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Uncaria rhynchophylla extract, commonly known as Gou Teng or Cat's Claw, is a traditional herbal remedy primarily used in Chinese medicine.
Uncaria rhynchophylla extract from this plant has gained popularity for its potential health benefits, and it is derived from the dried stems and leaves of the plant.
Uncaria rhynchophylla extract a cinnamate ester obtained by formal condensation of the carboxy group of trans-caffeic acid with the 5-hydroxy group of quinic acid.
CAS Number: 906-33-2
Molecular Formula: C16H18O9
Molecular Weight: 354.31
EINECS Number: 212-997-1
Synonyms:Neochlorogenic acid, 906-33-2, Neochlorogenate, (E)-Neochlorogenic Acid, 5-Caffeylquinic acid, UNII-O4601UER1Z, O4601UER1Z, (1R,3R,4S,5R)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxycyclohexane-1-carboxylic acid, 5-Caffeoylquinic acid, CHEBI:16384, 5-O-Caffeoylquinic acid, trans-Neochlorogenic acid, EINECS 212-997-1, MFCD10566639, 5-O-(trans-3,4-Dihydroxycinnamoyl)-D-quinic acid, 3-CQA, CHEMBL249450, trans-5-O-caffeoyl-D-quinic acid, trans-5-O-Caffeoylquinic acid, 3-O-(E)-CAFFEOYLQUINIC ACID, Cyclohexanecarboxylic acid, 3-((3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)-1,4,5-trihydroxy-, (1R-(1alpha,3alpha,4alpha,5beta))-, trans-5-O-caffeoyl-D-quinate, (1R,3R,4S,5R)-3-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]-1,4,5-trihydroxycyclohexanecarboxylic acid, 1D-[1(OH),3,4/5]-3-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]-1,4,5-trihydroxycyclohexanecarboxylic acid, 342811-68-1, CYCLOHEXANECARBOXYLIC ACID, 3-(((2E)-3-(3,4-DIHYDROXYPHENYL)-1-OXO-2-PROPEN-1-YL)OXY)-1,4,5-TRIHYDROXY-, (1R,3R,4S,5R)-, Cyclohexanecarboxylic acid,3-[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1,4,5-trihydroxy-,(1R,3R,4S,5R)-, 5-O-caffeoyl quinic acid, Nochlorogenic acid, neochlorogenic_acid, Neochlorogenic-acid, Quinic acid, 5-caffeoyl-, E-, SCHEMBL13567302, SCHEMBL18317299, ACon1_000392, CWVRJTMFETXNAD-NXLLHMKUSA-N, DTXSID301347903, HMS3886H18, HY-N0722, BDBM50163308, s9136, AKOS015901853, AC-6061, CCG-268077, CS-3770, Neochlorogenic acid, analytical standard, NCGC00169121-01, NCGC00169121-02, (1R,3R,4S,5R)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxy-cyclohexanecarboxylic acid, AS-75008, DA-66022, N1155, NS00097276, C17147, Q-100887, Q6992128, 656B3E48-4F1F-4FC8-A3B2-B0FADAB84AF5, NEOCHLOROGENIC ACID (CONSTITUENT OF ST. JOHN'S WORT), Neochlorogenic acid, from Lonicera japonica, >=98.0% (HPLC), NEOCHLOROGENIC ACID (CONSTITUENT OF ST. JOHN'S WORT) [DSC], (1R,3R,4S,5R)-3-((3-(3,4-dihydroxyphenyl)acryloyl)oxy)-1,4,5-trihydroxycyclohexane-1-carboxylic acid, (1R,3R,4S,5R)-3-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexane-1-carboxylic acid, (1R-(1.ALPHA.,3.ALPHA.,4.ALPHA.,5.BETA.))-3-((3-(3,4-DIHYDROXYPHENYL)-1-OXOALLYL)OXY)-1,4,5-TRIHYDROXYCYCLOHEXANECARBOXYLIC ACID, (1R-(1alpha,3alpha,4alpha,5beta))-3-((3-(3,4-Dihydroxyphenyl)-1-oxoallyl)oxy)-1,4,5-trihydroxycyclohexanecarboxylic acid, [1R - (1alpha,3alpha,4alpha,5beta )] - 3 - [[3 - (3,4 - dihydroxyphenyl) - 1 - oxoallyl]oxy] - 1,4,5 - trihydroxycyclohexanecarboxylic acid, CYCLOHEXANECARBOXYLIC ACID, 3-((3-(3,4-DIHYDROXYPHENYL)-1-OXO-2-PROPENYL)OXY)-1,4,5-TRIHYDROXY-, (1R-(1.ALPHA.,3.ALPHA.(E),4.ALPHA.,5.BETA.))