ZINC GLUCONATE

ZINC GLUCONATE=Zincgluconate=Zinc gluconate hydrate=Gluconic Acid Zinc(II) Salt

CAS NUMBER:4468-02-4    
EC NUMBER:224-736-9
Molecular Weight:455.7
Molecular Formula:C12H22O14Zn

⯈ DEFINITION OF ZINC GLUCONATE:
Zinc gluconate is the zinc salt of gluconic acid.
Zinc gluconate is an ionic compound consisting of two anions of gluconate for each zinc(II) cation.
Zinc gluconate is a popular form for the delivery of zinc as a dietary supplement providing 14.35% elemental zinc by weight.

In its pure form, Zinc gluconate is a white to off-white powder. 
Zinc gluconate can also be made by electrolytic oxidation, although this is a more expensive process. 
The advantages are a lower microbiological profile, and a more complete reaction, yielding a product with a longer shelf life.
Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA.

⯈ USES/BENEFITS OF ZINC GLUCONATE:
Zinc gluconate helps in strengthening body’s immune system and supporting enzymatic functions.
Zinc gluconate has contributory role in maintaining healthy functioning of the prostate and eyes.
Zinc gluconate is beneficial for the development of healthy skin, hair, nails.
Zinc gluconate plays an important role in maintaining normal taste and good eyesight.
Zinc stimulates collagen synthesis in the bone tissue and aids in bone formation speedily.
Zinc gluconate Also boosts cell growth and DNA formation in the body.
Zinc gluconate is an ingredient found in a variety of supplements and vitamins
Gluconate acts as an astringent and seboregulator agent.
Zinc gluconate is a substance that acts as anti-aging by stimulating the renewal of the collagen matrix. 
Zinc gluconate provides immunomodulation, DNA protection and calming effect.
In addition, Zinc gluconate tightens the pores and offers an anti-porous effectiveness. 
Zinc provides antiseptic properties, allows keratogenicity and is a cofactor of enzymes involved in the synthesis of nucleic acids and proteins
Zinc is an important mineral found in almost every cell in the human body. 
Zinc promotes the activity of about 100 enzymes.
Zinc deficiency is often associated with an increased risk of infection.
When zinc supplements are used to treat the common cold, zinc supplements may interfere with rhinovirus cleavage or adhesion and may play a role in protecting plasma membranes from microbial toxins and complement
Zinc supplementation has become a critical intervention for treating diarrheal episodes in children.
Studies suggest that administration of zinc along with new low osmolarity oral rehydration solutions/salts (oral rehydration solution), may reduce both the duration and severity of diarrheal episodes for up to 12 weeks
Zinc is vital for various aspects of health and has been associated with a diversity of benefits.

•Improves Immune Function
Many over-the-counter medications and natural remedies have zinc due to its ability to boost immune function and fight inflammation.
Zinc is also an antioxidant, helping reduce inflammation and protect against chronic conditions, like heart disease, cancer, and diabetes.
Your immune system is your body's first line of defense against disease and infection.
Zinc is an important micronutrient that is a key to several biological processes, including immune function.
Increased levels of zinc in the human body have proven effective in fighting pneumonia, diarrhea and infection.
•Promote Blood Sugar Control
Zinc is extremely well known for its role in blood sugar control and insulin secretion.
Insulin is the hormone mainly responsible for transporting sugar from your bloodstream to your tissues.
Some research suggests that zinc help keep blood sugar levels steady and improves your body’s sensitivity to insulin.
Zinc supplements are effective at enhancing both short-term and long-term blood sugar control in people with diabetes.
Research shows that zinc helps reduce insulin resistance, which can improve your body’s ability to use insulin efficiently to maintain normal blood sugar levels.
•May Improve Heart Health
Heart disease is a severe problem, accounting for approximately 33% of deaths worldwide. 
Zinc improves several risk factors for heart disease and even lower triglyceride and cholesterol levels. 
Research suggests that low levels of serum zinc may be associated with a higher risk of coronary heart disease. 
Therefore it is a wise choice to include zinc in your daily diet for better health.
•Slows Macular Degeneration
Macular degeneration is a prevalent eye disease and one of the main causes of vision loss around the globe. 
Zinc supplements are useful to slow the progression of age-related macular degeneration (AMD) and help protect against vision loss and blindness.

shortly,
•Immunity Booster
•Skin Support
•Nutrient 
•Dietary Ingredient

Category: Food & Beverage
Mechanism of action
Although the mechanism of action is not completely known, zinc supplementation may be used to increase immunity against viruses or may interfere with the replication of certain viruses, such as the human papillomavirus (HPV)

