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CAS Number: 60-35-5
EC Number: 200-473-5
Molar Mass: 59.07 g/mol
Chemical Formula: CH₃CONH₂
Acetamide (systematic name: ethanamide) is an organic compound with the formula CH3CONH2.
Acetamide is the simplest amide derived from acetic acid.
Acetamide finds some use as a plasticizer and as an industrial solvent.
The related compound N,N-dimethylacetamide (DMA) is more widely used, but Acetamide is not prepared from acetamide.
Acetamide can be considered an intermediate between acetone, which has two methyl (CH3) groups either side of the carbonyl (CO), and urea which has two amide (NH2) groups in those locations.
Acetamide is also a naturally occurring mineral with the IMA symbol: Ace.
Acetamide is also called Acetic acid amide, or Ethanamide or Acetimidic acid.
Acetamide is derived from acetic acid and is the simplest amide.
Acetamide is widely used as a plasticizer.
Ethanamide is obtained as a hygroscopic solid which is colourless and has a mousy odour.
Acetamide is readily soluble in water, chloroform, hot benzene, glycerol and slightly soluble in ether.
Acetamide is a member of the class of acetamides which results from the formal condensation of acetic acid (CH3COOH) with ammonia (NH3).
Acetamide is naturally found in red beetroot.
Acetamide, also known as ethanamid or acetic acid amide, belongs to the class of organic compounds known as carboximidic acids.
These are organic acids with the general formula RC(=N)-OH (R=H, organic group).
Acetamide is a mousy tasting compound.
Acetamide has been detected, but not quantified in, red beetroots.
This could make acetamide a potential biomarker for the consumption of these foods.
Acetamide is formally rated as a possible carcinogen (by IARC 2B) and is also a potentially toxic compound.
Based on a literature review a significant number of articles have been published on Acetamide.
Acetamide or acetic acid or ethanamide is an inorganic compound.
Furthermore, the simplest amide derived from acetic acid that’s why Acetamide is slightly acidic in nature.
Some of Acetamide uses are an industrial solvent and plasticizers.
Moreover, on a pH scale then Acetamide has a higher pH reading than acetone.
Acetamide is an inorganic compound having the chemical name Acetamide.
The chemical formula of Acetamide is C2H5NO.
Acetamide acetamide is also known as Ethanamide, or Acetic acid amide, or also Acetic acid.
Acetamide originated from acetic acid and Acetamide is the simplest amide - an acetamide widely used as a plasticizer.
Ethanamide is obtained as a hygroscopic solid, which is a colourless compound and has a mousy odour.
Acetamide is readily soluble in chloroform, water, glycerol, hot benzene, and soluble in ether slightly.
Acetamide is a member of the acetamides class, which results from the formal condensation of the acetic acid (CH3COOH) with ammonia (NH3).
Acetamide is found naturally in red beetroot.
Acetamide (or acetic acid amide or ethanamide), CH3CONH2, the amide of acetic acid, is a white crystalline solid in pure form.
Acetamide is produced by dehydrating ammonium acetate.
Acetamide is used as a plasticizer and in the synthesis of many other organic compounds.
Acetamide is not extremely combustible, but releases irritating fumes when ignited.
Acetamide is toxic by inhalation (of dust), ingestion, skin and eye contact.
Skin or eye contact may cause redness and pain.
The derivative N,N-dimethylacetamide (DMA), which has two methyl groups replacing the amine protons, is used as a solvent.
N-methylacetamide is often used as the simplest model in studies of the peptide bond.
Recent work on the Robert C. Byrd Green Bank Telescope has resulted in the discovery of several organic (carbon-based) compounds near the center of the Milky Way galaxy.
Acetamide has been detected.
This is particularly important as acetamide has an amide bond, similar to the essential bond between amino acids in proteins.
This supports the theory that organic molecules that can lead to life (as we know Acetamide on Earth) can form in space.
