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Anti-dandruff agent 290 is an imidazole-derived antifungal agent widely used in dermatological and cosmetic applications, particularly in anti-dandruff shampoos and topical formulations.
By disrupting ergosterol production, Anti-dandruff agent 290 compromises membrane integrity and suppresses the growth of fungi such as Malassezia species, which are strongly associated with dandruff and seborrheic dermatitis.
Because of its broad antifungal spectrum and safety profile, Anti-dandruff agent 290 is considered an important active ingredient in personal care products aimed at controlling fungal overgrowth on the skin and scalp.
CAS Number: 38083-17-9
EC Number: 253-775-4
Molecular Formula: C15H17ClN2O2
Molecular Weight: 292.76 g/mol
Synonyms: 1-(4-Chloro-phenoxy)-1-(2,5-dihydro-imidazole-1-yl)-3,3-dimethyl-butan-2-one, 1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone, BAY MEB-6401, Diadimefon, MEB-6401, Climbazole 0.1, 1-[(4-Chlorophenoxy)(tert-butylcarbonyl)Methyl]iMidazole, Crinipan AD, Climbazole, 38083-17-9, Climbazol, Baypival, Crinipan AD, BAY-E 6975, Baysan, Climbazolum, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one, Climbazol [INN-Spanish], Climbazolum [INN-Latin], Climbazole [INN:BAN], 2-Butanone, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-, EINECS 253-775-4, Bay e 6975, NSC-759808, BRN 0618020, CCRIS 8169, DTXSID6046555, 9N42CW7I54, MEB 6401, CLIMBAZOLE [INN], MFCD00055505, 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one, 1-(p-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethyl-2-butanone, CLIMBAZOLE [MART.], 1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone, CLIMBAZOLE [USP-RS], CLIMBAZOLE [WHO-DD], DTXCID4026555, 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone, CHEBI:83719, 1-(4-Clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone, 1-(p-Chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-butanone, EC 253-775-4, 5-23-04-00209 (Beilstein Handbook Reference), NSC 759808, NCGC00166153-01, 1-(4-Chlorophenoxy)-1-(1H-imidazolyl)-3,3-dimethyl-2-butanone, Climbazol (INN-Spanish), Climbazolum (INN-Latin), 2-BUTANONE, 1-(p-CHLOROPHENOXY)-3,3-DIMETHYL-1-(1-IMIDAZOLYL)-, CLIMBAZOLE (MART.), CLIMBAZOLE (USP-RS), 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl-2-butanone, (RS)-1-(4-CHLOROPHENOXY)-1-IMIDAZOL-1-YL-3,3-DIMETHYLBUTAN-2-ONE, CAS-38083-17-9, UNII-9N42CW7I54, Climbazole (Standard), CLIMBAZOLE [INCI], SCHEMBL39729, US9138393, Climbazole, US9144538, Climbazole, MLS004773943, BAY e-6975, CHEMBL1437764, CHEBI:83499, HY-B1151R, OWEGWHBOCFMBLP-UHFFFAOYSA-, BDBM181112, HMS2090O13, HMS3652P05, HMS3744O15, Pharmakon1600-01504833, HY-B1151, MEB-6401, Tox21 112343, Tox21_112343, AC-272, DL-358, NSC759808, s4178, AKOS015895513, Tox21_112343_1, CCG-213958, CS-4675, DB15580, FC20483, KS-5112, Climbazole 10 microg/mL in Cyclohexane, NCGC00166153-02, NCGC00166153-03, SMR001550495, DB-049235, C2025, NS00008150, SW219213-1, Climbazole, PESTANAL(R), analytical standard, H10384, SBI-0653493.0001, AB01275501-01, AB01275501_02, AB01275501_03, AO-295/40848554, Q629373, SR-05000001501, SR-05000001501-1, BRD-A61676498-001-01-7, BRD-A61676498-001-05-8, BRD-A61676498-001-06-6, Climbazole, United States Pharmacopeia (USP) Reference Standard, 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one, 1-(4-chlorophenoxy)-3,3-dimethyl-1-(imidazol-1-yl)-butan-2-one, 1-(p-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone, rac-1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one, 1-[(4-Chlorophenoxy)(tert-butylcarbonyl)methyl]imidazole, BAY-e 6975, Climbazole, 253-775-4, InChI=1/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3
Anti-dandruff agent 290 is an imidazole-derived antifungal agent widely used in dermatological and cosmetic applications, particularly in anti-dandruff shampoos and topical formulations.
