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EC / List no.: 606-191-2
CAS no.: 18979-61-8
Mol. formula: C10H14O2
4-Butylresorcinol, sometimes called 4-n-butylresorcinol, is a chemical used to treat hyperpigmentation of the epidermis.
Hyperpigmentation is believed to be related to the chemical tyrosinase which causes the production of melanin.
Among several chemicals known to inhibit tyrosinase production, such as hydroquinone, arbutin, and kojic acid, 4-butylresorcinol has been found to be the most powerful inhibitor by a wide margin.
resorcinol derivative
4-n-Butylresorcinol is a resorcinol derivative that inhibits both tyrosinase and tyrosinase-related protein-1 (TRP-1).
4-Butylresorcinol may be used to decrease skin irritation and is also known to inhibit melanin production.
Its hypopigmenting action was first reported in 1995, and many following studies have documented its efficacy and safety in melasma treatment with the 0.1% cream, but there is paucity of clinical studies that used the 0.3% cream.
The biochemical assay on inhibition of human tyrosinase activity has revealed the superiority of 4-n-butylresorcinol over other hypopigmenting agents.
Many studies show good efficacy and safety in treating melisma.
4-n-Butylresorcinol may be used to produce a safe cosmetic agent, with the clinical efficacy required of a pharmacological agent.
Furthermore, 4-n-butylresorcinol acts mainly by inhibition of tyrosinase activity and has no effect on MITF.
4-n-butylresorcinol showed an additive effect in combination with hinokitiol, which reduces MITF expression.
History 4-n-Butylresorcinol (Rucinol) (Obtained by POLA in 1998) was selected by screening synthetic resorcinol derivatives that can elicit strong competitive inhibition of tyrosinase activity.
Melanin synthesis is catalyzed by tyrosinase, together with tyrosinase-related proteins (TRP) -1 and -2, and Rucinol® has been shown to inhibit melanin synthesis in cultured mouse melanocytes via direct inhibition not only of tyrosinase activity, but also of TRP-1 activity.
A 0.3% Rucinol® -containing lotion was shown to be effective for treating hyperpigmentary disorders, such as melasma.
Uses
4-Butylresorcinol is considered a potential Cytochrome P450 inhibitor. 4-Butylresorcinol can cause hypopigmentation due to its direct inhibition of tyrosinase.
tyrosinase inhibitor
4-butylresorcinol is use as an effective treatment option for topical hyperpigmentation management. Similar to hydroquinone, 4-n-butylresorcinol is also a tyrosinase inhibitor.
4-Butylresorcinol has been characterized as a strong tyrosinase25 and TRP‐126 inhibitor.
We measured an IC50 in the human tyrosinase assay of 21μmol/L for 4‐butylresorcinol compared with 94 and 131 μmol/L for 4‐hexylresorcinol and 4‐phenylethylresorcinol respectively.
Also on skin models, 4‐butylresorcinol was most effective of all tested substances with an IC50 of 13.5 μmol/L.
Therefore, 4‐butylresorcinol was selected for several clinical studies to prove in vivo efficacy.
In comparison with 4‐hexylresorcinol and 4‐phenylethylresorcinol, 4‐butylresorcinol treated age spots showed a faster onset of improvement and also a higher degree of lightening after 12 weeks of treatment.
4-butylresorcinol is a derivative of resorcinol and a potent human tyrosinase inhibitor.
4-Butylresorcinol may be used to decrease skin irritation and is also known to inhibit melanin production.
A Powerful and Safe Whitening & Skin-lightening Agent
4-Butylresorcinol is a whitening and skin lightening agent with unique characteristics in terms of efficacy and safety on the skin.
Hyperpigmentation is due to melanin accumulation, which can occur because of aging or disorders like melasma.
The key regulator of melanin production is the enzime tyrosinase, and therefore this enzime is the most prominent target for all the whitening agents.
4-Butylresorcinol is a strong inhibitor of tyrosinase and peroxidase/H2O2, effective as skin lightener and ever-tone for normal and hyper-pigmented skin and even suitable for Melasma treatment.
4-Butylresorcinol showed a superior efficacy compared to plant extracts and especially to such products as hydroquinone, arbutin and kojic acid, the most powerful whitening agents on the market.
4-Butylresorcinol is absolutely safe, its whitening power being combined with a strong protective effect against H2O2-induced DNA damage and an anti-glycation property: a synergic action to improve the skin’s appearence.
Several clinical studies have proved the strong efficacy of this product in cream, serum, chemical peeling and skin treatments.
The most recent and innovative application is in rinse-off products.
Soap being used by consumers on daily basis, 4-Butylresorcinol was added to both liquid and solid soap formulations and showed its efficacy as skin lightening after only a few weeks of treatment.
4-Butylresorcinol shows that 4-Butylresorcinol (4-n-butylresorcinol) significantly inhibits melanin synthesis in a concentration-dependent manner.
In addition, it is also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme.
