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AZELAIC ACID


Azelaic acid = AzA = Nonanedioic acid


CAS NO:123-99-9
EC NO:204-669-1


Azelaic acid (AzA) is an organic compound with the formula HOOC(CH2)7COOH.
This saturated dicarboxylic acid exists as a white powder. 
Azelaic Acid is found in wheat, rye, and barley. 
Azelaic Acid is a precursor to diverse industrial products including polymers and plasticizers, as well as being a component of a number of hair and skin conditioners.
Azelaic Acid inhibits tyrosinase.


Production
Azelaic acid is industrially produced by the ozonolysis of oleic acid. The side product is nonanoic acid. 
Azelaic Acid is produced naturally by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. The bacterial degradation of nonanoic acid gives azelaic acid.


Biological function
In plants, azelaic acid serves as a "distress flare" involved in defense responses after infection.
Azelaic Acid serves as a signal that induces the accumulation of salicylic acid, an important component of a plant's defensive response.


Applications


Azelaic acid cream labeled in Russian.
Polymers and related materials
Esters of this dicarboxylic acid find applications in lubrication and plasticizers. In lubricant industries it is used as a thickening agent in lithium complex grease. With hexamethylenediamine, azelaic acid forms Nylon-6,9, which finds specialized uses as a plastic.


Medical
Azelaic acid is used to treat mild to moderate acne, both comedonal acne and inflammatory acne.
Azelaic Acid belongs to a class of medication called dicarboxylic acids.
Azelaic Acid works by killing acne bacteria that infect skin pores.
Azelaic Acid also decreases the production of keratin, which is a natural substance that promotes the growth of acne bacteria.
Azelaic acid is also used as a topical gel treatment for rosacea, due to its ability to reduce inflammation.
Azelaic Acid clears the bumps and swelling caused by rosacea. The mechanism of action is thought to be through the inhibition of hyperactive protease activity that converts cathelicidin into the antimicrobial skin peptide LL-37.
In topical pharmaceutical preparations and scientific research AzA is typically used in concentrations between 15% and 20% but some research demonstrates that in certain vehicle formulations the pharmaceutical effects of 10% Azelaic acid has the potential to be fully comparable to that of some 20% creams.


Acne treatment
Azelaic acid is effective for mild to moderate acne when applied topically at a 15%-20% concentration. In patients with moderate acne, twice daily application over 3 months of 20% 
Azelaic Acid significantly reduced the number of comedones, papules, and pustules; at this strength, it’s considered to be as effective as benzoyl peroxide 5%, tretinoin 0.05%, erythromycin 2%, and oral tetracycline at 500mg-1000mg.
 In a comparative review of effects of topical AzA, Salicylic acid, Nicotinamide, Sulfur, Zinc, and alpha-hydroxy acid, Azelaic Acid had more high-quality evidence of effectiveness than the rest. Results can be expected after 4 weeks of twice-daily treatment. The effectiveness of long term use is unclear, but it’s been recommended that AzA be used for at least 6 months continuously for maintenance.


Whitening agent
Azelaic acid has been used for treatment of skin pigmentation, including melasma and postinflammatory hyperpigmentation, particularly in those with darker skin types. 
Azelaic Acid has been recommended as an alternative to hydroquinone.As a tyrosinase inhibitor, azelaic acid reduces synthesis of melanin. According to one report in 1988, azelaic acid in combination with zinc sulfate in vitro was found to be a potent (90% inhibition) 5α-Reductase inhibitor, similar to the hair loss drugs finasteride and dutasteride. Middle 80s in vitro research evaluating acid's depigmenting (whitening) capability concluded it is effective (cytotoxic to melanocytes) at only high concentrations.
A more recent review claimed 20% AzA is more potent than 4% hydroquinone after a period of application of three months without the latter's adverse effects and even more effective if applied along with tretinoin for the same period of time.


Azelaic Acid is tyrosinase inhibitor.