⯈APPLICATIONS OF ZINC GLUCONATE:
Zinc gluconate is used as a source of zinc; it is permitted for use in fortified foods (as per Regulation 1925/2006), in food supplements (as per Directive 2002/46/EC), in processed cereal-based foods and baby foods for infants and young children (as per Directive 2006/125/EC, Regulation 609/2013) and total diet replacements for weight control (Regulation 609/2013 (replacing regulation 953/2009)).
Zinc gluconate is derived from gluconic ccid and zinc oxide and is suitable for vegans and vegetarians.
Zinc gluconate is most commonly used in zinc lozenges due to zinc’s role in immune health. 
Zinc gluconate is soluble in water but practically insoluble in anhydrous ethanol and in methylene chloride. 
Zinc gluconate is granular, making it suitable for tablet applications.
Zinc is a mineral that is used as a dietary supplement in people who do not get enough zinc from food.
Zinc gluconate lozenges are used to help make cold symptoms less severe or shorter in duration.
This includes sore throat, cough, sneezing, stuffy nose, and a hoarse voice.
Zinc gluconate is not effective in treating flu or allergy symptoms.
Zinc gluconate has been used in lozenges for treating the common cold.
However, controlled trials with lozenges which include zinc acetate have found it has the greatest effect on the duration of colds.
Zinc has also been administered nasally for treating the common cold, but has been reported to cause anosmia in some cases.
A zinc gluconate-based product, also containing arginine, is used as a veterinary chemical castration drug.
For dogs, the product is injected directly into the testicles.
Zinc gluconate has been sold under various brand names, including Neutersol and Esterilsol.
Zinc gluconate  is a good nutrition fortifier, can improve human immunity, improve taste and appetite, and can improve sexual function.
It has obvious promoting effect on the growth and development of infants and adolescents, and is one of the indispensable trace elements in the human body.
Zinc Gluconate can be used as a dietary ingredient and as a nutrient.
Zinc is an important antioxidant nutrient. 
Zinc is necessary for protein synthesis, wound healing, for blood stability, normal tissue function, and aids in the digestion and metabolism of phosphorus. 
Zinc also governs the contractility of muscles and maintains the body’s alkaline balance
Zinc is also found in the formulation of anti-acne preparations and cosmetic products.

In cosmetics and personal care products, gluconic acid and its derivatives can be used in the formulation of mouth rinses, bath products, cleaning products, skin care products and shampoo
Destined to elaborate:
• Anti-acne products
• Anti-aging products
• Astringent products
• Softening products
• Skin soothing products
• Protective products of the dermis

⯈ SAFETY MEASURES:
•First aid measures:
First-aid measures after inhalation : Remove person to fresh air and keep comfortable for breathing.
First-aid measures after skin contact : Wash skin with plenty of water.
First-aid measures after eye contact : Rinse eyes with water as a precaution.
First-aid measures after ingestion : Call a poison center/doctor/physician if you feel unwell.

•Firefighting Measures:
Suitable extinguishing media : Water spray. Dry powder. Foam.
Firefighting instructions : Contain the extinguishing fluids by bunding.
Protection during firefighting : Do not attempt to take action without suitable protective equipment. Self-contained breathing
apparatus. Complete protective clothing.
Fire hazard : Combustible.
Reactivity : Thermal decomposition generates toxic vapors. Carbon oxides (CO, CO2). Zinc oxide

•Handling and storage:
Technical measures : Comply with applicable regulations. Take all necessary measures to avoid accidental discharge
of products into drains and waterways due to the rupture of containers or transfer systems.
Storage conditions : Store in a clean, dry warehouse in the original unopened containers. Store in a well-ventilated
place. Keep cool.
Storage temperature : Typical warehouse conditions are sufficient to safeguard this product.
Packaging materials : plastics. polyethylene.
Conservation: In tightly closed containers. PROTECT FROM LIGHT AND MOISTURE

⯈ PHYSICAL PROPERTIES OF ZINC GLUCONATE:
Physical state : Solid
Appearance : Powder. Granules.
Color : White Off-white
Ignition temperature:>155 °C
Decomposition temperature : 165 °C
Melting Point:89.5 °C
pH value:6.5 (10 g/l, H₂O, 20 °C)
Solubility:7.5 g/l

⯈ SYNONYMS OF ZINC GLUCONATE:
Zinc gluconate 
Gluconic acid zinc salt 
bis(D-gluconato-O1,O2)zinc
Zincgluconate
Zinc gluconate hydrate
Gluconic Acid Zinc(II) Salt

⯈ ADDITIONAL INFORMATION ON ZINC GLUCONATE:
•Different zinc supplements will have different doses. Zinc supplements can contain several forms of zinc, including:
-zinc sulfate
-zinc acetate
-zinc gluconate

•What should I avoid while taking zinc gluconate?
Avoid taking too much zinc with foods that are high in calcium or phosphorus. It can make it harder for your body to absorb zinc gluconate. Foods high in calcium or phosphorus include milk, cheese, yogurt, ice cream, dried beans or peas, lentils, nuts, peanut butter, beer, cola soft drinks, and hot cocoa.

•How should I take zinc gluconate?
Use exactly as directed on the label, or as prescribed by your doctor.
Take a zinc gluconate tablet with food if it upsets your stomach.
The recommended daily dose of zinc gluconate changes with age.
Follow your healthcare provider's instructions. 
You may also consult the Office of Dietary Supplements of the NIH, or the USDA Nutrient Database of recommended daily allowances for more information.
Do not swallow a zinc gluconate lozenge whole.
Allow it to dissolve in your mouth completely.
Do not use more than 6 lozenges per day (or 4 per day for anyone 12 to 18 years old).
Start taking zinc lozenges as soon as possible after cold symptoms appear.
Call your doctor if your cold symptoms do not improve after 7 days.
Store at room temperature away from moisture and heat.
Throw away any lozenges not used within 6 months after opening.

•What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.
Do not take two doses at one time.

•What should I avoid while taking zinc gluconate?
Avoid eating or drinking anything for 15 minutes after dissolving a zinc gluconate lozenge in your mouth.

•What other drugs will affect zinc gluconate?
Ask a doctor or pharmacist before using zinc gluconate with any other medications, especially:
-an antibiotic; or
-a blood thinner (warfarin, Coumadin, Jantoven).