Zinc Pyrithione (ZPT) is the pyrithione complexes of zinc bromide, in the early 1930s, was already synthesized and used as a topical antifungal or antibacterial agent.
At room temperature Zinc Pyrithione (ZPT) is white to yellow crystalline powder.
Slight characteristic odor.
CAS: 13463-41-7
MF: C10H8N2O2S2Zn
MW: 317.7
EINECS: 236-671-3
Synonyms
1-HYDROXY-2-PYRIDINE THIONE, ZN SALT;1-HYDROXYPYRIDINE-2-THIONE ZINC;Pyrithione zincique;Bis[(1-oxylatopyridinium)-2-ylthio] zinc;Bis[(1-oxylatopyridinium-2-yl)thio]zinc;Bis[[(pyridine 1-oxide)-2-yl]thio] zinc salt;Bis(2-pyridylthio) Zinc 1,1'-Dioxide 1-Hydroxypyridine-2-thione Zinc Salt 2-Pyridinethiol 1-Oxide Zinc Salt Zinc Pyrithione;zincpolyanemine;Zinc pyrithione;13463-41-7;DTXSID7026314;DTXCID90820451;Bis((1-oxidopyridin-2-yl)thio)zinc;zinc;1-oxidopyridin-1-ium-2-thiolate;NCGC00091933-01;NCGC00183121-01;Zinc pt;Zinci pyrithionum;Finecide ZPT;Hokucide ZPT;Niccanon SKT;Biocut ZP;zinc bis(2-thioxopyridin-1(2H)-olate);1698050-37-1;Tomicide Z 50;Tomicide ZPT 50;CAS-13463-41-7;Evafine P 50;Caswell No. 923;Zinc Pyrithione Powder;BC-J;biokera;shampoo;bis(N-oxopyridine-2-thionato)zinc (II);Balancing;Chevance;Dandrene;Elementz;Medaclear;Treatment;Vanicream;Zincopan;Zolidyne;classic control;LuckyClassic;pyrthione zinc;DermaZinc;Zinc 2-pyridinethiol-1-oxide;Bioxsine Series;Dandruff Detox;Everyday Clean;Pyrithion-Zink;Pyrithionr Zinc;Pyrithions Zinc;Pyritione Zinc;Royal Dandruff;Zinc-pyrion;American Crew;CCRIS 4894;Classic Clean;Zinc Therapy;HairQ;Zinc soap;Zn-pyrion;Clean Apple;CyzoneBe Sexy;Four Season;Happy Cappy;Head Remedy;Itchy Scalp;LuckyDry Hair;piritiona cincica;Pyrithizone Zinc;Zinc pyridine-2-thiol 1-oxide;Shiny and Sleek;Dry Scalp;Free and Clear;Blue Cap;Crawford Dandruff;HSDB 4498;Vanicream Z-Bar;Zinc 1-hydroxy-2-pyridinethione;Blue Cap Cream;Dry Scalp Care;Smooth and glossy;Zinc bis(2-pyridylthio)-N-oxide;Bis(2-pyridinethiol-1-oxide)zinc;pyrithione (base);Piritionatocincico;Pyrithione zincique;LIFECELL Womens;Dry Scalp Dandruff;Lucky2in1 Classic;FSB 8332;Pyrithionum zincicum;EpochAva Puhi Moni;2 in 1 Dandruff;2-Pyridinethiol-1-oxide, zinc salt;Antidandruff Shampoo;Dandruff 2 in 1;EINECS 236-671-3;EquateEveryday Clean;Fresh Mint Dandruff;LIFECELL Mens;Vegetability Natural;2-Mercaptopyridine 1-oxide zinc salt;2-mercaptopyridine-1-oxide zinc salt;HEAD AND SHOULDERS CONDITIONER;Aloe Coal 01;ANTIDANDRUFF;Divine Dandrene 1%;Divine Dandrene 2%;FRUITOPIA;HEBDANDRUFF;Pyrithione Zinc 1%;REVOX;SAFEWAYDANDRUFF;AxeFeeze AntiDandruff;GKhair Anti-Dandruff;MOJELIM Dr;Sulfur 8 Aqua Blue;WeCare Anti-Dandruff;Anti-Dandruff Shampoo;Bis(2-pyridylthio)zinc 1,1'-dioxide;Control Anti-Dandruff;EPA Pesticide Chemical Code 088002;LEudine Anti-dandruff;Nioxin Scalp Recovery;NSC 