WILFARIN OA-7070

CAS:    112-80-1
MF:    C18H34O2
MW:    282.46
EINECS:    204-007-1

Description    
WILFARIN OA-7070 is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue. 
WILFARIN OA-7070 contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets. 
WILFARIN OA-7070 inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 μg/ml. 
WILFARIN OA-7070 also inhibits fMLF-induced neutrophil aggregation and degranulation by 55 and 68%, respectively, when used at a concentration of 5 μM, similar to arachidonic acid ( | 90010.1 | 10006607).
WILFARIN OA-7070 (60 μM) induces release of intracellular calcium in human platelets. 
In vivo, WILFARIN OA-7070 increases TNF-α, IL-8, IL-6, and IL-1β production, neutrophil accumulation, and apoptotic and necrotic cell death in mouse lung and has been used to induce lung injury in a mouse model of acute respiratory distress syndrome (ARDS).
WILFARIN OA-7070 molecules have an unsaturated double bond with the chemical properties of single unsaturated carboxylic acid. 
WILFARIN OA-7070 is capable for having addition reaction bromine. 
Add 2 mL of CCl4 and 0.5 mL of WILFARIN OA-7070 to a test tube and mix. 
Take another test tube, put into 1 mL of CCl4, add 1 drop of bromine and shake uniformly. 
The CCl4 of bromine solution is dropped into the CCl4 solution of oleic acid; shake the tube and the color of bromine will recede: C17H33COOH + Br2 → C17H33Br2COOH.

Physical and chemical properties    
WILFARIN OA-7070, also known as cis-9-octadecenoic acid, being of chemical properties of single unsaturated carboxylic acid and is widely presented in animal and vegetable oils. 
For example, olive oil contains about 82.6%; peanut oil contains 60.0%; sesame oil contains 47.4%; soybean oil contains 35.5%; sunflower seed oil contains 34.0%; cottonseed oil contains 33.0%; rapeseed oil contains 23.9%; safflower oil contains 18.7%; the content in the tea oil can be as high as 83%; in animal oil: lard oil contains about 51.5%; butter contains 46.5 %; whale oil contains 34.0%; cream oil contains 18.7%; Oleic acid has a stable (α-type) and unstable (β-type) two types. 
At low temperature, WILFARIN OA-7070 can appear as crystal; at high temperature, it appears as colorless transparent oily liquid with lard odor. 
WILFARIN OA-7070 has a relative molecular mass of 282.47, relative density of 0.8905 (20 ℃ liquid), M.p. of 16.3 ° C (α), 13.4 ° C (β), boiling point of 286 °C (13.3 103 Pa), 225 to 226 °C(1.33 103 Pa), 203 to 205 °C (0.677 103 Pa), and 170 to 175 °C (0.267 103 to 0.400 103 Pa), the Refractive index of 1.4582 and viscosity of 25.6 mPa • s (30 ° C).
WILFARIN OA-7070 is insoluble in water, being soluble in benzene and chloroform. 
WILFARIN OA-7070 is miscible with methanol, ethanol, ether and carbon tetrachloride. 

Because of containing double bond, WILFARIN OA-7070 can be easily subject to air oxidation, thus producing bad smell with the color turning yellow. 
Upon using nitrogen oxides, nitric acid, mercurous nitrate and sulfurous acid for treatment, WILFARIN OA-7070 can be converted to elaidic acid. 
WILFARIN OA-7070 can be converted into stearic acid upon hydrogenation. 
Double bond is easy to react with halogen to produce halogen stearic acid. 
WILFARIN OA-7070 can be obtained through the hydrolysis of olive oil and lard oil, followed by steam distillation and crystallization or extraction for separation. 
WILFARIN OA-7070 is an excellent solvent for other oils, fatty acids and oil-soluble substances. 
WILFARIN OA-7070 can be used for the manufacture of soap, lubricants, flotation agents, such as ointment and oleate.

