KSANTANOVAYA kamed'

KSANTANOVAYA kamed'

CAS: 11138-66-2

Ksantanovaya kamed' - eto polisakharid, kotoryy shiroko ispol'zuyetsya v promyshlennosti, v tom chisle kak obychnaya pishchevaya dobavka. Eto effektivnyy zagustitel' i stabilizator, predotvrashchayushchiy rassloyeniye ingrediyentov. Yego mozhno proizvodit' iz prostykh sakharov s pomoshch'yu protsessa fermentatsii, i on poluchil svoye nazvaniye ot vida ispol'zuyemykh bakteriy - Xanthomonas campestris.

SINONIMY: KSANTANOVAYA kamed; GUM XANTHAN; GLUCOMANNAN; GLUCOMANNAN MAYO; GALACTOMANNANE; XANTHANGUM,FCC; XANTHANGUM,NF; XANTHATEGUM; Xanthan Gummi; GLUCOMANNAN; GLUCOMANNAN MAYO; GALACTOMANNANE; RHODOPOL 23; XANTHAN; Corn sugar gum; E415; XC Polymer; Xanthomonas campestris; Kelzan; Goma Xantana; gomma; Gomme de Sucre de Maïs; Corn sugar gum; xantan gan; xanthan gum; ksantangam; gam; ksantan gam; xantan gum; xhanthan gum; Xanthan; Xanthan gum; Corn sugar gum; Xanthan; Xanthan gum; Xanthan gum [NF]; Corn Sugar Gum; Gummi Xanthanum; Xanthan Gum Oileld; Xanthan Gum Dispersible; Corn sugar gum; Xanthan; Gum xanthan; UNII-TTV12P4NEE; Xanthan-Gum; 11138-66-2 Xanthan gum; Xanthan gum from Xanthomonas campestris; Biozan R; xanthan; xanthan gum; 9H-Xanthene; XANTHENE; 92-83-1; Xanthan; 10H-9-Oxaanthracene; XANTHAN GUM; Dibenzo[a,e]pyran; NSC 46931; UNII-A762Z8101Y; Dibenzopyran, tricyclic;EINECS 202-194-4; BRN 0133939; AI3-01544; CHEBI:10057; GJCOSYZMQJWQCA-UHFFFAOYSA-N; SBB059332; A762Z8101Y; AK110825; 9H-xanthen; SMR000857210; Xanthane; 9h-xanthen-9-yl; Xanthene, 99%; XANTHAN GUMNF; XANTHANGUMNF; XANTHENE; xanthene; stabiliser, E415, thickenerXANTHAM; XANTHAN;Keltrol F;RHODOPOL 23;GLUCOMANNAN; GUM XANTHAN; XANTHAN GUM; XANTHATEGUM;XANTEMPO(TM); Xanthane gum; Gelatin Guar gum DEHYDROXANTHAN GUM Xanthan gum, acetate UNDECYLENOYL XANTHAN GUM HYDROXYPROPYL XANTHAN GUM XANTHAN GUM; 80 MESH PHARMA GRADE XANTHAN GUM; 80MESH; FOOD GRADE XANTHAN GUM FOOD GRADE XANTHAN GUM (INSTRUCTIONS XANTHAN GUM 200 MESH XANTHAN GUM; 200MESH; FOOD GRADE GUM XANTHAN GLUCOMANNAN GLUCOMANNAN MAYO GALACTOMANNANE; 11138-66-2 Carbohydrates RHODOPOL 23 Polysaccharide XANTHAN XANT; n; Xanthan gum; Corn sugar gum; Xanthan; Xanthan gum; Xanthan gum [NF]; Corn Sugar Gum; Gummi Xanthanum; Xanthan Gum Oileld; Xanthan Gum Dispersible; Corn sugar gum; Xanthan; Gum xanthan; UNIITTV12P4NEE; Xanthan-Gum

Nomer CAS: 11138-66-2
Khimicheskaya formula: C35H49O29 (monomer)
Molyarnaya massa: 933,748 g · mol' − 1.

