose H 300 P2 provides increased biostability, fast consistency development, high solution clarity and thermal stability, and low sag resitance and water demand. This grade of hydroxyethyl cellulose (HEC) is ideal for use in emulsion tile adhesives, exterior, interior, and silicone resin paints, drilling fluids, non-woven fabrics, and washing up liquids.


Tylose HEC (hydroxyethyl cellulose/Tylose H-grades) are soluble in water at any temperature. Tylose HEC are nonionic cellulose ethers, which are offered as free flowing powder or in granular form. Many Tylose HEC grades have a retarded solubility which ensures a lump free solution in aqueous systems.


Hydroxyethyl cellulose. Tylose H 300 P2 Provides effects like thickening, pseudoplastic properties, water retention, protective colloid effects, film forming and a high level of salt tolerance. Offers high gloss, high pigment compatibility, high thickening effect and high water retention. Exhibits moderate wet scrub resistance, anti-spattering, and pseudoplasticity. Used for paints and coatings applications like interior paints, solid paints, exterior paints, tinters, glazes, and silicon resin paints.
Hydroxyethylcellulose. Tylose H 300 P2 Acts as a thickening agent. Tylose H 300 P2 is available in powder form with delayed solubility. Used in shampoo.


Tylose H 300 P2 is a gelling and thickening agent derived from cellulose. It is widely used in cosmetics, cleaning solutions, and other household products.[1] Tylose H 300 P2 and methyl cellulose are frequently used with hydrophobic drugs in capsule formulations, to improve the drugs' dissolution in the gastrointestinal fluids. This process is known as hydrophilization.[2]
Tylose H 300 P2 is also used extensively in the oil & gas industry as a drilling mud additive under the name HEC as well in industrial applications, paint & coatings, ceramics, adhesives, emulsion polymerization, inks, construction, welding rods, pencils and joint fillers.


Tylose H 300 P2 is one of the main ingredients in the personal lubricant KY Jelly. It is also a key ingredient in the formation of big bubbles as it possesses the ability to dissolve in water but also provide structural strength to the soap bubble. Among other similar chemicals, it is often used as slime (and gunge, in the UK), a gooey substance often used on television and in fundraising events which is poured over individuals with the aim of causing embarrassment.
Tylose H 300 P2 acts as a demulcent by relieving inflammation or irritation and dryness of eyes. It acts as one of the key ingredient and viscosity-enhancing agent to prolong corneal contact time and increase intraocular drug levels.


Application
Tylose H 300 P2 is used as a gelling and thickening agent in the development of biostructures for the delivery of hydrophobic drugs. Tylose H 300 P2 is used in the development of polymer networks and block copolymers useful in separation technology such as capillary electrophoresis and in biofilms and coatings.
Tylose H 300 P2 polymers are largely used as water-binder and thickening agent in many industry applications, that is, personal care products, pharmaceutical formulations, building materials, adhesives, etc., and as stabilizer for liquid soaps.


General properties
Hydroxyethyl cellulose (Tylose H 300 P2) polymer is a hydroxyethyl ether of cellulose, obtained by treating cellulose with sodium hydroxide and reacting with ethylene oxide. Tylose H 300 P2 polymers are largely used as water-binder and thickening agent in many industry applications, that is, personal care products, pharmaceutical formulations, building materials, adhesives, etc., and as stabilizer for liquid soaps. They are available as white free-flowing granular powders that easily dissolve in cold and hot water to give transparent solutions with varying viscosities depending on polymer concentration, type and temperature.


Natrosol 250 Tylose H 300 P2 is available in 10 viscosity types, that go from low viscosity values (types L and J) ranging between 0.08 and 0.4 Pas at c = 5 wt.%, intermediate viscosity values (types E, G, K, M) ranging between 0.03 and 6.5 Pas at c = 2 wt.%, arriving to the highest viscosity values (types MH, H, HH) ranging between 0.8 and 5 Pas at c = 1 wt.% (informations are given in the producer booklet Aqualon, 1999). The molecular weight and the degree of polymerization of the Natrosol™ Tylose H 300 P2 types is directly proportional to their viscosity.
Being a nonionic polymer, Natrosol™ is less sensitive to pH changes; however, pH and temperature may slight affect the hydration and dissolution time of the polymer.