Properties
Chemical formula        C9H16O4
Molar mass        188.22 g/mol
Appearance        white solid
Density        1.443 g/mL
Melting point        109 to 111 °C (228 to 232 °F; 382 to 384 K)
Boiling point        286 °C (547 °F; 559 K) at 100 mmHg
Solubility in water        2.14 g/L
Acidity (pKa)        4.550, 5.498


Azelaic acid gel and foam is used to clear the bumps, lesions, and swelling caused by rosacea (a skin disease that causes redness, flushing, and pimples on the face). 
Azelaic acid cream is used to treat the pimples and swelling caused by acne. 
Azelaic acid is in a class of medications called dicarboxylic acids. 
Azelaic acid works to treat rosacea by decreasing the swelling and redness of the skin. 
Azelaic acid works to treat acne by killing the bacteria that infect pores and by decreasing production of keratin, a natural substance that can lead to the development of acne.


What is azelaic acid?
Azelaic acid is a naturally occurring acid found in grains such as barley, wheat, and rye.


Azelaic acid has antimicrobial and anti-inflammatory properties, which make it effective in the treatment of skin conditions like acne and rosacea. 
Azelaic acid can prevent future outbreaks and clean bacteria from your pores that causes acne.


Azelaic acid is applied to your skin and is available in gel, foam, and cream form. 
Because it takes some time to take effect, azelaic acid by itself isn’t typically a dermatologist’s first choice for treating acne. 
Azelaic acid also has some side effects, such as skin burning, dryness, and peeling. 


Uses of azelaic acid for acne
Azelaic acid works by:


clearing your pores of bacteria that may be causing irritation or breakouts
reducing inflammation so acne becomes less visible, less red, and less irritated
gently encouraging cell turnover so your skin heals more quickly and scarring is minimized


Other uses for azelaic acid
Azelaic acid is also used for other skin conditions, such as hyperpigmentation, rosacea, and skin lightening.


Azelaic acid for hyperpigmentation
After a breakout, inflammation can result in hyperpigmentation on some areas of your skin. 
Azelaic acid stops discolored skin cells from populating.


Azelaic acid for skin lightening
The same property that makes azelaic acid effective for the treatment of inflammatory hyperpigmentation also enables it to lighten skin that’s discolored by melanin.


Azelaic acid for rosacea
Azelaic acid can reduce inflammation, making it an effective treatment for symptoms of rosacea. Clinical studies demonstrate that azelaic acid gel can continually improve the appearance of swelling and visible blood vessels caused by rosacea.


Azelaic Acid is a naturally occurring dicarboxylic acid produced by Malassezia furfur and found in whole grain cereals, rye, barley and animal products. 
Azelaic acid possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity. 
Azelaic acid is bactericidal against Proprionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular proteins. 
Azelaic acid exerts its keratolytic and comedolytic effects by reducing the thickness of the stratum corneum and decreasing the number of keratohyalin granules by reducing the amount and distribution of filaggrin in epidermal layers.
Azelaic acid also possesses a direct anti-inflammatory effect due to its scavenger activity of free oxygen radical. 
Azelaic acid is used topically to reduce inflammation associated with acne and rosacea.


Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. 
Azelaic acid  is also produced by Malassezia furfur, also known as Pityrosporum ovale, which is a species of fungus that is normally found on human skin. 
Azelaic acid is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. 
Azelaic acid works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. 
Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.


Azelaic acid 20% cream is used topically in the treatment of mild to moderate inflammatory acne vulgaris.
Azelaic acid 15% gel is used topically for the treatment of inflammatory lesions (papules and pustules) associated with mild to moderate rosacea in adults.
Azelaic acid is mainly excreted unchanged in the urine, but undergoes some ß-oxidation to shorter chain dicarboxylic acids.
Azelaic acid is used in lacquers, alkyd resins, plasticizers, adhesives, polyamides, urethane elastomers, and organic syntheses. 
Azelaic acid is also used in treating of acne.
Azelaic acid is an indirect food additive for use only as a component of adhesives.