Ksantanovaya kamed' byla otkryta Allen Rozalind Dzhins i yeye issledovatel'skoy gruppoy v Ministerstve sel'skogo khozyaystva SSHA i zapushchena v kommercheskoye proizvodstvo kompaniyey CP Kelco pod torgovoy markoy Kelzan v nachale 1960-kh godov. On byl odobren dlya ispol'zovaniya v pishchevykh produktakh v 1968 godu i prinyat v kachestve bezopasnoy pishchevoy dobavki v SSHA, Kanade, yevropeyskikh stranakh i mnogikh drugikh stranakh s nomerom E E415 i nomerom CAS 11138-66-2.
Ksantanovaya kamed' poluchila svoye nazvaniye ot vida bakteriy, ispol'zuyemykh v protsesse fermentatsii, Xanthomonas campestris. Eto ta zhe samaya bakteriya, kotoraya vyzyvayet obrazovaniye chernoy gnili na brokkoli, tsvetnoy kapuste i drugikh listovykh ovoshchakh.

ISPOL'ZOVANIYe

Ksantanovaya kamed', 1%, mozhet privesti k znachitel'nomu uvelicheniyu vyazkosti zhidkosti. V pishchevykh produktakh ksantanovaya kamed' chasto ispol'zuyetsya v zapravkakh i sousakh dlya salatov. On pomogayet predotvratit' otdeleniye masla za schet stabilizatsii emul'sii, khotya on ne yavlyayetsya emul'gatorom. Ksantanovaya kamed' takzhe pomogayet uderzhivat' tverdyye chastitsy, takiye kak spetsii. Ksantanovaya kamed' pomogayet sozdat' zhelayemuyu teksturu vo mnogikh morozhenykh. Zubnaya pasta chasto soderzhit ksantanovuyu kamed' v kachestve svyazuyushchego, chtoby produkt ostavalsya odnorodnym. Ksantanovaya kamed' takzhe pomogayet sgushchat' kommercheskiye zameniteli yaits iz yaichnykh belkov, zamenyaya zhir i emul'gatory, soderzhashchiyesya v zheltkakh. Eto takzhe predpochtitel'nyy metod zagushcheniya zhidkostey dlya lyudey s narusheniyami glotaniya, poskol'ku on ne menyayet tsvet ili vkus pishchi ili napitkov pri tipichnykh urovnyakh ispol'zovaniya. V vypechke bez glyutena ksantanovaya kamed' ispol'zuyetsya dlya pridaniya testu ili testu lipkosti, kotoraya v protivnom sluchaye byla by dostignuta s glyutenom. V bol'shinstve pishchevykh produktov on ispol'zuyetsya v kontsentratsii 0,5% ili men'she. Ksantanovaya kamed' ispol'zuyetsya v shirokom diapazone pishchevykh produktov, takikh kak sousy, zapravki, produkty iz myasa i ptitsy, khlebobulochnyye izdeliya, konditerskiye izdeliya, napitki, molochnyye produkty i drugiye.
V neftyanoy promyshlennosti ksantanovaya kamed' ispol'zuyetsya v bol'shikh kolichestvakh dlya zagushcheniya burovogo rastvora. Eti zhidkosti vynosyat tverdyye chastitsy, vyrezannyye burovym dolotom, na poverkhnost'. Ksantanovaya kamed' obespechivayet otlichnuyu reologiyu "nizkogo urovnya". Kogda tsirkulyatsiya prekrashchayetsya, tverdyye chastitsy ostayutsya vzveshennymi v burovom rastvore. Shirokoye rasprostraneniye gorizontal'nogo bureniya i potrebnost' v khoroshem kontrole vyburennoy porody priveli k yego rasshireniyu. Yego dobavlyayut v beton, zalivayemyy pod vodoy, dlya uvelicheniya yego vyazkosti i predotvrashcheniya vymyvaniya.
V kosmetike ksantanovaya kamed' ispol'zuyetsya dlya prigotovleniya vodnykh geley. On takzhe ispol'zuyetsya v emul'siyakh maslo-v-vode dlya usileniya slipaniya kapel'. Ksantanovaya kamed' nakhoditsya v stadii predvaritel'nykh issledovaniy na predmet yeye potentsial'nogo ispol'zovaniya v tkanevoy inzhenerii dlya sozdaniya gidrogeley i karkasov, podderzhivayushchikh formirovaniye trekhmernoy tkani.

