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VISCOLOSE 20000 is a water-soluble polymer which can be used as a polyelectrolyte cellulose derivative.
VISCOLOSE 20000 is a white or slightly yellowish, almost odorless and tasteless hydroscopic powder, consisting of very fine particles, fine granules or fine fibers.
VISCOLOSE 20000 is also an especially effective binder that can be used in small amounts in compositions, where the binder can interfere with the intended effect (e.g., in strobe compositions).
CAS Number: 9004-32-4
EC Number: 618-378-6
Synonyms: 9004-32-4, sodium;2,3,4,5,6-pentahydroxyhexanal;acetate, Carboxymethylcellulose sodium (USP),Carboxymethylcellulose cellulose carboxymethyl ether, CMC powder,Celluvisc (TN),Carmellose sodium (JP17),CHEMBL242021,C.M.C. (TN) CHEBI:31357,E466,VISCOLOSE 20000 (MW 250000),D01544
VISCOLOSE 20000 is used for its thickening and swelling properties in a wide range of complex formulated products for pharmaceutical, food, home, and personal care applications, as well as in paper, water treatment, and mineral processing industries.
VISCOLOSE 20000 is the substituted product of cellulosic carboxymethyl group.
VISCOLOSE 20000 for oenological use is prepared exclusively from wood by treatment with alkali and monochloroacetic acid or its sodium salt.
VISCOLOSE 20000 inhibits tartaric precipitation through a "protective colloid" effect.
VISCOLOSE 20000 a colorless, odorless, water-soluble polymer.
VISCOLOSE 20000, NaCMC or CMC, was first developed in 1947.
Commonly known as carboxymethyl cellulose, it is composed of the sodium salt of an alkaline modified cellulose.
VISCOLOSE 20000 is water-soluble but will react with heavy metal salts to form films that are clear, tough and insoluble in water.
According to their molecular weight or degree of substitution, VISCOLOSE 20000 can be completely dissolved or insoluble polymer, the latter can be used as the weak acid cation of exchanger to separate neutral or basic proteins.
VISCOLOSE 20000 is tackifier, at room temperature, it is non-toxic tasteless white flocculent powder, it is stable and soluble in water, aqueous solution is neutral or alkaline transparent viscous liquid, it is soluble in other water-soluble gums and resins, it is insoluble in organic solvents such as ethanol.
VISCOLOSE 20000 is also an especially effective binder that can be used in small amounts in compositions, where the binder can intcrfere with the intended effect (e.g., in strobe compositions).
VISCOLOSE 20000 is also a natural polymeric derivative that can be used in detergents, food and textile industries.
VISCOLOSE 20000 is a water-soluble polymer.
As a solution in water, VISCOLOSE 20000 has thixotropic properties.
VISCOLOSE 20000 is a white or slightly yellowish, almost odourless and tasteless hydroscopic powder, consisting of very fine particles, fine granules or fine fibres.
VISCOLOSE 20000 is biodegradable, but not readily biodegradable, and it is not expected to bioaccumulate.
VISCOLOSE 20000 is components consist of polysaccharide composed of fibrous tissues of plants.
VISCOLOSE 20000 is a water dispersible sodium salt of carboxy-methyl ether of cellulose that forms a clear colloidal solution.
VISCOLOSE 20000 is a water soluble polymer which can be used as a polyelectrolyte cellulose derivative.
VISCOLOSE 20000 belongs to the class of anionic linear structured cellulose.
VISCOLOSE 20000 is thixotropic, becoming less viscous when agitated.
VISCOLOSE 20000 is widely used in oral and topical pharmaceutical formulations, primarily for its viscosity-increasing properties.
Viscous aqueous solutions are used to suspend powders intended for either topical application or oral and parenteral administration.