Industry Uses        
Adhesives and sealant chemicals
Lubricants and lubricant additives
Paint additives and coating additives not described by other categories
Plasticizers


Industry Processing Sectors
Adhesive manufacturing
Paint and coating manufacturing
Petroleum lubricating oil and grease manufacturing
Plastic material and resin manufacturing


Azelaic acid is a complex molecule with many diverse activities. 
The latter include anti-infective and anti-inflammatory action. 
Azelaic acid also inhibits follicular keratinization and epidermal melanogenesis. 
Due to the wide variety of biological activities, azelaic acid has been utilized as a management tool in a broad spectrum of disease states and cutaneous disorders.


Azelaic acid topical cream is used to treat mildly to moderately inflamed acne. The topical foam and gel are used to treat mild to moderate rosacea. For acne, it works by killing the bacteria that cause acne and by keeping the skin pores clean.


This medicine is available only with your doctor's prescription.


This product is available in the following dosage forms:
Cream
Foam
Gel/Jelly


Azelaic acid is:
Antibacterial - Azelaic acid reduces the growth of bacteria in the follicle (Proprionibacterium acnes and Staphylococcus epidermidis)
Keratolytic and comedolytic -Azelaic acid returns to normal the disordered growth of the skin cells lining the follicle
A scavenger of free radicals - i.e. Azelaic acid reduces inflammation.


Azelaic acid also helps reduce pigmentation, so it's particularly useful for darker skinned patients whose acne spots leave persistent brown marks (postinflammatory pigmentation) or who have melasma.


What is azelaic acid topical?
Azelaic acid is a naturally occurring acid.
Azelaic acid helps the skin to renew itself more quickly and therefore reduces pimple and blackhead formation. 
Azelaic acid also helps to kill the bacteria that cause acne and rosacea.
Azelaic acid topical (for the skin) is used to treat acne and rosacea.
Azelaic acid topical may also be used for purposes not listed in this medication guide.


ANTI-AGING, SKIN BRIGHTENING: Our leave on azelaic acid is formulated with a high concentration of glycinated azelaic acid, along with niacinamide, vitamin C and coffee seed extract, which minimizes skin imperfections such as congestion (blackhead remover), redness (rosacea treatment for face), dullness and discoloration.


POWERFUL, NON-IRRITATING FORMULA: Azelaic acid is a highly stable and effective topical acid that helps reduce redness and inflammation, as well as functioning as a safe and effective dark spot corrector.


UNCLOG PORES, REFINE SKIN TEXTURE: Our topical acid formula helps unclog pores and balance excess sebum to minimize skin imperfections and even skin texture for smoother, more radiant skin. Helpful with cystic acne treatment and blackhead removal.


BIOCOMPATIBLE AND SAFE: Optimized to work with the physiological process of the skin, our skincare is formulated with both potent natural ingredients and advanced synthetic ingredients


Benefits of Azelaic Acid for Skin
Azelaic acid is a multifunctional skincare ingredient that tackles a multitude of concerns related to breakouts and inflammation.


Exfoliates gently: 
Azelaic acid goes deep within the pores and removes dead skin cells that cause dull skin tone and clogged pores.


Reduces inflammation: 
Azelaic acid soothes irritation and helps to improve red bumps caused by inflammation.


Evens skin tone: 
Azelaic acid inhibits tyrosinase, which is an enzyme that leads to hyperpigmentation.
Azelaic acid’s effective on post-inflammatory hyperpigmentation from acne breakouts and can possibly have an effect on melasma as well.


Treats rosacea: Azelaic acid could help with pore-clogging, inflammation, and secondary infections caused by rosacea.


Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. 
Azelaic acid is also produced by Malassezia furfur, also known as Pityrosporum ovale, which is a species of fungus that is normally found on human skin. 
Azelaic acid is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. 
Azelaic acid works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. 
Azelaic acid's antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.


