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Zinc Pyrithione (Antidandruff) has been used for more than 60 years as an anti-dandruff agent in cosmetic products.
Zinc Pyrithione (Antidandruff) can be used in anti-dandruff formulas and solve the problem of seborrheic skin
Zinc Pyrithione (Antidandruff) is used as an antifungal.
CAS Number: 13463-41-7
EC Number: 236-671-3
MDL Number: MFCD00067336
Chem/IUPAC Name: Pyridine-2-thiol-1-oxide, zinc complex (2:1)
Chemical formula: C10H8N2O2S2Zn
SYNONYMS:
Zinc pyrethion, Zinc pyridine-2-thiol 1-oxide, Zinc pyridinethione, Zinc-pyrion, Zinc pyrithione, Zinc pyrithione, Zinc 1-hydroxy-2-pyridinethione, Zinc 2-mercaptopyridine N-oxide, Zinc Omadine, Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)-, Zinc, bis(2-pyridinylthio)-, N,N'-dioxide, Zinc, bis(2-pyridylthio)-, N,N'-dioxide, Zinc, bis(2-pyridylthio)-, 1,1′-dioxide, Zincpolyanemine, Zn – pyrion, ZnPT, bis(2-pyridylthio)zinc 1,1'-dioxide, ZnP, Pyrithione Zinc, Zinc OMADINE, ZnPT, Zinc pyrithione, OM-1563, Zinc pyridine thioneone, de-squaman, N-HYDROXYPYRIDINETHIONE ZINC SALT, zincpolyanemine, bis(1-hydroxy-2-(1h)-pyridinethionato) zinc, Zinc Pyrithione, 48% Aqueous Dispersion, Zinc Pyrithione 48% Aqueous Dispersion, Zinc Pyritione 48%, Zinc Pyrithione, T/N: Zinc Omadine 48% FPS, Zinc Pyridinethione, Zinc Omadine, Pyrithione Zinc, OM-1563, Zinc pyridine thioneone, de-squaman, N-HYDROXYPYRIDINETHIONE ZINC SALT, zincpolyanemine, bis(1-hydroxy-2-(1h)-pyridinethionato) zinc, bis(2-pyridylthio)zinc 1,1'-dioxide, ZnP, Pyrithione Zinc, Zinc OMADINE, ZnPT, Zinc pyrithione, OM-1563, Zinc pyridine thioneone, de-squaman, N-HYDROXYPYRIDINETHIONE ZINC SALT, zincpolyanemine, bis(1-hydroxy-2-(1h)-pyridinethionato) zinc, Zinc pyrithione, OM-1563, DTXSID7026314, DTXCID90820451, Bis((1-oxidopyridin-2-yl)thio)zinc, zinc;1-oxidopyridin-1-ium-2-thiolate, NCGC00091933-01, NCGC00183121-01, Zinc pt, Zinci pyrithionum, Finecide ZPT, Hokucide ZPT, Niccanon SKT, Biocut ZP, zinc bis(2-thioxopyridin-1(2H)-olate), 1698050-37-1, Tomicide Z 50, Tomicide ZPT 50, CAS-13463-41-7, Evafine P 50, Caswell No. 923, Zinc Pyrithione Powder, BC-J, Zincopan, Zolidyne, pyrthione zinc, DermaZinc, Zinc 2-pyridinethiol-1-oxide, Zinc-pyrion, Zn-pyrion, Pyrithizone Zinc, Zinc pyridine-2-thiol 1-oxide, Zinc 1-hydroxy-2-pyridinethione, Zinc bis(2-pyridylthio)-N-oxide, Bis(2-pyridinethiol-1-oxide)zinc, pyrithione (base), Piritionato cincico, Pyrithione zincique, FSB 8332, 2-Pyridinethiol-1-oxide, zinc salt, Pyrithione Zinc 1%, Bis(2-pyridylthio)zinc 1,1'-dioxide, NSC 290409, bis(N-oxopyridine-2-thionato)zinc (II), AI3-62421, Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)-, UNII-R953O2RHZ5, (T-4)-Bis(1-hydroxy-2(1H)-pyridinethionato-O,S)zinc, D11AX12, bis(1-oxidopyridin-2-ylthio)zinc, BDBM429354, Tox21_111182, Tox21_113399, Tox21_202180, Tox21_303205, MFCD00067336, AKOS040732194, OM 1563, ZINC PYRIDINE-2-THIONE-N-OXIDE, NCGC00257089-01, NCGC00259729-01, 1ST10354, 2-PYRIDINETHIOL N-OXIDE ZINC SALT, BIS(2-PYRIDINETHIOL 1-OXIDE)ZINC, ZINC 1-HYDROXY-2-PYRIDINE-THIONE, Bis(1-hydroxy-2-(1H)-pyridinethionato)zinc, 1-HYDROXY-2-PYRIDINETHIONE, ZINC SALT, BIS(2-PYRIDYLTHIO)ZINC, N,N'-DIOXIDE, BIS(2-PYRIDYLTHIO)ZINC, 1,1'-DIOXIDE, EC 236-671-3, F16428, Q-201649, 3590-23-6, 2(1H)-Pyridinethione, 