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ARTICHOKE LEAF EXTRACT

DESCRIPTION:

Artichoke (Cynara cardunculus) is a plant native to the Mediterranean area. 
The leaf, stem, and root are used to make extracts, which are used as medicine.

Artichoke is also commonly consumed as a food. 
Artichoke Leaf Extract contains chemicals that can reduce nausea and vomiting, spasms, and gas. 


These chemicals have also been shown to lower cholesterol and protect the liver.

People commonly use artichoke for indigestion and high levels of cholesterol or other fats in the blood. 
Artichoke Leaf Extract is also used for high blood pressure, hepatitis C, irritable bowel syndrome (IBS), and many other conditions, but there is no good scientific evidence to support most of these uses.

Artichoke Leaf Extract is obtained from the leaves of artichoke (Cynara scolymus L). 
The active ingredients contained in the extract are hydroxycinnamic derivatives. 
Extract is dissolved in propanediol, water, and glycerin. 


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Artichoke Leaf Extract Helps promote more resilient, shiny, frizz-free and disciplined hair.

Artichoke leaf extract, made from artichokes found in grocery stores, is thought by some to offer numerous health benefits, including lowering cholesterol in the blood.1 

Others contend that it can promote weight loss, treat acid reflux, prevent hangovers, or even "cleanse" the liver. 
The evidence supporting these claims is generally weak.

Artichoke leaf extracts are taken by mouth and mainly sold in capsule or gelcap forms. 
There are also concentrated liquid forms you can take with a dropper. 
Artichoke leaf extract is sometimes even infused into face creams for its purported anti-aging effects.


Possibly Effective for:
Indigestion (dyspepsia). Taking artichoke extract by mouth can reduce symptoms of indigestion, including nausea, vomiting, gas, and stomach pain. 
It seems to take 2 to 8 weeks of treatment to see these benefits.


High levels of cholesterol and other fats (lipids) in the blood (hyperlipidemia). 
Taking artichoke extract by mouth can slightly reduce total and low-density lipoprotein (LDL or "bad") cholesterol in people with high cholesterol. 
It seems to take 6 to 12 weeks of treatment to see these benefits.

HEALTH BENEFITS OF ARTICHOKES AND ARTICHOKE EXTRACT
Artichokes are rich in fiber, antioxidants, and other nutrients. 
They may also improve several aspects of health, including heart health and digestion.
Although often considered a vegetable, artichokes (Cynara cardunculus var. scolymus) are a type of thistle.

This plant originated in the Mediterranean and has been used for centuries for its potential medicinal properties (1Trusted Source).
Its alleged health benefits include lower blood sugar levels and improved digestion, heart health, and liver health.


Artichoke extract, which contains high concentrations of compounds found in the plant, is also increasingly popular as a supplement.
Here are the top 8 health benefits of artichokes and artichoke extract.


1. Loaded with nutrients
Artichokes are packed with powerful nutrients.
Each cup, or 170 grams (g), of cooked artichoke contains (2Trusted Source):
Calories: 90
Carbs: 20 g
Fiber: 10 g
Protein: 5 g
Fat: 0.6 g
Folate: 34% of the Daily Value (DV)
Copper: 21% of the DV
Magnesium: 15% of the DV
Vitamin C: 12% of the DV
Niacin: 10% of the DV
Riboflavin: 10% of the DV
Potassium: 9% of the DV
Phosphorus: 9% of the DV
Vitamin B6: 7% of the DV

Artichokes are low in fat while rich in fiber, vitamins, minerals, and antioxidants. 
Particularly high in folate and vitamin C, they also supply important minerals, such as magnesium, phosphorus, and potassium (2Trusted Source).
These delicious thistles come with only 90 calories per cooked cup (170 g) and around 5 g of protein, which is above average for a plant-based food (2Trusted Source).
To top it off, artichokes are also rich in a variety of antioxidants (3Trusted Source, 4Trusted Source).

Artichokes are low in fat, high in fiber, and loaded with vitamins and minerals like vitamin C, folate, phosphorus, and magnesium. 
They are also rich in antioxidants.

Artichoke Leaf Extract May improve cholesterol levels
Artichoke leaf extract may have a positive effect on cholesterol levels.
A large review in over 700 people found that supplementing with artichoke leaf extract daily for 5–13 weeks led to a reduction in total and LDL (bad) cholesterol (5Trusted Source).