Effect of extent of substitution on solubility
When highly polar hydroxyl groups on crystalline cellulose are substituted with hydroxyalkyl groups to manufacture HPC or Tylose H 300 P2, water solubility initially increases due to a reduction in crystallinity and hydr ogen bonding between the cellulose backbone chains. However, as the amount of hydroxyalkyl substitution continues to increase, the polymer becomes increasingly hydrophobic. As shown in Fig. 7.31, the equilibrium moisture content steadily decreases as MS increases from 2.0 to 5.0 for both Tylose H 300 P2 and HPC. A similar relationship has also been demonstrated for the cloud point.43 An exception to this behavior is polymers with ionic groups in their side chains. In this case, increasing the level of highly polar substituents will increase water solubility. For example, when the DS for sodium carboxymethyl cellulose is increased from 0.7 to 1.2, the equilibrium moisture content at 50% relative humidity increases from 13% to 18%.


Regenerated Tylose H 300 P2 is made by dissolving cellulose xanthate in 4–7% sodium hydroxide and contacting with aqueous sulfuric acid. These steps convert the cellulose xanthate back into cellulose, which may be spun into viscose rayon or cast into films. The fibers are used in textiles (artificial silk), tyre cords, and V belts. The films are used in packaging (Cellophane) or sausage casings. Weiner casings (70% regenerated cellulose, 12% glycerol, and 18% water) are peeled away after the meat emulsion is cooked. Hemp paper casings (23% paper, 46% regenerated cellulose, 21% glycerol, and 10% water) are used in bologna, salami, pepperoni, summer sausage, and liverwurst.
Tylose H 300 P2 moieties are highly reactive, allowing a variety of esters and ethers to be manufactured. Because each anhydroglucose has three hydroxyl groups, the maximum degree of substitution (DS) is three. Purified wood pulp or cotton linters (short fibers) are the industrial sources of ‘chemical cellulose.’


Tylose H 300 P2 Usage And Synthesis


Thickeners and binders    
Tylose H 300 P2 is a commonly used cellulose ethers organic water-based ink thickening agent, belongs to a water-soluble non-ionic compound, with good water thickening ability, degraded by oxygen, acid and enzyme, under alkaline conditions can be crosslinked by Cu2 +. Has thermal stability, when heated, does not appear gelation, does not occur precipitation under acidic conditions, the film-forming property is good, the aqueous solution can be made of a transparent film, can be derived from the reaction of alkali cellulose with ethylene oxide, having properties such as thickening, emulsifying, adhesive, suspension, film-forming, maintaining moisture and protectiving colloid. The role of thickener in the aqueous ink is thickened. The viscosity of the ink added a thickening agent increases, can improve the physical and chemical stability of the ink; due to the increased viscosity, rheology of the ink can be controlled at the time of printing; the pigment and filler in ink is not easy to precipitate, increasing the storage stability of the water-based ink.
Thickening agent is a cellulose-based material and (or) polyvinyl alcohol substances. Cellulose substances may be methyl cellulose, ethyl cellulose, hydroxymethyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, Tylose H 300 P2 and hydroxypropylmethyl cellulose; polyvinyl alcohol material may be an or several species of polyethylene 400, 600, 800, 1000, 1600, 2000, 4000, 6000.
The above information is edited by the chemicalbook of Liu Yujie.


Chemical properties
This product is white to yellowish fibrous or powdery solid, non-toxic, tasteless and soluble in water. Insoluble in common organic solvents. Having properties such as thickening, suspending, adhesive, emulsifying, dispersing, water holding. Different viscosity range of solution can be prepared. Having exceptionally good salt solubility to electrolyte.


Uses
1. This product is used for cracking method to extract polymerized dispersing agents such as oil water base gel fracturing fluid, polystyrene and polyvinyl chloride. Also for latex thickening agent in paint industry, hygristor in electronics industry, cement anti-coagulant agent and water retention agent in construction industry. Glazing in ceramic industry and toothpaste binder. Also widely used in many aspects such as printing and dyeing, textile, paper, pharmaceutical, health, food, cigarettes, pesticides and fire extinguishing agent.
2. Used as a water-based drilling fluids, and thickening agent and filtrate reducer of completion fluids, thickening agent has obvious effect on brine drilling fluid. Also can be used for filtrate reducer of oil well cement. Cross-linking with the polyvalent metal ions into a gel. 3. As surfactants, protective colloids, emulsion stabilizers in combination with emulsion such as vinyl chloride, vinyl acetate emulsion, and a tackifier, dispersant, dispersion stabilizer of emulsion. Widely used in many aspects such as coatings, fibers, dyeing, paper, cosmetics, pharmaceuticals, pesticides. There are many uses in oil exploitation and machinery industry.
4. As surfactants, latex thickening agent, protective colloid, oil exploitation fracture ing fluid and polystyrene and polyvinyl chloride dispersing agents, etc.


