PRODUCTS

1,6-HEXANEDIOL

1,6-Hexanediol is also applied in the manufacturing process of radiation-curable coatings, polycarbonate diols and as a reactive thinner for the formulation of epoxy systems which are used for the efficient production of rotor blades for modern wind turbines.
1,6-Hexanediol is used in polymer synthesis such as polyester, polyurethane and nylon.
1,6-Hexanediol is used as an intermediate to adhesives, acrylics and dyestuffs.

CAS Number: 629-11-8
EC (EINECS) Number: 211-074-0
Molecular Formula: C₆H₁₄O₂
Molecular Weight: 118.17 g/mol

SYNONYMS:
1,6-HEXANEDIOL, Hexane-1,6-diol, 629-11-8, Hexamethylene glycol, 1,6-Dihydroxyhexane, Hexamethylenediol, alpha,omega-Hexanediol, DTXSID1027265, ZIA319275I, DTXCID907265, CHEBI:43078, hexamethyleneglycol, RefChem:907046, 211-074-0, 1,6-Hexylene Glycol, .alpha.,.omega.-Hexanediol, 6-hydroxy-1-hexanol, MFCD00002985, 27236-13-1, HEZ, CCRIS 8982, HSDB 6488, NSC 508, EINECS 211-074-0, BRN 1633461, UNII-ZIA319275I, AI3-03307, 1,6hexanediol, 1.6-hexanediol, 1,6-hexandiol, 1.6-hexandiol, .omega.-Hexanediol, 1,6-hexane diol, 1,6-hexan-diol, hexan-1,6-diol, Hexanediol-(1,6), 1,6-Hexanediol, 97%, 1,6-Hexanediol, 99%, EC 211-074-0, WLN: Q6Q, HO(CH2)6OH, SCHEMBL15343, SCHEMBL272453, SCHEMBL331126, SCHEMBL596836, SCHEMBL735965, CHEMBL458616, NSC508, orb2939871, SCHEMBL2866023, SCHEMBL6387994, SCHEMBL11227979, 1,6-HEXANEDIOL [HSDB], HEXAMETHYLENE GLYCOL [MI], Tox21_200450, EBC-47180, SBB059915, AKOS003242194, CS-W011221, DB02210, FH34814, HY-W010505, MSK161015-100M, MSK161015-1000M, NCGC00248624-01, NCGC00258004-01, AS-12686, BP-21412, CAS-629-11-8, DB-027344, H0099, NS00001150, ST51046183, EN300-19325, G81203, 1,6-Hexanediol Solution in Methanol, 100ug/mL, 1,6-Hexanediol Solution in Methanol, 1000ug/mL, F242635, Q161563, doi:10.14272/XXMIOPMDWAUFGU-UHFFFAOYSA-N.1, F0001-1701, Z104473540, InChI=1/C6H14O2/c7-5-3-1-2-4-6-8/h7-8H,1-6H, α,ω-Hexanediol, Hexamethylene glycol, Hexamethylenediol, 1,6-Dihydroxyhexane, Hexanediol-(1,6), Hexane-1,6-diol, HDO, Hexane-1,6-diol, Hexamethylene glycol, 1,6-Dihydroxyhexane, 1,6-Hexylene glycol, Hexamethylenediol, HDO, HEXANE-1,6-DIOL, 1,6-Hexandiol, 1,6-HDO, HDO(R), ai3-03307, 6-Hexanediol, 1,6-HEXANEDIOL, 116-HEXANEDIOL, Hexan-1,6-diol, Hexanediol-(1,6), 1,6-dihydroxyhexane, hexamethylene glycol, hexamethylenediol, hexan-1,6-diol, alpha,omega-hexane diol, hexane-1,6-diol, hexanediol, 1,6-hexanediol, Hexamethylene glycol

1,6-Hexanediol (1,6-HDO) is a high-value, linear aliphatic diol characterized by its two primary hydroxyl groups positioned at each end of a six-carbon chain.
This structure grants 1,6-Hexanediol excellent solubility, reactivity, and flexibility, making it a versatile building block in the synthesis of advanced polymers and specialty chemicals.
1,6-Hexanediol is manufactured to meet stringent quality standards, ensuring consistent performance for our global clients in demanding applications.