VISCOLOSE 20000 can form highly viscous colloidal solution with adhesive, thickening, flowing, emulsifying, shaping, water, protective colloid, film forming, acid, salt, suspensions and other characteristics, and it is physiologically harmless, so it is widely used in the food, pharmaceutical, cosmetic, oil, paper, textiles, construction and other areas of production.
VISCOLOSE 20000 is a white or slightly yellowish powder.
VISCOLOSE 20000 or cellulose gum is a cellulose derivative with carboxymethyl groups (-CH2-COOH) bound to some of the hydroxyl groups of the glucopyranose monomers that make up the cellulose backbone.
VISCOLOSE 20000 may also be used as a tablet binder and disintegrant, and to stabilize emulsions.
This muco-adhesive property is used in products designed to prevent post-surgical tissue adhesions; and to localize and modify the release kinetics of active ingredients applied to mucous membranes; and for bone repair.
Encapsulation with carboxymethylcellulose sodium can affect drug protection and delivery.
There have also been reports of its use as a cyto-protective agent.
Higher concentrations, usually 3–6%, of the medium-viscosity grade are used to produce gels that can be used as the base for applications and pastes; glycols are often included in such gels to prevent them drying out.
VISCOLOSE 20000 is also used in self-adhesive ostomy, wound care, and dermatological patches as a muco-adhesive and to absorb wound exudate or transepidermal water and sweat.
In most cases, VISCOLOSE 20000 functions as a polyelectrolyte.
VISCOLOSE 20000 is used commercially in detergents, food product and as size for textiles and paper.
In conservation, VISCOLOSE 20000 has been used as an adhesive for textiles and paper.
VISCOLOSE 20000 is also used in cosmetics, toiletries, surgical prosthetics, and incontinence, personal hygiene, and food products.
VISCOLOSE 20000 is one of the most significant byproducts of cellulose ethers which are created by natural cellulose modification as a type of cellulose derivate with an ether structure.
Termed VISCOLOSE 20000, this polymer has a poor water solubility of the acid form of CMC and is typically preserved as sodium carboxymethylcellulose.
VISCOLOSE 20000 is utilized in numerous industries and is referred to as monosodium glutamate in the workplace.
VISCOLOSE 20000 is an offshoot of CMC.
Since the VISCOLOSE 20000 compound is typically poorly soluble in water, sodium CMC can be used to preserve it.
VISCOLOSE 20000 is suitable for use in food systems.
VISCOLOSE 20000 is physiologically inert.
VISCOLOSE 20000 is an anionic polyelectrolyte.
VISCOLOSE 20000 has dispersibility and is soluble in cold water.
Emulsifying dispersion and solid dispersion are two of sodium VISCOLOSE 20000's peculiar chemical properties.
VISCOLOSE 20000 can be categorized as a derivative of a natural polymer.
VISCOLOSE 20000 is also available in several different viscosity grades.
VISCOLOSE 20000 is highly soluble in water at all temperatures, forming clear solutions.
VISCOLOSE 20000s solubility depends on its degree of substitution.
VISCOLOSE 20000, one of major cellulosic ethers, is widely used as a binding, thickening and stabilising agent (Lee et al. 2018).
Pharmaceutical grades of VISCOLOSE 20000 are available commercially at degree of substitution (DS) values of 0.7, 0.9, and 1.2, with a corresponding sodium content of 6.5%–12% wt.
VISCOLOSE 20000 is a crucial by-product of cellulose ethers and is typically created by altering natural cellulose.
Aging studies indicate that most VISCOLOSE 20000 polymers have very good stability with negligible discoloration or weight loss.
VISCOLOSE 20000 is an anionic water-soluble polymer based on renewable cellulosic raw material.
VISCOLOSE 20000 functions as a rheology modifier, binder, dispersant, and an excellent film former.
These attributes make VISCOLOSE 20000 a preferred choice as a bio-based hydrocolloid in multiple applications.
VISCOLOSE 20000 acts as a thickener, binder, stabilizer, suspending agent and flow controlling agent.
