PRODUCTS

2-BROMOPROPANE

2-Bromopropane is also known as 75-26-3, 2-bromo-propane, isopropyl bromide, Propan-2-bromo with Molecular Formula of C3H7Br and Molecular Weight of 122.99168.
2-Bromopropane is manufactured by heating isopropyl alcohol with HBr and is available in colorless liquid form.
2-Bromopropane is also used as an intermediate to form alkylated amines and alkylated metallic compounds.

CAS Number: 75-26-3
EC Number: 200-855-1
Molecular Formula: 13C3H7Br
Molecular Weight: 125.97

2-Bromopropane, also known as isopropyl bromide and 2-propyl bromide, is the halogenated hydrocarbon with the formula CH3CHBrCH3.
2-Bromopropane is a colorless liquid.

2-Bromopropane is used for introducing the isopropyl functional group in organic synthesis.
2-Bromopropane is prepared by heating isopropanol with hydrobromic acid.

2-Bromopropane serves as an alkylating agent in organic synthesis.
2-Bromopropane is also used as an intermediate to form alkylated amines and alkylated metallic compounds.

Further, 2-Bromopropane acts as a solvent for industrial cleaning, degreasing, metal processing and finishing, electronics, aerospace and aviation, aerosols, textiles, adhesives and inks.
In addition, 2-Bromopropane is used for introducing the isopropyl functional group in organic synthesis.

2-Bromopropane is an organobromide compound.
2-Bromopropane is used for introducing the isopropyl functional group in organic synthesis.

2-Bromopropane is sometimes used as an alternative to ozone-depleting cleaning solvents such as chlorofluorocarbons.
2-Bromopropane is prepared by heating isopropanol with hydrobromic acid.

Some of 2-Bromopropane properties include Boiling Point of 59-60°C, Melting Point of -89.0°C, Density/Specific Gravity of 1.31 at 20°C/4°C with miscible solubility with chloroform, ether, alcohol, benzene; slight solubility in acetone and in water (3,180 mg/L at 20°C).
Further, 2-Bromopropane has Surface Tension of 3.5348X10-2 N/m at melting point, Vapor Density of 4.27 (Air=1) and Vapor Pressure of 216 mm Hg at 25°C.

2-Bromopropane, also known as isopropyl bromide or 2-propyl bromide, is used for introducing the isopropyl functional group in organic synthesis.
Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.

2-Bromopropane has proved to be a useful reagent for amino acids dissolved in dimethylsulfoxide/sodium hydride, except for the determination of arginine.
Methylation of acids with diazomethane has also been used for metabolic profiling despite the formation of artefacts.

Resin-mediated methylation of polyfunctional acids found in fruit juices has also proved successful.
Fumaric, succinic, malic, tartaric, isocitric and citric acids, isolated from fruit juices by trapping onto anionic ion exchange resins, can be efficiently converted to methyl esters by reaction with methyl iodide in both supercritical carbon dioxide and acetonitrile.

To provide for the analysis of even short chain fatty acids in serum, a procedure has been developed with benzyl bromide.
This has been successfully employed for serum and urine organic acid profiling.
The method cannot be used for citric acid or sugar-related acids.

Exposure to 2-Bromopropane has been associated with adverse reproductive effects in men and women.
There are also some reports suggesting that maternal formaldehyde exposure is related to delayed conception and miscarriage, and exposure to trinitrotoluene or trichloroethylene may be harmful for the reproductive health of men.
Formamide, dimethylformamide and n-methyl-2-pyrrolidone have also been shown to cause fetotoxic and teratogenic effects in laboratory animals, but there are no data on their effects in humans.

In summary, the epidemiologic evidence suggests that high maternal exposure to solvents may represent a hazard for the developing fetus and may impair female fertility.
The results for male fertility are less conclusive.

The findings on individual solvents must also be interpreted with caution, because coincident exposure to several agents makes 2-Bromopropane difficult to ascribe adverse effects to a specific compound.
Nevertheless, the study results are supportive of adverse effects of some glycol ethers, tetrachloroethylene, toluene, benzene and carbon disulfide on reproduction.
2-Bromopropane would be prudent to minimize exposure to organic solvents.