1,6-Hexanediol is a white waxy flakes.
1,6-Hexanediol is an organic compound that is frequently studied for its applications in polymer chemistry.
1,6-Hexanediol is a key monomer in the production of polyurethanes and polyester resins, where its diol functionality allows it to react with diisocyanates and diacid chlorides, respectively.

1,6-Hexanediol′s linear structure and symmetrical nature are of interest in research that aims to develop polymers with specific mechanical and thermal properties.
In addition to its use as a monomer, 1,6-Hexanediol is investigated for its role as a chain extender in polymer systems, which can affect the molecular weight and polydispersity of the resulting materials.

Research involving 1,6-Hexanediol is also focused on its potential to form polyesters that are biodegradable, as its aliphatic nature may lend itself to enzymatic degradation, which is important for creating more sustainable materials.
1,6-Hexanediol is a diol that is hexane substituted by hydroxy groups at positions 1 and 6.

1,6-Hexanediol is a primary alcohol and a diol.
1,6-Hexanediol derives from a hydride of a hexane.
1,6-Hexanediol is a metabolite found in or produced by Saccharomyces cerevisiae.

1,6-Hexanediol is soluble in water.
1,6-Hexanediol is hygroscopic.
1,6-Hexanediol is incompatible with acid chlorides, acid anhydrides, oxidizing agents, chloroformates and reducing agents.

1,6-Hexanediol is an organic compound with the formula (CH2CH2CH2OH)2.
1,6-Hexanediol is a colorless water-soluble solid.
1,6-Hexanediol is also an intermediate to acrylics as a crosslinking agent, e.g. hexanediol diacrylate.

Unsaturated polyester resins have also been made from 1,6-hexanediol, along with styrene, maleic anhydride and fumaric acid.
1,6-Hexanediol is an organic compound that is frequently studied for its applications in polymer chemistry.
1,6-Hexanediol is a key monomer in the production of polyurethanes and polyester resins, where its diol functionality allows it to react with diisocyanates and diacid chlorides, respectively.

1,6-Hexanediol′s linear structure and symmetrical nature are of interest in research that aims to develop polymers with specific mechanical and thermal properties.
In addition to 1,6-Hexanediol's use as a monomer,
1,6-Hexanediol is investigated for its role as a chain extender in polymer systems, which can affect the molecular weight and polydispersity of the resulting materials.

Research involving 1,6-Hexanediol is also focused on its potential to form polyesters that are biodegradable, as its aliphatic nature may lend itself to enzymatic degradation, which is important for creating more sustainable materials.
1,6-Hexanediol is a 6-carbon straight-chain diol with hydroxyl groups at both ends.

1,6-hexanediol is a no-irritating to the skin.
1,6-Hexanediol is a linear aliphatic diol containing two primary hydroxyl groups at both ends of a six-carbon chain.
1,6-Hexanediol is a water soluble, hygroscopic, colorless crystalline solid widely used for industrial polyester and polyurethane production.

1,6-Hexanediol is also identified by the synonyms Hexane-1,6-diol; 629-11-8; Hexamethylene glycol; 1,6-Dihydroxyhexane, and Hexamethylenediol.
1,6-Hexanediol’s long hydrocarbon chain gives the compound the ability to improve the flexibility and hardness of polyesters.
1,6-Hexanediol is a waxy hygroscopic solid compound that is white in colour.

1,6-Hexanediol is a linear diol that contains two primary hydroxyl groups that are located at the terminal.
1,6-Hexanediol’s linear hydrocarbon chain enables the compound to have enhanced hardness and flexibility of polyesters.
Moreover, this property is utilized in the extending chains in polyurethanes.

1,6-Hexanediol is a 6-carbon straight-chain diol with hydroxyl groups at both ends.
1,6-hexanediol is a no-irritating to the skin.

