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Zinc Pyrithione 48% aqueous dispersion also inhibits the growth of fungi, yeast, mold, and algae.
Zinc Pyrithione 48% aqueous dispersion should be noted, however, that the effectiveness of these shampoos is much smaller than these containing tars, corticosteroids or keratolytics.
Zinc Pyrithione 48% aqueous dispersion is very rapidly transformed by photolysis.
CAS Number: 13463-41-7
Molecular Formula: C10H8N2O2S2Zn
Molecular Weight: 317.7
EINECS Number: 236-671-3
Synonyms: Zinc pyrithione, 13463-41-7, DTXSID7026314, DTXCID90820451, Bis((1-oxidopyridin-2-yl)thio)zinc, zinc;1-oxidopyridin-1-ium-2-thiolate, NCGC00091933-01, NCGC00183121-01, Zinc pt, Zinci pyrithionum, Finecide ZPT, Hokucide ZPT, Niccanon SKT, Biocut ZP, zinc bis(2-thioxopyridin-1(2H)-olate), 1698050-37-1, Tomicide Z 50, Tomicide ZPT 50, CAS-13463-41-7, Evafine P 50, Caswell No. 923, Zinc Pyrithione Powder, BC-J, biokera, shampoo, bis(N-oxopyridine-2-thionato)zinc (II), Balancing, Chevance, Dandrene, Elementz, Medaclear, Treatment, Vanicream, Zincopan, Zolidyne, classic control, LuckyClassic, pyrthione zinc, DermaZinc, Zinc 2-pyridinethiol-1-oxide, Bioxsine Series, Dandruff Detox, Everyday Clean, Pyrithion-Zink, Pyrithionr Zinc, Pyrithions Zinc, Pyritione Zinc, Royal Dandruff, Zinc-pyrion, American Crew, CCRIS 4894, Classic Clean, Zinc Therapy, HairQ, Zinc soap, Zn-pyrion, Clean Apple, CyzoneBe Sexy, Four Season, Happy Cappy, Head Remedy, Itchy Scalp, LuckyDry Hair, Pyrithizone Zinc, Zinc pyridine-2-thiol 1-oxide, Shiny and Sleek, Dry Scalp, Free and Clear, Blue Cap, Crawford Dandruff, HSDB 4498, Vanicream Z-Bar, Zinc 1-hydroxy-2-pyridinethione, Blue Cap Cream, Dry Scalp Care, Smooth and glossy, Zinc bis(2-pyridylthio)-N-oxide, Bis(2-pyridinethiol-1-oxide)zinc, pyrithione (base), Piritionato cincico, LIFECELL Womens, Dry Scalp Dandruff, Lucky2in1 Classic, FSB 8332, Pyrithionum zincicum, EpochAva Puhi Moni, 2 in 1 Dandruff, 2-Pyridinethiol-1-oxide, zinc salt, Antidandruff Shampoo, Dandruff 2 in 1, EINECS 236-671-3, EquateEveryday Clean, Fresh Mint Dandruff, LIFECELL Mens, Vegetability Natural, 2-Mercaptopyridine 1-oxide zinc salt, 2-mercaptopyridine-1-oxide zinc salt, HEAD AND SHOULDERS CONDITIONER, Aloe Coal 01, ANTIDANDRUFF, Divine Dandrene 1%, Divine Dandrene 2%, FRUITOPIA, HEBDANDRUFF, Pyrithione Zinc 1%, REVOX, SAFEWAYDANDRUFF, AxeFeeze AntiDandruff, GKhair Anti-Dandruff, MOJELIM Dr, Sulfur 8 Aqua Blue, WeCare Anti-Dandruff, Anti-Dandruff Shampoo, Bis(2-pyridylthio)zinc 1,1'-dioxide, Control Anti-Dandruff, EPA Pesticide Chemical Code 088002, LEudine Anti-dandruff, Nioxin Scalp Recovery, NSC 290409, Simply Clean Dandruff, AxeFreeze AntiDandruff, DAMOAE THERAPY, PYRITHIONE ZINE, SHIKATRI CLASS, Vancide ZP Dispersion, 2 in 1 Antidandruff, BALLVIC SEBO, REBIRTH HAIR, Pert Plus 2 in 1, pyrithione zinc shampoo, SELEX DNA, X FOLATE, AxeAntiDandruff Styling, Everyday Clean Dandruff, Satinique Anti Dandruff, dandruff therapy shampoo, Equaline DandruffRefresh, HAIRJOY MSM HAIR, Personal CAREDry Scalp, Shampoo plus Conditioner, Control Dandruff Therapy, Pert Plus Dandruff Plus, AffirmCare Scalp Therapy, AI3-62421, HEAD AND SHOULDER, MEDECEAN SEBORRHEA, DR. SCALP ACTIVE, modesa 2 in 1 dandruff, Shelo NABEL Anti Caspa, Apex Crown Anti Dandruff, Daylogic Refresh Dandruff, Dermaharmony Zinc Therapy, Royal Dandruff Dry Scalp, Sereve Professional Scalp, Zincon Medicated Dandruff, Head and Shoulders 2in1, MSM