Structurally, Anti-dandruff agent 290 belongs to the class of azole antifungals, which act by inhibiting the biosynthesis of ergosterol, a key component of fungal cell membranes.
By disrupting ergosterol production, Anti-dandruff agent 290 compromises membrane integrity and suppresses the growth of fungi such as Malassezia species, which are strongly associated with dandruff and seborrheic dermatitis.
In practice, Anti-dandruff agent 290 is well tolerated by the skin and scalp, exhibits good stability in cosmetic formulations, and is often combined with other antifungal or keratolytic agents like zinc pyrithione or salicylic acid for enhanced therapeutic effect.
Because of its broad antifungal spectrum and safety profile, Anti-dandruff agent 290 is considered an important active ingredient in personal care products aimed at controlling fungal overgrowth on the skin and scalp.
Anti-dandruff agent 290 is an imidazole antifungal agent.
Anti-dandruff agent 290 inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro.
Anti-dandruff agent 290 also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo.
Anti-dandruff agent 290 increases the levels of cytochrome P450 in rat liver.
Formulations containing Anti-dandruff agent 290 have been used in the treatment of dandruff.
Anti-dandruff agent 290 is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3.
Anti-dandruff agent 290 is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether.
Anti-dandruff agent 290 is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners.
Anti-dandruff agent 290 may be accompanied by other active ingredients such as zinc pyrithione or triclosan.
Anti-dandruff agent 290 may cause localized irritation of the skin with symptoms including redness, rashes and itching.
Anti-dandruff agent 290 is an antifungal agent used in cosmetics to combat dandruff and various scalp conditions caused by fungal infections like Malassezia.
As a broad-spectrum antifungal, Anti-dandruff agent 290 works by inhibiting the growth of fungi, preventing their proliferation on the scalp.
Anti-dandruff agent 290 is commonly added to hair care products like shampoos and scalp treatments.
Anti-dandruff agent 290 is insoluble in water but can be dissolved in surfactants and perfume oils.
The chemical formula of Anti-dandruff agent 290 is C15H17ClN2O2 and it appears as a white crystal powder.
Anti-dandruff agent 290 is also largely safe for use at lower concentrations.
Anti-dandruff agent 290 is an antifungal agent that has been used by the cosmetic industry as an anti-dandruff ingredient.
The effectiveness of dandruff control by this active has already been demonstrated in scientific publications, proving the importance of this active for this purpose.
Anti-dandruff agent 290 is a potent antifungal agent widely recognized for its efficacy in treating various dermatological conditions.
Anti-dandruff agent 290 is particularly effective against Malassezia species, making it a popular choice in the formulation of anti-dandruff shampoos and topical treatments for seborrheic dermatitis.
Anti-dandruff agent 290's unique structure allows it to penetrate the skin effectively, providing rapid relief from itching and irritation while promoting a healthier scalp environment.
In addition to its antifungal properties, Anti-dandruff agent 290 also exhibits anti-inflammatory effects, making it suitable for use in cosmetic formulations aimed at soothing sensitive skin.
Researchers and formulators appreciate Anti-dandruff agent 290's stability and compatibility with a variety of other ingredients, enhancing its versatility in personal care products.
With its proven track record in both pharmaceutical and cosmetic applications, Anti-dandruff agent 290 stands out as a reliable choice for professionals seeking effective solutions for fungal infections and scalp health.
Anti-dandruff agent 290 is a chemical that has numerous applications in various industries.
Anti-dandruff agent 290 is also known as 1-(4-chlorophenoxy)-1H-imidazole-azole and has a CAS number of 38083-17-9.
Some of its other synonyms include Anti-dandruff agent 290, Baypase, and 1-(p-Chlorophenoxy)-1H-imidazole.
Anti-dandruff agent 290 has a white to off-white crystalline powder appearance and can be synthesized using various manufacturing procedures including halogenation, alkylation, and condensation reactions.
Anti-dandruff agent 290 has a molecular formula of C15H14ClN3O and a molecular weight of 291.75 g/mol.