2-Bromopropane, also known as isopropyl bromide and 2-propyl bromide, is the halogenated hydrocarbon with the formula CH3CHBrCH3.
2-Bromopropane is a colorless liquid.

2-Bromopropane is used for introducing the isopropyl functional group in organic synthesis.
2-Bromopropane is prepared by heating isopropanol with hydrobromic acid.

Applications of 2-Bromopropane:
2-Bromopropane is used for introducing the isopropyl functional group in organic synthesis.
2-Bromopropane is also used as an intermediate to form alkylated amines and alkylated metallic compounds.

2-Bromopropane is the insecticide fenvalerate, fenvalerate, propoxur, bactericide, rustamine, fluoroamide and herbicide, an intermediate of the phosphorus of sarcandra.
2-Bromopropane is used in organic synthesis and pharmaceutical industry

2-Bromopropane is used in organic synthesis and pharmaceutical, pesticide intermediates
2-Bromopropane is used as Grignard reagents and raw materials, intermediates of drugs and dyes are also used in the manufacture of pesticides (bisulfate) and the like.

Uses of 2-Bromopropane:
2-Bromopropane serves as an alkylating agent in organic synthesis.
2-Bromopropane is also used as an intermediate to form alkylated amines and alkylated metallic compounds.

2-Bromopropane is used as a freon substitute.
2-Bromopropane is used in organic synthesis.

2-Bromopropane is used in the synthesis of pharmaceuticals, dyes and other organics.
2-Bromopropane is an industrial and laboratory chemical.

Industry Uses:
Intermediates

Industrial Processes with risk of exposure:
Metal Degreasing

Nature of 2-Bromopropane:
2-Bromopropane is colorless volatile liquid.
2-Bromopropane is relative density is 1. 3140(20 ℃).

2-Bromopropane is melting Point -89 °c.
2-Bromopropane is boiling Point 59. 38 °c.

2-Bromopropane is refractive index 1.4251(20 degrees C).
2-Bromopropane is slightly soluble in water, with alcohol, ether, benzene, chloroform miscible.

Preparation of 2-Bromopropane:
2-Bromopropane is commercially available.
2-Bromopropane may be prepared in the ordinary manner of alkyl bromides, by reacting isopropanol with phosphorus and bromine, or with phosphorus tribromide.

Production Method of 2-Bromopropane:
From isopropyl alcohol and hydrobromic acid reaction.
Slowly add isopropyl alcohol into concentrated sulfuric acid under cooling, control the temperature below 30 ℃, add hydrobromic acid after adding, slowly heat and reflux for 4H, and then distill the appearance of oil droplets, the obtained crude product was washed with concentrated sulfuric acid, water and 5% sodium carbonate respectively, then dried, filtered and fractionated with anhydrous sodium carbonate, and the 58.5-60.5 ° C.

Fraction was collected as the finished product.
In addition, there is an isopropyl alcohol-sodium bromide method.
The preparation method is derived from the reaction of isopropyl alcohol and hydrobromic acid.

The reaction equation is as follows:
(CH3)2CHOH + HBr[H2SO4]→(CH3)2CHBr + H2O

Isopropanol is slowly added to concentrated sulfuric acid under cooling, and the temperature is controlled below 30 ℃, after the addition, hydrobromic acid was added, and the mixture was slowly heated and refluxed for 4 h, then distilled until oil droplets appeared.
The crude product was washed with concentrated sulfuric acid, water and 5% sodium carbonate respectively, and then dried with anhydrous sodium carbonate, filtration, fractionation, collection of 58.5~60.5 °c fraction, that is, the finished product.

MeSH Pharmacological Classification of 2-Bromopropane:

Solvents:
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar.

Mutagens:
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids.
A clastogen is a specific mutagen that causes breaks in chromosomes.

Stability and Reactivity of 2-Bromopropane:

Reactive Hazard:
None known, based on information available

Stability:
Stable under normal conditions.

Conditions to Avoid:
Incompatible products.
Excess heat.
Keep away from open flames, hot surfacesandsources of ignition.

Incompatible Materials:
Strong oxidizing agents, Strong bases

Hazardous Decomposition Products:
Carbon monoxide (CO), Carbon dioxide (CO2)

Hazardous Polymerization:
Hazardous polymerization does not occur.