1-hydroxy-, zinc complex, 2-Mercaptopyridine 1-oxide zinc salt, 2-Pyridinethiol-1-oxide, zinc salt, AI3-62421, BC-J, Biocut ZP, Bis(1-hydroxy-2(1H)-pyridinethionato)zinc, Bis(2-pyridinethiol-1-oxide)zinc, Bis(2-pyridylthio)zinc 1,1′-dioxide, CCRIS 4894, Caswell No. 923, EINECS 236-671-3, EPA Pesticide Chemical Code 088002, Evafine P 50, FSB 8332, Finecide ZPT, HSDB 4498, Hokucide ZPT, NSC 290409, Niccanon SKT, OM-1563, Omadine Zinc, Tomicide Z 50, Tomicide ZPT 50, Top Brass, Vancide P, Vancide ZP, ZNP Bar, ZPT, Zinc PT,
Zinc Pyrithione (Antidandruff), or zinc pyrithione or zinc pyridinethione, is a coordination complex consisted of pyrithione ligands chelated to zinc (2+) ions via oxygen and sulfur centers.
In the crystalline state, Zinc Pyrithione (Antidandruff) exists as a centrosymmetric dimer.
Dandruff is a common scalp disease affecting >40% of the world's adult population, and may be caused by fungi such as Malassezia globosa and M. restricta 3.
Zinc Pyrithione (Antidandruff) is commonly found as an active ingredient in OTC antidandruff topical treatments such as shampoos.
Zinc Pyrithione (Antidandruff) mediates its action by increasing the cellular levels of copper, and damaging iron-sulfur clusters of proteins essential for fungal metabolism and growth
1. Due to low solubility, Zinc Pyrithione (Antidandruff) released from the topical formulations is deposited and retained relatively well onto the target skin surfaces
2. Other uses of Zinc Pyrithione (Antidandruff) include additive in antifouling outdoor paints and algaecide.
While its use has been approved in the early 1960's by the FDA, safety and effectiveness of Zinc Pyrithione (Antidandruff) has been reported for decades.
Zinc Pyrithione (Antidandruff) is not shown to have any significant estrogenic activity according to the in vivo and in vitro assays.
The chemical formula of Zinc Pyrithione (Antidandruff) is C10H8N2O2S2Zn.
Zinc Pyrithione (Antidandruff) is insoluble in water and insoluble in oil Mixing time in the formula Blend to distribute evenly throughout the recipe.
And the formula should have an appropriate level of viscosity.
Enough to keep the Zinc Pyrithione (Antidandruff) powder from precipitating.
Zinc Pyrithione (Antidandruff) is a white liquid
Zinc Pyrithione (Antidandruff) (or pyrithione zinc) is a coordination complex of zinc.
Zinc Pyrithione (Antidandruff) is one of the substances mainly concerned by this project.
Zinc Pyrithione (Antidandruff) is used as an antifungal.
USES and APPLICATIONS of ZINC PYRITHIONE (ANTIDANDRUFF):
Antidandruff Agent: Zinc Pyrithione (Antidandruff) is used in shampoos to combat dandruff and seborrheic dermatitis.
Antifungal & Antimicrobial: Effective against Malassezia species, which cause scalp conditions.
Preservative: Zinc Pyrithione (Antidandruff) is used in cosmetics and personal care products to prevent microbial growth.
Industrial Applications: Added to paints, textiles, and coatings to prevent fungal contamination.
As the name implies, Zinc Pyrithione (Antidandruff) is generated from the chemical element zinc and is utilized in several haircare and skincare products.
Due to its dynamic fungistatic and bacteriostatic properties, Zinc Pyrithione (Antidandruff) is used to treat dandruff and seborrheic dermatitis.