4-Butylresorcinol does not induce ERK, Akt activation, or MITF degradation, and has no effect on cAMP response element binding protein (CREB) phosphorylation, which stimulates MITF expression.
4-Butylresorcinol strongly reduces tyrosinase activity in a cell-free system.
Moreover, 4-Butylresorcinol shows an additive effect in combination with hinokitiol, which reduces MITF expression.
4-BUTYLRESORCINOL is classified as :
Antioxidant
CAS Number 18979-61-8
COSING REF No: 54209
Chem/IUPAC Name: 1,3-Dihydroxy-4-N Butyl Benzene
Category
Antioxidants
Lightening / Whitening Agents
Application/Recommended for
Creams, lotions & gels
Skin care (Facial care, Facial cleansing, Body care, Baby care)
Sun care (Sun protection, After-sun & Self-tanning)
whitening
4-Butylresorcinol is a potent inhibitor of tyrosinase(IC50 : 11.27 μM), and is used in cosmetics as a depigmenting agent.
Shipping Condition
Evaluation sample solution: ship with blue ice.
All other available sizes: ship with RT, or blue ice upon request.
General tips
For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while.
Stock solution can be stored below -20°C for several months.
Product Description
N-4-Butylresorcinol is a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation.
The most prominent target for inhibitors of hyperpigmentation is tyrosinase, the key regulator of melanin production.
The present in vitro and in vivo data prove the high inhibitory capacity of 4-n-butylresorcinol on human tyrosinase activity, exceeding by far the potency of hydroquinone, arbutin and kojic acid.
The resulting clinical improvement of skin hyperpigmentations reveals 4-n-butylresorcinol as a very valuable active compound for the management of pigmentation disorders.
INCI name: 4-BUTYLRESORCINOL
Its functions (INCI)
Antioxidant: Inhibits reactions favored by oxygen, thus preventing oxidation and rancidity
4-n-butylresorcinol is a derivative of resorcinol and a potent human tyrosinase inhibitor.
4-Butylresorcinol may be used to decrease skin irritation and is also known to inhibit melanin production.
This product is furnished for LABORATORY RESEARCH USE ONLY.
Not for diagnostic or therapeutic use.
4-Butylresorcinol can be analyzed by this reverse phase (RP) HPLC method with simple conditions.
The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid.
For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid.
Smaller 3 µm particles columns available for fast UPLC applications.
This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation.
4-Butylresorcinol also suitable for pharmacokinetics.
4-Butylresorcinol is considered a potential Cytochrome P450 inhibitor.
4-Butylresorcinol can cause hypopigmentation due to its direct inhibition of tyrosinase.
Liposomes are preparations which have many advantages such as high solubility and good stability.
The 4-n-butylresorcinol has the effect of hypopigmentation and, similar to resorcinol, is unstable.
Liposomes could, therefore, assist the development of 4-n-butylresorcinol in a more appropriate dosage form.
The research presented in this article aimed to determine the effect of the concentration of soy lecithin phospholipids to the liposome particle size.
Subsequently, the effect of adding 4-n-butylresorcinol as the active compound to the liposomes in the particle size and morphology of the liposomes is also presented.
The preparation of liposomes was assisted by sonication, and subsequently, the active compound 4-n-butylrecorcinol was added.
Particle size and morphology of liposomes were then characterized as the observed parameters.
In this research, there was no evidence that the size of the liposomes was significantly affected by the concentration of phospholipids.
About 4-Butylresorcinol
Helpful information
4-Butylresorcinol is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 to < 10 per annum.
4-Butylresorcinol is used by consumers, in articles and in formulation or re-packing.
Consumer Uses
4-Butylresorcinol is used in the following products: cosmetics and personal care products.
Other release to the environment of 4-Butylresorcinol is likely to occur from: indoor use as processing aid.
Article service life
Other release to the environment of 4-Butylresorcinol is likely to occur from: indoor use as processing aid.
ECHA has no public registered data indicating whether or into which articles the substance might have been processed.
Widespread uses by professional workers
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the types of manufacture using 4-Butylresorcinol. ECHA has no public registered data on the routes by which 4-Butylresorcinol is most likely to be released to the environment.
Formulation or re-packing
4-Butylresorcinol is used in the following products: cosmetics and personal care products.
Release to the environment of 4-Butylresorcinol can occur from industrial use: formulation of mixtures.
Uses at industrial sites
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the types of manufacture using 4-Butylresorcinol. ECHA has no public registered data on the routes by which 4-Butylresorcinol is most likely to be released to the environment.
Manufacture
ECHA has no public registered data on the routes by which 4-Butylresorcinol is most likely to be released to the environment.
Chemical Name: 4-Butylresorcinol
Synonyms: 4-n-Butylresorcinol, Rucinol;4-BUTYLRESORCINOL,1,3-Benzenediol,4-butyl-;4-phenylbutane-1,3-diol;4-N-BUTYLRESORCINOL;
CAS: 18979-61-8
Molecular Formula: C10H14O2
Molecular Weight: 166.22
Melting point: 50.0 to 55.0 °C
Boiling point: 166°C/7mmHg(lit.)
