BIS-(2-DIMETHYLAMINOETHYL)ETHER

Bis-(2-dimethylaminoethyl)ether is used in the following products: adhesives and sealants, coating products and fillers, putties, plasters, modelling clay.
Bis-(2-dimethylaminoethyl)ether is used in the following areas: mining and building & construction work.
Bis-(2-dimethylaminoethyl)ether is used for the manufacture of: plastic products and machinery and vehicles.

CAS Number: 3033-62-3
EC Number: 221-220-5
IUPAC Name: Bis(2‑dimethylaminoethyl) ether — {2‑[2‑(dimethylamino)ethoxy]ethyl}dimethylamine
Molecular Formula: C₈H₂₀N₂O
Molecular Weight: 160.26 g/mol

SYNONYMS:
DMAEE, 2,2′‑Oxybis(N,N‑dimethylethylamine), Niax A‑99, Ethylamine, 2,2′‑oxybis‑(N,N‑dimethyl)-, Dabco BL‑11, Dabco BL‑19, JEFFCAT ZF-20, DBACO BL-19, NIAX Catalyst A-99, 2,2’-oxybis[n,n-dimethyl-ethanamin, 2,2’-oxybis[N,N-dimethyl-Ethanamine, A 99 (Amine), dabco bl11, dabco bl19, 2,2′-Oxybis(N,N-dimethylethylamine), 2-(Dimethylamino)ethyl ether, Bis(2-(dimethylamino)ethyl) ether, 2,2'-Oxybis(N,N-dimethylethylamine), DMAEE, 3033-62-3, BIS(2-DIMETHYLAMINOETHYL) ETHER, Bis(2-dimethylaminoethyl)ether, Kalpur PC, Niax A 1, Toyocat ET, Toyocat ETS, Dabco BL 11, Texacat ZF 20, Dabco BL 19I, Dabco BL 19, Niax A 4, Niax A 99, A 99 (Amine), Ethanamine, 2,2'-oxybis[N,N-dimethyl-, Bis(2-(dimethylamino)ethyl)ether, Bis(2-(dimethylamino)ethyl) ether, NSC 109887, 2,2'-Oxybis(N,N-dimethylethylamine), bis (2-dimethylaminoethyl) ether, Ethanamine, 2,2'-oxybis(N,N-dimethyl-, NL66Q36V7L, Bis[2-(dimethylamino)ethyl]ether, Bis[2-(dimethylamino)ethyl] ether, NSC-109887, DTXSID5027512, N,N,N',N'-Tetramethyl-3-oxapentane-1,5-diamine, 2,2'-Oxybis[N,N-dimethylethylamine], DTXCID807512, DMAEE, 2,2'-Oxybis(N,N-dimethyl ethylamine), NIAX A99, 221-220-5, Bis(dimethylaminoethyl) ether, 2,2'-oxybis(N,N-dimethylethanamine), Niax catalyst al, 2-Dimethylaminoethyl Ether, N,N,N',N'-Tetramethyl-2,2'-oxybis(ethylamine), EINECS 221-220-5, BRN 1739668, Ethylamine, 2,2'-oxybis(N,N-dimethyl-, Ethylamine, 2,2'-oxybis[N,N-dimethyl-, dimethylaminoethyl ether, HSDB 7903, {2-[2-(dimethylamino)ethoxy]ethyl}dimethylamine, 1,5-Bis(dimethylamino)-3-oxapentane, 2-[2-(dimethylamino)ethoxy]-N,N-dimethylethanamine, A 99, EC 221-220-5, 4-04-00-01441 (Beilstein Handbook Reference), 59948-21-9, BIS (2-DIMETHYLAMINOETHYL) ETHER [HSDB], N,N,N',N'-TETRAMETHYLBISAMINOETHYL ETHER, Minico TMDA, Kaolizer 12, Kaolizer 12P, CAS-3033-62-3, Jeffcat ZM 20, Texacat ZF 22, 2-(2-(dimethylamino)ethoxy)-N,N-dimethylethanamine, Bis[2-(N,N-dimethylamino)ethyl] ether, UNII-NL66Q36V7L, PC CAT NP 99, 2-(Dimethylamino)ethyl ether, NP 99, 2,2'-Oxybis(N,N-dimethylethanamine) (Bis[2-(dimethylamino)ethyl] Ether; N,N,N',N'-Tetramethyl(oxydiethylene)diamine), MFCD00059199, 2,N-dimethylethylamine], A 133, JEFFCAT ZF 20, A99 AMINE, PC CAT NP 90, SCHEMBL15091, Bis(2dimethylaminoethyl)ether, PC CAT NP 133, Bis(2dimethylaminoethyl) ether, bis(N,N-dimethylaminoethyl)ether, CHEMBL1899933, bis-(2-dimethylaminoethyl) ether, ZF 20, WLN: 1N1&2 2O, 2,2'Oxybis(N,Ndimethylethylamine), Clavulanate Potassium EP Impurity