Zinc Pyrithione (Antidandruff), also known as Pyrithione Zinc, is an antibacterial, antimicrobial, and antifungal agent that can be used to treat dandruff, scalp psoriasis, and acne.
Zinc Pyrithione (Antidandruff) has been used for more than 60 years as an anti-dandruff agent in cosmetic products.
Zinc Pyrithione (Antidandruff) is a compound commonly used in cosmetics and personal care products for its antifungal and antibacterial properties.
Zinc Pyrithione (Antidandruff) is an active ingredient designed to treat dandruff, seborrheic dermatitis, and various fungal infections of the skin and scalp.
Zinc Pyrithione (Antidandruff) works by inhibiting the growth of fungi and bacteria that contribute to these conditions, helping to reduce flakiness, itching, and irritation.
Additionally, Zinc Pyrithione (Antidandruff) aids in controlling sebum production, contributing to a healthier scalp environment.
Zinc Pyrithione (Antidandruff) has fungistatic (inhibiting the division of fungal cells) and bacteriostatic (inhibiting bacterial cell division) properties and is used in the treatment of seborrhoeic dermatitis and dandruff.
Zinc Pyrithione (Antidandruff) can be used in anti-dandruff formulas and solve the problem of seborrheic skin
Zinc Pyrithione (Antidandruff) is used as an antifungal.
-In the cosmetic industry, zinc and its salts are used in a variety of categories.
One of the most widely used zinc salt is Zinc Pyrithione (Antidandruff).
Zinc Pyrithione (Antidandruff) is an aromatic zinc compound used as an antidandruff, antiseborrhoeic, hair conditioning agent and preservative in cosmetics and personal care products.
Zinc Pyrithione (Antidandruff) has been used for more than 60 years as an anti-dandruff agent at concentration up to 1-2%.
The key ingredients Zinc Pyrithione (Antidandruff), Salicylic Acid, Bentonite Clay, and Colloidal Oatmeal work synergistically to promote scalp health:
*Zinc Pyrithione (Antidandruff) & Colloidal Oatmeal help to relieve itchiness.
*Salicylic Acid removes the dry skin cells & reducing flakiness.
*Bentonite Clay helps to purify the scalp.
*Colloidal oatmeal helps to soothe scalp irritation.
ZINC PYRITHIONE (ANTIDANDRUFF) SHAMPOO:
Zinc Pyrithione (Antidandruff) shampoo is found in many common antidandruff shampoos.
Zinc Pyrithione (Antidandruff) is antifungal, antibacterial, and antimicrobial, meaning it can kill fungus, bacteria, and microorganisms that can contribute to an itchy, flaky scalp.
ZINC PYRITHIONE (ANTIDANDRUFF) CREAM:
Seborrheic dermatitis often affects the scalp, but it can also cause rough, scaly patches on the skin.
Zinc Pyrithione (Antidandruff) cream is used to treat seborrheic dermatitis or psoriasis on the body.
For the treatment of mild seborrheic dermatitis, the National Eczema Foundation suggests daily use of a cleanser that contains 2% Zinc Pyrithione (Antidandruff) followed by a moisturizer.
You can also use the cream daily by applying it in a thin layer to the affected area.
ZINC PYRITHIONE (ANTIDANDRUFF) FACE WASH:
Zinc Pyrithione (Antidandruff) face wash can help alleviate redness and itching associated with seborrheic dermatitis on the face.
Zinc Pyrithione (Antidandruff) can also help alleviate some of the greasiness associated with eczema and seborrheic dermatitis.
There’s some evidence that using a medicated soap that contains 2% Zinc Pyrithione (Antidandruff) may help clear acne.
MEDICINE USES OF ZINC PYRITHIONE (ANTIDANDRUFF):
Zinc Pyrithione (Antidandruff) can be used to treat dandruff and seborrhoeic dermatitis.
Zinc Pyrithione (Antidandruff) also has antibacterial properties and is effective against many pathogens from the Streptococcus and Staphylococcus genera.
Zinc Pyrithione (Antidandruff)'s other medical applications include treatments of psoriasis, eczema, ringworm, fungus, athletes foot, dry skin, atopic dermatitis, tinea versicolor, and vitiligo.
PAINT USES OF ZINC PYRITHIONE (ANTIDANDRUFF):
Because of its low solubility in water (8 ppm at neutral pH), Zinc Pyrithione (Antidandruff) is suitable for use in outdoor paints and other products that protect against mildew and algae.