Hazardous Reactions:
None under normal processing

Handling and Storage of 2-Bromopropane:

Handling:
Use only under a chemical fume hood.
Wear personal protective equipment/faceprotection.

Do not get in eyes, on skin, or on clothing.
Keep away from open flames, hot surfaces and sources of ignition.

Use only non-sparking tools.
Use spark-proof tools and explosion-proof equipment.

Do not breathe (dust, vapor, mist, gas).
Do not ingest.

If swallowed then seek immediate medical assistance.
Take precautionary measures against static discharges.
To avoid ignition of vapors by static electricity discharge, all metal parts of the equipment mustbe grounded.

Storage:
Keep containers tightly closed in a dry, cool and well-ventilated place.
Keep away from heat, sparks and flame.

Storage Conditions:
Materials which are toxic as stored or which can decompose into toxic components should be stored in a cool, well ventilated place, out of the direct rays of the sun, away from areas of high fire hazard, and should be periodically inspected.
Incompatible materials should be isolated.

Safety of 2-Bromopropane:
Short-chain alkyl halides are often carcinogenic.

The bromine atom is at the secondary position, which allows the molecule to undergo dehydrohalogenation easily to give propene, which escapes as a gas and can rupture closed reaction vessels.
When this reagent is used in base catalyzed reactions, potassium carbonate should be used in place of sodium or potassium hydroxide.

Fire Fighting Procedures of 2-Bromopropane:

If material on fire or involved in fire:
Do not extinguish fire unless flow can be stopped.
Use water in flooding quantities as fog.

Solid streams of water may be ineffective.
Cool all affected containers with flooding quantities of water.

Use alcohol foam, dry chemical or carbon dioxide.
Keep run-off water out of sewers and water sources.

Accidental Release Measures of 2-Bromopropane:

Disposal Methods of 2-Bromopropane:
At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision.
Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Preventive Measures of 2-Bromopropane:

If material on fire or involved in fire:
Do not extinguish fire unless flow can be stopped.
Use water in flooding quantities as fog.

Solid streams of water may be ineffective.
Cool all affected containers with flooding quantities of water.

Use alcohol foam, dry chemical or carbon dioxide.
Keep run-off water out of sewers and water sources.

Personnel protection:
Avoid breathing vapors.
Do not handle broken packages unless wearing appropriate personal protective equipment.
If contact with the material anticipated, wear appropriate chemical protective clothing.

Identifiers of 2-Bromopropane:
CAS Number: 75-26-3
Beilstein Reference: 741852
ChEMBL: ChEMBL451810
ChemSpider: 6118
ECHA InfoCard: 100.000.778
EC Number: 200-855-1
PubChem CID: 6358
RTECS number: TX4111000
UNII: R651XOV97Z
UN number: 2344
CompTox Dashboard (EPA): DTXSID7030197
InChI: InChI=1S/C3H7Br/c1-3(2)4/h3H,1-2H3
Key: NAMYKGVDVNBCFQ-UHFFFAOYSA-N
SMILES: CC(C)Br

Catalogue Number: B687191
CAS Number: 220505-11-3
Molecular Formula: ¹³C₃H₇Br
Molecular Weight: 125.97

Properties of 2-Bromopropane:
Chemical formula: C3H7Br
Molar mass: 122.993 g·mol−1
Appearance: Colorless liquid
Density: 1.31 g mL−1
Melting point: −89.0 °C; −128.1 °F; 184.2 K
Boiling point: 59 to 61 °C; 138 to 142 °F; 332 to 334 K
Solubility in water: 3.2 g L−1 (at 20 °C)
log P: 2.136
Vapor pressure: 32 kPa (at 20 °C)
Henry's law
constant (kH): 1.0 μmol Pa−1 mol−1
Refractive index (nD): 1.4251
Viscosity: 0.4894 mPa s (at 20 °C)