VISCOLOSE 20000 forms fine films that are resistant to oils, greases, and organic solvents.
VISCOLOSE 20000 dissolves rapidly in cold water. 4) Acts as a protective colloid reducing water losses.
VISCOLOSE 20000 is the sodium salt of carboxymethyl cellulose, an anionic derivative.
VISCOLOSE 20000 is a family of chemically modified cellulose derivatives containing the carboxymethyl ether group (-O-CH2-COO-) bound to some of the hydroxyl groups of the glucopyranose monomers that make up the cellulose backbone.
When Carboxymethylcellulose is recovered and presented as the Sodium salt, the resulting polymer is what is known as VISCOLOSE 20000, and has the general chemical formula, [C6H7O2(OH)x(OCH2COONa)y]n.
VISCOLOSE 20000 was discovered shortly after Word War 1 and has been produced commercially since the early 1930s.
VISCOLOSE 20000, often abbreviated as Na-CMC or simply CMC, is a versatile and widely used chemical compound.
VISCOLOSE 20000 is derived from cellulose, a natural polymer found in the cell walls of plants.
VISCOLOSE 20000 is a water-soluble polymer and is used for a variety of purposes in various industries, including food, pharmaceuticals, cosmetics, and more.
VISCOLOSE 20000 is produced by treating cellulose with an aqueous sodium hydroxide solution followed by monochloroacetic acid or its sodium salt.
VISCOLOSE 20000 is often used as its sodium salt, VISCOLOSE 20000.
VISCOLOSE 20000 used to be marketed under the name Tylose, a registered trademark of SE Tylose.
A semisynthetic, water-soluble polymer in which CH 2 COOH groups are substituted on the glucose units of the cellulose chain through an ether link- age.
Since the reaction occurs in an alkaline medium, the prod- uct is the sodium salt of the carboxylic acid R-O- CH 2 COONa.
VISCOLOSE 20000 is useful in helping to hold the components of pyrotechnic compositions in aqucous suspension (e.g., in the making of black match).
VISCOLOSE 20000 is manufactured from cellulose by various proccsses that replacc some of the hy drogen atoms in the hydroxyl[OH] groups of the cellulose molecule with acidic carboxymethyl [-CH2CO.OH] groups，which are neutralized to form the corresponding sodium salt.
VISCOLOSE 20000 is used warm water or cold water when preparing the solution, and stir till it completely melts.
The amout of added water depends on variety and the use of multiple requirements.
High viscosity VISCOLOSE 20000 is a white or slightly yellow fibrous powder, hygroscopic, odorless, tasteless, non-toxic, easy to ferment, insoluble in acids, alcohols and organic solvents, easily dispersed to form colloidal solution in water.
The alkaline cellulose is then reacted with sodium monochloroacetate to produce VISCOLOSE 20000.
VISCOLOSE 20000 is reacted by the acid and fibrous cotton, it is mainly used for water-based drilling fluids tackifier, it has certain role of fluid loss, it has strong salt and temperature resistance especially.
VISCOLOSE 20000 is incompatible with strongly acidic solutions and with the soluble salts of iron and some other metals, such as aluminum, mercury, and zinc.
VISCOLOSE 20000 is also incompatible with xanthan gum.
Precipitation may occur at pH < 2, and also when it is mixed with ethanol (95%).
VISCOLOSE 20000 is odourless, tasteless, tasteless, hygroscopic and insoluble in organic solvents.
VISCOLOSE 20000 forms complex coacervates with gelatin and pectin.
VISCOLOSE 20000 is one of the most important products of cellulose ethers, which are formed by natural cellulose modification as a kind of cellulose derivate with an ether structure.
Due to the fact that the acid form of VISCOLOSE 20000 has poor water solubility, it is usually preserved as sodium carboxymethylcellulose, which is widely used in many industries and regarded as monosodium glutamate in industry.