Zinc Pyrithione (Antidandruff) is an algaecide.
Zinc Pyrithione (Antidandruff) is chemically incompatible with paints relying on metal carboxylate curing agents.
When Zinc Pyrithione (Antidandruff) is used in latex paints with water containing much iron, a sequestering agent that preferentially binds the iron ions is needed.
Zinc Pyrithione (Antidandruff) is decomposed by ultraviolet light slowly, providing years of protection in direct sunlight.
SPONGES OF ZINC PYRITHIONE (ANTIDANDRUFF):
Zinc Pyrithione (Antidandruff) is an antibacterial treatment for household sponges, as used by the 3M Corporation.
CLOTHING OF ZINC PYRITHIONE (ANTIDANDRUFF):
A process to apply Zinc Pyrithione (Antidandruff) to cotton with washable results was patented in the United States in 1984.
Zinc Pyrithione (Antidandruff) is used to prevent microbe growth in polyester.
Textiles with applied Zinc Pyrithione (Antidandruff) protect against odor-causing microorganisms.
Export of antimicrobial textiles reached US$497.4 million in 2015.
BENEFITS AND USES OF ZINC PYRITHIONE (ANTIDANDRUFF):
Zinc Pyrithione (Antidandruff) is highly effective, keeping in mind that it is gentle and mild on the skin.
Many anti-dandruff shampoos contain Zinc Pyrithione (Antidandruff).
Zinc Pyrithione (Antidandruff) is antifungal, antibacterial, and antimicrobial, which means it can fight fungus, bacteria, and germs that cause itchy, flaky skin on the scalp.
Zinc Pyrithione (Antidandruff) cream is used to treat psoriasis and seborrheic dermatitis also called dandruff.
Face washes containing Zinc Pyrithione (Antidandruff) can help relieve the redness and irritation caused by seborrheic dermatitis on the face.
Zinc Pyrithione (Antidandruff) can also assist with the greasiness that comes with eczema and seborrheic dermatitis.
HOW ZINC PYRITHIONE (ANTIDANDRUFF) WORKS:
Zinc Pyrithione (Antidandruff) works by inhibiting the growth of yeast, which is the main factor in dandruff.
Zinc Pyrithione (Antidandruff) works by supplying moisture to the skin and scalp, thereby hydrating them.
CONCENTRATION AND SOLUBILITY OF ZINC PYRITHIONE (ANTIDANDRUFF):
It is recommended that Zinc Pyrithione (Antidandruff) be used at a concentration of 0.5 to 1% for best results.
Zinc Pyrithione (Antidandruff) is soluble in water and alcohol but insoluble in volatile oils.
HOW TO USE OF ZINC PYRITHIONE (ANTIDANDRUFF):
Mix Zinc Pyrithione (Antidandruff) with water in the recommended concentration and stir until a homogeneous mixture is created.
Add Zinc Pyrithione (Antidandruff) other surfactants and enhancing ingredients like essential oils, depending on your product and need, and mix properly.
Add this mixture to the warm base of Zinc Pyrithione (Antidandruff) and stir until the desired thickness and texture are obtained.
WHAT IS ZINC PYRITHIONE (ANTIDANDRUFF) USED FOR?
Zinc Pyrithione (Antidandruff) is a beneficial compound owing to its antimicrobial properties and finds extensive application in personal care products and cosmetics.
Primarily utilized in cleansing formulations like shampoos and soap, this ingredient effectively targets dandruff, seborrheic dermatitis, and fungal skin infections by inhibiting the growth of fungi and bacteria responsible for these conditions.
Zinc Pyrithione (Antidandruff) also alleviates symptoms like itching, flaking, and redness on the scalp and skin.
Zinc Pyrithione (Antidandruff)’s ability to regulate microbial balance and control sebum production makes it an essential ingredient in products designed to promote scalp and skin health, offering consumers relief from common dermatological issues with proven efficacy.
ORIGIN OF ZINC PYRITHIONE (ANTIDANDRUFF):
Zinc Pyrithione (Antidandruff) is synthesized through a multistep chemical process.
Initially, 2-mercaptopyridine-N-oxide reacts with sodium hydroxide to form sodium pyrithione.
Zinc Pyrithione (Antidandruff) undergoes a double displacement reaction with zinc sulfate, yielding Zinc Pyrithione (Antidandruff) precipitate.
