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Alpha Lipoic Acid (Powder)(ALA) is an organosulfur compound used as a potent antioxidant supplement to support cellular energy and metabolic health.
Powder forms are typically mixed into water, smoothies, or thick foods like yogurt.
Alpha Lipoic Acid (Powder)(ALA) is a fatty acid that is found naturally in every cell within the body.
CAS: 1077-28-7
MF: C8H14O2S2
MW: 206.33
EINECS: 214-071-2
Synonyms
5 MG PNPP SUBSTRATE TABLETS REAGENT GR;DL-α-Lipoic acidUSP, 99.0-101.0% (Assay);5-(1,2)Dithiolan-3-yl-pentanoic acid for synthesis;TIMTEC-BB SBB003484;THIOOCTIC ACID;dl-1,2-Dithiolane3-valericacid;DL-6-Thioctic acid;dl-6-Thiocticacid
Alpha Lipoic Acid (Powder)(ALA) is soluble in both water and lipid-based tissues - and functions well alongside vitamins C and E as well as glutathione.
Alpha Lipoic Acid (Powder)(ALA) is a cyclic disulfide antioxidant that interconverts with its reduced dithiol form.
Alpha Lipoic Acid (Powder)(ALA) is an essential cofactor for decarboxylation reactions of the citric acid cycle, and acts as a general antioxidant.
Alpha Lipoic Acid (Powder)(ALA) can act as a direct radical scavenger, as a cofactor to regenerate reduced glutathione, and as a metal chelator.
Alpha Lipoic Acid (Powder)(ALA), also known as thioctic acid, is a naturally occurring compound that plays a crucial role in mitochondrial bioenergetics and acts as a cofactor for several enzyme complexes involved in energy metabolism.
Alpha Lipoic Acid (Powder)(ALA) is a dithiol compound, featuring two thiol groups that can undergo oxidation and reduction, allowing it to function as a potent antioxidant.
This dual nature enables Alpha Lipoic Acid (Powder)(ALA) to scavenge free radicals and regenerate other antioxidants, such as vitamins C and E.
Alpha Lipoic Acid (Powder)(ALA) is soluble in both water and organic solvents, which enhances its bioavailability and therapeutic potential.
Alpha Lipoic Acid (Powder)(ALA) is often used in dietary supplements for its purported benefits in managing conditions like diabetes, neuropathy, and oxidative stress.
Alpha Lipoic Acid (Powder)(ALA)'s chiral nature means it exists as a racemic mixture, containing both the R and S enantiomers, which may exhibit different biological activities.
Overall, Alpha Lipoic Acid (Powder)(ALA) is recognized for its multifaceted roles in cellular metabolism and antioxidant defense.
Alpha Lipoic Acid (Powder)(ALA) is a naturally occurring fatty acid that can be found in many foods such as yeast, spinach, broccoli, potatoes, and organ meats such as liver or kidney.
Alpha Lipoic Acid (Powder)(ALA) is an antioxidant that is made naturally in the body and is also found in foods.
Alpha Lipoic Acid (Powder)(ALA) is used to break down carbohydrates and to make energy.
Alpha Lipoic Acid (Powder)(ALA) Chemical Properties
Melting point: 60-62 °C
Boiling point: 160-165 °C(lit.)
density: 1.2888 (rough estimate)
bulk density: 260kg/m3
refractive index: 1.5200 (estimate)
Fp: 160-165°C
storage temp.: 2-8°C
solubility ethanol: 50 mg/mL
pka: 4.75±0.10(Predicted)
form: Crystals or Crystalline Powder
color: Yellow
biological source: synthetic
Water Solubility: 0.9 g/L (20 ºC)
Merck: 14,9326
BRN: 81853
Stability: Stable. Incompatible with strong oxidizing agents.
Cosmetics Ingredients Functions: ANTIOXIDANT
InChI: 1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
InChIKey: AGBQKNBQESQNJD-UHFFFAOYSA-N
LogP: 2.530 (est)
CAS DataBase Reference: 1077-28-7(CAS DataBase Reference)
NIST Chemistry Reference: Alpha Lipoic Acid (Powder)(ALA)(1077-28-7)
Uses
Alpha Lipoic Acid (Powder)(ALA) has been used in in vitro lipoylation studies and in the pyruvate dehydrogenase complex (PDC)-pyruvate dehydrogenase kinase (PDHK) functional assay.
Alpha Lipoic Acid (Powder)(ALA) has also been used to investigate its antioxidative effect on developing cerebellum of rats exposed to arsenic during postnatal period.
Biochem/physiol Actions
Antioxidant and coenzyme needed for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase.
Exogenous Alpha Lipoic Acid (Powder)(ALA) is reduced intracellularly by two or more enzymes.
The reduced form then influences a number of cell processes by direct radical scavenging, recycling of other antioxidants, increasing glutathione synthesis, and modulating transcription factor activity particularly that of NF-κB.
Decreases the phagocytosis of myelin by macrophages.