Consistency development:        moderate
Final consistency:        very low
Sag resistance:        very low
Water demand:        very low
Water retention:        low
Influence on cement hydration:        high
Heat stability:        very high


Appearance        White to off-white powder
Particle size        95% pass 80 mesh
Degree of substitution        0.7-1.5
PH value        6.0~8.5
Purity (%)        92min, 97min, 99.5min


Application: for reversible, flexible bondings and to glue paper; for gluing and fixing products sensible to water.


- high-quality thickening agent
- powder to produce a thin glue
- food-grade
- water-soluble


Tylose H 300 YP2 is a water-soluble, non-ionic hydroxyethyl cellulose powder with standard etherification. It displays very good temperature stability, good binding effects, high gloss appearance, pigment compatibility, and water retention, and moderate anti-spattering properties, wet scrub resistance, and foam stabilization. This grade of hydroxyethyl cellulose (HEC) is particularly well-suited for use in engobe, glaze, exterior paint, silicate paint, silicone resin paint, welding rod, hair conditioner, and shampoo applications.


Tylose H 300 YP2 is a gelling and thickening agent derived from cellulose. It is widely used in cosmetics, cleaning solutions, and other household products.[1] Tylose H 300 YP2 and methyl cellulose are frequently used with hydrophobic drugs in capsule formulations, to improve the drugs' dissolution in the gastrointestinal fluids. This process is known as hydrophilization.[2]


Tylose H 300 YP2 is also used extensively in the oil & gas industry as a drilling mud additive under the name HEC as well in industrial applications, paint & coatings, ceramics, adhesives, emulsion polymerization, inks, construction, welding rods, pencils and joint fillers.


Tylose H 300 YP2 is one of the main ingredients in the personal lubricant KY Jelly. It is also a key ingredient in the formation of big bubbles as it possesses the ability to dissolve in water but also provide structural strength to the soap bubble. Among other similar chemicals, it is often used as slime (and gunge, in the UK), a gooey substance often used on television and in fundraising events which is poured over individuals with the aim of causing embarrassment.


Item        Result
Appearance        White powder
Purity (GC), %        ≥99.0
 melting point        288-290°C(dec.)
PH        pH(20g/l,25℃) : 5.0~8.0
storage condition         indoor temperature
 solubility        H2O: ≤5 wt. % at 20 °C


Tylose H 300 YP2 Usage:


It is used as surfactant, latex thickener, colloid protector, fracturing fluid for petroleum exploitation and polystyrene and polyvinyl chloride dispersant.


Used as surfactant, colloid protectant, emulsion stabilizer of vinyl chloride, vinyl acetate and other emulsions, as well as viscosity enhancer, dispersant, dispersion stabilizing Chemicalbook stabilizer of latex. Widely used in coating, fiber, dyeing, paper, cosmetics, medicine, pesticide and other aspects. In oil mining, machinery industry also has many uses.


Used as surfactant, latex thickening agent, colloidal protector, oil exploitation fracturing fluid and polystyrene and polyvinyl chloride dispersant


Important characteristics:
As a non ionic surface-active agent, it possesses the following characteristics in addition to acts of thicker agent, suspending agent, adhesive agent, emulsification agent, coating agent, water keeping agent and protective agent.
1. Tylose H 300 YP2 can dissolve in both cool and hot water while it does not deposit when in hot or boiling water showing large range of non-gelatin capacity.
2. Because of non-ionic base, it can be coexist with other water-soluble polymizers, surface-active agent and salts.
3. Water keeping ability is twice that of Methyl Cellulose (MC)showing good flowage adjusting ability.
4.It is stable in viscosity and anti-mildew and makes coatings good open can effect ion as well as excellent floating-plain effects.
IV . Application:
Tylose H 300 YP2 is mainly used as adhesive protective gelatin, thicker agent and stabilizing agent as well as additives to make emulsion, frozen gelatin, lotion, eye clear agent, suppository and tablets. Tylose H 300 YP2 is also used for hydrophilic colloid, framework. Material, ready-made framework controlled release agent, and stabilizing agent in foodstuff.
It is also used in paint and coatings,oil feild and cosmetic.


Tylose H 300 YP2 is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ionic and water-soluble nature. It is often used as an ingredient in ophthalmic pharmaceutical preparations such as artificial tear solutions and adjunct agent in topical drug formulations to facilitate the delivery of drugs with hydrophobic character.


Tylose H 300 YP2 is a non-ionic, water soluble polymer used as a thickening agent for aqueous cosmetic and personal care formulations. It will produce crystal clear gel products and thicken the aqueous phase of cosmetic emulsions. It can be also be used to efficiently thicken shampoos, body washes and shower gels.


One of the problems normally associated with this and other water-soluble thickeners is the tendency of the particles to agglomerate or lump when first wetted with water. 