Zinc Pyrithione (Antidandruff) is then filtered, washed, and dried to obtain a fine powder.
WHAT DOES ZINC PYRITHIONE (ANTIDANDRUFF) DO IN A FORMULATION?
*Antidandruff
*Antimicrobial
*Hair conditioning
*Preservative
SAFETY PROFILE OF ZINC PYRITHIONE (ANTIDANDRUFF):
While generally safe for topical use, Zinc Pyrithione (Antidandruff) may cause mild side effects such as skin irritation, redness, or dryness, especially in individuals with sensitive skin.
Prolonged or excessive use can exacerbate these symptoms.
Additionally, some people may experience allergic reactions characterized by itching or swelling.
Zinc Pyrithione (Antidandruff) is advisable to perform a patch test before widespread application and discontinue use if adverse reactions occur.
ALTERNATIVES OF ZINC PYRITHIONE (ANTIDANDRUFF):
*KETOCONAZOLE,
*SELENIUM SULFIDE
MECHANISM OF ACTION OF ZINC PYRITHIONE (ANTIDANDRUFF):
*Antibacterial effect
Zinc Pyrithione (Antidandruff) is known to exhibit antibacterial activity by disrupting cell membrane integrity and essential metabolic functions in bacteria.
*Antifungal effect
Its antifungal effect is thought to derive from its ability to disrupt membrane transport by blocking the proton pump that energizes the transport mechanism.
A study from 2011 showed that antifungal effects of Zinc Pyrithione (Antidandruff) work by copper toxicity mechanism that targets critical iron–sulphur proteins.
STRUCTURE OF ZINC PYRITHIONE (ANTIDANDRUFF):
The pyrithione ligands, which are formally monoanions, are chelated to Zn2+ via oxygen and sulfur centers. In the crystalline state, Zinc Pyrithione (Antidandruff) exists as a centrosymmetric dimer (see figure), where each zinc is bonded to two sulfur and three oxygen centers.
In solution, however, the dimers dissociate via scission of one Zn-O bond.
Zinc Pyrithione (Antidandruff) was first described in the 1930s.
Pyrithione is the conjugate base derived from 2-mercaptopyridine-N-oxide (CAS# 1121-31-9), a derivative of pyridine-N-oxide.
BENEFITS OF ZINC PYRITHIONE (ANTIDANDRUFF):
*Zinc Pyrithione (Antidandruff) helps reduce scalp flaking and itching.
*Zinc Pyrithione (Antidandruff) provides long-lasting antimicrobial protection.
*Zinc Pyrithione (Antidandruff) is widely used in medicated shampoos, creams, and personal care formulations.
*Zinc Pyrithione (Antidandruff) extends the shelf life of various industrial and cosmetic products by preventing microbial growth.
DOSAGE OF ZINC PYRITHIONE (ANTIDANDRUFF):
Dosage recommendations of Zinc Pyrithione (Antidandruff) (Concentration that FDA, Thailand and Europe allow):
4% (=2% active) Rinse-off antidandruff hair care (dandruff treatment shampoo)
4% (=2% active) Rinse-off cleaning products (bath soap, bar or liquid, for treating septic derm)
1% (=0.5% active) Leave-on hair products that does not wash off, such as tonic)
0.5% (=0.25% active) Leave-on skin care (skin care cream product)
MIXING METHOD OF ZINC PYRITHIONE (ANTIDANDRUFF):
Mix Zinc Pyrithione (Antidandruff) in water or oil by blending at high speed to distribute evenly throughout the formula.
USAGE RATE OF ZINC PYRITHIONE (ANTIDANDRUFF):
Usage rate:
0.1-4% (Do not exceed 4% or equal to Active Zinc Pyrithione (Antidandruff) 2%.
SOLUBILITY OF ZINC PYRITHIONE (ANTIDANDRUFF):
Zinc Pyrithione (Antidandruff) cannot dissolve in water or oil. But it can be spread well in any product.
STORAGE OF ZINC PYRITHIONE (ANTIDANDRUFF):
Zinc Pyrithione (Antidandruff) can be stored at room temperature.
But close the bottle cap tightly.
Then completely protected from sunlight or heat.
Zinc Pyrithione (Antidandruff) has a minimum shelf life of 2 years.
TREAT OF DANDRUFF, ZINC PYRITHIONE (ANTIDANDRUFF):
There are so many ways to treat dandruff – but what makes Zinc Pyrithione (Antidandruff) the world’s number one anti-dandruff ingredient?