Acetamide, also known as ethanamid or acetic acid amide, belongs to the class of organic compounds known as carboximidic acids.
These are organic acids with the general formula RC(=N)-OH.
Acetamide is soluble in water and low molecular mass alcohols.
Acetamide forms deliquescent hexagonal crystals that are odorless when pure, but Acetamide frequently has a mousy odor.
Pure acetamide has a bitter taste.
Acetamide is used as a solvent and as a plasticizer.
Acetamide has been classified by the International Agency for Research on Cancer (IARC) as a Group 2B possible human carcinogen.
However, further studies need to be conducted to better understand the potential in vivo genotoxicity of acetamide.
Acetamide has also been investigated as a residue from some pesticides and as an impurity in the manufacture of pharmaceuticals.
Acetamide has been identified in milk, eggs, and meat.
Uses of Acetamide:
Acetamide is used as a plasticizer and an industrial solvent.
Molten acetamide is good solvent with a broad range of applicability.
Notably, Acetamide dielectric constant is higher than most organic solvents, allowing Acetamide to dissolve inorganic compounds with solubilities closely analogous to that of water.
Acetamide has uses in electrochemistry and the organic synthesis of pharmaceuticals, pesticides, and antioxidants for plastics.
Acetamide is a precursor to thioacetamide.
Acetamide is used as a solvent, plasticizer, and a wetting and penetrating agent.
Personal care - hair styling and care - hair spray
Used as a solvent, plasticizer, stabilizer, humectant for paper, hygroscopic agent, wetting agent, penetrating agent, and denaturant of alcohol.
Also used in lacquers, explosives, and soldering fluxes.
Used as a solvent in the following applications: plasticizers, lacquers, explosives, soldering flux, wetting agents, and synthesis of other agents.
Organic synthesis (reactant, solvent, peroxide stabilizer), general solvent, lacquers, explosives, soldering flux, hygroscopic agent, wetting agent, penetrating agent.
Acetamide suppresses acid buildup in printing inks, lacquers, explosives, and perfumes.
Acetamide is a mild moisturizer and is used as a softener for leather, textiles, paper, and certain plastics.
Acetamide and substituted acetamide-containing thiourea can be used for treatment of herpes viruses.
Derivatives can also be used as feeding behavior modifiers.
Acetamide is used as a solvent for many inorganic and organic compounds.
Acetamide is used in explosives.
Acetamide is used as a plasticizer.
Acetamide is used as a hygroscopic agent.
Acetamide is used to manufacture methylamine.
Acetamide is used as a stabilizer.
Acetamide is used as a penetrating agent.
Acetamide is used as a fire suppressant.
Mainly, Acetamide is used as a solvent for many inorganic and organic compounds and in explosives.
Furthermore, industries use Acetamide as a plasticizer and hygroscopic agent.
Also, they use Acetamide to manufacture methylamine and as a stabilizer.
Besides, Acetamide can act as a penetrating agent and fire suppressant.
Physical Properties of Acetamide:
We can identify Acetamide in the field as transparent to translucent, colorless or gray variations.
Also, Acetamide has a white streak.
The density of acetamide is 1.17 g/cm3 and hardness of 1 to 1.5 roughly close to talc or a slightly harder substance.
The melting point of acetamide is between 79 to 81oC, whereas Acetamide boiling point is 221.2oC.
Furthermore, Acetamide density is 1.159 g/cm3.
Besides, Acetamide is soluble in water (2000 g L-1), ethanol (500 g L-1), pyridine (166.67 g L-1), chloroform, glycerol, hot benzene, slightly soluble in ether.
Acetamide exists as hexagonal crystals.
The odor threshold for acetamide is 140 to 160 milligrams per cubic meter (mg/m3).
The chemical formula for acetamide is C2H5NO, and the molecular weight is 59.07 g/mol.
The vapor pressure for acetamide is 1 mm Hg at 65 °C, and Acetamide has a log octanol/water partition coefficient(log Kow) of -1.26.