HAIR SIGNATURE, Personal CAREDaily Clean, ZENOTRI Scalp Shampoo, Balmers Cooling Zone 31, Pyrithione Zinc 0.22%, Dermaharmony Tea Tree Bar, Dermaharmony Unscented Bar, Equate Dry Scalp Dandruff, Aloe Coal 02 Conditioner, BYE-BYE CRADLE CAP, CVS PHARMACYDANDRUFF, DG BODYSIMPLY CLEAN, Natural 17 Anti-Dandruff, P.O.V. Classic Dandruff, SAFEWAY CAREDANDRUFF, URBAN WASH DANDRUFF, Dermaharmony Face and Body, Dry Scalp CareDandruff MD, Head and Shoulders Coconut, Daylogic 2 in 1 Dandruff, Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)-, EQUALINECLASSIC CLEAN, ESIKAMen Effective Control, Head and Shoulders Grooming, Head and Shoulders Scalp X, MOISTURIZING DANDRUFF, OREAD BLUE Anti-Dandruff, SuaveMen 2 in 1 Dandruff, ZENOTRI Follicle Shampoo, Classic Control Antidandruff, 1-HYDROXY-2-PYRIDINE THIONE, ZN SALT;1-HYDROXYPYRIDINE-2-THIONE ZINC;Pyrithione zincique;Bis[(1-oxylatopyridinium)-2-ylthio] zinc;Bis[(1-oxylatopyridinium-2-yl)thio]zinc;Bis[[(pyridine 1-oxide)-2-yl]thio] zinc salt;Bis(2-pyridylthio) Zinc 1,1'-Dioxide 1-Hydroxypyridine-2-thione Zinc Salt 2-Pyridinethiol 1-Oxide Zinc Salt Zinc Pyrithione;zincpolyanemine
Zinc Pyrithione 48% aqueous dispersion is a regulator of keratinization, selenium sulfide has antimicrobial properties and ketoconazole is an antifungal agent (i.e.can provide the reduction of the lipophilic yeast Malassezia furfur).
Zinc Pyrithione 48% aqueous dispersion shampoos (in concentrations between 1 to 2%) and shampoos with selenium sulide have been reported to be effective in the treatment of scalp psoriasis.However,their efficacy has not been substantiated by controlled studies.
There is also some evidence that shampoos with antifungal agents (e.g.ketoconazole)can have a beneficial effect on scalp conditions.
Experiments conducted under sterile conditions with a light:dark cycle of 12:12 hours have shown that, under exposure to light, the concentration of [pyridine-2,6-14C]zinc pyrithione in pH 9 buffer was reduced to 33% of the radioactivity added in 15 min.
Data from this study also demonstrated that less than 5% of the 14C added occurred as Zinc Pyrithione 48% aqueous dispersion after 1 hour of exposure to light.
Similar results have been achieved when photolysis of Zinc Pyrithione 48% aqueous dispersion was investigated by use of artificial seawater.
In this study, the parent compound constituted 45% of the radioactivity added after 15 min while, after 24 hours, 1.3% of the added dose occurred as zinc pyrithione.
The estimated half-lives of the photolytic transformation of Zinc Pyrithione 48% aqueous dispersion was 13 min in pH 9 buffer and 17.5 min in artificial seawater.
Zinc Pyrithione 48% aqueous dispersion is a coordination complex of zinc and pyrithione that has antimicrobial and anticancer activities.
Zinc Pyrithione 48% is active against the bacteria E. coli, S. aureus, K. pneumoniae, A. baumannii, P. aeruginosa, E. faecium, E. faecalis, and E. cloacae (MICs = 1-4 μg/ml) and the fungus P. ovale when used at concentrations ranging from 0.01 to 10 μg/ml.
Zinc Pyrithione 48% aqueous dispersion reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 1 mg/kg per week for six weeks.
Formulations containing Zinc Pyrithione 48% aqueous dispersion have been used in the treatment of dandruff.
Zinc Pyrithione 48% aqueous dispersion is the most popular anti-dandruff ingredient in the world, offering bactericide-fungicide efficacy in shampoos, conditioners and leave-on products.