USES and APPLICATIONS of 1,6-HEXANEDIOL:
Plasticizers: 1,6-Hexanediol serves as an intermediate in the synthesis of plasticizers.
1,6-Hexanediol is widely used in industrial chemistry as a key intermediate in the production of polyurethanes, polyesters, and various resin systems due to its bifunctional alcohol structure.
Its presence in polymer formulations significantly enhances flexibility, toughness, and resistance to hydrolysis, making 1,6-Hexanediol especially valuable in coatings, adhesives, sealants, and elastomers.

In UV-curable systems, derivatives such as hexanediol diacrylate are commonly used to improve curing performance and mechanical strength.
Uses and Applications of 1,6-Hexanediol: Polyurethane production (foams, coatings, elastomers), Polyester resins (improves flexibility and durability), UV-curable coatings and inks (as diacrylate derivative), Adhesives and sealants, Plasticizers and lubricants, Cosmetics and personal care (limited use as humectant/intermediate).

1,6-Hexanediol is commonly used as a reactive building block in polymer chemistry, especially in the production of polyesters, polyurethanes, and acrylates.
Due to its symmetric structure and bifunctionality, 1,6-Hexanediol plays a crucial role in enhancing flexibility, durability, and chemical resistance in materials.
Adhesives: 1,6-Hexanediol is used as a building block for resins used for adhesives providing flexibility and adhesion

1,6-Hexanediol is used as an intermediate to adhesives, acrylics and dyestuffs.
Further, 1,6-Hexanediol is employed in gasoline refining and pharmaceutical production.
Uses of 1,6-Hexanediol: Solvent, intermediate for high polymers (nylon, polyesters), coupling agent, coil coating.

1,6-Hexanediol is widely used for industrial polyester and polyurethane production.
1,6-Hexanediol can improve the hardness and flexibility of polyesters as it contains a fairly long hydrocarbon chain.
In polyurethanes, 1,6-Hexanediol is used as a chain extender, and the resulting modified polyurethane has high resistance to hydrolysis as well as mechanical strength, but with a low glass transition temperature.

1,6-Hexanediol is used in polymer synthesis such as polyester, polyurethane and nylon.
1,6-Hexanediol is used as an intermediate to adhesives, acrylics and dyestuffs.
Further, 1,6-Hexanediol is employed in gasoline refining and pharmaceutical production.

In Acrylics: 1,6-hexanediol is utilized as an ingredient in the manufacture of the bifunctional hexanediol diacrylate which is a monomer that is normally used in conjunction with other acrylic monomers as a reactive diluent for decorative coatings and printing inks.
1,6-Hexanediol can be used as an additive for drilling fluids.

1,6-Hexanediol can also be used as a substrate in life science-related research.
1,6-hexanediol is incorporated into the production of other compounds used in polymeric thickeners, sizing agents, plasticizers for polyvinyl chloride, pesticides, and surfactants dyestuffs as a flexible building block.

1,6-Hexanediol is a widely used tool to probe liquid-liquid phase separation (LLPS) in cells.
1,6-Hexanediol disrupts hydrophobic interaction-induced phase separation assemblies both in vitro and in vivo.
1,6-Hexanediol dissolves LLPS condensates, such as P bodies, but not solid-like condensates, such as protein aggregates and cytoskeletal assemblies.

Typically used of 1,6-Hexanediol as a 3-10% solution (w/v).
1,6-Hexanediol disrupts cellular structures in yeast and alters cellular morphology in HeLa cells.
1,6-Hexanediol is also used as a chain extender in polyurethanes.

The resulting modified polyurethane has high resistance to hydrolysis as well as mechanical strength, but with a low glass transition temperature.
Additionally, 1,6-Hexanediol is used as an intermediate in the manufacture of acrylics, adhesives, and dyestuffs.
Styrene, maleic anhydride, fumaric acid, and unsaturated polyester resins have also been made from 1,6-hexanediol.