VISCOLOSE 20000 is used in cigarette adhesive, fabric sizing, footwear paste meal, home slimy.
Fabrics made of cellulose—e.g. cotton or viscose rayon—may also be converted into VISCOLOSE 20000.
Following the initial reaction, the resultant mixture produces approximately 60% VISCOLOSE 20000 and 40% salts (sodium chloride and sodium glycolate); this product is the so-called technical CMC, which is used in detergents.
An additional purification process is used to remove salts to produce pure VISCOLOSE 20000, which is used for alimentary and pharmaceutical applications.
An intermediate "semi-purified" grade is also produced, typically used in paper applications such as the restoration of archival documents.
VISCOLOSE 20000 is used as a thickener in the food industry, as a drug carrier in the pharmaceutical industry, as a binder and anti-retrogradation agent in the daily chemical industry.
VISCOLOSE 20000 is a water-soluble polymer derived from cellulose through a chemical modification process.
VISCOLOSE 20000 is a kind of cellulose widely used and used in the world today.
VISCOLOSE 20000 is used in interior painting architectural, building lines melamine, thickening mortar, concrete enhancement.
VISCOLOSE 20000 is synthesized by the alkali-catalyzed reaction of cellulose with chloroacetic acid.
Sodium chloride and sodium glycolate are obtained as by-products of this etherification.
Carboxymethyl groups (-CH2-COOH) are introduced into the cellulose structure.
These carboxymethyl groups make the cellulose molecule more water-soluble and provide it with its unique properties.
The viscosity of VISCOLOSE 20000 solutions can be controlled by adjusting the concentration of the polymer.
This property makes it suitable for a wide range of applications, from thin solutions in beverages to thick gels in some pharmaceutical formulations.
VISCOLOSE 20000 is stable over a wide pH range, making it suitable for use in both acidic and alkaline environments.
VISCOLOSE 20000 disperses easily in cold water, forming a smooth, uniform solution, which is advantageous in manufacturing processes.
VISCOLOSE 20000 can be used to form films or coatings.
This is particularly important in the food industry where it can be used in a variety of products with different pH levels.
VISCOLOSE 20000 is generally considered safe for consumption and topical use.
VISCOLOSE 20000 can be used to create edible films for various purposes, such as encapsulating flavors or improving food packaging.
VISCOLOSE 20000 is cost-effective and environmentally friendly because it is derived from renewable resources, such as wood pulp or cotton cellulose.
VISCOLOSE 20000 is used as a highly effective additive to improve the product and processing properties in various fields of application - from foodstuffs, cosmetics and pharmaceuticals to products for the paper and textile industries.
VISCOLOSE 20000 is non-toxic and non-allergenic, which contributes to its widespread use in food and pharmaceutical products.
VISCOLOSE 20000 is highly hydrophilic, meaning it has a strong affinity for water.
VISCOLOSE 20000, is a cellulose derivative with 100-2000 degree of polymerization of glucose, and its relative molecular weight is 242.16.
VISCOLOSE 20000 also forms a complex with collagen and is capable of precipitating certain positively charged proteins.
VISCOLOSE 20000 is available as a white to almost white, odourless, tasteless, granular powder.
VISCOLOSE 20000 is an anionic polymer with a clarified solution dissolved in cold or hot water.
VISCOLOSE 20000 functions as a thickening rheology modifier, moisture retention agent, texture/body building agent, suspension agent, and binding agent in personal products and toothpaste.
Food and pharmaceutical grade Carboxymethylcellulose is required by law to contain not less than 99.5% pure VISCOLOSE 20000 and a maximum of 0.5% of residual salts (sodium chloride and sodium glycolate).
The degree of substitution (DS) can vary between 0.2-1.5, although it is generally in the range of 0.6-0.95.
The DS determines the behaviour of VISCOLOSE 20000 in water: Grades with DS >0.6 form colloidal solutions in water that are transparent and clear, i.e the higher the content of carboxymethyl groups, the higher the solubility and smoother the solutions obtained.