Zinc Pyrithione 48% aqueous dispersion products have been providing dandruff relief and improved scalp health for over 50 years.
Zinc Pyrithione 48% aqueous dispersion is a mixture of ultra-fine particles of zinc pyrithione (ZPT), a dispersant and a stabilizing agent.
Zinc Pyrithione 48% aqueous dispersion is an effective inhibitor of microbe growth including algal, fungal (molds & yeasts) and bacterial (gram-positive & gram-negative).
Zinc Pyrithione 48% aqueous dispersion is an off-white 48% aqueous dispersion.
It is a mixture in water of very fine particles of zinc pyrithione, a dispersant, and a viscosity control agent.
Zinc Pyrithione 48% aqueous dispersion Antimicrobial inhibits the growth of a broad spectrum of both Gram-positive and Gram-negative bacteria.
Zinc Pyrithione 48% aqueous dispersion slight characteristic odor, insoluble in water.
Zinc Pyrithione 48% aqueous dispersion react with cationic and non-ionic surfactants forming insoluble precipitate, unstable in the light and oxidizer, when at higher temperatures ,it is not stable to acids and bases .
Zinc Pyrithione 48% aqueous dispersion is not compatible with EDTA, non-ionic surfactants make it partially deactivated.
Zinc Pyrithione 48% aqueous dispersion acts as an anti-dandruff and odor-controlling agent.
Offers bactericide-fungicide efficacy.
Zinc Pyrithione 48% aqueous dispersion is used in skincare, shampoos, conditioners and leave-on products.
Zinc Pyrithione 48% aqueous dispersion is the pyrithione complexes of zinc bromide, in the early 1930s, was already synthesized and used as a topical antifungal or antibacterial agent.
At room temperature it is white to yellow crystalline powder.
When with the presence of heavy metals, chelation or anti-sequestration will occur, and these chelates are insoluble in water.
Zinc Pyrithione 48% aqueous dispersion provide that maximum allowable concentration of mass fraction of zinc pyrithione on cosmetics is 0.5%, only for cleaning after using products.
General concentration 250~1000mg/kg (active), Zinc Pyrithione 48% aqueous dispersion can be used in gels, creams, lotions, talcum powder and anti-dandruff shampoo, deodorant and also for disinfecting articles.
Zinc Pyrithione 48% aqueous dispersion is a water-based suspension containing 48% Zinc Pyrithione (ZPT), an antimicrobial and antifungal agent commonly used in personal care products, industrial applications, and coatings.
This dispersion allows for easier formulation and incorporation into shampoos, paints, and other products where even distribution of the active ingredient is necessary.
Zinc Pyrithione 48% aqueous dispersion is widely recognized for its effectiveness in controlling dandruff, seborrheic dermatitis, and fungal infections, while also being utilized in paints and coatings to prevent mold, mildew, and bacterial growth on surfaces.
The aqueous dispersion ensures improved stability, enhanced solubility, and ease of handling compared to dry powder forms, making it a preferred choice for manufacturers in various industries.
Melting point: approximate 240℃
Density: 1.782 g/cm³ (Temp: 25°C)
Vapor pressure: 0 Pa at 25℃
Storage temp.: Sealed in dry, Room Temperature
Solubility: almost transparency in Pyridine
Form: Powder
Color: White to Orange to Green
Odor: Mild Characteristic
Water Solubility: Insoluble (<0.1 g/100 mL at 21 ºC)
Merck: 14,7994
InChI: InChI=1S/2C5H5NOS.Zn/c27-6-4-2-1-3-5(6)8;/h21-4,8H;/q;;+2/p-2
InChIKey: OTPSWLRZXRHDNX-UHFFFAOYSA-L
SMILES: C1(C=CC=C[N+]=1[O-])S[Zn]SC1C=CC=C[N+]=1[O-]
LogP: 0.9 at 25℃ and pH 7.5-7.7
Surface tension: 73 mN/m at 7.22 mg/L and 20℃
Zinc Pyrithione 48% aqueous dispersion is the most popular anti-dandruff ingredient in the world, offering bactericide-fungicide efficacy in shampoos, conditioners, and leave-on products.
Zinc Pyrithione 48% aqueous dispersion products have been providing dandruff relief and improved scalp health for over 50 years.
Zinc Pyrithione 48% aqueous dispersion highly effective bactericide-fungicide, the anti-dandruff agent establishes the market standard for any active ingredient solutions in anti-dandruff shampoos.
Its high antimicrobial efficacy combined with the acceptability for human use has made it the agent of choice for anti-dandruff shampoo manufacturers worldwide.