Chemical Properties of Acetamide:
We find Acetamide as hygroscopic solid that is colorless and has a mousy odor which depends on Acetamide purity.
Also, Acetamide has a bitter taste.
Furthermore, Acetamide is a member of the class of acetamides which results from the formal condensation of acetic acid (CH3COOH) with ammonia (NH3).
Most importantly, the carbonyl, methyl and anime groups share electrons with each other to form acetamide.
Acetamide Formula and Structure
The chemical formula of acetamide is C2H5NO or CH3CONH2.
Moreover, Acetamide molar mass is 59.07 g/mol.
The acetamide has a methyl group (-CH3) bound to a carbonyl (CO) and Amine (NH2).
Besides, the acetamide primarily comprises of carboxylic acid amide functional group that has a general structure RC (=O) NH2.
Furthermore, the acetamide belongs to the family of primary carboxylic acid amides.
Also, Acetamide exists in nature as a natural compound.
Production of Acetamide:
Laboratory scale:
Acetamide can be produced in the laboratory from ammonium acetate by dehydration:
[NH4][CH3CO2] → CH3C(O)NH2 + H2O
Alternatively acetamide can be obtained in excellent yield via ammonolysis of acetylacetone under conditions commonly used in reductive amination.
Acetamide can also be made from anhydrous acetic acid, acetonitrile and very well dried hydrogen chloride gas, using an ice bath, alongside more valuable reagent acetyl chloride.
Yield is typically low (up to 35%), and the acetamide made this way is generated as a salt with HCl.
Industrial scale:
In a similar fashion to some laboratory methods, acetamide is produced by dehydrating ammonium acetate or via the hydration of acetonitrile, a byproduct of the production of acrylonitrile:
CH3CN + H2O → CH3C(O)NH2
An excellent amount of acetamide produced through ammonolysis of acetylacetone under conditions commonly used in reductive amination.
Besides, anhydrous acetic acid is also used to produce Acetamide, acetonitrile and very well dried hydrogen chloride gas, using an ice bath, together with more valuable reagent acetyl chloride.
Typically, this product is low (up to 35 percent), and the acetamide produced in this way is generated as a salt with HCl.
However, on the industrial scale, they use a similar method that scientists use.
In industries, they produce acetamide by dehydrating ammonium acetate or via the hydration of acetonitrile a by-product of the production of acrylonitrile.
CH3CN + H2O → CH3C(O)NH2
Occurrence of Acetamide:
Acetamide has been detected near the center of the Milky Way galaxy.
This finding is potentially significant because acetamide has an amide bond, similar to the essential bond between amino acids in proteins.
This finding lends support to the theory that organic molecules that can lead to life (as we know Acetamide on Earth) can form in space.
On 30 July 2015, scientists reported that upon the first touchdown of the Philae lander on comet 67/P's surface, measurements by the COSAC and Ptolemy instruments revealed sixteen organic compounds, four of which – acetamide, acetone, methyl isocyanate, and propionaldehyde – were seen for the first time on a comet.
In addition, acetamide is found infrequently on burning coal dumps, as a mineral of the same name.
Generally, the acetamide occurs in burning waste coal piles that form between 50 and 150oC (122-302oF).
Also, Acetamide only appears in periods of dry weather.
Furthermore, the scientist has detected Acetamide presence near the center of the Milky Way galaxy.
Also, this finding is potentially significant for amino acids in proteins.
Moreover, this finding lends support to the theory that organic molecules that can lend to life can form in space.
Methods of Manufacturing of Acetamide:
Prepared by fractional distillation of ammonium acetate.
Interaction of ethyl acetate and ammonium hydroxide.
Acetamide can be produced by several methods.
Ammonia reacts vigorously with acetyl halides or acetic anhydride to produce acetamide.
Alkyl acetates also react with ammonia to yield acetamide.