Istoncheniye sdviga
Vyazkost' rastvorov ksantanovoy kamedi snizhayetsya s uvelicheniyem skorosti sdviga. Eto nazyvayetsya istoncheniyem pri sdvige ili psevdoplastichnost'yu. Eto oznachayet, chto produkt, podvergshiysya sdvigu pri smeshivanii, vstryakhivanii ili zhevanii, stanet zhidkim. Kogda sdvigayushchiye sily snimayutsya, pishcha snova stanovitsya gustoy. V zapravke dlya salatov dobavleniye ksantanovoy kamedi delayet yeye dostatochno gustoy v sostoyanii pokoya v butylke, chtoby smes' ostavalas' dostatochno odnorodnoy, no sily sdviga, voznikayushchiye pri vstryakhivanii i nalivanii, razzhizhayut yeye, poetomu yeye mozhno legko nalit'. Kogda on vykhodit iz butylki, sily sdviga snimayutsya, i on snova gusteyet, tak chto on prilipayet k salatu.
Ispol'zuyemyye summy
Chem bol'she dolya ksantanovoy kamedi, dobavlennoy k zhidkosti, tem gushche stanovitsya zhidkost'. Emul'siya mozhet byt' obrazovana s soderzhaniyem vsego 0,1% (po vesu). Uvelicheniye kolichestva kamedi dayet boleye gustuyu i stabil'nuyu emul'siyu s soderzhaniyem ksantanovoy kamedi do 1%. Chaynaya lozhka ksantanovoy kamedi vesit okolo 2,5 grammov i prinosit odnu chashku (250 ml) vody do kontsentratsii 1%.
Dlya polucheniya peny obychno ispol'zuyetsya 0,2–0,8% ksantanovoy kamedi. Chem bol'she kolichestvo, tem bol'she puzyr'ki i pena stanovitsya plotneye. Poroshok yaichnogo belka (0,2–2,0%) s 0,1–0,4% ksantanovoy kamedi dayet puzyri, pokhozhiye na myl'nyye puzyri.
Zdorov'ye
Otsenka rabochikh, podvergavshikhsya vozdeystviyu pyli ksantanovoy kamedi, pokazala nalichiye svyazi s respiratornymi simptomami.
20 maya 2011 goda FDA vypustilo press-reliz o SimplyThick, zagushchayushchey dobavke dlya pishchevykh produktov, soderzhashchey ksantanovuyu kamed' v kachestve aktivnogo ingrediyenta, preduprezhdaya roditeley, lits, osushchestvlyayushchikh ukhod, i meditsinskikh rabotnikov ne kormit' zagushchayushchim produktom SimplyThick nedonoshennym detyam. Bespokoystvo zaklyuchayetsya v tom, chto produkt mozhet vyzvat' u nedonoshennykh detey nekroticheskiy enterokolit.

Bezopasnost'
Soglasno obzoru bezopasnosti 2017 goda, provedennomu nauchnoy gruppoy Yevropeyskogo agentstva po bezopasnosti pishchevykh produktov (EFSA), ksantanovaya kamed' (yevropeyskaya pishchevaya dobavka nomer E 415) intensivno perevarivayetsya vo vremya kishechnoy fermentatsii i ne vyzyvayet pobochnykh effektov dazhe pri bol'shikh dozakh. Panel' EFSA ne vyyavila opaseniy po povodu genotoksichnosti pri dlitel'nom upotreblenii. EFSA prishlo k vyvodu, chto pri upotreblenii ksantanovoy kamedi v kachestve pishchevoy dobavki dlya naseleniya v tselom net nikakikh opaseniy po povodu bezopasnosti.
Podgotovka
Ksantanovaya kamed' proizvoditsya fermentatsiyey glyukozy i sakharozy. Polisakharid poluchayut putem inokulirovaniya bakteriy v steril'nyy vodnyy rastvor uglevodov, istochnika azota, dikaliyfosfata i nekotorykh mikroelementov. Sreda khorosho aeriruyetsya i peremeshivayetsya, a ksantanovyy polimer vydelyayetsya v sredu vnekletochno. Cherez odin-chetyre dnya polimer osazhdayut iz sredy dobavleniyem izopropilovogo spirta, i osadok sushat i izmel'chayut s polucheniyem poroshka, kotoryy legko rastvorim v vode ili rassole.
On sostoit iz povtoryayushchikhsya zven'yev pentasakharida, vklyuchayushchikh glyukozu, mannozu i glyukuronovuyu kislotu v molyarnom sootnoshenii 2: 2: 1.
Byl razrabotan shtamm X. campestris, kotoryy budet rasti na laktoze, chto pozvolyayet ispol'zovat' yego dlya obrabotki syvorotki, otkhodov proizvodstva syra. Eto mozhet dat' 30 g / l ksantanovoy kamedi na kazhdyye 40 g / l poroshka syvorotki. Ksantanovaya kamed', poluchennaya iz syvorotki, obychno ispol'zuyetsya vo mnogikh kommercheskikh produktakh, takikh kak shampuni i zapravki dlya salatov.
Detal' biosinteza