In terms of solubility, Anti-dandruff agent 290 is soluble in ethanol, acetone, and water, with a melting point of 147-150 °C.
Anti-dandruff agent 290 is commonly used in the cosmetics industry as a potent antifungal agent that inhibits the growth of various types of fungi and bacteria.
Anti-dandruff agent 290 is a popular ingredient in anti-dandruff shampoos, hair conditioners and personal care products.
Its anti-fungal properties also make Anti-dandruff agent 290 suitable for the treatment of fungal infections on the skin, nails, and scalp.
Furthermore, Anti-dandruff agent 290 has been found to exhibit anti-cancer properties that are actively being researched.
According to some studies, Anti-dandruff agent 290 can help inhibit the growth of certain cancer cells, making it a potentially useful therapeutic agent in cancer research.
Anti-dandruff agent 290 has a density of 1.32 g/cm3 and is characterized by its efficacy as an antifungal and antibacterial agent, making it a valuable ingredient in many industries.
Its diverse range of applications makes Anti-dandruff agent 290 an important material for an array of products.
Anti-dandruff agent 290 is an imidazole-based antifungal compound that has gained significant importance in both pharmaceutical dermatology and cosmetic science due to its strong efficacy against fungal infections of the skin and scalp.
Chemically, Anti-dandruff agent 290 belongs to the class of azole antifungals, which exert their action by interfering with the biosynthesis of ergosterol, an essential sterol component of fungal cell membranes.
By inhibiting the enzyme lanosterol 14α-demethylase, Anti-dandruff agent 290 disrupts the production of ergosterol, leading to structural and functional damage in the fungal cell membrane, ultimately suppressing fungal growth and survival.
This mechanism makes Anti-dandruff agent 290 particularly effective against fungi of the Malassezia genus, which are strongly implicated in conditions such as dandruff, seborrheic dermatitis, pityriasis versicolor, and other superficial mycoses.
From a practical standpoint, Anti-dandruff agent 290 is most widely formulated into anti-dandruff shampoos, hair tonics, and topical creams, where it is often used at low concentrations due to its high potency.
Anti-dandruff agent 290 exhibits good stability, is compatible with a variety of surfactant systems, and maintains its effectiveness in cosmetic formulations over time.
Importantly, Anti-dandruff agent 290 demonstrates excellent tolerability on human skin and scalp, with minimal irritation or sensitization, making it suitable for long-term use in personal care products.
In many formulations, Anti-dandruff agent 290 is combined with other agents such as zinc pyrithione, piroctone olamine, ketoconazole, or salicylic acid to provide a synergistic effect, targeting not only fungal growth but also excessive scaling and inflammation.
Beyond dandruff control, Anti-dandruff agent 290 also plays a role in reducing fungal colonization that may worsen acne-like conditions or skin irritation, thereby contributing to overall scalp and skin health.
Because of its broad-spectrum antifungal activity, cosmetic versatility, and favorable safety profile, Anti-dandruff agent 290 has become a cornerstone ingredient in modern dermatological care and personal hygiene products designed to restore balance to the skin’s microbiome while ensuring user comfort and cosmetic elegance.
Market Overview of Anti-Dandruff Agent 290:
The global Anti-dandruff agent 290 market is experiencing steady growth, driven by increasing consumer awareness of skin and scalp health, rising demand for effective antifungal agents in personal care, and the expanding popularity of over-the-counter self-care products.
Valued between USD 90–120 million in 2023–2024, the market is projected to grow at a CAGR of 6–9%, reaching nearly USD 230–250 million by 2032–2033.
The Asia-Pacific region dominates both production and consumption, supported by rapid urbanization, higher cosmetic usage, and strong manufacturing bases in China and surrounding countries.
In North America and Europe, demand is fueled by premium personal care products and dermatological formulations, with the U.S. market alone expected to expand from USD 90 million in 2022 to USD 150 million by 2030.
Anti-dandruff agent 290’s strong efficacy against Malassezia species, compatibility in cosmetic formulations, and favorable safety profile ensure its position as a preferred active ingredient in anti-dandruff shampoos, skin creams, and antifungal treatments.
Looking forward, innovation in product formulations and synergistic blends with other agents like zinc pyrithione and salicylic acid are expected to further strengthen its market presence across both pharmaceutical and cosmetic industries.