Benefits    
WILFARIN OA-7070 is a fatty acid found in animal and vegetable oils. 
WILFARIN OA-7070 is a mono-saturated fat generally believed to be good for one's health. 
Indeed, WILFARIN OA-7070 is the chief fatty acid found in olive oil, comprising 55 to 85 percent of the important substance, which is commonly used in Mediterranean cuisine and has been hailed for its therapeutic characteristics since antiquity. 
Modern studies support the notion of the benefits of consuming olive oil, since evidence suggests that oleic acid helps lower levels of harmful low-density lipoproteins (LDLs) in the bloodstream, while leaving levels of beneficial high-density lipoproteins (HDLs) unchanged. 
Found also in significant quantities in canola, cod liver, coconut, soybean, and almond oils, oleic acid can be consumed from a variety of sources, some of which may soon contain even higher levels of the valuable fatty acid due to the efforts of genetic engineers.
WILFARIN OA-7070 occurs naturally in greater quantities than any other fatty acid. 

WILFARIN OA-7070 is present as glycerides in most fats and oils. High concentrations of oleic acid can lower blood levels of cholesterol. 
WILFARIN OA-7070 is used in the food industry to make synthetic butters and cheeses. 
WILFARIN OA-7070 is also used to flavor baked goods, candy, ice cream, and sodas.
According to the American Diabetes Association, more than 25 million Americans have diabetes. 
In addition, 7 million have undiagnosed diabetes, and 79 million others have prediabetes. 
In a study published in February 2000 in the medical journal "QJM," researchers in Ireland found that diets rich in oleic acid improved the participants' fasting plasma glucose, insulin sensitivity and blood circulation. 
Lower fasting glucose and insulin levels, along with enhanced blood flow, suggest better diabetes control and less risk for other diseases. 
For millions of people with diagnosed diabetes and prediabetes, consuming foods rich in oleic acid may be beneficial in controlling the disease.

Uses    
WILFARIN OA-7070 is an unsaturated fatty acid that functions as a lubricant, binder, and defoamer.
WILFARIN OA-7070 is a monounsaturated omega-9 fatty acid. 
WILFARIN OA-7070 is obtained by the hydrolysis of various animal and vegetable fats and oils. 
WILFARIN OA-7070 is used as an emulsifying or solubilizing agent i n aerosol products.
WILFARIN OA-7070 is also known as omega-9. oleic acid can improve the skinpenetration abilities of a preparation’s other components. 
An essential fatty acid, WILFARIN OA-7070 is obtained from various animal and vegetable fats and oils, and may be mildly irritating to the skin.

Production method    
WILFARIN OA-7070 and other fatty acids together, are presented in all kinds of animal and vegetable oil fats in the form of glycerides. 
In animal fats, WILFARIN OA-7070 can account for about 40-50% of the fatty acids. 
WILFARIN OA-7070's content in the vegetable oil can vary largely with the content in tea oil being as high as 83%, being 54% in peanut oil while the coconut oil only contains about 5-6%. 
WILFARIN OA-7070 is the co-product upon the production of stearic acid. 
The industrial stearic acid and industrial WILFARIN OA-7070 actually both contain other fatty acids. 
There are many oil fats raw materials used for the production of stearic acid and oleic acid. 
The industry generally take mixed fat formulations, such as 30% melting beef tallow, 10% melting lard, 40% of bone oil and 20% of cottonseed oil.
In the mixed fatty acid obtained through refinement and hydrolysis of oil fat, the difference of the melting point between the saturated and unsaturated acid is large. 
The yield of stearic acid and oleic acid depends mainly on the oil ester formula. 

Under normal circumstances, cold compressing can give 30-50% oleic acid and 50-70% stearic acid. 
Put the animal and vegetable oils and emulsions to hydrolysis at 105 ℃; remove the stearic acid after one step of compressing. 
Separate out the crude WILFARIN OA-7070 and conduct dehydration, distillation and freezing; then conduct the second time compressing to remove palmitic acid, and finally obtain the finished product through refinement and dehydration.
This method can be applied for co-production of stearic acid. 
For the same logic, use WILFARIN OA-7070 for production of stearic acid will also produce oleic acid. 
Fixed consumption amount of raw materials: animal and vegetable oils and fats: 1950 kg/t, sulfuric acid (98%) 210kg/t.
Use oil fat containing a certain amount of WILFARIN OA-7070 as raw materials, for example, tallow, lard, palm oil and hydrolyze out the fatty acids. 
Use solvent to dissolve fatty acids and cool WILFARIN OA-7070 to remove solid fatty acids and obtain the crude oleic acid. 
Then further dissolve WILFARIN OA-7070 in the solvent, cooling at low temperature to crystallize the oleic acid out.