Sintez proiskhodit iz glyukozy kak substrata dlya sinteza predshestvennikov sakharnykh nukleotidov UDP-glyukoza, UDP-glyukuronat i GDP-mannoza, kotoryye neobkhodimy dlya postroyeniya povtoryayushcheysya yedinitsy pentasakharida. Eto svyazyvayet sintez ksantana s metabolizmom uglevodov. Povtoryayushchiyesya yedinitsy obrazuyutsya na lipidnykh nositelyakh undekaprenilfosfata, kotoryye zakrepleny v tsitoplazmaticheskoy membrane.
Spetsificheskiye glikoziltransferazy posledovatel'no perenosyat sakharnyye fragmenty nukleotidnykh sakharnykh predshestvennikov ksantana na lipidnyye nositeli. Ostatki atsetila i piruvila dobavlyayutsya v kachestve neuglevodnykh ukrasheniy. Zrelyye povtoryayushchiyesya yedinitsy polimerizuyutsya i eksportiruyutsya sposobom, napominayushchim Wzy-zavisimyy mekhanizm sinteza polisakharidov Enterobacteriaceae. Produkty klastera gena kamedi upravlyayut sintezom, polimerizatsiyey i eksportom povtoryayushcheysya yedinitsy.

Khimicheskiye svoystva

vyazkost' 1% rastvora 1,200-1600 mPa · s

Khimicheskiye svoystva

Ksantanovaya kamed' predstavlyayet soboy sypuchiy tonkiy poroshok kremovogo ili belogo tsveta bez zapakha.

Ispol'zuyet

Ksantanovaya kamed' - eto kamed', poluchennaya putem mikrobnoy fermentatsii iz organizma xanthomonas campestris. on ochen' ustoychiv k izmeneniyu vyazkosti pri izmenenii temperatury, pH i kontsentratsii soli. on takzhe ochen' psevdoplastichen, chto privodit k snizheniyu vyazkosti s uvelicheniyem sdviga. on vzaimodeystvuyet sinergeticheski s guarovoy kamed'yu i kamed'yu tary, obespechivaya uvelicheniye vyazkosti, i s kamed'yu rozhkovogo dereva, obespechivaya uvelicheniye vyazkosti ili geleobrazovaniye. on ispol'zuyetsya v zapravkakh dlya salatov, sousakh, desertakh, vypechke i napitkakh v kontsentratsii 0,05–0,50%.

V produktakh pitaniya, farmatsevtike i kosmetike v kachestve stabilizatora i zagustitelya. Dlya kontrolya reologii v sistemakh na vodnoy osnove. V zhidkostyakh dlya bureniya i zakanchivaniya nefti i gaza.
Ksantanovaya kamed' (kamed' kukuruznogo krakhmala) pridayet tekstuliruyushchiy i zagushchayushchiy sostav. Eta zhevatel'naya rezinka proizvoditsya putem fermentatsii uglevodov i Xanthomonas campestris.

Metody proizvodstva

Ksantanovaya kamed' predstavlyayet soboy polisakharid, poluchennyy putem aerobnoy fermentatsii chistoy kul'tury uglevoda s pomoshch'yu Xanthomonas campestris. Zatem polisakharid ochishchayut putem vydeleniya propan-2-olom, sushat i izmel'chayut.