Uses of Anti-Dandruff Agent 290:
Anti-dandruff agent 290 is widely used in dermatology, cosmetics, pharmaceuticals, and commercial applications because of its strong antifungal activity and safety profile.
In dermatological practice, Anti-dandruff agent 290 is the most common anti-dandruff agent in shampoos and scalp treatments, where it reduces dandruff by targeting Malassezia fungi that cause flaking and itching.
Anti-dandruff agent 290 creams and lotions are also effective in seborrheic dermatitis, helping to control fungal overgrowth and relieve redness, irritation, and scaling.
Additionally, Anti-dandruff agent 290 antifungal creams are used in the treatment of pityriasis versicolor, a superficial fungal infection that leads to skin discoloration.
In the cosmetic and personal care sector, Anti-dandruff agent 290 is frequently included in anti-dandruff shampoos and hair tonics, often combined with zinc pyrithione, ketoconazole, or piroctone olamine to boost antifungal activity.
Anti-dandruff agent 290 is also incorporated into lotions, face washes, and creams to help balance the skin microbiome and prevent fungal overgrowth that can worsen acne-like conditions or irritation.
Furthermore, Anti-dandruff agent 290 is combined with salicylic acid for keratolytic effects or with menthol and plant extracts for soothing properties.
In pharmaceutical and medical use, Anti-dandruff agent 290 topical antifungal creams are applied to treat mild to moderate fungal infections such as athlete’s foot, jock itch, and ringworm, while long-term formulations are used to prevent recurrence of dandruff and fungal growth.
Finally, in industrial and commercial contexts, Anti-dandruff agent 290 is approved as a cosmetic ingredient in many countries at regulated concentrations, typically ≤0.5% in leave-on products and ≤2% in rinse-off formulations, and it is found in a wide range of over-the-counter antifungal and anti-dandruff products because of its strong efficacy, good stability, and low irritation potential.
Anti-dandruff agent 290 is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.
Anti-dandruff agent 290 is a phenomenal ingredient for hair care products with the ability to improve overall hair and scalp health.
Anti-dandruff agent 290 has anti-dandruff properties that clean the scalp thoroughly and prevent microbial growth.
Anti-dandruff agent 290 also reduces the sensation of irritation and itching, allowing for healthy hair growth that feels softer and lustrous.
Apart from hair care, Anti-dandruff agent 290 extends its goodness to skin care formulations to combat fungal-related skin conditions like tinea versicolor and seborrheic dermatitis.
Further, Anti-dandruff agent 290 is a renowned preservative that inhibits the development of bacteria in formulations - increasing their shelf life.
Anti-dandruff agent 290 has broad-spectrum bactericidal properties, mainly used for anti-itch and anti-dandruff conditioning shampoo, hair care shampoo.
But also for antibacterial soap, shower gel, drug toothpaste, mouthwash, etc.
Anti-dandruff agent 290 is a topical antifungal agent used to treat human fungal skin infections.
Anti-dandruff agent 290 can be included in over-the-counter Anti Dandruff Shampoo preparations and skin treatment compositions to treat dandruff and eczema in which the cause is fungal infection.
Although Anti-dandruff agent 290 is difficult to dissolve in water, it is easily soluble in toluene and some alcohols, and can be dissolved in a variety of surfactants.
Surfactants only need a small amount to make the interface state of their solution system change significantly, with fixed hydrophilic and lipophilic groups, which can be soluble in both water and organic solvents.
Therefore, Gambol can be dissolved in a suitable surfactant and then mixed with water.
Dermatological Uses:
Anti-dandruff agent 290 is the most common anti-dandruff agent used in shampoos and scalp treatments to reduce dandruff by targeting Malassezia fungi, which are strongly linked to flaking and itching.
Anti-dandruff agent 290 creams or lotions help control fungal overgrowth in seborrheic dermatitis, easing redness, irritation, and scaling.
Anti-dandruff agent 290 antifungal creams are used to treat pityriasis versicolor (tinea versicolor), a superficial fungal infection that causes skin discoloration.
Cosmetic & Personal Care Uses:
Anti-dandruff agent 290 is frequently included in anti-dandruff shampoos and hair tonics alongside zinc pyrithione, ketoconazole, or piroctone olamine for enhanced antifungal activity.