In addition, an important characteristic of this molecule is that it is efficacious against various bacteria species associated with producing odor on the skin.
Zinc Pyrithione 48% aqueous dispersion is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor.
Zinc Pyrithione 48% aqueous dispersion remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both.
It is substantive to the hair, allowing continued therapeutic effect after washing.
Zinc Pyrithione 48% aqueous dispersion is a specialized formulation in which Zinc Pyrithione, an antimicrobial and antifungal compound, is suspended in water at a concentration of 48%.
This dispersion is commonly used in a variety of industries, including personal care, coatings, textiles, and plastics, due to its broad-spectrum effectiveness against bacteria, fungi, and other microorganisms.
In the personal care industry, it is widely incorporated into anti-dandruff shampoos, conditioners, and skincare products to help combat conditions such as dandruff, seborrheic dermatitis, and other scalp disorders caused by fungal overgrowth.
Zinc Pyrithione 48% aqueous dispersions ability to inhibit microbial activity makes it a highly effective ingredient in maintaining scalp health and preventing flaking or irritation.
Beyond personal care applications, Zinc Pyrithione 48% aqueous dispersion is also utilized in industrial and material preservation processes.
Zinc Pyrithione 48% aqueous dispersion is frequently added to paints, coatings, and sealants to prevent the growth of mold, mildew, and algae, which can degrade surfaces and reduce longevity.
In the textile and polymer industries, it is used as an antimicrobial treatment for fabrics, plastics, and other synthetic materials to provide long-lasting protection against microbial contamination.
The aqueous dispersion form offers multiple advantages over powder forms, including improved ease of handling, better dispersion in liquid formulations, enhanced stability, and reduced dust-related safety concerns during manufacturing.
This highly effective antimicrobial agent works by disrupting the cellular processes of microorganisms, ultimately leading to their destruction.
Due to its versatility, Zinc Pyrithione in aqueous dispersion is an essential component in numerous formulations designed to enhance hygiene, prolong material durability, and provide effective antimicrobial protection across a wide range of consumer and industrial applications.
The toxicity of the active substance zinc pyrithione has been investigated in standard laboratory tests with a number of aquatic organisms living in fresh water (the green alga Selenastrum capricornutum, the crustacean Daphnia magna, the fish rainbow trout (Oncorhynchus mykiss) and fathead minnow (Pimephales promelas)) and in seawater (the crustacean Mysidopsis bahia, the fish sheepshead minnow (Cyprinodon variegatus) and the oyster.
Organometallics, such as Zinc Pyrithione 48% aqueous dispersion, are reactive with many other groups.
Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents.
Often reactive with water to generate toxic or flammable gases.
Flash point data for Zinc Pyrithione 48% aqueous dispersion are not available, but Zinc pyrithione is probably combustible.
Uses Of Zinc Pyrithione 48% aqueous dispersion:
Zinc Pyrithione 48% aqueous dispersion is widely utilized across various industries due to its potent antimicrobial, antifungal, and antibacterial properties, which make it highly effective in inhibiting the growth of harmful microorganisms such as bacteria, fungi, and algae.
In the personal care and cosmetic industry, this ingredient is a key component in the formulation of anti-dandruff shampoos, conditioners, scalp treatments, and skincare products, where it is specifically used to treat and prevent conditions such as dandruff, seborrheic dermatitis, and other fungal-related scalp disorders that cause itching, flaking, and irritation.
By effectively controlling the overgrowth of Malassezia, a yeast-like fungus that contributes to dandruff formation, Zinc Pyrithione helps maintain a healthier scalp environment while reducing discomfort and improving overall hair and scalp health.
In addition to its applications in personal care products, Zinc Pyrithione 48% aqueous dispersion is also extensively used in industrial and material preservation processes, where its antimicrobial properties play a crucial role in preventing the deterioration of various materials.
Zinc Pyrithione 48% is frequently incorporated into paints, coatings, and sealants to provide long-lasting protection against mold, mildew, algae, and other microbial growth that can degrade surfaces, reduce durability, and negatively impact aesthetics, particularly in humid and moisture-prone environments.
The ability of Zinc Pyrithione 48% aqueous dispersion to resist microbial contamination makes it an essential additive in the formulation of high-performance coatings used in construction, marine applications, and outdoor protective finishes.
Furthermore, in the textile and polymer industries, Zinc Pyrithione 48% aqueous dispersion is utilized as an antimicrobial treatment for fabrics, synthetic fibers, and plastic materials, helping to prevent odor development, bacterial growth, and fungal contamination in products such as sportswear, footwear, upholstery, and medical textiles.