Farmatsevticheskoye primeneniye

Ksantanovaya kamed' shiroko ispol'zuyetsya v farmatsevticheskikh sostavakh dlya peroral'nogo i mestnogo primeneniya, kosmetike i pishchevykh produktakh v kachestve suspendiruyushchego i stabiliziruyushchego agenta. On takzhe ispol'zuyetsya v kachestve zagustitelya i emul'gatora. On netoksichen, sovmestim s bol'shinstvom drugikh farmatsevticheskikh ingrediyentov, obladayet khoroshey stabil'nost'yu i vyazkost'yu v shirokom diapazone pH i temperatur. Geli ksantanovoy kamedi demonstriruyut psevdoplasticheskiye svoystva, prichem razzhizheniye pri sdvige pryamo proportsional'no skorosti sdviga. Vyazkost' vozvrashchayetsya k norme srazu posle snyatiya napryazheniya sdviga.
Ksantanovaya kamed' ispol'zovalas' v kachestve suspendiruyushchego agenta dlya obychnykh sukhikh suspenziy s zamedlennym vysvobozhdeniyem. Kogda ksantanovaya kamed' smeshivayetsya s nekotorymi neorganicheskimi suspendiruyushchimi agentami, takimi kak silikat magniya i alyuminiya, ili organicheskiye kamedi, voznikayut sinergeticheskiye reologicheskiye effekty. Kak pravilo, smesi ksantanovoy kamedi i silikata magniya-alyuminiya v sootnoshenii ot 1: 2 do 1: 9 obespechivayut optimal'nyye svoystva. Tochno tak zhe optimal'nyye sinergicheskiye effekty dostigayutsya pri sootnoshenii ksantanovaya kamed': guarovaya kamed' ot 3: 7 do 1: 9.

Khotya ksantanovaya kamed' v osnovnom ispol'zuyetsya v kachestve suspendiruyushchego agenta, yeye takzhe ispol'zovali dlya prigotovleniya matrichnykh tabletok s zamedlennym vysvobozhdeniyem. Tabletki s kontroliruyemym vysvobozhdeniyem diltiazema gidrokhlorida, poluchennyye s ispol'zovaniyem ksantanovoy kamedi, kak soobshchalos', podderzhivayut vysvobozhdeniye lekarstvennogo sredstva predskazuyemym obrazom, i profili vysvobozhdeniya lekarstvennogo sredstva etikh tabletok ne zavisyat ot pH i skorosti peremeshivaniya. Ksantanovaya kamed' takzhe ispol'zuyetsya dlya proizvodstva neposredstvenno pressovannykh matrits, kotoryye demonstriruyut vysokuyu stepen' nabukhaniya iz-za pogloshcheniya vody i nebol'shuyu eroziyu iz-za relaksatsii polimera. Yego takzhe ispol'zovali v kombinatsii s khitozanom, guarovoy kamed'yu, galaktomannanom i al'ginatom natriya dlya prigotovleniya matrichnykh tabletok s zamedlennym vysvobozhdeniyem. Ksantanovaya kamed' ispol'zuyetsya v kachestve svyazuyushchego, a v kombinatsii s glyukomannanom Konzhak ispol'zuyetsya v kachestve vspomogatel'nogo veshchestva dlya kontroliruyemoy dostavki lekarstvennogo sredstva v tolstuyu kishku. Ksantanovaya kamed' s bosvelliyey (3: 1) i guarovaya kamed' (10: 20) prodemonstrirovali nailuchshiye profili vysvobozhdeniya dlya sistem 5-ftoruratsila s kompressionnym pokrytiyem dlya tolstoy kishki dlya lecheniya kolorektal'nogo raka. Ksantanovaya kamed' takzhe ispol'zovalas' s guarovoy kamed'yu dlya razrabotki plavayushchey sistemy dostavki lekarstv. Ona takzhe byla derivatizirovana do karboksimetilksantanovoy kamedi natriya i sshita ionami alyuminiya dlya polucheniya mikrochastits v kachestve nositelya dlya dostavki belka. Ksantanovaya kamed' vklyuchena v oftal'mologicheskuyu zhidkuyu lekarstvennuyu formu, kotoraya vzaimodeystvuyet s mutsinom, tem samym pomogaya prodlit' uderzhaniye lekarstvennoy formy v prekorneal'noy oblasti. Pri dobavlenii k zhidkim oftal'mologicheskim sredstvam ksantanovaya kamed' zaderzhivayet vysvobozhdeniye aktivnykh veshchestv, uvelichivaya terapevticheskuyu aktivnost' farmatsevticheskikh sostavov.
Ksantanovaya kamed' mozhet ispol'zovat'sya dlya povysheniya bioadgezivnoy sily v vaginal'nykh preparatakh. Ksantanovaya kamed' sama po sebe ili s karbopolom 974P ispol'zovalas' v kachestve mukoadgezivnogo napolnitelya s kontroliruyemym vysvobozhdeniyem dlya transbukkal'noy dostavki lekarstvennogo sredstva. Modifitsirovannyye ksantanovyye plenki ispol'zovali v kachestve matrichnoy sistemy dlya transdermal'noy dostavki atenolola. Ksantanovaya kamed' takzhe ispol'zovalas' v kachestve zheliruyushchego agenta dlya sostavov dlya mestnogo primeneniya, vklyuchayushchikh tverdyye lipidnyye nanochastitsy vitamina A ili mikroemul'siyu ibuprofena. Kombinirovannaya polimernaya sistema, sostoyashchaya iz ksantanovoy kamedi, karboksimetiltsellyulozy i polimera na osnove polivinilpirrolidona, byla ispol'zovana dlya oblegcheniya simptomov kserostomii. Ksantanovuyu kamed' takzhe mozhno ispol'zovat' v kachestve napolnitelya dlya protsessov raspylitel'noy sushki i sublimatsionnoy sushki dlya dostizheniya luchshikh rezul'tatov. On uspeshno ispol'zovalsya otdel'no ili v sochetanii s agarom dlya mikrobnykh kul'tural'nykh sred.