290409;Simply Clean Dandruff;AxeFreeze AntiDandruff;DAMOAE THERAPY;PYRITHIONE ZINE;SHIKATRI CLASS;Vancide ZP Dispersion;2 in 1 Antidandruff;BALLVIC SEBO;REBIRTH HAIR;Pert Plus 2 in 1;pyrithione zinc shampoo;SELEX DNA;X FOLATE;AxeAntiDandruff Styling;Everyday Clean Dandruff;Satinique Anti Dandruff;dandruff therapy shampoo;Equaline DandruffRefresh;HAIRJOY MSM HAIR;Personal CAREDry Scalp;Shampoo plus Conditioner;Control Dandruff Therapy;Pert Plus Dandruff Plus;AffirmCare Scalp Therapy;AI3-62421;HEAD AND SHOULDER;MEDECEAN SEBORRHEA;DR. SCALP ACTIVE;modesa 2 in 1 dandruff;Shelo NABEL Anti Caspa;Apex Crown Anti Dandruff;Daylogic Refresh Dandruff;Dermaharmony Zinc Therapy;Royal Dandruff Dry Scalp;Sereve Professional Scalp;Zincon Medicated Dandruff;Head and Shoulders 2in1;MSM HAIR SIGNATURE;Personal CAREDaily Clean;ZENOTRI Scalp Shampoo.;Balmers Cooling Zone 31;Pyrithione Zinc 0.22%;Dermaharmony Tea Tree Bar;Dermaharmony Unscented Bar;Equate Dry Scalp Dandruff;Aloe Coal 02 Conditioner;BYE-BYE CRADLE CAP;CVS PHARMACYDANDRUFF;DG BODYSIMPLY CLEAN
A pH optimum range of 4.5 to 9.5; mass fraction of 10% suspension pH3.6.
Zinc pyrithione react with cationic and non-ionic surfactants forming insoluble precipitate, unstable in the light and oxidizer, when at higher temperatures ,Zinc Pyrithione (ZPT) is not stable to acids and bases.
Zinc Pyrithione (ZPT) is not compatible with EDTA, non-ionic surfactants make it partially deactivated.
When with the presence of heavy metals, chelation or anti-sequestration will occur, and these chelates are insoluble in water.
EEC and GB7916-87 provide that maximum allowable concentration of mass fraction of Zinc Pyrithione (ZPT) on cosmetics is 0.5%, only for cleaning after using products.
General concentration 250~1000mg/kg (active), Zinc Pyrithione (ZPT) can be used in gels, creams, lotions, talcum powder and anti-dandruff shampoo, deodorant and also for disinfecting articles.
Zinc Pyrithione (ZPT) shampoos (in concentrations between 1 to 2%) and shampoos with selenium sulide have been reported to be effective in the treatment of scalp psoriasis.
However,their efficacy has not been substantiated by controlled studies.
There is also some evidence that shampoos with antifungal agents (e.g.ketoconazole)can have a beneficial effect on scalp conditions.
Zinc Pyrithione (ZPT) should be noted, however, that the effectiveness of these shampoos is much smaller than these containing tars, corticosteroids or keratolytics.
Zinc Pyrithione (ZPT) is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor.
Zinc Pyrithione (ZPT) remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both.
Zinc Pyrithione (ZPT) is substantive to the hair, allowing continued therapeutic effect after washing.