VISCOLOSE 20000 with a DS below 0.6 tends to be only partially soluble.
VISCOLOSE 20000 is used warm water or cold water when preparing the solution, and stir till it completely melts.
The amout of added water depends on variety and the use of multiple requirements.
VISCOLOSE 20000 is desirable because the catalysis product (glucose) is easily measured using a reducing sugar assay, such as 3,5-dinitrosalicylic acid.
Using VISCOLOSE 20000 in enzyme assays is especially important in screening for cellulase enzymes that are needed for more efficient cellulosic ethanol conversion.
VISCOLOSE 20000 was misused in early work with cellulase enzymes, as many had associated whole cellulase activity with CMC hydrolysis.
High viscosity VISCOLOSE 20000 is a white or slightly yellow fibrous powder, hygroscopic, odorless, tasteless, non-toxic, easy to ferment, insoluble in acids, alcohols and organic solvents, easily dispersed to form colloidal solution in water.
Alkali cellulose is prepared by steeping cellulose obtained from wood pulp or cotton fibers in sodium hydroxide solution.
Uses of VISCOLOSE 20000:
VISCOLOSE 20000 is used in food under the E number E466 or E469 (when it is enzymatically hydrolyzed), as a viscosity modifier or thickener, and to stabilize emulsions in various products, including ice cream.
VISCOLOSE 20000 acts as a stabilizer in foods.
VISCOLOSE 20000 is also employed in pharmaceuticals as a suspending agent and excipients for tablets.
VISCOLOSE 20000 can be used as soap and washing powder detergent active additives, as well as other industrial production on the dispersion, emulsification, stability, suspension, film, paper, polishing and the like.
Quality product can be used for toothpaste, medicine, food and other industrial sectors.
VISCOLOSE 20000 is frequently called simply carboxymethyl cellulose and also known as cellulose gum.
VISCOLOSE 20000 is derived from purified cellulose from cotton and wood pulp.
VISCOLOSE 20000 is a water dispersible sodium salt of carboxy-methyl ether of cellulose that forms a clear colloidal solution.
VISCOLOSE 20000 is a hygroscopic material that has the ability to absorb more than 50% of water at high humidity.
VISCOLOSE 20000 can also help to reduce the amount of egg yolk or fat used in making the biscuits.
Use of VISCOLOSE 20000 in candy preparation ensures smooth dispersion in flavor oils, and improves texture and quality.
VISCOLOSE 20000 is used in chewing gums, margarines and peanut butter as an emulsifier.
VISCOLOSE 20000 has been used extensively to characterize enzyme activity from endoglucanases (part of the cellulase complex); it is a highly specific substrate for endo-acting cellulases, as its structure has been engineered to decrystallize cellulose and create amorphous sites that are ideal for endoglucanase action.
VISCOLOSE 20000 is used as a soil suspension polymer designed to deposit onto cotton and other cellulosic fabrics, creating a negatively charged barrier to soils in the wash solution.
VISCOLOSE 20000 is also used as a thickening agent, for example, in the oil-drilling industry as an ingredient of drilling mud, where it acts as a viscosity modifier and water retention agent.
VISCOLOSE 20000 is also a natural polymeric derivative that can be used in detergents, food and textile industries.
VISCOLOSE 20000 can be used as a binder in the preparation of graphene nano-platelet based inks for the fabrication of dye sensitized solar cells (DSSCs).
VISCOLOSE 20000 can also be used as a viscosity enhancer in the development of tyrosinase based inks for the formation of electrodes for biosensor applications.
VISCOLOSE 20000's water solubility allows for less toxic and costly processing than with non-water-soluble binders, like the traditional polyvinylidene fluoride (PVDF), which requires toxic n-methylpyrrolidone (NMP) for processing.