M, Tox21_202013, Tox21_303216, Ethanamine,2'-oxybis[N,N-dimethyl-, Ethylamine,2'-oxybis[N,N-dimethyl-, NSC109887, bis[2-(n,n-dimethylamino)ethyl]ether, AKOS006220473, NCGC00164210-01, NCGC00164210-02, NCGC00257033-01, NCGC00259562-01, Bis-[2-(N,N-dimethylamino)ethyl] ether, BS-22895, DB-323257, Ethylamine, 2,2'-Oxybis-(N,N-dimethyl)-, B1291, CS-0077112, NS00005315, Bis[2-(N,N-dimethylamino)ethyl] ether, 97%, EN300-205166, ethane, 1-dimethylamino-2-dimethylaminoethoxy-, ethanamine, 2,2'-oxybis(N,N-dimethylethylamine), 2-(2-dimethylaminoethoxy)-N,N-dimethyl-ethanamine, BIS (2-DIMETHYLAMINOETHYL) ETHER (DMAEE), Q20965408, F0001-0931, Z276157630, N-(2-[2-(Dimethylamino)ethoxy]ethyl)-N,N-dimethylamine #, {2-[2-(dimethylamino)ethoxy]ethyl}dimethylamine, Ethylamine, 2,2'-oxybis[N,N-dimethyl-, A 99, A 99 (Amine), Kalpur PC, Niax A 1, Niax A 4, 2,2'-Oxybis[N,N-dimethylethylamine], Niax catalyst al, 1,5-Bis(dimethylamino)-3-oxapentane, Dabco BL 11, Dabco BL 19, Dabco BL 19I, N,N,N',N'-Tetramethyl-2,2'-oxybis(ethylamine), Niax A 99, NSC 109887, Texacat ZF 20, Toyocat ET, Toyocat ETS, 2,2'-Oxybis(N,N-dimethylethylamine), A 99 (Amine), Bis(2-dimethylaminoethyl) ether, Bis(2-dimethylaminoethyl)ether, Dabco BL 11, Dabco BL 19, Dabco BL 19I, Kalpur PC, Niax A 1, Niax A 4, Niax A 99, Niax catalyst al, Texacat ZF 20, Toyocat ET, Toyocat ETS, [ChemIDplus], Ethanamine, 2,2'-oxybis[N,N-dimethyl-, Ethylamine, 2,2'-oxybis[N,N-dimethyl-, A 99, A 99 (Amine), Kalpur PC, Niax A 1, Niax A 4, 2,2'-Oxybis[N,N-dimethylethylamine], Niax catalyst al, 1,5-Bis(dimethylamino)-3-oxapentane, Dabco BL 11, Dabco BL 19, Dabco BL 19I, N,N,N',N'-Tetramethyl-2,2'-oxybis(ethylamine), Niax A 99, NSC 109887, Texacat ZF 20, Toyocat ET, Toyocat ETS, 2,2'-oxybis[n,n-dimethyl-ethanamin,2,2'-oxybis[N,N-dimethyl-Ethanamine,A 99,A 99 (Amine),a99(amine),dabcobl11,dabcobl19,dabcobl19i, 2,2'-Oxybis[N,N-dimethylethanamine, 1,5-Bis(dimethylamino)-3-oxapentane, Bis(dimethylaminoethyl) Ether, Bis[2-(dimethylamino)ethyl] Ether,Kalpur PC, Kaolizer 12, Kaolizer 12P, Minico TMDA, N,N,N',N'-Tetramethyl-2,2'-oxybis[ethylamine], N,N,N',N'-Tetramethyl-3-oxapentane-1,5-diamine, N,N,N',N'-Tetramethylbis-aminoethyl Ether, Ethanamine, 2,2'-oxybis[N,N-dimethyl-, Ethylamine, 2,2'-oxybis[N,N-dimethyl- (6CI,7CI,8CI), 2,2'-Oxybis[N,N-dimethylethanamine], 1,5-Bis(dimethylamino)-3-oxapentane, 2,2'-Oxybis[N,N-dimethylethylamine], A 1, A 133, A 99, A 99 (amine), Addocat 108, BL 11, BL 19, Bis(dimethylaminoethyl) ether, Bis[2-(dimethylamino)ethyl] ether, DY 1, Dabco BL 11, Dabco BL 19, Dabco BL 19I, ET 33B, Jeffcat Z 20, Jeffcat ZF 20, Jeffcat ZM 20, Kalpur PC, Kaolizer 12, Kaolizer 12P, Minico TMDA, N,N,N',N'-Tetramethyl-2,2'-oxybis[ethylamine], N,N,N',N'-Tetramethyl-3-oxapentane-1,5-diamine, N,N,N',N'-Tetramethylbisaminoethyl ether, NP 99, NSC 109887, Niax A 1, Niax A 99, Niax Catalyst A 1, PC CAT NP 133, PC CAT NP 90, PC CAT NP 99, Tetramethyl bis(aminoethyl) ether, Texacat ZF 20, Texacat ZF 22, Toyocat ET, Toyocat ET 33B, Toyocat ETS, ZF 20, 2,2’-Oxybis(N,N-dimethylethanamine), Potassium Clavulanate Impurity M, bis 2-dimethylaminoethyl ether, niax catalyst al, kalpur pc, toyocat ets, niax a 1, texacat zf 20, dabco bl 19i, dabco bl 11, dabco bl 19, Ethanamine, 2,2'-oxybis[N,N-dimethyl-