Widespread uses by professional workers
Azelaic acid is used in the following products: washing & cleaning products, laboratory chemicals, polishes and waxes and cosmetics and personal care products.
Azelaic acid is used in the following areas: formulation of mixtures and/or re-packaging and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment.
Azelaic acid is used for the manufacture of: textile, leather or fur.
Release to the environment of Azelaic acid can occur from industrial use: formulation of mixtures and in processing aids at industrial sites.
Other release to the environment of Azelaic acid is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.


Formulation or re-packing
Azelaic acid is used in the following products: pH regulators and water treatment products, leather treatment products, polymers, lubricants and greases, coating products, fillers, putties, plasters, modelling clay, finger paints, inks and toners, textile treatment products and dyes and cosmetics and personal care products.
Release to the environment of Azelaic acid can occur from industrial use: formulation in materials, formulation of mixtures and in processing aids at industrial sites.


Uses at industrial sites
Azelaic acid is used in the following products: leather treatment products, washing & cleaning products, polymers, pH regulators and water treatment products, lubricants and greases and textile treatment products and dyes.
Azelaic acid is used in the following areas: formulation of mixtures and/or re-packaging and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment.
Azelaic acid is used for the manufacture of: textile, leather or fur.
Release to the environment of Azelaic acid can occur from industrial use: in processing aids at industrial sites, in the production of articles, as processing aid and as processing aid.
Other release to the environment of Azelaic acid is likely to occur from: indoor use as processing aid.


Description        
Azelaic acid is a topical antiacne agent which exerts its therapeutic action through a myriad of antimicrobial, antiproliferative and cytostatic effects. In vitro, azelaic acid hasbeen shown to inhibit DNA polymerases in several tumor cell lines.


Chemical Properties        
Azelaic acid is an organic compound with the formula (CH2)7(CO2H)2. 
This saturated dicarboxylic acid exists as a white powder. 
Azelaic acid is found in wheat, rye, and barley.
Azelaic acid is a component of a number of hair and skin conditioners.


Chemical Properties        
white to cream solid


Chemical Properties        
Nonanedioic acid is the best known dicarboxylic acid.
 Its name stems from the action of nitric acid (azote, nitrogen, or azotic, nitric) oxidation of oleic or elaidic acid. 
Azelaic acid was detected among products of rancid fats.
Azelaic acid s origin explains for its presence in poorly preserved samples of linseed oil and in specimens of ointment removed from Egyptian tombs 5000 years old. 
Azelaic acid was prepared by oxidation of oleic acid with potassium permanganate, but now by oxidative cleavage of oleic acid with chromic acid or by ozonolysis. 
Azelaic acid is used, as simple esters or branched-chain esters) in the manufacture of plasticizers (for vinyl chloride resins, rubber), lubricants and greases. 
Azelaic acid is now used in cosmetics (treatment of acne). 
Azelaic acid displays bacteriostatic and bactericidal properties against a variety of aerobic and anaerobic micro-organisms present on acne-bearing skin. 
Azelaic acid was identified as a molecule that accumulated at elevated levels in some parts of plants and was shown to be able to enhance the resistance of plants to infections.


Uses        
antiacne, antiproliferative agent
antifungal, binds to membrane sterols
Azelaic acid is used in lacquers, alkyd resins, plasticizers, adhesives, polyamides, urethane elastomers, and organic syntheses. 
Azelaic acid is also used in treating of acne.


Application        
Azelaic acid, also known as azalea acid, is a white to slightly yellow powder. 
Azelaic acid is a medium-long chain dibasic acid. In recent years, with the rapid development of the organic synthetic chemical industry, the demand for medium and long chain dibasic acids is increasing. 
The medium and long chain dibasic acids and their derivatives have a wide range of industrial applications and a broad product market.


Application        
Polymers and related materials
Esters of this dicarboxylic acid find applications in lubrication and plasticizers. With hexamethylenediamine azelaic acid forms Nylon - 6,9, which finds specialized uses as a plastic.