Consumer applications of 1,6-Hexanediol include use in the manufacture of ink, toner, and colorant products as well as for paint and coatings production.
1,6-Hexanediol is used across a wide range of end-industries, including coatings, adhesives, and resins.
Thanks to its chemical structure, 1,6-Hexanediol is commonly applied in polyurethane and polyester production, providing enhanced mechanical and physical properties to its final products.

-In Adhesives use of 1,6-Hexanediol:
Urethanes and co-terephthalates that are based on 1,6-hexanediol provide faster better tack properties and crystallization.
Due to its low glass transition property, 1,6-hexanediol offers high flexibility as well as excellent adhesive properties.

-1,6-Hexanediol can be used for a variety of applications such as:
*a structure-directing agent for the synthesis of ZSM-5 zeolite
*a solvent for titanium tetraisopropoxide to form titanium oxide (TiO2) nanocrystals
*a phase change material in combination with lauric acid for thermal energy storage applications

-Polyurethanes use of 1,6-Hexanediol:
1,6-Hexanediol is widely utilized in the manufacture of polyesterols such as sebacates, azelates, and adipates.
These compounds are resistant to hydrolysis and have low glass transition temperature as well as high mechanical levels.
1,6-hexanediol is used as an ingredient in the preparation of a wide range of tailor-made products for numerous specialty and standard applications.

-Coatings use of 1,6-Hexanediol:
1,6-Hexanediol is used as a building block for the production of polyester and polyurethane resins.
Good balance between hardness and flexibility, adhesion, weatherability or hydrolysis resistance.

-Industrial Flooring & Coatings use of 1,6-Hexanediol:
1,6-Hexanediol is widely used in high-performance epoxy floorings for factories, warehouses, and commercial spaces.
1,6-Hexanediol provides good leveling, a durable surface resistant to abrasion and chemicals, and a manageable pot life for application.

-Epoxy Resin Curing Agent uses of 1,6-Hexanediol:
1,6-Hexanediol is widely used as a room-temperature curing agent for epoxy resins in coatings, adhesives, flooring, and composites.
1,6-Hexanediol offers a balanced cure profile, good adhesion, and chemical resistance in the cured product.

-Polyurethane Foam Production uses of 1,6-Hexanediol:
TEDA is predominantly used as a gelling catalyst in the production of various polyurethane foams, including flexible, semi-rigid, and rigid foams.
1,6-Hexanediol excellently balances the foaming and curing reactions, which is critical for forming fine, uniform foam structures with optimal physical properties.

-Key Applications of 1,6-Hexanediol:
• Polyurethane and Elastomer Production
• UV-Curable Coatings and Inks
• Epoxy Resin Modification
• Plasticizers and Polymer Additives

USES of 1,6-HEXANEDIOL TO STUDY BIOMOLECULAR CONDENSATES:
1,6-Hexanediol has been used to characterize biomolecular condensates.
The material properties of condensates can be examined to determine if they are solid or liquid condensates.
1,6-Hexanediol has been reported to interfere with weak hydrophobic protein-protein or protein-RNA interactions that comprise liquid condensates.
1,6-Hexanediol has been reported to dissolve liquid but not solid condensates.
2,5-Hexanediol and 1,4-butanediol have been observed to have minimal effect on behavior of disorderd proteins as compared to 1,6-hexanediol.

PROPERTIES of 1,6-HEXANEDIOL:
As 1,6-hexanediol contains hydroxyl groups, it undergoes the typical chemical reactions of alcohols such as dehydration, substitution, and esterification.
Oxidation with pyridinium chlorochromate gives adipaldehyde.
Dehydration of 1,6-hexanediol gives oxepane, 2-methyltetrahydropyran and 2-ethyltetrahydrofuran.
Corresponding thiophene and pyrrolidone can be made by reacting 1,6-hexanediol with hydrogen sulfide and ammonia respectively.