Bis-(2-dimethylaminoethyl)ether is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.
Bis-(2-dimethylaminoethyl)ether appears as a clear or yellow liquid.

Bis-(2-dimethylaminoethyl)ether is an efficient tertiary amine catalyst, which is suitable for the production of almost all foam products, mainly for the production of flexible foam products, especially for high resilience and RIM products.

It is characterized by high catalytic activity, smooth foaming, large tolerance to tin, easy to adjust the formulation, and the physical and chemical properties of products produced with Bis-(2-dimethylaminoethyl)ether, such as resilience and elongation, are better than other products.

Bis-(2-dimethylaminoethyl)ether, with the CAS number 3033-62-3, is an organic compound characterized by its ether functional group and two dimethylaminoethyl substituents.
Bis-(2-dimethylaminoethyl)ether typically appears as a colorless to pale yellow liquid with a distinctive amine-like odor.

Bis-(2-dimethylaminoethyl)ether is soluble in water and various organic solvents, which enhances its utility in chemical applications.
The presence of dimethylamino groups imparts basic properties, making Bis-(2-dimethylaminoethyl)ether a potential nucleophile in various chemical reactions.

Bis-(2-dimethylaminoethyl)ether acts as a tridentate tertiary amine ligand, strongly basic.
Bis-(2-dimethylaminoethyl)ether reacts exothermically with acids; may form peroxide if exposed to air.
Bis-(2-dimethylaminoethyl)ether is infinitely soluble in water, and the aqueous solution is alkaline.

Bis-(2-dimethylaminoethyl)ether is one of the important amine catalysts in the polyurethane industry.
Bis-(2-dimethylaminoethyl)ether has extremely high catalytic activity and selectivity for the foaming reaction.
The pure product, Bis-(2-dimethylaminoethyl)ether, has high activity.

Usually, Bis-(2-dimethylaminoethyl)ether is diluted into a solution with glycols for more convenient use.
Bis-(2-dimethylaminoethyl)ether, also known as 2,2'-oxybis(N,N-dimethylethylamine) or DMAEE, belongs to the class of organic compounds known as trialkylamines.

These are organic compounds containing a trialkylamine group, characterized by exactly three alkyl groups bonded to the amino nitrogen.
Based on a literature review very few articles have been published on Bis-(2-dimethylaminoethyl)ether.
Bis-(2-dimethylaminoethyl)ether has been identified in human blood as reported by (PMID: 31557052).