-, CYCLOHEXANECARBOXYLIC ACID, 3-((3-(3,4-DIHYDROXYPHENYL)-1-OXO-2-PROPENYL)OXY)-1,4,5-TRIHYDROXY-, (1R-(1.ALPHA.,3.ALPHA.,4.ALPHA.,5.BETA.))-, CYCLOHEXANECARBOXYLIC ACID, 3-((3-(3,4-DIHYDROXYPHENYL)-1-OXO-2-PROPENYL)OXY)-1,4,5-TRIHYDROXY-, (1R-(1alpha,3alpha(E),4alpha,5beta)), [1R-(1alpha,3alpha,4alpha,5beta)]-3-[[3-(3,4-dihydroxyphenyl)-1-oxoallyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylic acid;Neochlorogenic acid;5-O-CAFFEOYLQUINICACID;(1R,3R,4S,5R)-5-[(E)-3-(3,4-Dihydroxyphenyl)prop-2-enoyl]oxy-1,3,4-trihydroxycyclohexane-1-carboxylic acid;5-Caffeoylquinic acid;trans-5-O-Caffeoyl-D-quinate;Neochlorogenic acid，5-Caffeoylquinic acid，trans-5-O-Caffeoyl-D-quinate;(1R)-3β-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1β,4β,5α-trihydroxycyclohexane-1α-carboxylic acid
Uncaria rhynchophylla extract is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities).
Uncaria rhynchophylla extract value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Uncaria rhynchophylla extract has been found to have an inhibitory effect on the biosynthesis of melanin.
Therefore Uncaria rhynchophylla extract can be used on harvested fruits to prevent brown rot infection caused by?Monilinia laxa.
It also shows impressive antioxidant, antibacterial, antiviral and antipyretic characteristics.
Uncaria rhynchophylla extract has the potential to be used in the management of acute and chronic inflammatory diseases due to its anti-inflammatory activity.
It may function as chemopreventive compounds due to growth inhibition seen in breast cancer cell line MDA-MB-435.
Uncaria rhynchophylla extract contains various alkaloids (like rhynchophylline and isorhynchophylline), flavonoids, and other phytochemicals that contribute to its therapeutic effects.
Some studies suggest that Uncaria rhynchophylla may have neuroprotective effects, potentially benefiting conditions like Alzheimer's and Parkinson's disease.
Uncaria rhynchophylla extract is believed to possess anti-inflammatory properties, which may help reduce symptoms of inflammatory diseases.
Uncaria rhynchophylla extract may help combat oxidative stress due to its antioxidant properties.
Some research indicates potential benefits for cardiovascular health by improving circulation and lowering blood pressure.
There is evidence suggesting that the extract may have antimicrobial properties against certain bacteria and fungi.
In traditional Chinese medicine, Uncaria rhynchophylla is often used for calming the liver, treating headaches, and reducing hypertension.
Uncaria rhynchophylla Uncaria rhynchophylla extract is available in various forms, including:
While generally considered safe for most people, Uncaria rhynchophylla extract’s essential to consult a healthcare professional before using Uncaria rhynchophylla, especially for individuals with existing health conditions or those taking medications, as interactions may occur.
Uncaria rhynchophylla extract is a member of the Rubiaceae family and is native to Southeast Asia, particularly China, where it is traditionally used in herbal medicine.
Uncaria rhynchophylla extract is often confused with other species of Uncaria, such as Uncaria tomentosa (commonly known as Cat’s Claw), but they have different active compounds and health benefits.
The main active constituents are indole alkaloids, including:
Known for its potential neuroprotective and antihypertensive effects.