Another review of 14 studies concluded that supplementing with artichoke could significantly reduce levels of triglycerides, total cholesterol, and LDL cholesterol (6Trusted Source).
Additionally, a 2012 animal study reported a 30% reduction in LDL cholesterol and a 22% reduction in triglycerides after regular consumption of artichoke extract (7Trusted Source).

According to some older research, artichoke extract may affect cholesterol in several ways.
First, artichokes contain luteolin, an antioxidant which prevents cholesterol formation (8Trusted Source).


Second, artichoke leaf extract encourages your body to process cholesterol more efficiently, leading to lower overall levels (9Trusted Source).
Artichoke extract may reduce triglycerides and total and LDL (bad) cholesterol, which could support heart health.


Artichoke Leaf Extract May help regulate blood pressure
Artichoke extract may aid people with high blood pressure.
In fact, several reviews have found that artichoke supplementation could significantly reduce systolic and diastolic blood pressure in people with high blood pressure levels (10Trusted Source, 11Trusted Source).

How artichoke extract reduces blood pressure is not fully understood.
However, some older test-tube and animal studies indicate that artichoke extract promotes the enzyme eNOS, which plays a role in widening blood vessels (8Trusted Source, 12Trusted Source).

In addition, artichokes are a good source of potassium, which helps regulate blood pressure (2Trusted Source, 13Trusted Source).
That said, it is unclear whether consuming whole artichokes provides the same benefits, as the artichoke extract used in these studies is highly concentrated.

Artichoke extract may help lower blood pressure in people with already elevated levels.
Artichoke Leaf Extract May improve liver health
Artichoke leaf extract may protect your liver from damage and promote the growth of new tissue (14Trusted Source, 15Trusted Source).

Artichoke Leaf Extract also increases the production of bile, which helps remove harmful toxins from your liver (8Trusted Source).
In one study, artichoke leaf extract decreased inflammation and liver cell death in mice with non-alcoholic fatty liver disease (16Trusted Source).
Studies in humans also show positive effects on liver health.


For example, one trial in 90 people with non-alcoholic fatty liver disease revealed that consuming 600 milligrams (mg) of artichoke extract daily for 2 months led to improved liver function (17Trusted Source).
Other reviews have found that artichoke supplementation could reduce levels of liver enzymes. 
Elevated liver enzymes often indicate inflammation or damage to the liver (18Trusted Source, 19Trusted Source).

Still, more research is needed to confirm the role of artichoke extract in treating liver disease.
Regular consumption of artichoke extract may help reduce inflammation and protect your liver from damage. 
However, more research is needed.


Artichoke Leaf Extract May improve digestive health
Artichokes are a great source of fiber, which can help keep your digestive system healthy by promoting friendly gut bacteria, reducing your risk of certain bowel cancers, and alleviating constipation and diarrhea (20Trusted Source, 21Trusted Source).
Artichokes contain inulin, a type of fiber which acts as a prebiotic (22Trusted Source).
In one 2010 study, consuming 10 g of inulin derived from globe artichokes led to improvements in the composition of the gut microbiome after 3 weeks (23Trusted Source).


According to some older studies, artichoke extract may also provide relief from symptoms of indigestion, such as bloating, nausea, and heartburn (24Trusted Source, 25Trusted Source).
One small study found that taking a supplement that contained ginger and artichoke before meals improved the movement of food through the digestive tract, which could potentially help ease indigestion (26Trusted Source).


However, because the supplement also contained ginger, it’s unclear how much of these results can be attributed to artichoke alone (26Trusted Source).
Artichoke leaf extract may maintain digestive health by boosting friendly gut bacteria and alleviating symptoms of indigestion.


Artichoke Leaf Extract May ease symptoms of irritable bowel syndrome
Irritable bowel syndrome (IBS) is a condition that affects your digestive system and can cause stomach pain, cramping, diarrhea, bloating, constipation, and flatulence (27Trusted Source).
In one older study in people with IBS, consuming artichoke leaf extract daily for 6 weeks helped ease symptoms. 


What’s more, 96% of participants rated the extract equally as effective as — if not better than — other IBS treatments, such as antidiarrheals and laxatives (28Trusted Source).
Another 2004 study in 208 people with IBS discovered that 1-2 capsules of artichoke leaf extract, consumed daily for 2 months, reduced symptoms by 26% and improved quality of life by 20% (29Trusted Source).
Artichoke extract may relieve symptoms in several ways.