Synonyms
oleic acid
112-80-1
cis-9-Octadecenoic acid
oleate
(Z)-Octadec-9-enoic acid
Elaidoic acid
cis-Oleic acid
Wecoline OO
Vopcolene 27
Glycon wo
Pamolyn 100
Glycon RO
Metaupon
Oelsauere
Groco 5l
Groco 2
Groco 4
Groco 6
Tego-oleic 130
Emersol 211
9Z-Octadecenoic acid
cis-Octadec-9-enoic acid
Industrene 105
Industrene 205
Industrene 206
Pamolyn
Z-9-Octadecenoic acid
9-Octadecenoic acid (Z)-
Oleinic acid
Emersol 210
Emersol 213
9-Octadecenoic acid (9Z)-
L'Acide oleique
Century cd fatty acid
Emersol 6321
Extraolein 90
Oleine 7503
9-Octadecenoic acid, (Z)-
Emersol 205
Emersol 233LL
Hy-phi 105
Hy-phi 1088
Hy-phi 2066
Hy-phi 2088
Hy-phi 2102
Elaic acid
Priolene 6906
9-octadecenoic acid
White oleic acid
Wochem no. 320
(9Z)-octadec-9-enoic acid
Emersol 220 white oleic acid
FEMA No. 2815
Extra Oleic 80R
Extra Oleic 90
Extra Oleic 99
Extra Olein 80
Extra Olein 90R
Lunac O-CA
Lunac O-LL
Lunac O-P
neo-Fat 92-04
Priolene 6907
Priolene 6928
Priolene 6930
Priolene 6933
Elainic acid
Emersol 6313NF
cis-Oleate
delta9-cis-Oleic acid
(9Z)-Octadecenoic acid
FEMA Number 2815
D 100 (fatty acid)
Emersol 221 low titer white oleic acid
K 52
Oelsaeure
9-cis-Octadecenoic acid
HSDB 1240
Red oil
D 100
(9Z)-9-Octadecenoic acid
Oleic acid [NF]
9-octadecylenic acid
Emersol 233
OLEICACID
18:1Delta9cis
Priolene 6936
CHEBI:16196
NSC-9856
9,10-Octadecenoic acid
C18:1n-9
neo-Fat 90-04
.delta.9-cis-Oleic acid
9-(Z)-octadecenoic acid
(Z)-9-Octadecanoic acid
9-Octadecenoic acid, cis-
cis-.delta.9-Octadecenoate
2UMI9U37CP
CHEMBL8659
cis-.delta.9-Octadecenoic acid
cis-Delta(9)-octadecenoic acid
NSC9856
Oleic acid (NF)
Osteum
MFCD00064242
C18:1 n-9
FA 18:1
Octadec-9-enoic acid
NCGC00091119-02
18:1 n-9
C18:1
cis-9-octadecenoate
(9Z)- Octadecenoic acid
DSSTox_CID_5809
18:1(n-9)
Oleic acid, pure
DSSTox_RID_77930
DSSTox_GSID_25809
Oleic acid (natural)
Caswell No. 619
Wecoline OO (VAN)
Acide oleique [French]
Acide oleique
cis-delta9-octadecenoic acid
l'Acide oleique [French]
CAS-112-80-1
SMR000326739
CCRIS 682
NAA 35
Sulfurized oleic acid
Sulphurized oleic acid
Oleic acid, sulfurized
cis-delta(sup 9)-Octadecenoic acid
NSC 9856
EINECS 204-007-1
UNII-2UMI9U37CP
EPA Pesticide Chemical Code 031702
BRN 1726542
Distoline
Oleinate
oleaic acid
Rapinic acid
AI3-01291
1gni
1hms
1vyf
2lkk
Oleic acid Liquid
Lunac OA
Edenor ATiO5
Edenor FTiO5
Industrene 104
Z-9-Octadecenoate
EINECS 270-164-8
Oleic acid, p.a.
Emersol 213NF
Emersol 214NF
Pamolyn 125
Priolene 6900
9,10-Octadecenoate
9-Octadecenoic acid (Z)-, sulfurized
Oleic acid (8CI)
oleic acid extra pure
cis-Octadec-9-enoate
Pamolyn 100 FG
Pamolyn 100 FGK
9-(Z)-octadecenoate