Dandruff treatment can take one of two approaches:
treat the symptoms – this is designed to address the visible symptoms like flakes or inflammation.
However, theunderlying cause of dandruff is still working away.
By tackling the cause you can achieve more completerelief and prevent the symptoms from reappearing, so Zinc Pyrithione (Antidandruff)’s a good long-term solution.
Meet the products that just treat the symptoms of dandruff
Those dandruff treatments that merely work on the symptoms include coal tar and salicylic acid.
In fact, in clinical testing these products are far less effective at treating flakes than 1% Zinc Pyrithione (Antidandruff) shampoos.
Easily the best way to treat dandruff and keep it away for good is to use an anti-dandruff shampoo with an active ingredient that tackles the root cause of dandruff.
That’s where Zinc Pyrithione (Antidandruff) comes in.
Zinc Pyrithione (Antidandruff) both removes and helps prevent the formation of scalp irritants, to keep your scalphealthy and comfortable.
With smaller particles, the dandruff-fighting active can:
*give longer lasting protection – because it’s smaller, it goes deeper into the pores, so it doesn’t rinse out and continues to protect you against dandruff long after the shower
*clean better – the small particles help to create more lather as you wash your hair
*leave your hair and scalp healthier – the particles spread more easily across the scalp and stay there for longer, giving your scalp the protection it needs and allowing your hair to grow from a healthier base
ZINC AND ZINC PYRITHIONE (ANTIDANDRUFF):
Zinc is a trace mineral, vital to the human body and all forms of life, having catalytic, structural and regulatory functions.
Nevertheless, high levels of dietary zinc can cause anemia, decreased absorption levels of copper and iron, and reduction of enzyme activities in several tissues.
In 2003, the Scientific Committee on Food (SCF) established a tolerable total uptake level (UL) of Zinc up to 25 mg.
In the cosmetic industry, Zinc and zinc salts are used in a variety of categories.
Cosmetic products might account for maximum 10% of the UL. One of the most widely used zinc salt is Zinc Pyrithione (Antidandruff).
Zinc Pyrithione (Antidandruff) is an aromatic zinc compound used as an antidandruff, antiseborrhoeic, hair conditioning agent and preservative in cosmetics and personal care products.
Zinc Pyrithione (Antidandruff) has been used for more than 60 years as an anti-dandruff agent in concentration up to 1-2%.
The U.S. Food and Drug Administration (FDA) allows the use of Zinc Pyrithione (Antidandruff) as an active ingredient in Over-The-Counter (OTC) dandruff and seborrheic dermatitis drug products.
Zinc Pyrithione (Antidandruff) liquid type (48-50% active) for eliminating dandruff. and solve skin problems that are sebderm ( sebderm or seborrheic dermatitis) due to its effectiveness in killing fungi and bacteria (antifungal, antimicrobial)
PHYSICAL and CHEMICAL PROPERTIES of ZINC PYRITHIONE (ANTIDANDRUFF):
Appearance：Aqueous Suspension of White or Creamy Color
Assay, %: 48.0～50.0
Zinc, % :9.3～11.3
pH: 6.5～8.0
Particle size: D90,μm≤0.5
Particle size: D100,μm ≤1.5
Heavy metals(as Pb),: ppm≤20
Aerobic Plate Count,: <100cfu/g
CAS No.: 13463-41-7
UN No.: 2811
Molecular Formula: C10H8N2O2S2Zn
InChIKeys: InChIKey=PICXIOQBANWBIZ-UHFFFAOYSA-N
Molecular Weight: 317.69300
Exact Mass: 315.93200
UN Number: 2811
DSSTox ID: DTXSID7026314
HScode: 2933399010
Product Name: Pyrithione zinc
CAS No.: 13463-41-7
PSA: 101.52000
XLogP3: 3.34050
Appearance: Off-white to tan powder
Density: 1.782 g/cm3 @ Temp: 25 °C
Melting Point: 240 °C (decomp)
Boiling Point: 253.8ºC at 760 mmHg
Flash Point: 107.3ºC
Water Solubility: H2O: insoluble
Storage Conditions: Keep in a cool, dry, dark location in a tightly sealed container or cylinder.
Vapor Pressure: 0.00275mmHg at 25°C
Air and Water Reactions: Insoluble in water.
