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CAS Number: 27083-27-8 - 32289-58-0

VANTOCIL TG is an antimicrobial agent.

VANTOCIL TG is a broad spectrum, fast acting bactericide for the formulation of disinfectants and sanitisers. 
VANTOCIL TG is a 20 % aqueous solution of poly(hexamethylenebiguanide) hydrochloride, also known as PHMB. 

VANTOCIL TG is used in industrial, institutional, agricultural, food, beverage and domestic disinfection applications, primarily as a solid surface disinfectant, specifically for hospitals, veterinary establishments, dairies, milking parlors, breweries, air-conditioning units, and pasteurizers in canned food & beverage bottling plants.
VANTOCIL TG has a non-specific mode of biocidal action which means that bacterial resistance is very unlikely to occur

VANTOCIL TG is a broad spectrum, fast acting bactericide for the formulation of disinfectants and sanitisers, for use in industrial, institutional, agricultural, food, beverage and domestic disinfection applications. 
VANTOCIL TG is a 20% aqueous solution of poly(hexamethylenebiguanide) hydrochloride, also known as PHMB.

VANTOCIL IB and VANTOCIL TG are aqueous solutions of the powerful antibacterial preservative poly(hexamethylene biguanide) hydrochloride, an active offering broad pH tolerance, low foam and good heat stability.  
Applications are varied, and include surface care, fabric care and automotive care.

Poly (hexamethylene biguanide) hydrochloride (PHMB), the active ingredient in our VANTOCIL range is a fast-acting and broad spectrum bactericide with a wide formulation latitude. 
Consequently, by careful selection of appropriate co-formulants, a wide range of professional and domestic products can be formulated which meet the stringent demands of today's disinfection and hygiene industries.

VANTOCIL antimicrobials can be used to formulate a wide variety of applications including:

Professional disinfection:
Liquid hard surface disinfectants for surfaces and floors.
Solid disinfection tablets (slow release and effervescent).
Water cooling towers.
Tunnel pasteurisers.
Room fogging.
Disinfectants for medical devices and equipment.

Household products:
Antimicrobial surface disinfectants.
Antimicrobial fabric conditioners.
Sanitizing wet wipes (for surfaces and hands)
Antimicrobial hand soaps

Domestic and Institutional Hygiene:
VANTOCIL TG activity has been further demonstrated under conditions representative of practical use, and a range of use concentrations is provided in show below.
However, VANTOCIL TG is recommended that field tests under practical conditions be undertaken to determine the most cost-effective dose for your application.
This data and information on the compatibility of VANTOCIL TG with a range of formulating chemicals is available on request.

Applications of VANTOCIL TG:
VANTOCIL TG is effective in a wide range of industrial disinfection applications, primarily as a solid surface disinfectant.

Application areas include:
Veterinary establishments,
Milking parlours,
Poultry hatcheries,
Food processing plants,
Pasteurisers in canned food & beverage bottling plants,
Yoghurt fermentation,
Air-conditioning units,
Cheese moulds,
Beer glass cleaners.

Amount to Use of VANTOCIL TG:
VANTOCIL TG can be used alone or in combination with other biocides to create products for a wide range of disinfection applications.
Considerable data exists which provides a measure of the intrinsic antimicrobial activity of VANTOCIL TG, generated via European suspension test protocols relevant to application in Food, Industrial,

Typical Properties of VANTOCIL TG:
VANTOCIL TG is a very pale yellow liquid without odour. 
VANTOCIL TG pH is acid (pH=5.7). 

VANTOCIL TG has a relative density of 1.04 at 20 °C. 
VANTOCIL TG is a free flowing mobile liquid with a low viscosity of 4.15 mPa.s. 

Experience in use indicates that the product does not foam. 
A study should be provided at the product authorisation stage for confirmation. 

Data on the surface tension measured with VANTOCIL TG is required at the product authorisation stage.
VANTOCIL TG is stable 14 days at 54°C. 

Low temperature stability (7 days at 0°C) and a shelf life study (2 years at ambient temperature) including measure of VANTOCIL TG (adsorbed on container after storage were not submitted and should be required).
VANTOCIL TG is not flammable and has neither oxidising nor explosive properties.

VANTOCIL TG is a dusty solid/powder, off white with a strong ammonia smell. 
VANTOCIL TG has a glass transition temperature of 90-91°C (non crystalline polymer) and decomposes at 205-210°C before boiling. 

VANTOCIL TG (has manufactured, 20% in water) has a boiling point of 100.2°C. 
The relative density of VANTOCIL TG is 1.20 at 20°C and the relative density of the TK is 1.04 at 20°C. 

As a polymer, VANTOCIL TG is not considered to be volatile. 
Henry’s Law Constant is not applicable as VANTOCIL TG is not considered to be volatile and is present in ionic form at neutral pH. 

VANTOCIL TG is assumed that has only slight possibility to go from water to air. 
VANTOCIL TG is very soluble in water (426 g/L). 