Dehydration of ammonium acetate is the standard procedure for preparation of acetamide.
Finally, acetonitrile is hydrolyzed to yield acetamide in the presence of an acid or base catalyst.
Formulations/Preparations of Acetamide:
In 1963 available in USA as technical grade (99% minimum acetamide and 0.3% maximum free acid) and as chemically pure, odorless grade (99.5-99.9% acetamide and trace of free acid).
Grades: Technical; CP /chemically pure: a grade designation signifying a minimum of impurities, but not 100% purity/ (odorless)
Intermediate
Reagent.
Pharmacology and Biochemistry of Acetamide:
Absorption, Distribution and Excretion of Acetamide:
The volume of distribution was about 1 mL/g, total body clearance was 0.27 mL/min and renal clearance was 0.19 mL/min.
Approximately 64 72% of (14)C acetamide was excreted in the urine, while only 0.5 0.8% appeared in exhaled air during the first 6 hr after dosing.
Thus, approximately 30% of the administered dose was not recovered and Acetamide was suggested that metabolized acetamide enters the acetate pool.
Biological Half-Life of Acetamide:
The half life of radioactivity in blood after intravenous dosing of (14)C acetamide to rats averaged 20.6 + or - 0.3 hr after a 10 mg/kg bw dose and 16.1 + or - 1.6 hr after a 50 mg/kg bw dose.
Human Metabolite Information of Acetamide:
Cellular Locations:
Cytoplasm
Extracellular
Identification of Acetamide:
Analytic Laboratory Methods:
Method: OSHA 2084
Procedure: gas chromatography with a nitrogen-phosphorous detector
Analyte: acetamide
Matrix: air
Detection Limit: 10 ng/sample.
A sensitive gas chromatographic mass spectrometric (GC-MS) method has been established for the simultaneous determination of acetamide (AA), propanamide (PA), and butyramide (BA) in surface and drinking water based on derivatization with 9-xanthydrol.
Deuterated acrylamide was chosen as the internal standard for analyzing the water sample.
The derivatization of AA, PA, and BA was performed directly in water and the reaction conditions (10.0-mM 9-xanthydrol, 0.5-M HCl, 20-min reaction time, and ambient temperature) were established.
Under these conditions, the detection limit of the analytes was 0.03 ug/L, and the interday relative standard deviation was less than 16% at concentrations of 1.0, 5.0 and 10.0 ug/L.
The proposed GC-MS method enables the reliable analysis of trace AA, PA, and BA in environmental water.
A method is described for the simultaneous determination of two short-chained amides, acrylamide and acetamide (classified by the International Agency for Research on Cancer as probable and possible human carcinogens, respectively), in total particulate matter using gas chromatography-on-column injection and mass spectrometric detection.
Sample preparation is kept to a minimum, and the proposed analytical procedure proves to be fast, sensitive, and precise.
Validation studies show good linearity with a regression coefficient of r2=.000 for both compounds.
Quantitation limits are 32 ng/mL for acrylamide and 70 ng/mL for acetamide.
In the particulate phase of mainstream smoke from the University of Kentucky Reference Cigarette 2R4F, 2.3 ug/cig acrylamide and 4.7 ug/cig acetamide are found; no acetamide and only 0074 ug/cig acrylamide is found in the gas phase.
Possible mechanisms of formation in cigarette smoke are discussed.
Thin layer chromatography analysis of acid amides, including acetamide is mentioned.
Amounts down to 10 ug were detectable.
Handling and Storage of Acetamide:
Nonfire Spill Response of Acetamide:
SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container.
Use absorbent paper dampened with water to pick up any remaining material.
Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal.
Wash all contaminated surfaces with a strong soap and water solution.
Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should keep this material in a tightly-closed container under an inert atmosphere, and store Acetamide at refrigerated temperatures.
Storage Conditions of Acetamide:
Keep container tightly closed in a dry and well-ventilated place.
Moisture sensitive.
Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
Gloves must be inspected prior to use.
Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with Acetamide.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
Should be stored in a cool, well-ventilated area.
Store in a dry area away from water because of deliquescent properties.
Sources of ignition, such as smoking and open flames, are prohibited where this chemical is used, handled, or stored in a manner that could create a potential fire explosion hazard.
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for expt need to be carried.
Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties) that bears appropriate label.
An inventory should be kept, showing quantity of carcinogen & date Acetamide was acquired.
Facilities for dispensing should be contiguous to storage area.
Stability/Shelf Life of Acetamide:
Stable under recommended storage conditions.
Industrial Processes with risk of exposure:
Soldering
Pulp and Paper Processing
Painting (Solvents)
First Aid of Acetamide:
EYES: First check the victim for contact lenses and remove if present.
Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician.
IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing.
Gently wash all affected skin areas thoroughly with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop.
Provide proper respiratory protection to rescuers entering an unknown atmosphere.
Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: DO NOT INDUCE VOMITING.
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center.
Be prepared to transport the victim to a hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body.
DO NOT INDUCE VOMITING.
IMMEDIATELY transport the victim to a hospital.
OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring.
Recommendations from the physician will depend upon the specific compound, Acetamide chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure.
Fire Fighting of Acetamide:
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Use water spray, powder.
Fire Fighting Procedures of Acetamide:
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.
Use dry chemical, carbon dioxide, water spray, or alcohol foam extinguishers.
If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters.
Notify local health and fire officials and pollution control agencies.
From a secure, explosion-proof location, use water spray to cool exposed containers.
If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position.
The only respirators recommended for firefighting are self-contained breathing apparatuses that have full face-pieces and are operated in a pressure-demand or other positive-pressure mode.
Accidental Release Measures of Acetamide:
Spillage Disposal of Acetamide:
Personal protection: P2 filter respirator for harmful particles.
Sweep spilled substance into covered containers.
If appropriate, moisten first to prevent dusting.
Carefully collect remainder.
Then store and dispose of according to local regulations.
Cleanup Methods of Acetamide:
ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment.
Avoid dust formation.
Avoid breathing vapors, mist or gas.
Ensure adequate ventilation.
Evacuate personnel to safe areas.
Avoid breathing dust.
Environmental precautions: Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust.
Sweep up and shovel.
Keep in suitable, closed containers for disposal.
Evacuate persons not wearing protective equipment from area of spill or leak until cleanup is complete.
Remove all ignition sources.
Collect powdered material in the most convenient and safe manner and deposit in sealed containers.
Ventilate area after cleanup is complete.
Material is very water soluble and hydrolyzes slowly to ammonia and acetate salts.
May be removed from alkaline solutions with adsorbent carbon.
Acetamide may be necessary to contain and dispose of this chemical as a hazardous waste.
If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters.
PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms.
Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially.
Filters should be placed in plastic bags immediately after removal.
The plastic bag should be sealed immediately.
The sealed bag should be labelled properly.
Waste liquids should be placed or collected in proper containers for disposal.
The lid should be secured & the bottles properly labelled.
Once filled, bottles should be placed in plastic bag, so that outer surface is not contaminated.
The plastic bag should also be sealed & labelled.
Broken glassware should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators.
Disposal Methods of Acetamide:
Recycle any unused portion of the material for Acetamide approved use or return Acetamide to the manufacturer or supplier.
Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations.
If Acetamide is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.
Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations.
Concentrations shall be lower than applicable environmental discharge or disposal criteria.
Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur.
Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal.
If Acetamide is not practicable to manage the chemical in this fashion, Acetamide must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.
Product: Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber; Contaminated packaging: Dispose of as unused product.
PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction published have not been tested on all kinds of carcinogen-containing waste.
Preventive Measures of Acetamide:
ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment.
Avoid dust formation.
Avoid breathing vapors, mist or gas.
Ensure adequate ventilation.