Zinc Pyrithione (ZPT) is a coordination complex of zinc.
Zinc Pyrithione (ZPT) has fungistatic (inhibiting the division of fungal cells) and bacteriostatic (inhibiting bacterial cell division) properties and is used in the treatment of seborrhoeic dermatitis and dandruff.
Zinc Pyrithione (ZPT) is a compound commonly used in cosmetics and personal care products for its antifungal and antibacterial properties.
Zinc Pyrithione (ZPT) is an active ingredient designed to treat dandruff, seborrheic dermatitis, and various fungal infections of the skin and scalp.
Zinc Pyrithione (ZPT) works by inhibiting the growth of fungi and bacteria that contribute to these conditions, helping to reduce flakiness, itching, and irritation.
Additionally, Zinc Pyrithione (ZPT) aids in controlling sebum production, contributing to a healthier scalp environment.
The chemical formula of Zinc Pyrithione (ZPT) is C10H8N2O2S2Zn.
ZPT: Zinc Pyrithione (ZPT) is an effective antimicrobial to fungi and bacteria, which can effectively kill the fungi that cause dandruff.
Zinc Pyrithione (ZPT) has long been used as anti-dandruff agent and widely used in various popular shampoos.
Zinc Pyrithione (ZPT) is supplied as a powder or as a 50% water suspension emulsion.
The fine particle size of Zinc Pyrithione (ZPT) can effectively prevent precipitation and double the antimicrobial effect.
Zinc Pyrithione (ZPT) Chemical Properties
Melting point: approximate 240℃
Density: 1.782 g/cm3(Temp: 25 °C)
Vapor pressure: 0Pa at 25℃
Storage temp.: Sealed in dry,Room Temperature
Solubility: almost transparency in Pyridine
Form: Powder
Color: White to Orange to Green
Odor: Mild Characteristic
Water Solubility: Insoluble (<0.1 g/100 mL at 21 ºC)
Merck: 14,7994
InChI: InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2
InChIKey: OTPSWLRZXRHDNX-UHFFFAOYSA-L
LogP: 0.9 at 25℃ and pH7.5-7.7
Surface tension: 73mN/m at 7.22mg/L and 20℃
CAS DataBase Reference: 13463-41-7(CAS DataBase Reference)
EPA Substance Registry System: Zinc pyrithione (13463-41-7)
Structure of the compound
The Zinc Pyrithione (ZPT) ligands, which are formally monoanions, are chelated to Zn2+ via oxygen and sulfur centers.
In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers.
In solution, however, the dimers dissociate via scission of one Zn-O bond.
Zinc Pyrithione (ZPT) was first described in the 1930s.
Zinc Pyrithione (ZPT) is the conjugate base derived from 2-mercaptopyridine-N-oxide, a derivative of pyridine-N-oxide.
Uses
Shampoo for dandruff, Zinc Pyrithione (ZPT) can inhibit Gram positive and negative bacteria and mold growth,Care hair Effectively , delay hair aging ,control white hair and hair loss generation.
Zinc Pyrithione (ZPT) is also used as a cosmetic preservative, oil, paint biocide.
Zinc Pyrithione (ZPT) has a strong killing power on fungi and bacteria so that it can effectively kill dandruff fungus,playing a role in dandruff.
Zinc Pyrithione (ZPT) is a preservative against bacteria, fungi, and yeast.
Zinc Pyrithione (ZPT) is unstable in light and in the presence of oxidizing agents.
Zinc Pyrithione (ZPT) is useful in gels, creams, heavy lotions, and talcum powder.
Reactions may lead to photosensitive eczema and actinic reticuloid syndrome.
Zinc Pyrithione (ZPT) is used as antifungal, antibacterial and antiseborrheic agent used in many shampoos and hair creams.
Zinc Pyrithione (ZPT) is directly cytotoxic and has antimicrobial effects.
Zinc Pyrithione (ZPT) is found in many shampoos (DHS-Zinc, Head and Shoulders) and should be applied for 5 minutes daily for 2 weeks.