Ksantanovaya kamed' takzhe ispol'zuyetsya v kachestve gidrokolloida v pishchevoy promyshlennosti, a v kosmetike ona ispol'zuyetsya v kachestve zagustitelya v shampunyakh. Polifosfat s ksantovoy kamed'yu v bezalkogol'nykh napitkakh effektiven dlya umen'sheniya erozii emali.

Bezopasnost'

Ksantanovaya kamed' shiroko ispol'zuyetsya v farmatsevticheskikh sostavakh dlya peroral'nogo i mestnogo primeneniya, kosmetike i pishchevykh produktakh, i obychno schitayetsya netoksichnoy i ne vyzyvayushchey razdrazheniya kontsentratsiy, ispol'zuyemykh v kachestve farmatsevticheskogo napolnitelya.
Raschetnaya dopustimaya sutochnaya doza ksantanovoy kamedi ustanovlena VOZ na urovne do 10 mg / kg massy tela.
U krolikov ne nablyudalos' razdrazheniya glaz ili kozhi, a u morskikh svinok posle vozdeystviya na kozhu ne nablyudalos' kozhnoy allergii. Pri dlitel'nykh issledovaniyakh kormleniya krys (do 1000 mg / kg / den') i sobak (do 1000 mg / kg / den') pobochnykh effektov ne nablyudalos'. V issledovanii reproduktsii trekh pokoleniy na krysakh (do 500 mg / kg) pobochnykh effektov ne nablyudalos':> 45 g / kg
LD50 (mysh', peroral'no):> 1 g / kg
LD50 (mysh', IP):> 50 mg / kg
LD50 (mysh', v / v): 100–250 mg / kg.