One older animal study found that certain compounds in artichokes may have antispasmodic properties, meaning that they could help stop muscle spasms common in IBS (30Trusted Source).
Another 2010 study showed that the prebiotics found in artichoke could support gut health by improving the composition of the gut microbiome (23Trusted Source).


While artichoke extract seems promising for treating IBS symptoms, more recent, high quality human studies are needed.

Artichoke leaf extract may help treat IBS symptoms by reducing muscle spasms and improving the balance of beneficial bacteria in the gut. However, more research is necessary.
Artichoke Leaf Extract May help lower blood sugar
Artichokes and artichoke leaf extract may help lower blood sugar levels.
In fact, one animal study found that certain compounds in artichoke could reduce blood sugar and improve cholesterol and triglyceride levels in rats, which could be due to its antioxidant effects (31Trusted Source).


In another small study, artichoke extract supplementation enhanced blood sugar control and improved several other aspects of metabolic health — such as cholesterol levels and waist circumference — after 8 weeks (32Trusted Source).
What’s more, a review of nine studies concluded that artichoke and artichoke products could significantly reduce fasting blood sugar levels in humans (33Trusted Source).

However, keep in mind that more research is still needed on the effects of artichoke consumption on blood sugar control.
Some evidence suggests that artichokes and artichoke leaf extract may lower blood sugar levels. However, more research is needed.


Artichoke Leaf Extract May have anticancer effects
Animal and test-tube studies note that artichoke extract impaired cancer growth (34Trusted Source, 35Trusted Source, 36Trusted Source).
Certain antioxidants — including rutin, quercetin, silymarin, and gallic acid — in artichokes are thought to be responsible for these anticancer effects (8Trusted Source).


However, despite these promising results, no human studies exist. More research is needed.

Test-tube and animal studies suggest that artichoke extract may fight the growth of cancer cells. 
However, no human studies exist, so more research is needed before conclusions can be drawn


Anti-Aging
Artichoke leaf extract is sometimes infused into face creams claiming it has anti-aging effects.
A 2018 study published in the journal Molecule suggested that artichoke extract cream reduces inflammation and improves blood circulation in the skin. 
By doing so, it may help reduce sagging and roughness.2 
The study authors reported the artichoke extract cream resulted in a 19.74% improvement in skin roughness and an 11.45% improvement in skin elasticity compared to the placebo cream.


Liver Disease
There are claims that artichoke extract "cleanses" the liver. 
Some studies suggest that it may reduce liver inflammation in adults with fatty liver disease, but there is no evidence that it can either reduce or reverse liver toxicity.3

A 2016 study in the International Journal of Hepatology concluded that 2,700 milligrams (mg) of artichoke extract taken daily reduced liver enzymes in 30 adults with advanced metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as non-alcoholic fatty liver disease or NAFLD) compared to 30 adults given a placebo (sham drug).4

More research is needed to confirm the benefits to liver health, but artichoke extract won't prevent or reverse liver injury caused by excessive alcohol intake.

High Blood Pressure
Two separate reviews of seven and eight studies, respectively, concluded that artichoke supplementation showed a statistically significant reduction in systolic and diastolic blood pressure in people with hypertension.56

It isn't currently known how the supplement lowers blood pressure. 
It's also unclear whether eating artichokes would provide the same blood pressure-lowering benefit since the artichoke extract used in the studies is highly concentrated.


Kidney Disease
A 2016 study in the Pakistan Journal of Pharmacological Science reported that artichoke extract delivered by injection normalized kidney function in rats with drug-induced kidney disease.7 These same effects have yet to be demonstrated in humans.

Weight Loss
A 2018 study published in the journal Nutrients reported that artichoke leaf extract reversed the symptoms of metabolic syndrome, including waist circumference and high blood sugar, in obese rats fed a high-fat diet.8 
The same has yet to be shown in humans.
There are also claims that artichoke leaf extract has anti-cancer properties and can reduce the symptoms associated with irritable bowel syndrome (IBS). 

However, the studies were done in animals, not humans, or were conducted two decades ago and haven't been studied further.
To date, there is not enough evidence to support the use of artichoke leaf extract in treating any of the above health conditions.