Physical State Liquid
Appearance: Colorless, Light brown
Odor: Odorless
Odor Threshold: No information available
pH: No information available
Melting Point/Range: -89 °C / -128.2 °F
Boiling Point/Range: 59 °C / 138.2 °F @ 760 mmHg
Flash Point: 1 °C / 33.8 °F
Evaporation Rate: No information available
Flammability (solid,gas): Not applicable
Flammability or explosive limits:
Upper: No data available
Lower: 4.6 vol %
Vapor Pressure: 224 mbar @ 20 °C
Vapor Density: No information available
Specific: Gravity 1.310
Solubility: No information available
Partition coefficient; n-octanol/water: No data available
Autoignition: Temperature No information available
Decomposition: Temperature 251 °C
Viscosity: No information available
Molecular Formula: C3 H7 Br
Molecular Weight: 122.99

Physical State: Liquid
Usage: Commerical
Purity: 99% min
Boiling Point: 58-60degree C
Moisture: 0.5% max
Density: 1.31(w/w)

Molecular Weight: 122.99
XLogP3-AA: 1.8
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 0
Rotatable Bond Count: 0
Exact Mass: 121.97311
Monoisotopic Mass: 121.97311
Topological Polar Surface Area: 0 Å²
Heavy Atom Count: 4
Complexity: 10.8
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

Specifications of 2-Bromopropane:
Product Name: ISO Propyl Bromide/(2 Bromopropane)
Cas No: 75-26-3
Assay: 99% MIN
Test: Standard
Colour: Colourless liquid
Density: 1.31(w/w)
Moisture: 0.5% max
Boiling Point: 58-60°C
Purity: 99% min

Appearance (Clarity): Clear
Appearance (Colour): Colourless to pale yellow
Appearance (Form): Liquid
Colour (APHA): max. 30
Assay (GC): min. 99%
Density (g/ml) @ 20°C: 1.305-1.315
Refractive Index (20°C): 1.424-1.425
Boiling Range: 58-60°C
Stabilizer (Ag wire): Present

Thermochemistry of 2-Bromopropane:
Heat capacity (C): 135.6 J K mol−1
Std enthalpy of formation (ΔfH⦵298): −129 kJ mol−1
Std enthalpy of combustion (ΔcH⦵298): −2.0537–−2.0501 MJ mol−1

Related compounds of 2-Bromopropane:

Related alkanes:
Bromoethane
1-Bromopropane
tert-Butyl bromide
1-Bromobutane
2-Bromobutane

Related Products of 2-Bromopropane:
Hydroxynorketamine-d6 Hydrochloride
(S)-Ketamine-d6 Hydrochloride
Norketamine-d4
S-(-)-Norketamine-d6 Hydrochloride
Phencyclidine-d5 Hydrochloride

Names of 2-Bromopropane:

Preferred IUPAC name:
2-Bromopropane

Other name:
Isopropyl bromide

Synonyms of 2-Bromopropane:
2-Bromopropane
75-26-3
ISOPROPYL BROMIDE
Propane, 2-bromo-
Isopropylbromide
2-BROMO-PROPANE
sec-Propyl bromide
2-bromo propane
UN2344
R651XOV97Z
MFCD00000147
CCRIS 7919
HSDB 623
EINECS 200-855-1
UNII-R651XOV97Z
i-propylbromide
AI3-18127
2-brompropan
iso-propylbromide
i-propyl bromide
2-bromanylpropane
2-propyl bromide
1-isopropylbromide
iso-propyl bromide
i-PrBr
iso-C3H7Br
1-bromo-1-methylethane
2-Bromopropane, 99%
EC 200-855-1
2-Bromopropane [UN2344] [Flammable liquid]
2-Bromopropane, >=99%
SCHEMBL10251
ISOPROPYL BROMIDE [MI]
CHEMBL451810
DTXSID7030197
2-Bromopropane, analytical standard
AMY37129
ZINC2041293
Tox21_200356
BBL027287
BR1118
STL146524
AKOS000119846
UN-2344
CAS-75-26-3
NCGC00091451-01
NCGC00091451-02
NCGC00257910-01
VS-08520
2-Bromopropane, purum, >=99.0% (GC)
B0639
FT-0611602
EN300-20069
D87619
A838364
Q209323
J-508539
F0001-1897

MeSH Entry Terms of 2-Bromopropane:
2-bromopropane
isopropyl bromide