BENEFITS AND CHARACTERISTICS of 1,6-HEXANEDIOL:
One of the major benefits of 1,6-hexanediol is its ability to impart a balance between hardness and elasticity in polymer networks, which is critical in high-performance materials.
Additionally, its relatively low toxicity and good biodegradability profile make 1,6-Hexanediol more favorable compared to aromatic diols in certain applications.
1,6-Hexanediol is also valued for its chemical stability, compatibility with a wide range of formulation components, and its effectiveness in improving moisture resistance and durability of end products.
These characteristics make 1,6-Hexanediol an essential building block in modern material science and industrial manufacturing.

PHASE SEPARATION of 1,6-HEXANEDIOL:
The aliphatic alcohol, 1,6-hexanediol (1,6-HD), is a widely used tool to probe liquid-liquid phase separation (LLPS) in cells.
Disrupts hydrophobic interaction-induced phase separation assemblies both in vitro and in vivo.
1,6-hexanediol has been widely used to study the formation process of the membrane-less cytoplasmic/nuclear condensates/bodies, presumably formed by LLPS.

1,6-Hexanediol inhibits weak hydrophobic protein-protein or protein-RNA interactions required to form liquid droplet-like condensates/bodies (droplet melting activity).
1,6-Hexanediol was originally noticed for its ability to disrupt FG repeat interactions between nucleoporins in the nuclear pore complex and interactions between RNA-binding proteins in RNA-protein (RNP) granules in vitro.

More recently, 1,6-Hexanediol was used to disrupt nuclear condensates/bodies associated with chromatin, which are thought to be formed by LLPS.
Furthermore, 1,6-Hexanediol has been used to examine liquid droplet formation of chromatin or protein/chromatin complexes.

However, although 1,6-Hexanediol is widely used to study protein/RNA condensates/bodies, some reports have pointed out significant limitations and caveats to its use in the context of biomolecular condensates/bodies.
Indeed, the cellular effects of 1,6-Hexanediol, especially its effects on chromatin in living cells, remain unclear.

PREPARING STOCK SOLUTIONS FOR 1,6-HEXANEDIOL
The following data is based on the product molecular weight 118.18.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

ADDITIONAL PHYSICOCHEMICAL CHARACTERISTICS of 1,6-HEXANEDIOL:
*Low volatility
*High boiling point relative to molecular weight
*Flexible aliphatic chain contributes to polymer elasticity
*Good compatibility with many polymer systems
*Low toxicity compared to aromatic diols

PHYSICAL AND CHEMICAL PROPERTIES of 1,6-HEXANEDIOL:
1,6-Hexanediol is a white, low-melting crystalline solid with a relatively mild odor and high boiling point, which reflects its low volatility and thermal stability.
1,6-Hexanediol is highly soluble in water and also dissolves readily in various organic solvents such as alcohols, making it easy to incorporate into different chemical systems.
Structurally, 1,6-Hexanediol contains two primary hydroxyl groups located at each end of a flexible six-carbon aliphatic chain, which gives it significant reactivity in condensation and polymerization reactions.

Chemically, 1,6-Hexanediol behaves as a typical diol, readily forming esters with carboxylic acids and reacting efficiently with isocyanates to produce polyurethane materials.
1,6-Hexanediol is generally stable under normal handling conditions, exhibits neutral behavior in aqueous environments, and shows moderate hygroscopicity.
Its relatively low vapor pressure and high boiling point make 1,6-Hexanediol suitable for high-temperature processing applications.

HISTORY AND SYNTHESIS of 1,6-HEXANEDIOL:
W. H. Perkin Jr. and his graduate student Edward Haworth first prepared the compound in 1894 during their research on cyclohexane.
They boiled 1,6-dibromohexane (which they were also the first to synthesize) with dilute potassium carbonate solution and named the product hexamethylene glycol.
1,6-Hexanediol is industrially made by the hydrogenation of adipic acid or its esters.
Laboratory preparation could be achieved by reduction of adipates with lithium aluminium hydride, although this method is impractical on a commercial scale.

