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2-Aminoacetic acid (Glycine)



CAS NO:  56-40-6


MW: 75.07

EINECS: 200-272-2


Melting point: 240 °C (dec.)(lit.)

Boiling point: 233°C

Density: 1.595

vapor pressure: 0.0000171 Pa (25 °C)


refractive index  1.4264 (estimate)

Flash point: 176.67°C

storage temp. 2-8°C

solubility H2O: 100 mg/mL

pka 2.35(at 25℃)

form  powder

color  <5 (200 mg/mL)(APHA)

Odor Odorless

PH 4(0.2 molar aqueous solution)

PH Range 4

Water Solubility  25 g/100 mL (25 ºC)

Λmax  λ: 260 nm Amax: 0.05  λ: 280 nm Amax: 0.05

Merck 14,4491

JECFA Number 1421

BRN  635782

Stability: Stable. Combustible. Incompatible with strong oxidizing agents.



Safety Information

Risk Statements 33

Safety Statements 22-24/25

WGK Germany 2

RTECS MB7600000


HS Code 29224910

Toxicity LD50 orally in Rabbit: 7930 mg/kg



Glycine is an amino acid that has a single hydrogen atom as its side chain. It is the simplest stable amino acid (carbamic acid is unstable), with the chemical formula NH2CH2COOH. Glycine is one of the proteinogenic amino acids. It is encoded by all the codons starting with GG (GGU, GGC, GGA, GGG). Glycine is integral to the formation of alpha-helices in secondary protein structure due to its compact form. For the same reason, it is the most abundant amino acid in collagen triple-helices. Glycine is also an inhibitory neurotransmitter – interference with its release within the spinal cord (such as during a Clostridium tetani infection) can cause spastic paralysis due to uninhibited muscle contraction. Glycine is a colorless, sweet-tasting crystalline solid. It is the only achiral proteinogenic amino acid. It can fit into hydrophilic or hydrophobicenvironments, due to its minimal side chain of only one hydrogen atom. The acyl radical is glycyl.