By incorporating this ingredient into the manufacturing process, manufacturers can enhance the longevity and hygiene of their products, ensuring that textiles and polymers remain fresher, cleaner, and resistant to microbial degradation over time.
Zinc Pyrithione 48% aqueous dispersion is also commonly used in the formulation of adhesives, sealants, and elastomers, where its antimicrobial activity prevents microbial-induced damage, ensuring the longevity and integrity of the materials.
Additionally, it plays a crucial role in the preservation of aqueous-based formulations, including emulsions, suspensions, and dispersions used in industrial applications, where it helps extend product shelf life by preventing microbial spoilage and contamination.
Due to its broad-spectrum antimicrobial efficacy, versatility, and compatibility with various formulations, Zinc Pyrithione 48% aqueous dispersion is regarded as an essential ingredient in multiple industries that require effective microbial control, product preservation, and enhanced durability.
Whether used in personal care products, coatings, textiles, or industrial applications, this powerful antimicrobial agent continues to be a valuable solution for maintaining hygiene, preventing microbial-induced damage, and ensuring the long-term performance of diverse consumer and industrial products.
Shampoo for dandruff, Zinc Pyrithione 48% aqueous dispersion can inhibit Gram positive and negative bacteria and mold growth, Care hair Effectively , delay hair aging ,control white hair and hair loss generation.
Zinc Pyrithione 48% aqueous dispersion is also used as a cosmetic preservative, oil, paint biocide.
Zinc Pyrithione 48% aqueous dispersion has a strong killing power on fungi and bacteria so that it can effectively kill dandruff fungus, playing a role in dandruff.
Zinc Pyrithione 48% aqueous dispersion is a preservative against bacteria, fungi, and yeast.
It is unstable in light and in the presence of oxidizing agents.
Zinc Pyrithione 48% aqueous dispersion is useful in gels, creams, heavy lotions, and talcum powder.
Reactions may lead to photosensitive eczema and actinic reticuloid syndrome.
Zinc Pyrithione 48% aqueous dispersion is used as antifungal, antibacterial and antiseborrheic agent used in many shampoos and hair creams.
Zinc Pyrithione 48% aqueous dispersion is directly cytotoxic and has antimicrobial effects.
Zinc Pyrithione 48% aqueous dispersion is found in many shampoos (DHS-Zinc, Head and Shoulders) and should be applied for 5 minutes daily for 2 weeks.
Zinc Pyrithione 48% aqueous dispersion is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor.
It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both.
Zinc Pyrithione 48% aqueous dispersion is substantive to the hair, allowing continued therapeutic effect after washing.
Zinc Pyrithione 48% aqueous dispersion is widely used in antidandruff shampoos and is a classic allergen.
Concomitant reactions are expected to both zinc and sodium pyrithione.
Zinc Pyrithione 48% aqueous dispersion is used as an additive to protect paints (such as industrial and marine) against microbe (algal, fungal and bacterial) and crustacean growth.
It acts as a low metal fouling agent with long-lasting efficacy that does not induce galvanic corrosion making it suitable for metal hulls and marine environments.
It can be applied to some textiles to prevent microbe growth and used in cosmetics for a variety of skin related benefits including anti-dandruff properties.
Safety Profile Of Zinc Pyrithione 48% aqueous dispersion:
Direct contact with Zinc Pyrithione 48% aqueous dispersion can cause skin irritation, redness, and discomfort, especially for individuals with sensitive skin.
Prolonged or repeated exposure may lead to dermatitis.
If Zinc Pyrithione 48% aqueous dispersion comes into contact with the eyes, it can cause significant irritation, redness, and burning sensations, requiring immediate rinsing and medical attention.
Inhalation of Zinc Pyrithione 48% aqueous dispersion in mist or aerosol form can be harmful, potentially leading to respiratory irritation, coughing, shortness of breath, and discomfort.
Prolonged exposure to airborne particles in occupational settings, such as manufacturing facilities, may pose a greater risk of respiratory tract irritation.
Zinc Pyrithione 48% aqueous dispersion, while highly effective in antimicrobial applications, also presents certain hazards that need to be carefully considered in handling, usage, and disposal.
Due to its chemical composition and potential toxicity, exposure to this substance can pose risks to human health, the environment, and materials it comes into contact with.
Poison by ingestion, skin contact, intraperitoneal, and intravenous routes.
Moderately toxic by subcutaneous route an experimental teratogen.
Experimental reproductive effects an eye irritant when heated to decomposition it emits very toxic fumes of NOx, SOx, and ZnO.
Used as an anti- dandruff agent in shampoos.