VANTOCIL TG is also soluble in methanol (41%), in ethanol (0.5%) and sparingly soluble in organic solvents (10-3 g/L). 
The pKa is calculated as approximately 4.4 at 25°C. Log Pow is -

2.3 at pH=7.4 and 25°C. 
VANTOCIL TG is not highly flammable, and does not have oxidizing and explosive properties. 
A surface tension study should be performed but VANTOCIL TG is not expected to be surface active based on structural considerations.

Antimicrobial Properties of VANTOCIL TG:
The levels of VANTOCIL TG needed to prevent the growth of problem micro-organisms are listed in show below.
MICs do not represent effective use levels but do indicate the intrinsic broad spectrum of activity of VANTOCIL TG.

VANTOCIL TG has a non-specific mode of biocidal action which means that bacterial resistance is very unlikely to occur. 
Detailed information on the mode of action of VANTOCIL TG is available on request. 

Minimum Inhibitory Concentrations (MICs):

VANTOCIL TG (ppm product)

Bacillus subtilis NCIB 3610 1.5
Enterobacter cloacae NCIB 8271 40
Escherichia coli 0157:H7 NCTC 12900 80
Legionella pneumophila — 5
Listeria monocytogenes ATCC 15313 30
Proteus vulgaris NCTC 4175 40
Pseudomonas aeruginosa ATCC 15442 40
Pseudomonas putida — 25
Salmonella choleraesius ATCC 13311 120
Salmonella typhimurium ATCC 14028 160
Staphylococcus aureus ATCC 6538 30
Streptococcus faecalis — 5
Streptococcus lactis NCTC 7944 20

Candida albicans ATCC 10231 300
Rhodotorula rubra NCYC 1659 7.5
Saccharomyces cerevisiae ATCC 9763 300

Acanthamoeba polyphaga — 5

Methods of Analysis of VANTOCIL TG:
VANTOCIL TG is impossible to determine directly VANTOCIL TG since it is not a single chemical entity but a polymeric mixture with a range of molecular weight. 
Adequate methodology exists for the characterisation of the active ingredient and the determination of the known impurities in the VANTOCIL TG but more validation data are required.

Justifications for non submission of analytical methods for residues of the active substance in soil, water, air and body fluids and tissues, in food or feedstuffs were submitted.
For polymeric substances VANTOCIL TG may be difficult to develop an adequate residue analytical method. 

A limited residue definition in form of a marker will be required if VANTOCIL TG is proposed for approval.

Residue definition:
A proposal of residue definition for drinking water and body fluid and tissues is required 6 months before the date of approval.

Compatibility of VANTOCIL TG: 
Effective and stable over pH range 1-11.
Compatible with nonionic surfactants, glycols, glycol ethers, most strong acids and common chelating agents such as EDTA, NTA, IDS. 
Limited compatibility with anionic surfactants, strong alkalis, complex phosphates and strong oxidisers.

Storage of VANTOCIL TG:
Storage Stability Stable under normal conditions of storage down to 0°C. 
If frozen, allow to thaw at room temperature and stir thoroughly before use. 
Active agent is heat-stable and non-volatile.

Physical Properties of VANTOCIL TG:
Composition: An aqueous solution of PHMB
Active Agent: 20% w/w
Physical Form: Slightly opalescent colourless to pale yellow liquid
Viscosity at 25°C: 5 mPa s.
pH at 25°C: 5.0-6.0
Boiling Point: 102°C

Flash Point: Boils without flashing
Density at 25°C: 1.04
Odour: No strong odour
Foaming/Surface Tension Has significantly less tendency to tension foam than quaternary ammonium compounds. 
VANTOCIL TG is not surface active.

Characterisation Specifications of VANTOCIL TG:
Strength: 18-22%
VANTOCIL TG in dried material: ≥ 95.6%
molecular weight by number (Mn): 1449-1771
molecular weight by mass (Mw): 2687-3285
Polydispersity: 1.80-1.91
The biguanide / guanide ratio in chain: 90/10 to 92/8
Total fraction: <1000 Da 16.6-24.5 %

Other Descriptions of VANTOCIL TG:
Chemical Family: Biguanides
Chemical Name: Poly(hexamethylenebiguanide) Hydrochloride

Cleaning Ingredient Functions:
Anti-Microbial Agent

Cleaning Ingredients — Microbial Control & Preservation
Other Disinfectants & Antimicrobials

CAS No.: 32289-58-0,27083-27-8,133029-32-0
Use: Biocide, Disinfectant
Package: 25kg/drum

Synonyms of VANTOCIL TG:
Poly(hexamethylene biguanidine) hydrochloride;
hexamethylenediamine polymer hydrochloride    
PHMB hydrochloride    
polihexanide HCl    
polihexanide hydrochloride    
poly(hexamethylenebiguanide) hydrochloride    
poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) hydrochloride    
Brand Names     
Cosmoquil CQ    
poly(hexamethylene) biguanide hydrochloride    
Reputex 20    

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