Medical
Azelaic acid is used to treat mild to moderate acne, both comedonal acne and inflammatory acne . 
Azelaic acid belongs to a class of medication called dicarboxylic acids. 
Azelaic acid works by killing acne bacteria that infect skin pores.
Azelaic acid also decreases the production of keratin, which is a natural substance that promotes the growth of acne bacteria. 
Azelaic acid is also used as a topical gel treatment for rosacea, due to its ability to reduce inflammation .
Azelaic acid clears the bumps and swelling caused by Rosacea. 
Azelaic acid has been used for treatment of skin pigmentation including melasma and post inflammatory hyper pigmentation , particularly in those with darker skin types.
Azelaic acid has been recommended as an alternative to hydroquinone (HQ). As a tyrosinase inhibitor, azelaic acid reduces synthesis of melanin.

     
Azelaic acid is a naturally occurring dicarboxylic acid produced by the yeast Malassezia furfur. 
Azelaic acid inhibits tyrosinase, a rate-limiting enzyme in the synthesis of the pigment melanin. This may explain why diminution of melanin pigmentation occurs in the skin of some patients with pityriasis versicolor, a disease caused by M. furfur. 
Azelaic acid is bacteriostatic against a number of species thought to participate in the pathogenesis of acne, including Propionibacterium acnes. The drug may also reduce microcomedo formation by promoting normalization of epidermal keratinocytes.


Production Methods        
Azelaic acid is industrially produced by the ozonolysis of oleic acid. 
Azelaic acid is nonanoic acid. 
Azelaic acid is produced naturally by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. The bacterial degradation of nonanoic acid gives azelaic acid.


Azelaic acid is a dicarboxylic acid that exhibits anti-inflammatory activity. 
It is known for it's anti acne activity in vitro. 
Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and upregulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPARν is thought to drive these effects. 
Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis.


Appearance :Powder
Physical State :Solid
Solubility :Soluble in water (2.4 mg/ml at 20° C), ethanol (5%), DMSO, methanol (70 mg/ml), and alcohol.
Storage :Store at 4° C
Melting Point :109-111° C (lit.)
Boiling Point :286° C (lit.) at 100 mmHg
Density :1.03 g/cm3
Refractive Index :n20D 1.48 (Predicted)
pK Values :pKa: 4.55 at 25° C


Product name
Azelaic acid (Nonanedioic acid), 5alpha reductase inhibitor


Description
5α reductase inhibitor. PPARγ activator.


Biological description
5α reductase inhibitor. PPARγ activator. Competitively inhibits tyrosinase and thioredoxin reductase (Ki values are 3 mM and 13 μM respectively). Cytotoxin to melanocytes. Reduces skin hyperpigmentation. Induces salicylic acid accumulation in plants. Shows anti-inflammatory and antibiotic effects in vivo.


Purity
> 98%


Useful in lubrication and plasticizers.
Azelaic acid is used to treat acne.
Azelaic Acid, dicarboxylic acid with 9 carbon atoms, is a white flake or powdered crystal. 
Azelaic Acid is resolved in ethanol, ether and soluble slightly in water. 
Azelaic Acid can be prepared by ozonolysis which uses ozone is to cleave the alkene bonds. Example of ozonolysis in commerce is the production of odd carbon number carboxylic acids such as azelaic acid and pelargonic acid and simple carboxylic acids such as formic acid and oxalic acid. Odd chain number carboxylic acids are relatively high cost material. 
Azelaic acid is produced naturally on normal skin by a yeast called Malassezia furfur. 
Azelaic acid is used as a dermatologic agent to treat acnes. 
Azelaic acid is also known as a 5-alpha reductase inhibitor which is applicable to prevent hair loss. Dicarboxylic acid can yield two kinds of salts, as they contain two carboxyl groups in its molecules. 
Azelaic Acid and its derivatives have a variety of industrial uses as plasticizers, lubricants, hydraulic fluids, cosmetics, candles, etc.
Azelaic Acid is used in the synthesis of polyamide and alkyd resins.  
Azelaic Acid is also used as an intermediate for aromatics, antiseptics and painting materials.