VISCOLOSE 20000 is often used in conjunction with styrene-butadiene rubber (SBR) for electrodes requiring extra flexibility, e.g. for use with silicon-containing anodes.
VISCOLOSE 20000 is also used in ice packs to form a eutectic mixture resulting in a lower freezing point, and therefore more cooling capacity than ice.
Aqueous solutions of VISCOLOSE 20000 have also been used to disperse carbon nanotubes, where the long VISCOLOSE 20000 molecules are thought to wrap around the nanotubes, allowing them to be dispersed in water.
VISCOLOSE 20000 acts as a stabilizer and prevents ingredients from separating in products like beverages, including soft drinks and fruit juices.
In salad dressings, VISCOLOSE 20000 helps create stable emulsions of oil and water, preventing them from separating.
In the pharmaceutical industry, VISCOLOSE 20000 can be used as a binder in tablet formulations to hold the ingredients together.
In oral suspensions and liquid medications, VISCOLOSE 20000 helps to suspend solid particles uniformly in the liquid, ensuring consistent dosing.
In cosmetics and personal care products, VISCOLOSE 20000 can be used to improve the moisture retention properties of creams and lotions.
VISCOLOSE 20000 is used in paper manufacturing to coat the surface of paper, improving its printability and smoothness.
VISCOLOSE 20000 is sometimes used in the textile industry as a sizing agent to improve the weaving process.
For its thickening and swelling properties, VISCOLOSE 20000 is used in a variety of intricately formulated products for the pharmaceutical, food, home, and personal care industries as well as the paper, water treatment, and mineral processing industries.
Thorough knowledge of the concentration-dependent rheology and relaxation response is required to design VISCOLOSE 20000 solutions for applications.
Alkali cellulose and sodium chloroacetate react to form a gummy substance that is either soluble in water or swells in water.
VISCOLOSE 20000 is primarily used as a thickening, emulsifying, and stabilizing agent (as in sizes for textiles and paper and pharmaceutical ointments) as well as a bulk laxative and antacid in medicine.
In conservation-restoration, VISCOLOSE 20000 is used as an adhesive or fixative (commercial name Walocel, Klucel).
VISCOLOSE 20000 is used as a support material for a variety of cathodes and anodes for microbial fuel cells.
VISCOLOSE 20000 is used in refractory fiber, ceramic production molding bond.
VISCOLOSE 20000 can be used as a flocculant, chelator, emulsifier, thickener, water-retentive, sizing, and film-forming substance, among other things.
Electronics, pesticides, leather, plastics, printing, ceramics, and the daily-use chemical industry are just a few of the industries that heavily utilize VISCOLOSE 20000.
Additionally, VISCOLOSE 20000 has a wide range of applications due to its excellent properties, widespread use, and emerging potential fields.
VISCOLOSE 20000 used as sizing agent and printing paste in printing and dyeing industry.
VISCOLOSE 20000 can be used as a component of oil recovery fracturing fluid in the petrochemical industry.
VISCOLOSE 20000 is a widely used ionic cellulose ether, widely used in petroleum, food, medicine, construction and ceramics industries, so it is also known as "industrial monosodium glutamate".
VISCOLOSE 20000 is frequently used as a thickening agent in a wide range of food products, such as salad dressings, sauces, and ice cream.
VISCOLOSE 20000 imparts viscosity and helps to stabilize these products.
VISCOLOSE 20000 is sometimes used as an electrode binder in advanced battery applications (i.e. lithium ion batteries), especially with graphite anodes.
VISCOLOSE 20000 is also used extensively in gluten-free and reduced-fat food products.
VISCOLOSE 20000 is used to achieve tartrate or cold stability in wine, an innovation that may save megawatts of electricity used to chill wine in warm climates.
VISCOLOSE 20000 is more stable than metatartaric acid and is very effective in inhibiting tartrate precipitation.
VISCOLOSE 20000 is reported that KHT crystals, in presence of CMC, grow slower and change their morphology.