Synonms: glycine2-Aminoacetic acid56-40-6aminoacetic acidGlycocollAminoethanoic acidGlycolixirPadilGlycostheneAciportGlicoaminL-GlycineH-Gly-OHHampshire glycineAmitoneLeimzuckerAcetic acid, amino-AminoazijnzuurGlycine, non-medicalSucre de gelatineGyn-hydralinGLY (IUPAC abbrev)GlycinumCorilinGlycinum [INN-Latin]Glicina [INN-Spanish]Glycine [INN]glycyl radicalGlyzinFEMA No. 3287glyAcide aminoacetique [INN-French]Acido aminoacetico [INN-Spanish]Acidum aminoaceticum [INN-Latin]CCRIS 5915HSDB 495AI3-04085amino-Acetic acidUNII-TE7660XO1CMFCD00008131NSC 25936[14C]glycineCHEMBL773Glycine iron sulphate (1:1)TE7660XO1CCHEBI:154282-aminoaceticacidAZD-4282NSC25936AthenonNSC-25936polyglycineNCGC00024503-01GlicinaDSSTox_CID_667Glycine, free basePolyglycine IIAcido aminoaceticoAcide aminoacetiqueDSSTox_RID_75720DSSTox_GSID_20667Acidum aminoaceticumGlycine, 99%, ACS reagentGlycine, 99+%, for analysisGlykokollAminoessigsaeureHglyCAS-56-40-6Glycine, labeled with carbon-14Glycine [USP:INN]GLYCINE 1.5% IN PLASTIC CONTAINEREINECS 200-272-2H2N-CH2-COOHAMINOACETIC ACID 1.5% IN PLASTIC CONTAINERGlycine, homopolymer (VAN)Aminoethanoateamino-Acetate2-aminoacetateGlycine; glycine USPGlycine Technicalglycine-13c[3H]glycineGlycine, EP/USPH-GlyL-GlyGly-COGly-OHL-Glycine,(S)[14C]-glycineCorilin (Salt/Mix)25718-94-9Glycine 1 M solutionTocris-0219Glycine (H-Gly-OH)NH2CH2COOHGlycine, >=99%Glycine (JP17/USP)Glycine, 99%, FCCBiomol-NT_000195bmse000089bmse000977WLN: Z1VQEC 200-272-2H-[15N]Gly-OHGly-253GTPL727AB-131/40217813Glycine, Electrophoresis GradeBPBio1_001222GTPL4084GTPL4635N[C]C(O)=ODTXSID9020667BDBM18133Buffer Concentrate, pH 11.01Glycine, >=99.0% (NT)Glycine, 98.5-101.5%Pharmakon1600-013000212-Aminoacetic acid;Aminoacetic acidBCP25965CS-B1641HY-Y0966ZINC4658552Glycine, ACS reagent, >=98.5%Tox21_1135752-amino-1-$l^{1}-oxidanylethanoneANW-32505Glycine, 99%, natural, FCC, FGNSC760120s4821STL194276Glycine, purum, >=98.5% (NT)Glycine, tested according to Ph.Eur.AKOS000119626Glycine, for electrophoresis, >=99%Tox21_113575_1AM81781CCG-266010DB00145MCULE-2415764032NSC-760120Glycine, BioUltra, >=99.0% (NT)Glycine, BioXtra, >=99% (titration)Glycine, SAJ special grade, >=99.0%NCGC00024503-02NCGC00024503-0318875-39-3AK-77854BP-31024BR-77854Glycine, Vetec(TM) reagent grade, 98%Glycine, 0.2M buffer solution, pH 2.5Glycine, 0.2M buffer solution, pH 3.0Glycine, 0.2M buffer solution, pH 3.5DB-029870FT-0600491FT-0669038G0099G0317Glycine, ReagentPlus(R), >=99% (HPLC)A20662C00037D00011M-6155M03001L001246Q620730SR-01000597729Glycine, certified reference material, TraceCERT(R)Q-201300SR-01000597729-1Q27115084B72BA06C-60E9-4A83-A24A-A2D7F465BB65F2191-0197Glycine, European Pharmacopoeia (EP) Reference StandardZ955123660Glycine, BioUltra, for molecular biology, >=99.0% (NT)UNII-0O72R8RF8A component DHMQDGOQFOQNFH-UHFFFAOYSA-NGlycine, United States Pharmacopeia (USP) Reference StandardGlycine, Pharmaceutical Secondary Standard; Certified Reference MaterialTris-tricine buffer; Tris-glycine buffer;Tris glycine buffer concentrateGlycine, analytical standard, for nitrogen determination according to Kjeldahl methodGlycine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, >=98.5%Glycine, meets analytical specification of Ph. Eur., BP, USP, 99-101% (based on anhydrous substance)Glycine, PharmaGrade, Ajinomoto, EP, JP, USP, manufactured under appropriate GMP controls for Pharma or Biopharmaceutical production, suitable for cell cultureGlycine, puriss. p.a., Reag. Ph. Eur., buffer substance, 99.7-101% (calc. to the dried substance)


Glycine is an amino acid, a building block for protein. It is not considered an “essentialamino acid” because the body can make it from other chemicals. A typical diet contains about 2 grams of glycine daily. The primary sources are protein-rich foods including meat, fish, dairy, and legumes. Glycine is used for treating schizophreniastrokebenign prostatic hyperplasia (BPH), and some rare inherited metabolic disorders. It is also used to protect kidneys from the harmful side effects of certain drugs used after organ transplantation as well as the liverfrom harmful effects of alcohol. Other uses include cancer prevention and memoryenhancement. Some people apply glycine directly to the skin to treat leg ulcers and heal other wounds. The body uses glycine to make proteins. Glycine is also involved in the transmission of chemical signals in the brain, so there is interest in trying it for schizophrenia and improving memory. Some researchers think glycine may have a role in cancer prevention because it seems to interfere with the blood supply needed by certain tumors.


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