Quick Search
Occupational contact dermatitis can occur in people producing 1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione, in those producing the powder coat paint and in sprayers.
1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione be used for curing agent of polyester and acrylic resin carboxyl-containing powder coating, manufacturing an electrical insulating laminates, adhesives, plastics stabilizers.
1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione is used as cross-linker in heat-cured polyester paints, such as laminated sheetings, printed circuits, tools, inks, adhesives, lining materials etc.
CAS: 2451-62-9
MF: C12H15N3O6
MW: 297.26
EINECS: 219-514-3
Synonyms
Triglycidyl Isocyanate;HARDENER TGIC-P (TRIGLYCIDYL ISOCYANURATE MICROPOWDER GRADE);HARDENER TGIC-SP (MICROPOWDER WITH LOW CHLORINE CONTENT);TRIGLYCIDY ISOCYANURATE (TGIC);6(1h,3h,5h)-trione,1,3,5-tris(2,3-epoxypropyl)-s-triazine-4;6(1h,3h,5h)-trione,tris(2,3-epoxypropyl)-s-triazine-4;glycidylisocyanurate;n,n’,n’’-triglycidylisocyanurate
1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione is a chemical compound characterized by its structure, which includes three glycidyl ether groups attached to an isocyanurate ring.
1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione is primarily used as a crosslinking agent in epoxy resins and coatings, enhancing their thermal and chemical resistance.
1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione is a white to off-white solid at room temperature and is known for its low viscosity when melted, making it suitable for various applications in the coatings industry.
1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione is also recognized for its ability to improve the mechanical properties of materials, contributing to durability and longevity.
However, 1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione is classified as a potential sensitizer and may pose health risks upon exposure, necessitating appropriate safety measures during handling.
1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione's reactivity allows it to participate in various polymerization processes, making it valuable in the production of advanced composite materials.
Overall, 1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione is an important substance in the field of polymer chemistry, particularly in applications requiring robust and resilient materials.
1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione Chemical Properties
Melting point: 95-98°C
Boiling point: 438.78°C (rough estimate)
density: 1,42 g/cm3
vapor pressure: 0.007Pa at 20℃
refractive index: 1.5290 (estimate)
storage temp.: Store at 4°C
solubility: DMSO: 50 mg/mL (168.20 mM)
form: powder to crystal
pka: -2.44±0.20(Predicted)
color: White to Almost white
Water Solubility: <0.1 g/100 mL at 20 ºC
InChI: InChI=1S/C12H15N3O6/c16-10-13(1-7-4-19-7)11(17)15(3-9-6-21-9)12(18)14(10)2-8-5-20-8/h7-9H,1-6H2
InChIKey: OUPZKGBUJRBPGC-UHFFFAOYSA-N
LogP: -0.8 at 20℃
CAS DataBase Reference: 2451-62-9(CAS DataBase Reference)
EPA Substance Registry System: 1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione (2451-62-9)
Uses
1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione is widely used as a cross-linking agent or curing agent in powder coating industry,
1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione is used also in the printed circuit board industry, electrical insulation and as a stabilizer in plastic industry.
Typical applications of polyester TGIC powder coatings are where sharp edges and corners exist such as on automotive wheels, air conditioners, lawn furniture, and air conditioner cabinets.
Industrial Application
1,3,5-triglycidyl isocyanurate (TGIC) is a white powder or granular solid and is normally sold under the trade name ARALDITE PT810R or TEPIC G R.
As a tri-functional epoxy monomer, 1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione is used in large scale as curing agent for powder coatings or for cross-linking elastomers.
Rosin acids of natural origin may also be cured with TGIC for versatile applications.
1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione has also been used for pharmaceutical purposes, in membranes, for curing intelligent gels or liquid crystal elastomers.
Especially, this curing agent has been widely used in dry powder coating for over 40 years.
Health Toxicity
1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione has been known that TGIC is toxic by inhalation and if swallowed.
1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione is a severe eye irritant, and a mild skin and nasal irritant, although it has the potential to cause skin sensitisation in people which can lead to severe skin rashes.
Exposure to 1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione in powder paints may cause not only contact dermatitis, but also occupational asthma.
Kidney damage has also been observed in rats repeatedly exposed to 1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione by oral dosing, and damage to the developing sperm cells has been observed in mice repeatedly exposed to 1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione orally and by inhalation.
There is an evidence that exposure of males to 1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione produces genetic changes in the sperm which may lead to heritable effects in the offspring.
There is cause for concern that these effects could occur in humans, so that TGIC has been classified in the EU as a Category 2 mutagen.
Exposures to 1,3,5-Tris(2,3-epoxypropyl)-1,3,5-triazine-2,4,6-trione during manufacturing procedures have been identified as hazardous to workers.