Their shape becomes flatter because they lose 2 of the 7 faces, changing their dimensions.
Constituents are any of several fibrous substances consisting of the chief part of a plant’s cell walls (often extracted from wood pulp or cotton).
VISCOLOSE 20000 salt is used in drilling muds, in detergents as a soil-suspending agent, in resin emulsion paints, adhesives, printing inks, textile sizes and protective colloid.
VISCOLOSE 20000 is used in oil drilling, exploration address slurry thickening, reducing water loss, quality paper surface sizing.
VISCOLOSE 20000 is resistant to bacterial decomposition and provides a product with uniform viscosity.
VISCOLOSE 20000 can prevent skin moisture loss by forming a film on the skin’s surface, and also help mask odor in a cosmetic product.
VISCOLOSE 20000 is used as viscosity modifiers to stabilize the emulsions.
VISCOLOSE 20000 is used as a lubricant in artificial tears and it is used to characterize enzyme activity from endoglucanases.
VISCOLOSE 20000 is used in a variety of applications ranging from food production to medical treatments.
VISCOLOSE 20000 is commonly used as a viscosity modifier or thickener, and to stabilize emulsions in various products, both food and non-food.
VISCOLOSE 20000 is used primarily because it has high viscosity, is nontoxic, and is generally considered to be hypoallergenic, as the major source fiber is either softwood pulp or cotton linter.
VISCOLOSE 20000 molecules, negatively charged at wine pH, interact with the electropositive surface of the crystals, where potassium ions are accumulated.
The slower growth of the crystals and the modification of their shape are caused by the competition between VISCOLOSE 20000 molecules and bitartrate ions for binding to the KHT crystals.
VISCOLOSE 20000 powder is widely used in the ice cream industry, to make ice creams without churning or extremely low temperatures, thereby eliminating the need for conventional churners or salt ice mixes.
VISCOLOSE 20000 is used in baking breads and cakes.
The use of VISCOLOSE 20000 gives the loaf an improved quality at a reduced cost, by reducing the need of fat.
VISCOLOSE 20000 is also used as an emulsifier in biscuits.
Non-food products include products such as toothpaste, laxatives, diet pills, water-based paints, detergents, textile sizing, reusable heat packs, various paper products, filtration materials, synthetic membranes, wound healing applications, and also in leather crafting to help burnish edges.
Safety Profile of VISCOLOSE 20000:
The WHO has not specified an acceptable daily intake for VISCOLOSE 20000 as a food additive since the levels necessary to achieve a desired effect were not considered to be a hazard to health.
VISCOLOSE 20000 is also widely used in cosmetics, toiletries, and food products, and is generally regarded as a nontoxic and nonirritant material.
Hypersensitivity and anaphylactic reactions have occurred in cattle and horses, which have been attributed to VISCOLOSE 20000m in parenteral formulations such as vaccines and penicillins.
However, oral consumption of large amounts of VISCOLOSE 20000 can have a laxative effect; therapeutically, 4–10 g in daily divided doses of the medium- and high-viscosity grades of carboxymethylcellulose sodium have been used as bulk laxatives.
However, in animal studies, subcutaneous administration of VISCOLOSE 20000 has been found to cause inflammation, and in some cases of repeated injection fibrosarcomas have been found at the site of injection.
VISCOLOSE 20000 is used in oral, topical, and some parenteral formulations.
Properties of VISCOLOSE 20000:
Melting point: 274 °C (dec.)
Density: 1,6 g/cm3
FEMA: 2239 | CARBOXYMETHYLCELLULOSE
storage temp.: room temp
solubility: H2O: 20 mg/mL, soluble
form: low viscosity
pka: 4.30(at 25℃)
color: White to light yellow
Odor: Odorless
PH Range: 6.5 - 8.5
PH: pH (10g/l, 25℃) 6.0～8.0