Uncaria rhynchophylla extract that provide antioxidant properties, helping to scavenge free radicals and reduce oxidative stress.
Uncaria rhynchophylla extract may contribute to the anti-inflammatory and antimicrobial activities of the extract.
Known for their potential health benefits, including anti-inflammatory and antioxidant effects.
Animal studies suggest that Uncaria rhynchophylla extract may help protect neurons from damage and promote cognitive function.
Uncaria rhynchophylla extract has been noted for its potential to inhibit neuroinflammation and apoptosis (cell death).
May be beneficial for neurodegenerative diseases like Alzheimer’s and Parkinson’s.
Melting point: 204-206 °C (decomp)
Boiling point: 665.0±55.0 °C(Predicted)
Density: 1.65±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated)
form: Solid
pka: 3.90±0.50(Predicted)
color: White to Off-White
Stability: Hygroscopic
InChIKey: CWVRJTMFETXNAD-NXLLHMKUSA-N
LogP: 0.370 (est)
Uncaria rhynchophylla extract present may help lower blood pressure by promoting vasodilation (widening of blood vessels).
Some studies have reported a reduction in blood pressure in hypertensive rats treated with Uncaria rhynchophylla.
Uncaria rhynchophylla extract has been shown to reduce inflammation and pain in animal models, making it a candidate for treating conditions like arthritis.
Traditional uses include relief from headaches, muscle pain, and general body aches.
The flavonoids and phenolic compounds contribute to the extract’s ability to reduce oxidative stress, which is linked to many chronic diseases.
In vitro studies have demonstrated activity against various bacteria and fungi, suggesting potential applications in treating infections.
Uncaria rhynchophylla extract is believed to help with symptoms of liver qi stagnation, such as irritability and anger.
Regular use is thought to aid in maintaining healthy blood pressure levels.
Due to its potential sedative effects, it may be used to alleviate insomnia.
Commonly prescribed for headaches, especially those associated with tension and stress.
The dried stems and leaves are boiled in water to extract their beneficial compounds.
This method is commonly used in traditional Chinese herbal medicine.
Dried plant material can be ground into a powder, which can be added to teas or smoothies.
Standardized extracts are encapsulated for easier dosing.
Uncaria rhynchophylla extract alcohol-based extracts provide a concentrated form of the active ingredients.
While there is a growing body of research on Uncaria rhynchophylla extract, it is important to note that much of the evidence comes from preclinical studies or traditional usage rather than extensive clinical trials.
A study published in the journal Phytotherapy Research indicated that Uncaria rhynchophylla extract might enhance memory and cognitive function in mice by reducing oxidative stress and inflammation in the brain.
Research published in the Journal of Ethnopharmacology suggested that the extract could lower blood pressure in animal models, providing a basis for its traditional use in managing hypertension.
Studies have shown that Uncaria rhynchophylla extract can inhibit pro-inflammatory cytokines, contributing to its analgesic and anti-inflammatory effects.
Uncaria rhynchophylla extract is generally considered safe when used as directed, some precautions should be noted:
Potential side effects may include gastrointestinal upset, headache, or allergic reactions in sensitive individuals.
Uncaria rhynchophylla extract may interact with blood pressure medications, anticoagulants, or other pharmaceuticals, so consulting a healthcare provider is advisable before use.
Safety during pregnancy and breastfeeding has not been established; therefore, caution is recommended.
Uses:
Uncaria rhynchophylla extract is an antioxidant compound used in the treatment of oxidative stress and related afflictions.
Often used for its potential to support memory and cognitive function, particularly in the context of aging and neurodegenerative diseases.
May help protect neurons from damage due to oxidative stress and inflammation, potentially benefiting conditions like Alzheimer's and Parkinson's diseases.
Traditionally used to help manage hypertension by promoting vasodilation and improving circulation.
Some studies suggest it may support healthy cholesterol levels.
Uncaria rhynchophylla extract is used to alleviate pain associated with inflammatory conditions, such as arthritis or muscle aches.
Commonly prescribed for tension-type headaches and migraines.
The antioxidant properties of the extract may help combat oxidative stress, which is linked to chronic diseases and aging.