PRODUCTION METHODS of 1,6-HEXANEDIOL:
1,6-Hexanediol is produced industrially by the catalytic hydrogenation of adipic acid or of its esters.
Mixtures of dicarboxylic acids and hydroxycarboxylic acids with C6 components formed in other processes (e.g., in cyclohexane oxidation) are also used.

Esterifification of "distillation heavies" with lower alcohols is often carried out before hydrogenation.
The acids are hydrogenated continuously at 170-240 ℃ and at 15.0-30.0 MPa on a suitable catalyst either in a trickle-flflow (downflflow) or a bubble-flflow (upflflow) fifixed-bed reactor.
The reactor temperature is controlled by circulating part of the reactor discharge.

The hydrogen required for the hydrogenation is fed together with the recycle gas through the recycle gas compressor to the reactor.
Side products of the synthesis are alcohols, ethers, diols, and esters.
Pure 1,6-hexanediol is obtained by fractional distillation of the crude reactor discharge.

For the hydrogenation of dicarboxylic acids, catalysts containing cobalt, copper, or manganese are suitable.
For the hydrogenation of esters, catalysts such as copper chromite or copper with added zinc and barium are used as "full catalysts" or on inert carriers.
Ruthenium, platinum, or palladium on inert supports can also be used.

Gas-phase hydrogenation of esters of adipic or 6-hydroxyhexanoic acid can be carried out at 1-7 MPa.
Both acids and esters also may be hydrogenated using suspended catalysts.
Oligomeric esters of 1,6-Hexanediol and adipic acid can also be hydrogenated.

BIOLOGICAL ACTIVITY FOR 1,6-HEXANEDIOL:
1,6-Hexanediol is a widely used tool to probe liquid-liquid phase separation (LLPS) in cells.
Disrupts hydrophobic interaction-induced phase separation assemblies both in vitro and in vivo.
Dissolves LLPS condensates, such as P bodies, but not solid-like condensates, such as protein aggregates and cytoskeletal assemblies.
Typically used as a 3-10% solution (w/v).
Disrupts cellular structures in yeast and alters cellular morphology in HeLa cells.

PREPARATION of 1,6-HEXANEDIOL:
1,6-Hexanediol is produced by a propriety process that is based on BASF technology.
Industrially, 1,6-Hexanediol is prepared by the hydrogenation of adipic acid.
Conversely, in the laboratory, 1,6-Hexanediol can be synthesized by the reduction of adipic acid with lithium aluminum hydride.

QUALITY AND ANALYSIS of 1,6-HEXANEDIOL:
The assay of the pure product is about 98 %; impurities are various diols and -caprolactone as well as traces of water.
The color number of the product determined photometrically according to the Pt/Co scale must not exceed 15 APHA.
Above 70 ℃, 1,6-Hexanediol tends to turn yellow.

DISSOLUTION AND ESTERIFICATION of 1,6-HEXANEDIOL:
During 1,6-Hexanediol production process, adipic acid (also known as hexanedioic acid) undergoes esterification and is dissolved and then undergoes esterification into dimethyl adipate.
Esterification technology minimises your feedstock use and achieves almost complete conversion of the adipic acid into dimethyl adipate.
1,6-Hexanediol achieves this by using our reactive distillation system and highly selective, heterogeneous catalyst which is easy to manage.
The reaction column also includes a smart system that allows on-line replacement of the solid catalyst with no loss of production to increase uptime.

HYDROGENATION OF DIMETHYL ADIPATE
Following esterification in 1,6-Hexanediol production, hydrogenation is carried out in the vapour phase using a heterogeneous, low-cost, base metal catalyst.
1,6-Hexanediol production technology leverages our vapour-phase hydrogenation loop, which creates less by-product and is inherently safer to operate than liquid-phase hydrogenation loops.
1,6-Hexanediol enables low pressure operation, eliminates hot spots and can easily and quickly be put in a safe condition.
These features also result in an extended catalyst life, meaning that the catalyst delivers high conversion for many years before it needs to be replaced, thereby extending increasing uptime.

REFINING 1,6-HEXANEDIOL
Finally, the crude 1,6-Hexanediol is refined to the high purity required for polymer production, using an advanced distillation system with high energy efficiency.