Azelaic acid is a dicarboxylic acid found in cereals and animal products. 
Azelaic acid is bactericidal against Proprionibacterium acnes and Staphylococcus epidermidis by inhibiting synthesis in microbial cellular proteins. 
Azelaic acid is found to be useful in controlling several skin conditions, including acne and hyperpigmentation. In melanoma cells azelaic acid inhibits DNA synthesis, leading to a significant reduction in proliferation.
Azelaic acid could be produced by ozone cracking of unsaturated fatty acid and is commonly used in grease, cosmetics and pharmaceuticals.
Azelaic acid is an organic compound produced by the ozonolysis of oleic acid; component of a number of hair and skin conditioners.
Azelaic acid (nonanedioic acid) is a dicarboxylic acid and is a white crystalline powder available in various purity grades depending on the final application.
Azelaic acid is used in many pharmaceutical preparations as an active ingredient in acne rosacea, due to its therapeutic effectiveness.


The innovative production process achieves azelaic acid with very high purity and low monocarboxylic content, fundamental features for its use as an intermediate in polymerization processes, typically as an alternative to sebacic acid and adipic acid.


Azelaic acid, formally nonanedioic acid, is a white crystalline solid with a melting point of 106.5 °C. 
Azelaic acid occurs naturally in grains such as wheat, rye, and barley and is produced industrially by ozonolyzing oleic acid. 
Azelaic acid is used topically to treat acne and rosacea. Some plants release azelaic acid as a "distress flare" to signal cells to activate their defenses against attacking pathogens.


Azelaic acid is produced industrially by the ozonolysis of oleic acid. The by- product is nonanoic acid.
Azelaic acid is produced naturally by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. The bacterial degradation of nonanoic acid produces azelaic acid.


Azelaic acid is soluble in hot water, alcohol and organic solvents.
Azelaic acid is used in the manufacture of adhesives and sealant chemicals; lubricants and lubricant additives; paint and coating additives, and plasticizers.
Medically, Azelaic acid is used to treat mild to moderate acne, both comedonal acne and inflammatory acne.


Azelaic acid, also known as 1,9-nonanedioate, AZA or azelex, is a saturated nine-carbon dicarboxylic acid. 
Azelaic acid ocurrs in all living organisms, ranging from bacteria to humans. 
Azelaic acid possesses a variety of in vitro and in vivo biological activities. In aerobic bacteria, azelaic acid reversibly inhibits several oxidoreductive enzymes including tyrosinase, mitochondrial enzymes of the respiratory chain, thioredoxin reductase, 5-alpha-reductase, and DNA polymerases.
Azelaic acid is currently used as a topical treatment of mild to moderate inflammatory acne vulgaris, due to its antibiotic effects on skin bacteria. Its effectiveness is similar to that of other agents without the systemic side effects of oral antibiotics or the allergic sensitization of topical benzoyl peroxide and with less irritation than tretinoin. 
Azelaic acid is less expensive than certain other prescription acne preparations, but it is much more expensive than nonprescription benzoyl peroxide preparations. 
Whether Azelaic acid is safe and effective when used in combination with other agents is not known. In plants, azelaic acid serves as a "distress flare" involved in defense responses after infection.
Azelaic acid serves as a signal that induces the accumulation of salicylic acid, an important component of the plants defensive response . 
Azelaic acid is found in high abundance in several crop plants including wheat, rye, and barley. 
Azelaic acid has been detected, but not quantified in, a few different foods, such as asparagus, common beans, and potato. This could make azelaic acid a potential biomarker for the consumption of these foods. 
Azelaic acid is a precursor to a number of industrial products including polymers and plasticizers, as well as being a component of a number of hair and skin conditioners.