Exhibits activity against certain bacteria and fungi, suggesting potential use in treating infections.
Uncaria rhynchophylla extract is used for its potential calming effects, which may help reduce anxiety and promote relaxation.
Some traditional uses include aiding in sleep quality and reducing insomnia.
Believed to support liver function and relieve symptoms of liver qi stagnation, such as irritability and stress.
Uncaria rhynchophylla extract sometimes used in herbal formulas aimed at detoxifying the body.
May contribute to overall immune function and enhance the body’s defenses against illness.
Traditionally used to improve digestion and alleviate gastrointestinal discomfort.
Compounds like Uncaria rhynchophylla extract may enhance synaptic plasticity and improve cognitive processes.
This could benefit individuals with mild cognitive impairment or those at risk of neurodegenerative disorders.
Some animal studies indicate improvements in learning and memory tasks, supporting its traditional use for enhancing brain health.
Uncaria rhynchophylla extract may protect neurons by reducing oxidative stress and inflammation, which are key contributors to neurodegeneration.
In vitro studies have shown that Uncaria rhynchophylla extract can inhibit neuroinflammation and prevent neuronal cell death.
Uncaria rhynchophylla extract may lower blood pressure through vasodilation and reducing peripheral resistance.
Animal studies suggest significant reductions in systolic and diastolic blood pressure, supporting its traditional use in managing hypertension.
Uncaria rhynchophylla extract in Uncaria rhynchophylla might influence lipid metabolism and reduce LDL cholesterol levels.
Preliminary studies indicate potential effects on lipid profiles, but further clinical research is needed.
The anti-inflammatory properties can alleviate pain associated with inflammatory conditions by inhibiting pro-inflammatory cytokines and enzymes.
Various studies indicate that Uncaria rhynchophylla extract can reduce inflammation in models of arthritis and other inflammatory conditions.
Commonly used for tension-type headaches, migraines, and general headache relief, often in combination with other herbs.
Uncaria rhynchophylla extract contains flavonoids and phenolic compounds that scavenge free radicals and inhibit oxidative damage.
Studies have shown that Uncaria rhynchophylla extract can increase antioxidant enzyme activity and reduce markers of oxidative stress in various biological models.
Uncaria rhynchophylla extract may inhibit the growth of certain pathogens through its bioactive compounds.
In vitro studies indicate effectiveness against bacteria such as Staphylococcus aureus and fungi like Candida albicans, though clinical trials are limited.
Uncaria rhynchophylla extract may modulate neurotransmitter systems, promoting relaxation and reducing anxiety symptoms.
Often included in formulations aimed at managing stress and anxiety.
Some traditional uses suggest it can help improve sleep quality, though scientific research specifically on sleep is limited.
Used to promote liver qi circulation and detoxification.
Commonly part of herbal formulas aimed at liver support, particularly in addressing conditions related to liver dysfunction.
Often used in detox protocols, believed to support the body's natural detoxification processes.
Uncaria rhynchophylla extract may enhance immune function through its antioxidant and anti-inflammatory effects.
Often included in herbal supplements aimed at boosting overall immunity, particularly during cold and flu seasons.
Traditionally used to improve digestion and alleviate gastrointestinal discomfort such as bloating or cramps.
Uncaria rhynchophylla extract is often combined with other herbs in Chinese medicine to enhance its effects.
Often paired to support liver health and relieve headaches.
Uncaria rhynchophylla extract is used together for enhanced energy and cognitive function.
Safety Profile:
Some users may experience stomach upset, nausea, diarrhea, or abdominal pain, particularly when taking higher doses or when first starting the supplement.
In rare cases, individuals may have an allergic reaction to Uncaria rhynchophylla, presenting as rashes, itching, or other allergy symptoms.
Some users report dizziness, lightheadedness, or fatigue, particularly if the extract has a sedative effect.
Uncaria rhynchophylla extract may lower blood pressure, it could enhance the effects of antihypertensive drugs, leading to hypotension (low blood pressure).
Uncaria rhynchophylla extract may have mild blood-thinning properties, which could increase the risk of bleeding when taken with blood thinners like warfarin or aspirin.