Evacuate personnel to safe areas.
Avoid breathing dust.
Environmental precautions: Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Precautions for safe handling: Avoid contact with skin and eyes.
Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
PRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory.
All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used.
They should wash hands, preferably using dispensers of liq detergent, & rinse thoroughly.
Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant.
No standard procedure can be recommended, but the use of organic solvents should be avoided.
Safety pipettes should be used for all pipetting.
PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes.
Clothing should be changed daily but discarded immediately if obvious contamination occurs also, workers should shower immediately.
In chemical laboratory, gloves & gowns should always be worn however, gloves should not be assumed to provide full protection.
Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection.
If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab.
Identifiers of Acetamide:
CAS Number: 60-35-5
ChEBI: CHEBI:27856
ChEMBL: ChEMBL16081
ChemSpider: 173
DrugBank: DB02736
ECHA InfoCard: 100.000.430
EC Number: 200-473-5
IUPHAR/BPS: 4661
KEGG: C06244
PubChem CID: 178
RTECS number: AB4025000
UNII: 8XOE1JSO29
CompTox Dashboard (EPA): DTXSID7020005
InChI:
InChI=1S/C2H5NO/c1-2(3)4/h1H3,(H2,3,4)
Key: DLFVBJFMPXGRIB-UHFFFAOYSA-N
InChI=1/C2H5NO/c1-2(3)4/h1H3,(H2,3,4)
Key: DLFVBJFMPXGRIB-UHFFFAOYAC
SMILES: O=C(N)C
Properties of Acetamide:
Chemical formula: C2H5NO
Molar mass: 59.068 g·mol−1
Appearance: colorless, hygroscopic solid
Odor:
odorless
mouse-like with impurities
Density: 1.159 g cm−3
Melting point: 79 to 81 °C (174 to 178 °F; 352 to 354 K)
Boiling point: 221.2 °C (430.2 °F; 494.3 K) (decomposes)
Solubility in water: 2000 g L−1
Solubility:
ethanol 500 g L−1
pyridine 166.67 g L−1
soluble in chloroform, glycerol, benzene
log P: −1.26
Vapor pressure: 1.3 Pa
Acidity (pKa): 15.1 (25 °C, H2O)[3]
Magnetic susceptibility (χ): −0.577 × 10−6 cm3 g−1
Refractive index (nD): 1.4274
Viscosity: 2.052 cP (91 °C)
Molecular Weight: 59.07
XLogP3-AA: -0.9
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 0
Exact Mass: 59.037113783
Monoisotopic Mass: 59.037113783
Topological Polar Surface Area: 43.1 Ų
Heavy Atom Count: 4
Complexity: 33
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Specifications of Acetamide:
Assay (GC, area%): ≥ 99.0 % (a/a)
Melting range (lower value): ≥ 77 °C
Melting range (upper value): ≤ 80 °C
Identity (IR): passes test
Structure of Acetamide:
Crystal structure: trigonal
Thermochemistry of Acetamide:
Heat capacity (C): 91.3 J·mol−1·K−1
Std molar entropy (So298): 115.0 J·mol−1·K−1
Std enthalpy of formation (ΔfH⦵298): −317.0 kJ·mol−1
Related Products of Acetamide:
1-(3,5-dichloropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
