PRODUCTS

2-METHYL-2H-ISOTHIAZOL-3-ONE

2-methyl-2H-isothiazol-3-one, is a powerful synthetic biocide and preservative within the group of isothiazolinones.
2-methyl-2H-isothiazol-3-one is used to control slime-forming bacteria, fungi, and algae in pulp/paper mills, cooling water systems, oil field operations, industrial process waters, and air washer systems.
And 2-methyl-2H-isothiazol-3-one is incorporated into adhesives, coatings, fuels, metal working fluids, resin emulsions, paints, and various other specialty industrial products as a preservative.

CAS:   2682-20-4
MF:   C4H5NOS
MW:   115.15
EINECS:   220-239-6

Synonyms
1-(4-CHLOROPHENYL)-3-(3,4-DICHLOROPHENYL)UREA;2-METHYL-4-ISOTHIAZOLIN-3-ONE;2-METHYL-4-ISOTHIAZOLINE-3-ONE;2-METHYL-3(2H)-ISOTHIAZOLONE;N-METHYL-3-OXODIHYDRO ISOTHIAZOLE;2-methyl-3(2h)-isothiazolon;Isothiazolone,2-methyl-;Methylisothiazolinone;2682-20-4;2-Methyl4-isothiazolin-3-one;Methylisothiazolinone;2-Methyl-3(2H)-isothiazolone;2-methylisothiazol-3(2h)-one;2-Methyl-4-isothiazoline-3-one;Neolone;3(2H)-Isothiazolone, 2-methyl-;Caswell No. 572A;Microcare MT;Kordek MLX;2-methyl-3-isothiazolone;MIT (biocide);Acticide M 10;Acticide M 20;Bestcide 600;Kordek 50;Kordek 50C;EINECS 220-239-6;Kordek 573F;Kathon CG 243;2-METHYL-2H-ISOTHIAZOL-3-ONE;N-Methyl-3-oxodihydroisothiazole;N-METHYL-3-OXODIHYDRO ISOTHIAZOLE;n-methylisothiazolin-3-one;2-methyl-1,2-thiazol-3(2H)-one;UNII-229D0E1QFA;DTXSID2034259;MIT;CHEBI:53620;HSDB 8200;MIT 950;MT 10;2-Methyl-4-isothiazoline-3-ketone;KB 838;MFCD01742315;229D0E1QFA;DTXCID0014259;2682-20-4 (free base);METHYLISOTHIAZOLINONE [II];METHYLISOTHIAZOLINONE [MI];METHYLISOTHIAZOLINONE [VANDF];METHYLISOTHIAZOLINONE [MART.];methyl-isothiazolinone;METHYLISOTHIAZOLINONE (II);METHYLISOTHIAZOLINONE (MART.;2-methyl-1,2-thiazol-3-one;methylisothiazolidinone;243-K-Cg;Neolone 950; 2-Methyl-4-isothiazolin-3-one; 2-Methylisothiazol-3-one;2-Methyl-4-isothiazolin-3-one (MI);2Methyl2Hisothiazol3one;2Methyl4isothiazolin3one;2-methyl-2,3-dihydro-1,2-thiazol-3-one;2Methyl3(2H)isothiazolone;2Methylisothiazol3(2H)one;2-methyl-4-isothiazolinone;2-methyl-isothiazol-3-one;SCHEMBL17863;3(2H)Isothiazolone, 2methyl;SCHEMBL113898;Methylisothiazolinone free base;2Methyl2,3dihydroisothiazol3one;Methylisothiazolinone (Standard);CHEMBL1620780;2-Methyl-4-isothiazolin-3-one 100 microg/mL in Acetonitrile;2-Methyl-3(2H)-isothiazolone #;HY-W010520R;METHYLISOTHIAZOLINONE [INCI];Tox21_303814;BBL104136;STL557951;AKOS007930246;CS-W011236;FM16100;HY-W010520;2-Methyl-4-isothiazolin-3-one, 95%;2-Methyl-4-isothiazolin-3-one - 96%;2Methyl4isothiazolin3one calcium chloride;NCGC00357093-01;FM164967;CAS-2682-20-4;DB-005250;NS00003875;F21330;EN300-1708622;Q423870;2-Methyl-4-isothiazolin-3-one, analytical standard;2-Methyl-4-isothiazolin-3-one - 50% aqueous solution;Z3227502095

2-methyl-2H-isothiazol-3-one is also used to control the growth of mold, mildew, and sapstain on wood products.
2-methyl-2H-isothiazol-3-one is generally recommended for use only in rinse-off and leave-on cosmetic products (maximum concentration of 100 ppm) as preservative such as shampoo, conditioner, hair color, body wash, lotion, sunscreen, mascara, shaving cream, baby lotion, baby shampoo, hairspray, makeup remover, liquid soaps, and detergents.
Nevertheless, methylisothiazolinone is allergenic.
2-methyl-2H-isothiazol-3-one is reported that methylisothiazolinone in rinse-off products causes allergic contact dermatitis.
2-methyl-2H-isothiazol-3-one is an isothiazolinone-derived biocide used for controlling microbial growth in industrial and household products, often in a mixture with 5-chloro-2-methyl-3-isothiazolone (MCI).
2-methyl-2H-isothiazol-3-one is active against Gram-positive and Gram-negative bacteria, fungi, and yeast with MIC values of 0.0045, 0.0015, >0.01, and 0.0065% (w/w) for S. aureus, P. aeruginosa, A. niger, and C. albicans, respectively, when used alone.
2-methyl-2H-isothiazol-3-one values are 7 to 200-fold lower when MI is used in combination with MCI.