Bis-(2-dimethylaminoethyl)ether is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives.
Technically, Bis-(2-dimethylaminoethyl)ether is part of the human exposome.

Bis-(2-dimethylaminoethyl)ether belongs to the class of organic compounds known as trialkylamines.
These are organic compounds containing a trialkylamine group, characterized by exactly three alkyl groups bonded to the amino nitrogen.
Bis-(2-dimethylaminoethyl)ether appears as a clear or yellow liquid.

Bis-(2-dimethylaminoethyl)ether is infinitely soluble in water, and the aqueous solution is alkaline.
Bis-(2-dimethylaminoethyl)ether is one of the important amine catalysts in the polyurethane industry.

Bis-(2-dimethylaminoethyl)ether has extremely high catalytic activity and selectivity for the foaming reaction.
Usually, Bis-(2-dimethylaminoethyl)ether is diluted into a solution with glycols for more convenient use.

USES and APPLICATIONS of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
Bis-(2-dimethylaminoethyl)ether is used in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.
Release to the environment of Bis-(2-dimethylaminoethyl)ether can occur from industrial use: of articles where the substances are not intended to be released and where the conditions of use do not promote release.

Other release to the environment of Bis-(2-dimethylaminoethyl)ether is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

Bis-(2-dimethylaminoethyl)ether can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones).
Bis-(2-dimethylaminoethyl)ether is used in the following products: adhesives and sealants, coating products and fillers, putties, plasters, modelling clay.

Bis-(2-dimethylaminoethyl)ether is used in the following areas: mining and building & construction work.
Bis-(2-dimethylaminoethyl)ether is used for the manufacture of: plastic products and machinery and vehicles.

Other release to the environment of Bis-(2-dimethylaminoethyl)ether is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).
Bis-(2-dimethylaminoethyl)ether is used in the following products: adhesives and sealants and polymers.

Release to the environment of Bis-(2-dimethylaminoethyl)ether can occur from industrial use: formulation of mixtures and formulation in materials.
Bis-(2-dimethylaminoethyl)ether is used in the following products: polymers, adhesives and sealants, coating products and fillers, putties, plasters, modelling clay.

Bis-(2-dimethylaminoethyl)ether is used in the following areas: mining.
Bis-(2-dimethylaminoethyl)ether is used for the manufacture of: plastic products, machinery and vehicles and furniture.

Release to the environment of Bis-(2-dimethylaminoethyl)ether can occur from industrial use: in the production of articles, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).
Release to the environment of Bis-(2-dimethylaminoethyl)ether can occur from industrial use: manufacturing of the substance.

As a high-efficiency tertiary amine catalyst, Bis-(2-dimethylaminoethyl)ether is suitable for the production of almost all foam plastic products, mainly for the production of flexible foam products, especially for high resilience and RIM products.
Bis-(2-dimethylaminoethyl)ether is characterized by high catalytic activity, stable foaming, large tolerance to tin, and easy adjustment of the formula.

The products produced with Bis-(2-dimethylaminoethyl)ether have better physical and chemical properties such as resilience and elongation than other products.
Bis-(2-dimethylaminoethyl)ether is used in the manufacturing of flexible polyurethane foams.

Catalyst in polyurethane foam production—Bis-(2-dimethylaminoethyl)ether is particularly flexible and high-resilience foams (RIM).
Bis-(2-dimethylaminoethyl)ether is employed in formulations requiring tertiary amine catalysts with tin tolerance and adjustable properties.

Bis-(2-dimethylaminoethyl)ether is used ligand in coordination and exchange reactions.
Bis-(2-dimethylaminoethyl)ether is often used as a reagent in organic synthesis, particularly in the production of polymers and as a catalyst in certain reactions.

ALTERNATIVE PARENTS of BIS-(2-DIMETHYLAMINOETHYL)ETHER:     
*Dialkyl ethers 
*Organopnictogen compounds 
*Hydrocarbon derivatives 

SUBSTITUENTS of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
*Tertiary aliphatic amine
*Ether
*Dialkyl ether
*Organic oxygen compound
*Organopnictogen compound
*Hydrocarbon derivative
*Organooxygen compound
*Aliphatic acyclic compound

REACTIVITY PROFILE of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
Bis-(2-dimethylaminoethyl)ether reacts as a base.
Reacts exothermically with acids.
May form explosive peroxides upon exposure to the air.