4-n-butylresorcinol(4-Butylresorcinol ) is one of the resorcinol derivatives, with an inhibitory effect on both tyrosinase and tyrosinase-related protein, and widely used as whitening & Skin-lightening Agent.
4-N-Butylresorcinol is a synthetic compound used as an active ingredient for skin lightening and treatment of hyperpigmentation.
The active ingredient 4-N-Butylresorcinol is designed to stop melanin production by inhibiting enzymes required for melanin synthesis.
As a result, melanin formation is generally inhibited.
4-N-Butylresorcinol is widely used in sunscreen and other sun care as well as cosmetic products.
Empirical Formula: C10H14O2
Molecular Weight: 166.217
IUPAC Name: 4-butylbenzene-1,3-diol
Product Categories: Miscellaneous;Benzene derivates
Appearance: Yellow or white powder
Nominal Mass: 166 Da
Average Mass: 166.217 Da
Monoisotopic Mass: 166.09938 Da
Index of Refraction: 1.555
Molar Refractivity: 48.83 cm3
Molar Volume: 152.1 cm3
Surface Tension: 44.7 dyne/cm
Density: 1.092 g/cm3
Flash Point: 144.5 °C
Enthalpy of Vaporization: 56.25 kJ/mol
Boiling Point: 300.7 °C at 760 mmHg
Vapour Pressure: 0.000616 mmHg at 25°C
Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring, and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices.
4-butylresorcinol has an inhibitory effect on the melanogenesis of cultured B16 melanoma cells by its direct inhibition of tyrosinase activity, as well as the suppression of tyrosinase synthesis, without inducing any cytotoxicity.
Thus, 4-butylresorcinol is widely used as a broad-spectrum sun block reagent.
Characteristics :
Uv absorption, chemical sunscreen
Higher sun protection
Applications:
Inhibit excessive pigmentation
Inhibits human's tyrosinase chemical
Sunscreen protection.
IUPAC NAMES:
1,3-Dihydroxy-4-N Butyl Benzene
4-Butylbenzene-1,3-diol
4-butylbenzene-1,3-diol
4-Butylresorcinol
4-Butylresorcinol
4-N-Butyl Resorcinol
4-N-butylresorcinol
4-n-butylresorcinol
SYNONYMS:
4-BUTYLRESORCINOL,98+%
4-Butylbenzene-1,3-diol
4-Butylresorcinol
1,3-Benzenediol,4-butyl-
4-N-BUTYLRESORCINOL
2,4-DIHYDROXY-N-BUTYL BENZENE
4-phenylbutane-1,3-diol
2,4-DIHYDROXY-N-BUTYL BENZEN
2,4-Dihydroxy-n-bytyl benzen
4-06-00-06003 (Beilstein Handbook Reference)
N-BUTYLRESEOCINOL
Nano Liposomal N-BUTYLRESEOCINOL
2,4-Dihydroxy-n-bytyl benzene
4-BUTYLBENZENE-1 3-DIOL(COSMOBRITE)
4-n-Butylresorcinol, Rucinol
Nano-Liposomal 4-Butylresorcinol
Butylresorcinol
4-Butylresorcinol >
4-n-Butylresorcinol fandachem
4-Butylresorcinol fandachem
4-Butylresorcinol
4-butylbenzene-1,3-diol
18979-61-8
4-n-Butylresorcinol
Rucinol
Resorcinol, 4-butyl-
N-butylresorcinol
1,3-Benzenediol, 4-butyl-
UNII-2IK4UQ3ZGA
2IK4UQ3ZGA
CHEMBL450195
2,4-Dihydroxy-N-butyl benzene
Butylresorcinol
CHEBI:81689
4-Butylresorcin
BRN 1942645
Kopcinol
2,4-Dihydroxy-n-butyl benzen
4-(2,4-dihydroxyphenyl)butane
n-butyl resorcinol
Rucinol (TN)
EC 606-191-2
ACMC-1CA91
SCHEMBL68792
4-06-00-06003 (Beilstein Handbook Reference)
AMY472
DTXSID50172403
HMS3749K09
1,3-Dihydroxy-4-N butyl benzene
BCP08128
ZINC3630922
9886AA
AC-349
ANW-23463
BDBM50248158
MFCD01684800
s4997
4-Butylresorcinol, analytical standard
AKOS006277916
AS07002
CCG-266331
CS-7786
VZ35538
AS-10742
HY-107369
B3773
4-Butylresorcinol;4-n-Butylresorcinol, Rucinol
C18343
979D618
A813362
Q-200189
Q2171802
1,3-Benzenediol, 4-butyl-;Butylresorcinol;4-n-butylresorcinol;4-butylbenzene-1,3-diol;2,4-Dihydroxy-n-butyl benzen