Zinc Pyrithione (ZPT) is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor.
Zinc Pyrithione (ZPT) remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both.
Zinc Pyrithione (ZPT) is substantive to the hair, allowing continued therapeutic effect after washing.
Zinc Pyrithione (ZPT) is a beneficial compound owing to its antimicrobial properties and finds extensive application in personal care products and cosmetics.
Primarily utilized in cleansing formulations like shampoos and soap, Zinc Pyrithione (ZPT) effectively targets dandruff, seborrheic dermatitis, and fungal skin infections by inhibiting the growth of fungi and bacteria responsible for these conditions.
Zinc Pyrithione (ZPT) also alleviates symptoms like itching, flaking, and redness on the scalp and skin.
Zinc Pyrithione (ZPT)’s ability to regulate microbial balance and control sebum production makes it an essential ingredient in products designed to promote scalp and skin health, offering consumers relief from common dermatological issues with proven efficacy.
Medicine
Zinc Pyrithione (ZPT) can be used to treat dandruff and seborrhoeic dermatitis.
Zinc Pyrithione (ZPT) also has antibacterial properties and is effective against many pathogens from the Streptococcus and Staphylococcus genera.
Zinc Pyrithione (ZPT)'s other medical applications include treatments of psoriasis, eczema, ringworm, fungus, athletes foot, dry skin, atopic dermatitis, tinea versicolor, and vitiligo.
Paint
Because of its low solubility in water (8 ppm at neutral pH), Zinc Pyrithione (ZPT) is suitable for use in outdoor paints and other products that protect against mildew and algae.
Zinc Pyrithione (ZPT) is an algaecide.
Zinc Pyrithione (ZPT) is chemically incompatible with paints relying on metal carboxylate curing agents.
When Zinc Pyrithione (ZPT) is used in latex paints with water containing much iron, a sequestering agent that preferentially binds the iron ions is needed.
Zinc Pyrithione (ZPT) is decomposed by ultraviolet light slowly, providing years of protection in direct sunlight.
Sponges
Zinc Pyrithione (ZPT) is an antibacterial treatment for household sponges, as used by the 3M Corporation.
Clothing
A process to apply Zinc Pyrithione (ZPT) to cotton with washable results was patented in the United States in 1984.
Zinc Pyrithione (ZPT) is used to prevent microbe growth in polyester.
Textiles with applied Zinc Pyrithione (ZPT) protect against odor-causing microorganisms.
Export of antimicrobial textiles reached US$497.4 million in 2015.
Pharmaceutical Applications
Zinc Pyrithione (ZPT) is a regulator of keratinization, selenium sulfide has antimicrobial properties and ketoconazole is an antifungal agent.
Synthesis
1000 g of sodium pyrithione, 20% aqueous solution (1.34 mmol of sodium pyrithione) was added to a 2L reactor equipped with a mechanical agitator and warmed to 70 °C with stirring.
To the solution was added 190 g of 50 % zinc chloride (0.7 mmol of zinc chloride) over 10 minutes.
After the completion of the addition, the solution was stirred at 70 °C for one hour, dehydrated and then washed with 500 g of distilled water.
The solid thus obtained was dried with a heated-air drier at 70 °C to have a moisture content of less than 0.5 % and ground with a hammer mill to obtain a find powder of Zinc Pyrithione (ZPT).
The Zinc Pyrithione (ZPT) thus obtained was 212 g with a yield of 99.5 %.
Health effects
Zinc Pyrithione (ZPT) is approved for over-the-counter topical use in the United States as a treatment for dandruff and is the active ingredient in several anti-dandruff shampoos and body wash gels.
In its industrial forms and strengths, Zinc Pyrithione (ZPT) may be harmful by contact or ingestion.
Zinc Pyrithione (ZPT) can in the laboratory setting trigger a variety of responses, such as DNA damage in skin cells.