2-methyl-2H-isothiazol-3-one decreases neurite outgrowth of rat cortical neurons when used at concentrations of 0.1-3 μM and inhibits Src family kinases in cell-free assays.
MI, alone and as a mixture with MCI, can elicit contact sensitization.
2-methyl-2H-isothiazol-3-one is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom.
2-methyl-2H-isothiazol-3-one is a powerful biocide and preservative and is the minor active ingredient in the commercial product Kathon(TM).
2-methyl-2H-isothiazol-3-one has a role as an antifouling biocide, an antimicrobial agent and an antifungal agent.
2-methyl-2H-isothiazol-3-one, is the organic compound with the formula S(CH)2C(O)NCH3.
2-methyl-2H-isothiazol-3-one is a white solid.

Isothiazolinones, a class of heterocycles, are used as biocides in numerous personal care products and other industrial applications.
2-methyl-2H-isothiazol-3-one and related compounds have attracted much attention for their allergenic properties, e.g. contact dermatitis.
2-methyl-2H-isothiazol-3-one is prepared by cyclization of cis-N-methyl-3-thiocyanoacrylamide:
2-methyl-2H-isothiazol-3-one is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom.
2-methyl-2H-isothiazol-3-one is a powerful biocide and preservative and is the minor active ingredient in the commercial product Kathon(TM).
2-methyl-2H-isothiazol-3-one has a role as an antifouling biocide, an antimicrobial agent and an antifungal agent.

2-methyl-2H-isothiazol-3-one Chemical Properties
Melting point: 254-256 °C(lit.)
Boiling point: bp0.03 93°
Density: 1.25 (14% aq.)
Vapor pressure: <0.1 mm Hg ( 25 °C)
Storage temp.: 2-8°C
Solubility: Chloroform, Ethyl Acetate
Form: Solid
pka: -2.03±0.20(Predicted)
Color: Yellow
Water Solubility: 489g/L at 20℃
BRN: 606203
InChIKey: BEGLCMHJXHIJLR-UHFFFAOYSA-N
LogP: -0.486 at 20℃
CAS DataBase Reference: 2682-20-4(CAS DataBase Reference)
NIST Chemistry Reference: 3(2H)-isothiazolone, 2-methyl-(2682-20-4)
EPA Substance Registry System: 2-methyl-2H-isothiazol-3-one (2682-20-4)

2-methyl-2H-isothiazol-3-one is a colorless,clear liquid with amild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene.
2-methyl-2H-isothiazol-3-one is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%.

Uses
2-methyl-2H-isothiazol-3-one as it is sometimes known, is a preservative used in cosmetics and beauty products.
2-methyl-2H-isothiazol-3-one is a powerful biocide, or “chemical substance capable of killing living organisms, usually in a selective way.
Ultimately, 2-methyl-2H-isothiazol-3-one is used to prevent a wide variety of bacteria and fungi from growing in cosmetics and beauty products, most often in shampoo.
2-methyl-2H-isothiazol-3-one is only approved for use in rinse-off formulas and at low concentrations.
2-methyl-2H-isothiazol-3-one is a isothiazolinone based biocide and preservative used in personal care products.
2-methyl-2H-isothiazol-3-one is also used for controlling microbial growth in water-c ontaining solution.
2-methyl-2H-isothiazol-3-one is a preservative compound widely used in cosmetics.
2-methyl-2H-isothiazol-3-one is a contact allergen and sensitiser.
2-methyl-2H-isothiazol-3-one has recently been identified as a neurotoxin that can damage nerve endings with repeated exposure.
2-methyl-2H-isothiazol-3-one is an isothiazolinone-based biocide and preservative used in personal care products.
2-methyl-2H-isothiazol-3-one may also be an allergen.
2-methyl-2H-isothiazol-3-one is also used to control the growth of microorganisms in aqueous solutions.

Preparation
2-methyl-2H-isothiazol-3-one is prepared by cyclization of cis-N-methyl-3-thiocyanoacrylamide:
NCSCH=CHC(O)NHCH3?SCH=CHC(O)NCH3+HCN

Side effects
Early on, dermatitis may occur only on part of the exposed skin.
Common patterns include: hand dermatitis，perianal dermatitis, perivulval dermatitis, napkin dermatitis, facial dermatitis, eyelid swelling, and scalp dermatitis.
Later, more extensive and severe whole-body contact dermatitis may occur in very sensitive people.