PHYSICAL and CHEMICAL PROPERTIES of 1,6-HEXANEDIOL:
Molecular Formula / Molecular Weight:C6H14O2 = 118.18
Physical State (20 deg.C):Solid
Storage Temperature:Room Temperature (Recommended in a cool and dark place, <15°C)
Store Under Inert Gas:Store under inert gas
Condition to Avoid:Hygroscopic
CAS RN:629-11-8
Reaxys Registry Number:1633461
PubChem Substance ID:87570545
SDBS (AIST Spectral DB):2231
Merck Index (14):4690

MDL Number:
MFCD00002985
Molecular Weight:118.17 g/mol
XLogP3-AA:0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:118.099379685 Da
Monoisotopic Mass:118.099379685 Da

Topological Polar Surface Area:40.5 Å²
Heavy Atom Count:8
Formal Charge:0
Complexity:31.5
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:0
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0

Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
CAS:629-11-8
IUPAC Name:hexane-1,6-diol
Molecular Formula:C6H14O2
InChI Key:XXMIOPMDWAUFGU-UHFFFAOYSA-N
SMILES:OCCCCCCO
Molecular Weight (g/mol):118.18
Synonym:hexane-1,6-diol α,ω-hexanediol

Identification (FTIR):Conforms
Appearance (Color):Colorless or white to pale yellow
Form:Crystalline powder or fused solid or flakes/prills/pellets/chunks or liquid as melt
Assay (Silylated GC):≥96.0%
Melting Point (clear melt):39-44?C
Water Content (Karl Fischer Titration):≤1.0%
Chemical formula:C6H14O2
Molar mass:118.176 g·mol−1

Density:0.967
Melting point:42 °C (108 °F; 315 K)
Boiling point:250 °C (482 °F; 523 K)
Solubility in water:500g/L
Solubility:soluble in ethanol and acetone, slightly soluble in diethyl ether, insoluble in benzene.
Flash point:102 °C (216 °F; 375 K)
CBNumber:CB4160863
Molecular Formula:C6H14O2

Molecular Weight:118.17
MDL Number:MFCD00002985
MOL File:629-11-8.mol
Melting point:38-42 °C (lit.)
Boiling point:250 °C (lit.)
Density:0.96
bulk density:530kg/m3
vapor pressure:0.53 mm Hg ( 20 °C)

refractive index:1.457
Flash point:215 °F
storage temp.:Store below +30°C.
solubility:H2O: 0.1 g/mL, clear, colorless
form:Waxy Flakes
pka:14.87±0.10(Predicted)
color:White
PH:7.6 (900g/l, H2O, 20℃)

explosive limit:6.6-16%(V)
Water Solubility:500 g/L
Sensitive:Hygroscopic
λmax:λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.1
Merck:14,4690
BRN:1633461
Cosmetics Ingredients Functions:SOLVENT
InChI:1S/C6H14O2/c7-5-3-1-2-4-6-8/h7-8H,1-6H2

InChIKey:XXMIOPMDWAUFGU-UHFFFAOYSA-N
SMILES:OCCCCCCO
LogP:0 at 25℃
Indirect Additives used in Food Contact Substances:HEXAMETHYLENE GLYCOL
FDA 21 CFR:178.3570
CAS DataBase Reference:629-11-8(CAS DataBase Reference)
FDA UNII:ZIA319275I
NIST Chemistry Reference:1,6-Hexanediol(629-11-8)
EPA Substance Registry System:1,6-Hexanediol (629-11-8)
UNSPSC Code:12352200

NACRES:NA.26
CAS Number:629-11-8
EC (EINECS) Number:211-074-0
Molecular Formula:C6H14O2
Molecular Weight:118.17 g/mol
Physical state:Solid (low-melting crystalline solid)
Color:White
Odor:Mild or nearly odorless