Tylose H 300 YP2 is one of those ingredients that you may think sounds like some sort of synthetic, harsh chemical. But just because this ingredient has a name that looks suspicious and difficult to pronounce, doesn’t mean it’s harmful or unnatural. In fact, many common ingredients have suspicious-sounding names. Two examples are: sodium chloride, better known by its common name; salt, or sodium bicarbonate; better known by its common name; baking soda. Both of these are common ingredients found in both food and body care products and most of us consider these ingredients to be pretty harmless as far as toxicity is concerned.


What is Tylose H 300 YP2?
Tylose H 300 YP2 is a natural gum derived from pine and spruce tree trunks (debarked logs) grown and harvested from plantations in the United States, France, Norway, and Canada. Tylose H 300 YP2 is an excellent thickening agent and a non-ionic rheology modifier . When using this natural gum, the viscosity of your product will be modified to a thicker texture depending on the amount used.  Of all the natural gums, Tylose H 300 YP2 creates crystal clear serums and makes an excellent delivery mechanism for other actives in your formulations.  Tylose H 300 YP2 will also help enhance the foaming action of surfactants. This allows you to use less surfactant, making your shampoos and cleansers more gentle and more effective.


How do I use Tylose H 300 YP2?
Tylose H 300 YP2 is also one of the easiest gums to use but it must be fully hydrated to avoid clumping and “fish eyes”. Fish eyes are those balls of goo that develop when you add certain ingredients to your water phase without properly hydrating first. In order to properly hydrate this gum, turn your high shear mixer (or handheld stick blender) on and gently sprinkle the powder into your water phase. You will notice that as you add the powder, your water phase will quickly start to thicken so you may need to increase the speed of your mixer or stick blender. Generally you may add this gum to your formulation at anywhere between 0.5% to 2% for best results.


Tylose H 300 YP2 is an ingredient that you may not have heard of before. This is because Tylose H 300 YP2 doesn’t convey any benefit to the skin but instead improves the texture and sensory feel of skincare formulations. Tylose H 300 YP2 is a cellulose-derived polymer that is used in cosmetics and skincare products as a thickening agent, that also works as a rheology modifier.


Tylose H 300 YP2 is a water-soluble polymer derived from cellulose. Cellulose is a natural sugar that is found in the cell wall of plants. In fact, cellulose is the most abundant organic sugar on Earth. While cellulose is naturally derived, Tylose H 300 YP2 is synthetically made by reacting ethylene oxide with alkali-cellulose. Modified cellulose products such as Tylose H 300 YP2 are widely used in skincare and cosmetic formulations and also find use in cleaning and household products. Additionally, Tylose H 300 YP2 is commonly used in capsules for carrying medicines into the body and improving the drugs’ dissolution in the stomach.


Why Is Tylose H 300 YP2 Used In Skincare?
In cosmetics and skincare products, hydroxyethylcellulose functions to improve the texture and feel of formulations.  


Thickener
Thickening agents are an important part of cosmetic formulation. They not only help to improve the feel of a product but also ensure the product spreads evenly and smoothly across the skin. This is particularly important when the skin is flaky or has an uneven complexion. There are more than 500 thickeners are used in skincare formulating due to their importance in the formulating process.


Cellulose derivatives are popular water-based thickeners.Tylose H 300 YP2 has the ability to thicken the water-based ingredients in the formulation. Dry Tylose H 300 YP2 exists as white, free-flowing granular powder when water is added to Tylose H 300 YP2 it causes the powder to swell into a crystal clear gel. In fact, of all the natural polymers, Tylose H 300 YP2 creates the clearest serums and gels.


Rheology modifier
Tylose H 300 YP2 is also considered to be a rheology modifier. Rheology can be defined as “the science or study of how things flow”, and it is a requirement of skincare products that they flow in the right way. For example, a skin cream should have a rich, thick appearance in the jar, but should be capable of being easily picked up and spread into the skin. Rheology modifiers can be added to a formulation to adjust the product flow.


Often, the term ‘rheology modifier’ is used interchangeably with ‘thickener’. While increasing the apparent thickness will produce a feeling of ‘quality’ to the formulation, this is only one aspect of rheological control. For instance, Tylose H 300 YP2 not only adds thickness to creams and lotions but also gives them a softer feel.


 In shampoos and cleansers, Tylose H 300 YP2 enhances foam creaminess and richness. This allows the manufacturer to use less surfactant or detergents while also reducing the irritation potential, thus making the cleanser more gentle and effective. Lastly, Tylose H 300 YP2 is an excellent choice for clear hair gel where it will offer soft hold and a nice feel on the hair without stickiness or flaking.


 

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