Anti-dandruff agent 290 is incorporated into skin care formulations such as lotions, face washes, and creams to balance the skin’s microbiome and prevent fungal overgrowth that may worsen acne-like conditions or irritation.
Anti-dandruff agent 290 is often combined with salicylic acid for keratolytic action or menthol/plant extracts to improve soothing effects and overall product appeal.
Pharmaceutical & Medical Uses:
Anti-dandruff agent 290 topical antifungal creams are used in the treatment of mild to moderate fungal skin infections such as athlete’s foot, jock itch, and ringworm, although they are less common than systemic azoles.
Anti-dandruff agent 290 formulations are applied in long-term scalp and skin care routines to prevent the recurrence of fungal growth and dandruff.
Industrial/Commercial Applications:
Anti-dandruff agent 290 is approved as a cosmetic ingredient in many countries for use in formulations at regulated concentrations (usually ≤0.5% in leave-on products and ≤2% in rinse-off products).
Anti-dandruff agent 290 is found in widely marketed over-the-counter antifungal and anti-dandruff products due to its strong safety profile and low irritation potential.
Benefits of Anti-Dandruff Agent 290:
Anti-dandruff agent 290 offers multiple benefits in both dermatological and cosmetic applications due to its broad-spectrum antifungal activity, stability, and skin compatibility.
One of Anti-dandruff agent 290's primary benefits is its proven effectiveness against Malassezia fungi, making it highly reliable in the treatment and prevention of dandruff and seborrheic dermatitis, where it reduces flaking, itching, and scalp irritation.
Anti-dandruff agent 290 also helps restore and maintain a healthy skin and scalp microbiome, preventing fungal overgrowth that can worsen acne-like symptoms or cause discoloration such as in pityriasis versicolor.
Another important benefit is its cosmetic versatility: Anti-dandruff agent 290 can be easily incorporated into shampoos, hair tonics, lotions, face washes, and creams without losing stability, ensuring long-lasting efficacy in different formulations.
Anti-dandruff agent 290 is often well tolerated, causing minimal irritation or sensitization compared to stronger systemic antifungals, which makes it suitable for long-term preventive care.
In addition, Anti-dandruff agent 290 enhances product appeal when combined with other active ingredients such as salicylic acid (for exfoliation) or menthol and plant extracts (for soothing effects), offering consumers both therapeutic and sensory benefits.
From an industrial standpoint, Anti-dandruff agent 290 is valued for its regulatory approval in many countries, its low concentration effectiveness (≤0.5% in leave-on and ≤2% in rinse-off products), and its role in over-the-counter personal care products, ensuring safe, accessible, and effective antifungal treatment for widespread consumer use.
Production of Anti-Dandruff Agent 290:
The production of Anti-dandruff agent 290 is based on organic synthesis of imidazole derivatives, as it is not a naturally occurring compound but a fully synthetic antifungal agent.
Industrial manufacturing typically begins with imidazole as the core structure, which undergoes substitution and coupling reactions with chlorinated phenyl derivatives and appropriate alkylating agents to form the Anti-dandruff agent 290 molecule, known chemically as (RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one.
The synthesis process requires strictly controlled reaction conditions, including regulated pH, temperature, and solvent systems, to ensure high yield and purity of the final crystalline product.
After synthesis, the raw compound undergoes purification steps such as recrystallization or chromatography, followed by quality control testing (e.g., HPLC, NMR, IR spectroscopy) to confirm molecular identity, purity, and stability.
In large-scale production, manufacturers in China, India, and Germany dominate the market, with companies such as Jiangsu Luye, Jiangsu Subin, and Symrise being key suppliers for the global cosmetics and pharmaceutical industries.
The final product is usually delivered as a white to off-white crystalline powder, which is then incorporated into cosmetic formulations (shampoos, creams, lotions) or pharmaceutical preparations at regulated concentrations.
Because of increasing demand in personal care, modern production processes also emphasize cost-efficiency, high stability, and compliance with international cosmetic regulations, ensuring that Anti-dandruff agent 290 maintains its position as a reliable antifungal ingredient worldwide.
Synthesis of Anti-Dandruff Agent 290:
Anti-dandruff agent 290 is produced through a multi-step synthetic route starting from pinacolone (3,3-dimethyl-2-butanone).