1,3-dimethyl-1H,4H,5H,6H-pyrazolo[3,4-b][1,4]thiazin-5-one
2-(3,5-dichlorophenyl)-2-(ethylamino)acetic acid hydrochloride
6,7-dichloro-2-methyl-2,3-dihydro-1-benzofuran-3-one
2-{[(3,4-dichlorophenyl)carbamoyl]amino}-3-(1H-indol-3-yl)propanoic acid
Names of Acetamide:
Preferred IUPAC name of Acetamide:
Acetamide
Systematic IUPAC name of Acetamide:
Ethanamide
Other names of Acetamide:
Acetic acid amide
Acetylamine
Synonyms of Acetamide:
acetamide
60-35-5
Ethanamide
Acetic acid amide
Methanecarboxamide
Acetimidic acid
Amide C2
Ethanimidic acid
Amid kyseliny octove
Caswell No. 003H
Acetimidic acid (VAN)
CCRIS 2
NCI-C02108
HSDB 4006
CH3CONH2
UNII-8XOE1JSO29
Acetamide, homopolymer
AI3-02060
8XOE1JSO29
CHEBI:27856
MFCD00008023
acetamid
acetoamide
Ethanamid
74330-92-0
Amid kyseliny octove [Czech]
EINECS 200-473-5
NSC 25945
acetylamine
BRN 1071207
Essigsaeureamid
imidoacetic acid
N-Methylformamde
DSSTox_CID_5
Acetamide, >=98%
ACETAMIDE, REAGENT
Lopac-A-0500
bmse000825
bmse000895
EC 200-473-5
Acetamide, sublimed, 99%
WLN: ZV1
Acetic acid amide;Ethanamide
DSSTox_RID_75317
Acetamide, ~99% (GC)
DSSTox_GSID_20005
Lopac0_000003
4-02-00-00399 (Beilstein Handbook Reference)
MLS002153504
Acetamide, analytical standard
BIDD:ER0566
CHEMBL16081
GTPL4661
DTXSID7020005
Acetamide, crystalline, >=99%
CHEBI:49028
Acetamide, >=98.0% (GC)
Acetamide, >=99.0% (GC)
HMS3260A07
Acetamide (6CI,7CI,8CI,9CI)
BCP26153
HY-Y0946
NSC25945
STR01066
ZINC8034818
Tox21_300776
Tox21_500003
NSC-25945
s6011
STL283915
AKOS000118788
AKOS015917387
CCG-204099
DB02736
LP00003
MCULE-9280264861
SDCCGSBI-0049992.P002
CAS-60-35-5
Benzeneacetic?acid,?|A-amino-4-methyl-
NCGC00015030-01
NCGC00015030-02
NCGC00015030-03
NCGC00015030-04
NCGC00015030-05
NCGC00015030-06
NCGC00093530-01
NCGC00093530-02
NCGC00254680-01
NCGC00260688-01
SMR000326670
A0007
CS-0015934
EU-0100003
FT-0603458
FT-0621721
FT-0621725
FT-0625737
A 0500
C06244
A832706
Q421721
SR-01000076247
J-523678
SR-01000076247-1
Acetamide, zone-refined, purified by sublimation, 99%
F1908-0077
02U
Acetamid
Acetamide, monosodium salt
Acetate amide
Acetic acid amide
Acetimidic acid
ACM
Amid kyseliny octove
Azetamid
CH3CONH2
Essigsaeureamid
Ethanamid
Ethanamide
Methanecarboxamide
200-473-5
53318-35-7
544-44-5
60-35-5
Acetamid
Acetamide
Acétamide
Ethanamide
formamide, methyl-
methanimidic acid, methyl-
Methylcarbylamine
METHYLFORMAMIDE
MFCD00008023
monomethylformamide
02U
10-Methylundecanoic acid
14-METHYLHEXADEC-9-ENOIC ACID
23724-60-9
2-Phenyl-1,3,2-dioxaborinane
3'-DEOXY-3'-ACETAMIDO-URIDINE
5786-68-5
ACE
Acetaldehyde Ammonia
acetamidate
acetamide radical
acetamide, crystal, reagent
acetamide, reagent
Acetamide-2,2,2-d3
acetic acid amide
acetimidic acid
acetoamide
acetyl amine
ACETYLAMINE
ACM
ADU
Amide C2200-473-5MFCD00008023
Azetamid
CNM
Essigsaeureamid
Ethanamid
Ethinamide
imidoacetic acid
LNG
M12
methanecarboxamide
STR01066
WLN: ZV1