Ksantanovaya kamed' - stabil'nyy material. Vodnyye rastvory stabil'ny v shirokom diapazone pH (pH 3–12), khotya maksimal'nuyu stabil'nost' oni demonstriruyut pri pH 4–10 i temperaturakh 10–60 ° C. Na rastvory ksantanovoy kamedi s kontsentratsiyey meneye 1% mas. / Ob. Mogut otritsatel'no povliyat' boleye vysokiye temperatury, chem okruzhayushchiye: naprimer, vyazkost' snizhayetsya. Ksantanovaya kamed' obespechivayet takiye zhe zagushchayushchiye, stabiliziruyushchiye i suspendiruyushchiye svoystva pri dlitel'nom khranenii pri povyshennykh temperaturakh, chto i v usloviyakh okruzhayushchey sredy. Krome togo, on obespechivayet otlichnuyu stabil'nost' pri zamorazhivanii-ottaivanii. Rastvory takzhe stabil'ny v prisutstvii fermentov, soley, kislot i osnovaniy. Vanzan NF-ST spetsial'no razrabotan dlya ispol'zovaniya v sistemakh, soderzhashchikh vysokiye kontsentratsii soley, poskol'ku on rastvoryayetsya neposredstvenno v solevykh rastvorakh, a yego vyazkost' otnositel'no ne zavisit ot vysokogo soderzhaniya soli po sravneniyu s markami obshchego naznacheniya.

Sypuchiy material sleduyet khranit' v khorosho zakrytoy tare v prokhladnom sukhom meste.

Nesovmestimosti
Ksantanovaya kamed' yavlyayetsya anionnym materialom i obychno nesovmestima s kationnymi poverkhnostno-aktivnymi veshchestvami, polimerami ili konservantami, poskol'ku proiskhodit osazhdeniye. Anionnyye i amfoternyye poverkhnostno-aktivnyye veshchestva v kontsentratsiyakh vyshe 15% mas. / Ob. Vyzyvayut osazhdeniye ksantanovoy kamedi iz rastvora.
V sil'no shchelochnykh usloviyakh iony mnogovalentnykh metallov, takikh kak kal'tsiy, vyzyvayut geleobrazovaniye ili osazhdeniye; eto mozhet byt' ingibirovano dobavleniyem sekvestranta glyukogeptonata. Prisutstviye nizkikh urovney boratov (<300 ppm) takzhe mozhet vyzvat' geleobrazovaniye. Etogo mozhno izbezhat', uvelichiv kontsentratsiyu iona bora ili sniziv pH sostava do urovnya nizhe pH 5. Dobavleniye etilenglikolya, sorbita ili mannita takzhe mozhet predotvratit' eto geleobrazovaniye.
Ksantanovaya kamed' sovmestima s bol'shinstvom sinteticheskikh i prirodnykh agentov, povyshayushchikh vyazkost', so mnogimi sil'nymi mineral'nymi kislotami i do 30% neorganicheskikh soley. Yesli yego nuzhno kombinirovat' s proizvodnymi tsellyulozy, to sleduyet ispol'zovat' ksantanovuyu kamed', ne soderzhashchuyu tsellyulazy, dlya predotvrashcheniya depolimerizatsii proizvodnogo tsellyulozy. Rastvory ksantanovoy kamedi stabil'ny v prisutstvii do 60% smeshivayemykh s vodoy organicheskikh rastvoriteley, takikh kak atseton, metanol, etanol ili propan-2-ol. Odnako pri prevyshenii etoy kontsentratsii proiskhodit osazhdeniye ili geleobrazovaniye.
Vyazkost' rastvorov ksantanovoy kamedi znachitel'no uvelichivayetsya ili proiskhodit geleobrazovaniye v prisutstvii nekotorykh materialov, takikh kak tseratoniya, guarovaya kamed' i silikat magniya-alyuminiya. Etot effekt naiboleye vyrazhen v deionizirovannoy vode i umen'shayetsya v prisutstvii soli. Eto vzaimodeystviye mozhet byt' zhelatel'nym v nekotorykh sluchayakh i mozhet ispol'zovat'sya dlya umen'sheniya kolichestva ksantanovoy kamedi, ispol'zuyemoy v preparate.
Ksantanovaya kamed' nesovmestima s okislitelyami, nekotorymi plenochnymi pokrytiyami tabletok, natriyevoy karboksimetiltsellyulozoy, sukhim gelem gidroksida alyuminiya i nekotorymi aktivnymi ingrediyentami, takimi kak amitriptilin, tamoksifen i verapamil.,