Reactive Group: Salts, Basic
Reactivity Profile:
ZINC PYRITHIONE is a coordination compound where zinc is chelated
by oxygen and sulfur donor atoms on the pyrithione ligand.
It is a basic salt.
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information:
Surface tension: 73 mN/m at 20 °C
CAS No: 13463-41-7
Molecular Formula: C10H8N2O2S2Zn
Molecular Weight: 362.08
Appearance: White Powder
Boiling Point: 350.20°C
Melting Point: 240°C
Solubility: Soluble in water
Viscosity: Low to moderate
Molecular Weight: 317.7 g/mol
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 2
Exact Mass: 315.931862 g/mol
Monoisotopic Mass: 315.931862 g/mol
Topological Polar Surface Area: 52.9Ų
Heavy Atom Count: 17
Formal Charge: 0
Complexity: 183
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes
MELTING POINT: ≥240℃
PH(5%solution):6.5-8.5
LOD :NMT 0.5%
Particle size :D70<5 micron; D100<12 micron
Boiling Point:253.8C at 760 mmHg
flash point:107.3C
PSA:101.52000
logP:3.34050
Solubility:Insoluble (<0.1 g/100 mL at 21 C)
Appearance: White powder
Assay, %: ≥98.0
Melting Point, ℃: ≥240
D50, μm: ≤5
D90, μm: ≤10
pH: 6.0~9.0
Loss on drying, %: ≤0.5
Physical state: powder
Color: beige
Odor: odorless
Melting point/freezing point
Melting point/range: 267 °C
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: 0,00493 g/l at 20 °C
Partition coefficient: n-octanol/water:
log Pow: 0,9 at 25 °C
Vapor pressure: No data available
Density: 1,76 g/cm3 at 20,1 °C
Relative density: No data available
Chemical Name: Zinc pyrithione
CAS: 13463-41-7
Molecular Fomula: C10H8N2O2S2Zn
Molecular Weight: 317.7
Appearance: White latex（48%), White to slight yellow powder(98%)
Chemical formula: C10H8N2O2S2Zn
Molar mass: 317.70 g/mol
Appearance: colourless solid
Melting point: 240 °C (464 °F; 513 K) (decomposition)
Boiling point: decomposes
Solubility in water: 8 ppm (pH 7)
CAS No:13463-41-7
Other Names:Zinc pyrithione
MF:C10H8N2O2S2Zn
EINECS No:236-671-3
Density:1.782 (25 C)
Melting point:262
Boiling Point:253.8C at 760 mmHg
flash point:107.3C
PSA:101.52000
logP:3.34050
Solubility:Insoluble (<0.1 g/100 mL at 21 C)
Chemical formula: C10H8N2O2S2Zn
Molar mass: 317.70 g/mol
Appearance: colourless solid
Melting point: 240 °C (464 °F; 513 K) (decomposition)
Boiling point: decomposes
Solubility in water: 8 ppm (pH 7)
MF:C10H8N2O2S2Zn
EINECS No:236-671-3
Density:1.782 (25 C)
Melting point:262
Boiling Point: 350.20°C
Melting Point: 240°C
Solubility: Soluble in water
Viscosity: Low to moderate
FIRST AID MEASURES of ZINC PYRITHIONE (ANTIDANDRUFF):
-Description of first-aid measures:
*General advice:
First aiders need to protect themselves.
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
Immediately call in physician.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
Consult a physician.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed:
Give water to drink (two glasses at most).
Seek medical advice immediately.
-Indication of any immediate medical attention and special treatment needed:
No data available
ACCIDENTAL RELEASE MEASURES of ZINC PYRITHIONE (ANTIDANDRUFF):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up carefully.
Dispose of properly.
Clean up affected area.
FIRE FIGHTING MEASURES of ZINC PYRITHIONE (ANTIDANDRUFF):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system
EXPOSURE CONTROLS/PERSONAL PROTECTION of ZINC PYRITHIONE (ANTIDANDRUFF):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter type P3
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of ZINC PYRITHIONE (ANTIDANDRUFF):
-Precautions for safe handling:
*Advice on safe handling:
Work under hood.
*Hygiene measures:
Immediately change contaminated clothing.
Apply preventive skin protection.
Wash hands and face after working with substance.
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
Keep in a well-ventilated place.
Keep locked up or in an area accessible only to qualified or authorized persons.
Store at Room Temperature.
STABILITY and REACTIVITY of ZINC PYRITHIONE (ANTIDANDRUFF):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
no information available