Melting point:~41–43 °C
Boiling point:~250 °C
Density:~0.96 g/cm³ (at 20–25 °C)
Vapor pressure:Very low (due to high boiling point)
Viscosity:Low to moderate when molten
Solubility:Highly soluble in water
Soluble in alcohols and many organic solvents

Functional groups:Two primary alcohol (–OH) groups
Chemical nature:Neutral, non-ionic compound
Reactivity:Reacts with acids → forms esters
Reacts with isocyanates → forms polyurethanes
Undergoes oxidation → forms aldehydes/acids
pH:Neutral in aqueous solution
Hygroscopicity:Slightly hygroscopic
Thermal stability:Stable under normal conditions

Molecular Weight:118.18
Formula:C6H14O2
Storage:Store at RT
Purity:≥98%
CAS Number:629-11-8
PubChem ID:12374
InChI Key:XXMIOPMDWAUFGU-UHFFFAOYSA-N
SMILES:OCCCCCCO

ECHA EINECS - REACH Pre-Reg:211-074-0
FDA UNII:ZIA319275I
Nikkaji Web:J6.886A
Beilstein Number:1633461
MDL:MFCD00002985
XlogP3-AA:0.30 (est)
Molecular Weight:118.17598000
Formula:C6 H14 O2
Appearance:white crystals (est)
Assay:95.00 to 100.00

Food Chemicals Codex Listed:No
Melting Point:42.00 to 45.00 °C @ 760.00 mm Hg
Boiling Point:250.00 °C @ 760.00 mm Hg
Boiling Point:239.00 to 240.00 °C @ 760.00 mm Hg (est)
Vapor Pressure:0.000500 mmHg @ 25.00 °C
Vapor Density:4.07 (Air = 1)
Flash Point:215.00 °F TCC (101.67 °C)
logP (o/w):-0.068 (est)

Soluble in:alcohol, water, 2.265e+004 mg/L @ 25 °C (est)
CAS No:0629-11-8
Purity:0.97
Formula:C6 H14 O2
Molecular Weight:118.18
Synonyms:Hexamethylene glycol
UNSPSC:12352104
MFCD:2985
Density:0.96
Melting Point:40°C - 43°C

Boiling Point:253°C - 260°C (760mmHg)
Flash Point:147°C
pH:7.6 (50% aq.sol.)
Refractive Index:1457
Viscosity:30mPa.s (60°C)
Physical Properties:Hygroscopic
Shelf Life:5 years
Method of Transport:Air/Sea/Road

Linear Formula:HO(CH2)6OH
CAS Number:629-11-8
Molecular Weight:118.17
UNSPSC Code:12162002
NACRES:NA.23
PubChem Substance ID:24854405
EC Number:211-074-0
Beilstein/REAXYS Number:1633461
MDL number:MFCD00002985

Physical state:flakes
Color:white
Odor:No data available
Melting point/freezing point:Melting point/range:38 - 42 °C - lit.
Initial boiling point and boiling range:250 °C - lit.
Flammability (solid,gas):No data available
Upper/lower flammability or explosive limits:Upper explosion limit:16 %(V)
Lower explosion limit:6,6 %(V)

Flash point:102 °C - closed cup
Autoignition temperature:320 °C at 1.013 hPa
Decomposition temperature:No data available
pH:5,7 at 500 g/l at 20 °C
Viscosity:Viscosity,kinematic:No data available
Viscosity,dynamic:No data available
Water solubility:1.000 g/l at 20 °C
Partition coefficient:n-octanol/water log Pow:0 at 25 °C - Bioaccumulation is not expected.

Vapor pressure:<0,01 hPa at 20 °C
Density:0,96 g/cm3 at 20 °C
Relative density:No data available
Relative vapour density:No data available
Particle characteristics:No data available
Explosive properties:No data available
Oxidizing properties:none
Other safety information:No data available

FIRST AID MEASURES of 1,6-HEXANEDIOL:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of 1,6-HEXANEDIOL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of 1,6-HEXANEDIOL:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of 1,6-HEXANEDIOL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of 1,6-HEXANEDIOL:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of 1,6-HEXANEDIOL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available