Emersol 7021
9-Octadecenoic acid (9Z)-, sulfurized
(Z)-9-Octadecanoate
Emersol 6313 NF
Emersol 6333 NF
Oleic acid-9,10-t
(9Z)-9-Octadecenoate
z-octadeca-9-enoic acid
OLEIC ACID [II]
OLEIC ACID [MI]
OLEIC ACID [FCC]
Epitope ID:187036
OLEIC ACID [FHFI]
OLEIC ACID [HSDB]
OLEIC ACID [INCI]
Oleic acid, natural, FCC
Emersol 220 White Oleate
OLEIC ACID [VANDF]
Oleic acid, technical grade
SCHEMBL1138
Delta9-cis-Octadecenoic acid
OLEIC ACID [MART.]
WLN: QV8U9-C
OLEIC ACID [USP-RS]
OLEIC ACID [WHO-DD]
4-02-00-01641 (Beilstein Handbook Reference)
99148-48-8
MLS001056779
MLS002153498
MLS002454427
9-octadecenoic acid, (9Z)-
(9Z)-9-Octadecenoic acid #
GTPL1054
Oleic acid, analytical standard
DTXSID1025809
Oleic acid, >=93% (GC)
Oleic acid, >=99% (GC)
REGID_for_CID_445639
1g74
OLEIC ACID [EP MONOGRAPH]
HMS2234O13
HMS3649H21
HMS3885H18
Oleic acid, technical grade, 90%
HY-N1446
ZINC6845860
ENDOCINE COMPONENT OLEIC ACID
Tox21_111086
Tox21_201967
Tox21_303324
BDBM50150484
cis-9-Octadecenoic acid;Elainic acid
HSCI1_000362
LMFA01030002
s4707
9-Octadecenoic acid (9Z)- (9CI)
cis-9-Octadecenoic-9,10-3H2 acid
Emersol 221 Low Titer White Oleate
AKOS017343225
cis-.delta.(sup 9)-Octadecenoic acid
AT13415
CCG-267270
9-Octadecenoic-9,10-t2 acid, (Z)-
NCGC00091119-01
NCGC00091119-03
NCGC00257233-01
NCGC00259516-01
68412-07-7
AC-33767
AS-16066
BP-24023
FA(18:1(9Z))
Oleic acid, SAJ first grade, >=70.0%
Oleic acid, Selectophore(TM), >=99.0%
CS-0016886
O0011
O0180
C00712
D02315
EN300-306800
Oleic acid, from suet, natural, >=60% (GC)
AB00641912_08
9-Octadecenoic-9,10-t2 acid, (9Z)- (9CI)
A894525
Oleic acid, suitable for cell culture, BioReagent
Q207688
SR-01000780573
OLEIC ACID (CONSTITUENT OF SPIRULINA) [DSC]
SR-01000780573-6
9-Octadecenoic acid(Z)-,oxidized,sulfonated,sodium salts
F0001-0262
OLEIC ACID (CONSTITUENT OF FLAX SEED OIL) [DSC]
OLEIC ACID (CONSTITUENT OF SAW PALMETTO) [DSC]
Oleic acid, certified reference material, TraceCERT(R)
Z2412194967
OLEIC ACID (CONSTITUENT OF BORAGE SEED OIL) [DSC]
Oleic acid, European Pharmacopoeia (EP) Reference Standard
459CE4C0-C836-4249-8E2D-69874B714E9C
OLEIC ACID (C18:1) (CONSTITUENT OF KRILL OIL) [DSC]
OLEIC ACID (CONSTITUENT OF EVENING PRIMROSE OIL) [DSC]
Oleic acid, United States Pharmacopeia (USP) Reference Standard
Oleic acid, meets analytical specification of Ph, Eur., 65.0-88.0% (GC)
Oleic Acid, Pharmaceutical Secondary Standard; Certified Reference Material
Oleic Acid-Water Soluble, powder, BioReagent, suitable for cell culture
Oleic acid, PharmaGrade, Manufactured under appropriate controls for use as raw material in pharma or biopharmaceutical production.