Step 1 – α,α-Dihalogenation:
Pinacolone is first halogenated at the α-carbon next to the carbonyl group, usually with chlorine or bromine, to form 1,1-dihalo-3,3-dimethyl-2-butanone.
This step introduces good leaving groups on the α-carbon, which makes Anti-dandruff agent 290 reactive toward nucleophilic substitution.
Step 2 – Imidazole Substitution:
One halogen atom is substituted by imidazole, typically under basic conditions in a polar aprotic solvent such as acetonitrile or DMF.
This gives 1-(imidazol-1-yl)-1-halo-3,3-dimethyl-2-butanone.
Step 3 – 4-Chlorophenoxy Substitution:
The remaining halogen is then replaced with 4-chlorophenoxide, which is generated from 4-chlorophenol and a base.
This step installs the second substituent on the α-carbon and yields the final Anti-dandruff agent 290 structure.
Step 4 – Workup and Purification:
The crude product is quenched, extracted, and purified by recrystallization or chromatography to obtain pure Anti-dandruff agent 290 as a white crystalline solid.
Quality control is performed using analytical techniques such as NMR, IR, MS, and HPLC to confirm structure, purity, and stability.
Because the central carbon is prochiral, the substitution leads to a racemic mixture (RS form) of Anti-dandruff agent 290.
On an industrial scale, this synthesis is optimized for yield, purity, and cost efficiency, with production mainly concentrated in China, India, and Germany by companies supplying the pharmaceutical and cosmetic industries.
Handling and Storage of Anti-Dandruff Agent 290:
Anti-dandruff agent 290 should be handled in accordance with good laboratory and industrial hygiene practices.
Avoid contact with skin, eyes, and clothing, and prevent inhalation of dust or aerosols.
Handle in a well-ventilated area and wear appropriate protective equipment.
Store in a tightly closed container in a cool, dry, and well-ventilated place, away from direct sunlight, heat sources, and incompatible substances such as strong oxidizers or strong acids.
Keep away from food, beverages, and animal feed.
Stability and Reactivity of Anti-Dandruff Agent 290:
Anti-dandruff agent 290 is considered stable under recommended storage conditions.
Anti-dandruff agent 290 is non-volatile, and not prone to spontaneous decomposition at ambient temperatures.
Avoid exposure to excessive heat, open flames, strong oxidizing agents, and strong acids/bases, as these may lead to degradation or hazardous by-products.
Thermal decomposition may generate carbon oxides, nitrogen oxides, and hydrogen chloride vapors.
First Aid Measures of Anti-Dandruff Agent 290:
Inhalation:
Remove the exposed individual to fresh air.
If breathing difficulties occur, provide oxygen and seek medical attention.
Skin Contact:
Wash thoroughly with soap and water.
Remove contaminated clothing.
Seek medical advice if irritation persists.
Eye Contact:
Rinse immediately with plenty of water for at least 15 minutes while holding eyelids apart.
Obtain medical attention if irritation occurs.
Ingestion:
Rinse mouth thoroughly with water.
Do not induce vomiting unless directed by medical personnel.
Seek immediate medical advice.
Firefighting Measures of Anti-Dandruff Agent 290:
Anti-dandruff agent 290 is not highly flammable but may burn if exposed to high heat.
Suitable extinguishing media include water spray, dry chemical powder, foam, or carbon dioxide.
Firefighters should wear self-contained breathing apparatus (SCBA) and full protective clothing.
Combustion may produce hazardous gases such as CO, CO₂, NOₓ, and HCl.
Accidental Release Measures of Anti-Dandruff Agent 290:
In case of a spill, avoid raising dust.
Use appropriate personal protective equipment (gloves, goggles, respirator if necessary).
Sweep or vacuum the material into a suitable container for disposal, following local regulations.
Clean the affected area with water and detergent to remove residues.
Prevent the product from entering drains or waterways.
Exposure Controls / Personal Protection of Anti-Dandruff Agent 290:
Engineering Controls:
Work in a well-ventilated area, preferably with local exhaust ventilation.
Respiratory Protection:
Use an approved respirator if dust or aerosols are generated.
Skin Protection:
Wear protective gloves (e.g., nitrile) and protective clothing to minimize skin contact.