Azelaic acid is commonly used as a thickener in lithium complex greases. 
In addition, Azelaic Acid is an intermediate in the production of industrial products including polymers and plasticizers. 
Azelaic acid is also a component of a number of hair and skin conditioners. In personal care or pharmaceutical applications, 
Azelaic acid can be used as an active ingredient in acne treatment products.


Medical: Azelaic acid is an active ingredient in many topical creams and other prescription treatments for light-to-moderate acne. Like other dicarboxylic acids, it is effective at killing acne-causing bacteria and decreasing keratin production. 
Azelaic acid’s also effective at reducing inflammation, making it a good treatment for rosacea and other inflammatory skin conditions. 
Products containing azelaic acid are also used to treat rosacea, melasma and other skin pigmentation problems.


Polymers: Azelaic acid esters are used as a basic component of renewable and degradable plastics. Because our product is derived entirely from plant sources, it is better for the environment than plastics produced wholly from fossil fuels. 
Azelaic acid is also used to prepare PVC plasticizers.


Lubricants and Corrosion Inhibitors: Azelaic acid is a component of synthetic lubricants and corrosion inhibitors, and is frequently used as a thickening agent in lithium complex greases.


Azelaic acid, a saturated dicarboxylic acid chemically identified as 1,7-heptanedicarboxylic acid, has been shown to be the real workhorse.
Azelaic acid refers to an organic compound that exists as a white powder.
Azelaic acid is an organic compound with a saturated dicarboxylic acid which is found in wheat, barley and rye. It is also known as nonanedioic acid.


IUPAC names
1,7-Heptanedicarboxylic acid
acid azelaic
AZELAIC ACID
Azelaic Acid
Azelaic acid
azelaic acid
Azelaic acid
azelaic acid
Azelainsäure
Azeleic Acid
Nonanedioic acid
nonanedioic acid
Nonanedioic acid
Nonanedionic acid


SYNONYMS:
azelaicacid,technicalgrade
Azelainic acid
Emerox 1110
Emerox 1144
emerox1110
emerox1144
Emery's L-110
ninandioic acid
AZELAIC ACID TECH. 85-90% FLAKES
AZELAIC ACID 98+%
Anchoec acid
AZELAIC ACID, ULTRAPURE
Azelaic acid, tech., flakes, 85-90%
nonanedionic acid
nonadioic acid
Azelainsure
Azelaic acid, 85-90%, tech., flakes
Heptanedicarboxylic acid
heptanedicarboxylicacid
n-Nonanedioic acid
Skinoren
ZK-62498
AZELAIC ACID [1,7-HEPATANEDICARBOXYLIC ACID]
Azelaic acid, 95+%
1,7-HEPTANEDICARBOXYLIC
ANCHOIC ACID
LEPARGYLIC ACID
AZELAIC ACID
DICARBOXYLIC ACID C9
NONANEDIOC ACID
NONANEDIOIC ACID
N-HEPTANE-1,7-DICARBOXYLIC ACID
RARECHEM AL BO 0186
1,9-NONANEDIOIC ACID
1,7-HEPTANEDICARBOXYLIC ACID
Azalaic Acid
Azelaicacidtech
BioaActive Azelaic acid
Nanoactive Azelaic acid
Soluble Azelaic acid
Nanoactive Aze
1,7-heptane dicarloxylic acid
1,9-nonanedioicaid
1,7-Dicarboxyheptane
azelaic
Azelaic acid, technical grade
Azelaic acid, tech., flakes
Azeloic acid
Azelaic acid( Micronized )
Azelaic acid, 98% 25GR
Azelaic Acid 98%
1,7-Heptanedicarboxylic Acid Nonanedioic Acid
Azelaic acid(Nonanedioic acid)
Azelaic Acid,1,7-Heptanedicarboxylic Acid
Nonanedioic acid 1,7-Heptanedicarboxylic Acid
1.7-Heptanedic
Azelaic acid technical, ~85% (GC)
Azelaic acid Vetec(TM) reagent grade


 

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