Spotlight on Artichokes and High Cholesterol
It is not yet clear how effective artichokes are in lowering cholesterol. Studies thus far have been mixed.
With that said, some studies suggest that artichoke leaf extract works similarly to statin drugs commonly used to treat hypercholesterolemia (high cholesterol). 


Statins work by blocking an enzyme called HMG-CoA reductase that plays a role in cholesterol production

Artichoke Extract - Proprietary High Glucuronic Acid Extract - 5% extracts decrease the active ingredient glucuronic acid that supports the liver and gallbladder the best Globe artichoke (Cynara cardunculus) is a traditional component of the Mediterranean diet.
Artichoke extrac is a rich dietary sources of polyphenols with high bioavailability, and contains high-quality inulin fiber and minerals. 
Clinical studies have shown that the bioactive properties of globe artichoke extract are due to the high content of polyphenolic compounds in flower heads and leaves, in particular hydroxycinnamates and flavonoids.


The total antioxidant capacity of artichoke flower heads is one of the highest reported for vegetables. 
Product Features: Helps maintain healthy digestion. 
Each tablet contains standardized artichoke leaf dry extract (Cynara socolymus L.). Belonging to the same botanical family as the milk thistle and the daisy, the artichoke is one of nature's best-kept secrets when it comes to looking after your digestive health. 

Scientific research has shown that within the leaves of the artichoke plant is a powerful substance called Cynarin.
Thisilyn Artichoke contains Cynarin, extracted from the leaves at the base of the Globe Artichoke plant, which contains the highest concentration of the active constituents. Artichokes contain a myriad of active ingredients. 
The most important is the bitter substance cynarin. 

Further natural ingredients include flavonoids, vitamins such as A, B, C and K as well as minerals such as calcium and phosphorus.
Standardized to 2.5% cynarin Gluten-free, lactose-free, fructose-free, vegan Without magnesium stearate and silicon dioxide. 

Safety Information: Do not exceed the recommended daily intake. 
Food supplements are not able to replace a balanced and diverse nutrition or a healthy way of living. 
Please store this product away from children. 
Directions: 1 to 3 Capsules Daily


How to add them to your diet:
Preparing and cooking artichokes is not as intimidating as it seems.
They can be steamed, boiled, grilled, roasted, or sautéed. 
You can also prepare them stuffed or breaded, adding spices and other seasonings for an extra burst of flavor.


Steaming is the most popular cooking method and usually takes 20–40 minutes, depending on the size. 
Alternatively, you can bake artichokes for 40 minutes at 350°F (177°C).
Keep in mind that both the leaves and the heart can be eaten.
Once cooked, the outer leaves can be pulled off and dipped in sauce, such as aioli or herb butter. 

Simply remove the edible flesh from the leaves by pulling them through your teeth.
Once the leaves are removed, carefully spoon out the fuzzy substance called the choke until you reach the heart. 
You can then scoop out the heart to eat alone or atop pizza or salad.

The edible parts of the artichoke include the outer leaves and heart. 
Once cooked, artichokes can be eaten hot or cold and served with different dipping sauces.

SAFETY INFORMATION ABOUT ARTICHOKE LEAF EXTRACT
First aid measures:
Description of first aid measures:
General advice:
Consult a physician. 
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:
 
If inhaled:
If breathed in, move person into fresh air. 
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately. 
Wash off with soap and plenty of water.
Consult a physician.
 
In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.
 
If swallowed:
Do NOT induce vomiting. 
Never give anything by mouth to an unconscious person. 
Rinse mouth with water. 
Consult a physician.
 
Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
 
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. 
 
Avoid breathing vapours, mist or gas. 
Evacuate personnel to safe areas.
 
Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
 
Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste. 
Keep in suitable, closed containers for disposal.
 
Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.
 
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place. 
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials
 
Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
 
Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles. 
Faceshield (8-inch minimum). 
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
 
Skin protection:
Handle with gloves. 
Gloves must be inspected prior to use. 
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product. 
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. 
Wash and dry hands.
 
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.
 
Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. 
 
If the respirator is the sole means of protection, use a full-face supplied air respirator. 
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. 
Do not let product enter drains.
Discharge into the environment must be avoided.
 
Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions. 
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.
 
Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company. 
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.

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