Eye Protection:
Use safety goggles or face shield to prevent eye exposure.
Hygiene Measures:
Wash hands thoroughly after handling.
Do not eat, drink, or smoke while handling the material.
Remove contaminated clothing and wash before reuse.
Identifiers of Anti-Dandruff Agent 290:
IUPAC Name: 1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one
Common Name: Climbazole
CAS Number: 38083-17-9
EC Number (EINECS): 253-775-4
Molecular Formula: C₁₅H₁₇ClN₂O₂
Molecular Weight: 292.76 g/mol
InChI: InChI=1S/C15H17ClN2O2/c1-15(2,11(19)10-18-8-7-17-9-18)20-13-5-3-12(16)4-6-13/h3-9,10H2,1-2H3
InChI Key: HCKHBLNVXPGLGX-UHFFFAOYSA-N
SMILES Notation: CC(C)(C(=O)C1=CN=CN1)OC2=CC=C(C=C2)Cl
Preferred IUPAC Name: 1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one
CAS Number: 38083-17-9
EC Number (EINECS): 253-775-4
PubChem CID: 9572756
ChemSpider ID: 7844701
UNII: V6S89Q5B82
Molecular Formula: C₁₅H₁₇ClN₂O₂
Molecular Weight: 292.76 g/mol
Exact Mass: 292.1031 g/mol
Monoisotopic Mass: 292.1031 g/mol
Heavy Atom Count: 20
InChI: InChI=1S/C15H17ClN2O2/c1-15(2,11(19)10-18-8-7-17-9-18)20-13-5-3-12(16)4-6-13/h3-9,10H2,1-2H3
InChI Key: HCKHBLNVXPGLGX-UHFFFAOYSA-N
Canonical SMILES: CC(C)(C(=O)C1=CN=CN1)OC2=CC=C(C=C2)Cl
Isomeric SMILES: CC(C)(C(=O)C1=CN=CN1)OC2=CC=C(C=C2)Cl
Appearance: White to off-white crystalline powder
Melting Point: ~94–97 °C
Boiling Point: Not well-defined (decomposes)
Density: ~1.26 g/cm³ (estimated)
LogP (octanol/water partition coefficient): ~3.6 (lipophilic)
Solubility:
Sparingly soluble in water
Freely soluble in ethanol, methanol, propylene glycol, and organic solvents
Properties of Anti-Dandruff Agent 290:
Melting point: 96-100°C
Boiling point: 447.5±40.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
Vapor pressure: 0.001Pa at 25℃
Refractive index: 1.54
Storage temp.: Inert atmosphere,Room Temperature
Solubility: Insoluble in water
Form: Solid
Pka: 5.66±0.22(Predicted)
Color: White to Almost white
Water Solubility: 58mg/L at 25℃
BRN: 618020
InChIKey: OWEGWHBOCFMBLP-UHFFFAOYSA-N
LogP: 3.83 at 25℃
CAS DataBase Reference: 38083-17-9(CAS DataBase Reference)
Appearance: White to off-white crystalline powder
Molecular Formula: C₁₅H₁₇ClN₂O₂
Molecular Weight: 292.76 g/mol
Exact Mass: 292.103 g/mol
Melting Point: ~94–97 °C
Boiling Point: Not well-defined (decomposes before boiling)
Density: ~1.26 g/cm³ (estimated)
Refractive Index: n20/D ≈ 1.57 (estimated)
LogP (octanol/water): ~3.6 → moderately lipophilic
pKa: ~6.8 (imidazole protonation, estimated)
Vapor Pressure: Negligible at ambient temperature (non-volatile)
Appearance: White to off-white crystalline solid/powder
Odor: Odorless or faint chemical odor
Taste: Not available (not intended for ingestion)
Melting Point: 94–97 °C
Boiling Point: Not clearly defined; decomposes before boiling
Flash Point: >150 °C (estimated, solid)
Density: ~1.26 g/cm³ (solid, estimated)
Vapor Pressure: Negligible at ambient temperature (non-volatile solid)
Partition Coefficient (LogP): ~3.6 → lipophilic, favors lipid solubility
Refractive Index: ~1.57 (estimated, crystalline)
pKa: ~6.8 (imidazole group)
Surface Tension: Not applicable (solid)
Viscosity: Not applicable (solid)