PREPARATION of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
The main methods for the synthesis of Bis-(2-dimethylaminoethyl)ether are:
(1) reaction of sodium dimethylaminoethanol and SO₃ or chlorosulfonic acid;
(2) Reaction of trimethylamine with dichloroethyl ether or dimethylaminoethoxyethyl ether;
(3) One-step synthesis of dimethylamine and monoethyleneglycol under solid catalyst.

PHYSICAL and CHEMICAL PROPERTIES of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
Appearance: Clear to yellow liquid 
Odor: Amine‑like, characteristic 
Boiling Point: ~188–189 °C (≈372 °F) 
Flash Point: ~56–66 °C (closed cup)
Melting/Freezing Point: ~–20 °C
Density: ~0.84–0.85 g/mL @25 °C 
Refractive Index: ~1.43 D @20 °C 
Solubility: Soluble/miscible in water, alcohols, benzene 
Linear Formula: ((CH3)2N(CH2CH2))2O

CAS Number: 3033-62-3
Molecular Weight: 160.26
EC Number: 221-220-5
MDL number: MFCD00059199
UNSPSC Code: 12352100
PubChem Substance ID: 24884926
NACRES: NA.22
Chemical Formula: C8H20N2O
Average Molecular Weight: 160.261
Monoisotopic Molecular Weight: 160.157563272

IUPAC Name: {2-[2-(dimethylamino)ethoxy]ethyl}dimethylamine
Traditional Name: {2-[2-(dimethylamino)ethoxy]ethyl}dimethylamine
CAS Registry Number: Not Available
SMILES: CN(C)CCOCCN(C)C
InChI Identifier: InChI=1S/C8H20N2O/c1-9(2)5-7-11-8-6-10(3)4/h5-8H2,1-4H3
InChI Key: GTEXIOINCJRBIO-UHFFFAOYSA-N
Physical state: liquid

Color: Amber
Odor: Ammonia odor
Melting point/freezing point: No data available
Initial boiling point and boiling range: 189 °C at 1.013 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits:
Upper explosion limit: 5.1 % (V)

Lower explosion limit: 1 % (V)
Flash point: 66.11 °C
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity:
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available

Water solubility: Soluble
Partition coefficient: n-octanol/water: No data available
Vapor pressure: 0.37 hPa at 21 °C
Density: 0.841 g/cm³ at 25 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available

Explosive properties: No data available
Oxidizing properties: No data available
Relative vapor density 5.53 (Air = 1.0)
Molecular Weight: 160.26 g/mol
Computed by PubChem 2.2 (PubChem release 2025.04.14)
XLogP3-AA: 0.2
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 3

Rotatable Bond Count: 6
Exact Mass: 160.157563266 Da
Monoisotopic Mass: 160.157563266 Da
Topological Polar Surface Area: 15.7 Ų
Heavy Atom Count: 11
Formal Charge: 0
Complexity: 74.2
Isotope Atom Count: 0

Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Molecular Formula / Molecular Weight: C8H20N2O = 160.26
Physical State (20 °C): Liquid
Storage Temperature: Room Temperature (Recommended in a cool and dark place, <15 °C)

CAS RN: 3033-62-3
Reaxys Registry Number: 1739668
PubChem Substance ID: 87564225
SDBS (AIST Spectral DB): 18646
MDL Number: MFCD00059199
CAS: 3033-62-3
IUPAC Name: {2-[2-(dimethylamino)ethoxy]ethyl}dimethylamine
Molecular Formula: C8H20N2O
InChI Key: GTEXIOINCJRBIO-UHFFFAOYSA-N

SMILES: CN(C)CCOCCN(C)C
Molecular Weight (g/mol): 160.26
Form: Liquid
Appearance (Color): Clear colorless
Refractive Index: 1.4280–1.4320 @ 20 °C
Assay (GC): ≥97.5%
CAS: 3033-62-3
MF: C8H20N2O
MW: 160.26
EINECS: 221-220-5

FIRST AID MEASURES of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available