BIS-(2-DIMETHYLAMINOETHYL)ETHER

Bis-(2-dimethylaminoethyl)ether is often used as a reagent in organic synthesis, particularly in the production of polymers and as a catalyst in certain reactions.
Bis-(2-dimethylaminoethyl)ether is widely used in flexible polyether slabstock and moulded foams using TDI or MDI formulations.
Bis-(2-dimethylaminoethyl)ether can be used alone or with other amine catalyst to balance the blowing and gelation reactions.

CAS Number: 3033-62-3
EC Number: 221-220-5
IUPAC Name: Bis(2‑dimethylaminoethyl) ether — {2‑[2‑(dimethylamino)ethoxy]ethyl}dimethylamine
Molecular Formula: C₈H₂₀N₂O
Molecular Weight: 160.26 g/mol

SYNONYMS:
DMAEE, 2,2′‑Oxybis(N,N‑dimethylethylamine), Niax A‑99, Ethylamine, 2,2′‑oxybis‑(N,N‑dimethyl)-, Dabco BL‑11, Dabco BL‑19, JEFFCAT ZF-20, DBACO BL-19, NIAX Catalyst A-99, 2,2’-oxybis[n,n-dimethyl-ethanamin, 2,2’-oxybis[N,N-dimethyl-Ethanamine, A 99 (Amine), dabco bl11, dabco bl19, 2,2′-Oxybis(N,N-dimethylethylamine), 2-(Dimethylamino)ethyl ether, Bis(2-(dimethylamino)ethyl) ether, 2,2'-Oxybis(N,N-dimethylethylamine), DMAEE, 3033-62-3, BIS(2-DIMETHYLAMINOETHYL) ETHER, Bis(2-dimethylaminoethyl)ether, Kalpur PC, Niax A 1, Toyocat ET, Toyocat ETS, Dabco BL 11, Texacat ZF 20, Dabco BL 19I, Dabco BL 19, Niax A 4, Niax A 99, A 99 (Amine), Ethanamine, 2,2'-oxybis[N,N-dimethyl-, Bis(2-(dimethylamino)ethyl)ether, Bis(2-(dimethylamino)ethyl) ether, NSC 109887, 2,2'-Oxybis(N,N-dimethylethylamine), bis (2-dimethylaminoethyl) ether, Ethanamine, 2,2'-oxybis(N,N-dimethyl-, NL66Q36V7L, Bis[2-(dimethylamino)ethyl]ether, Bis[2-(dimethylamino)ethyl] ether, NSC-109887, DTXSID5027512, N,N,N',N'-Tetramethyl-3-oxapentane-1,5-diamine, 2,2'-Oxybis[N,N-dimethylethylamine], DTXCID807512, DMAEE, 2,2'-Oxybis(N,N-dimethyl ethylamine), NIAX A99, 221-220-5, Bis(dimethylaminoethyl) ether, 2,2'-oxybis(N,N-dimethylethanamine), Niax catalyst al, 2-Dimethylaminoethyl Ether, N,N,N',N'-Tetramethyl-2,2'-oxybis(ethylamine), EINECS 221-220-5, BRN 1739668, Ethylamine, 2,2'-oxybis(N,N-dimethyl-, Ethylamine, 2,2'-oxybis[N,N-dimethyl-, dimethylaminoethyl ether, HSDB 7903, {2-[2-(dimethylamino)ethoxy]ethyl}dimethylamine, 1,5-Bis(dimethylamino)-3-oxapentane, 2-[2-(dimethylamino)ethoxy]-N,N-dimethylethanamine, A 99, EC 221-220-5, 4-04-00-01441 (Beilstein Handbook Reference), 59948-21-9, BIS (2-DIMETHYLAMINOETHYL) ETHER [HSDB], N,N,N',N'-TETRAMETHYLBISAMINOETHYL ETHER, Minico TMDA, Kaolizer 12, Kaolizer 12P, CAS-3033-62-3, Jeffcat ZM 20, Texacat ZF 22, 2-(2-(dimethylamino)ethoxy)-N,N-dimethylethanamine, Bis[2-(N,N-dimethylamino)ethyl] ether, UNII-NL66Q36V7L, PC CAT NP 99, 2-(Dimethylamino)ethyl ether, NP 99, 2,2'-Oxybis(N,N-dimethylethanamine) (Bis[2-(dimethylamino)ethyl] Ether; N,N,N',N'-Tetramethyl(oxydiethylene)diamine), MFCD00059199, 2,N-dimethylethylamine], A 133, JEFFCAT ZF 20, A99 AMINE, PC CAT NP 90, SCHEMBL15091, Bis(2dimethylaminoethyl)ether, PC CAT NP 133, Bis(2dimethylaminoethyl) ether, bis(N,N-dimethylaminoethyl)ether, CHEMBL1899933, bis-(2-dimethylaminoethyl) ether, ZF 20, WLN: 1N1&2 2O, 2,2'Oxybis(N,Ndimethylethylamine), Clavulanate Potassium EP Impurity M, Tox21_202013, Tox21_303216, Ethanamine,2'-oxybis[N,N-dimethyl-, Ethylamine,2'-oxybis[N,N-dimethyl-, NSC109887, bis[2-(n,n-dimethylamino)ethyl]ether, AKOS006220473, NCGC00164210-01, NCGC00164210-02, NCGC00257033-01, NCGC00259562-01, Bis-[2-(N,N-dimethylamino)ethyl] ether, BS-22895, DB-323257, Ethylamine, 2,2'-Oxybis-(N,N-dimethyl)-, B1291, CS-0077112, NS00005315, Bis[2-(N,N-dimethylamino)ethyl] ether, 97%, EN300-205166, ethane, 1-dimethylamino-2-dimethylaminoethoxy-, ethanamine, 2,2'-oxybis(N,N-dimethylethylamine), 2-(2-dimethylaminoethoxy)-N,N-dimethyl-ethanamine, BIS (2-DIMETHYLAMINOETHYL) ETHER (DMAEE), Q20965408, F0001-0931, Z276157630, N-(2-[2-(Dimethylamino)ethoxy]ethyl)-N,N-dimethylamine #, {2-[2-(dimethylamino)ethoxy]ethyl}dimethylamine, Ethylamine, 2,2'-oxybis[N,N-dimethyl-, A 99, A 99 (Amine), Kalpur PC, Niax A 1, Niax A 4, 2,2'-Oxybis[N,N-dimethylethylamine], Niax catalyst al, 1,5-Bis(dimethylamino)-3-oxapentane, Dabco BL 11, Dabco BL 19, Dabco BL 19I, N,N,N',N'-Tetramethyl-2,2'-oxybis(ethylamine), Niax A 99, NSC 109887, Texacat ZF 20, Toyocat ET, Toyocat ETS, 2,2'-Oxybis(N,N-dimethylethylamine), A 99 (Amine), Bis(2-dimethylaminoethyl) ether, Bis(2-dimethylaminoethyl)ether, Dabco BL 11, Dabco BL 19, Dabco BL 19I, Kalpur PC, Niax A 1, Niax A 4, Niax A 99, Niax catalyst al, Texacat ZF 20, Toyocat ET, Toyocat ETS, [ChemIDplus], Ethanamine, 2,2'-oxybis[N,N-dimethyl-, Ethylamine, 2,2'-oxybis[N,N-dimethyl-, A 99, A 99 (Amine), Kalpur PC, Niax A 1, Niax A 4, 2,2'-Oxybis[N,N-dimethylethylamine], Niax catalyst al, 1,5-Bis(dimethylamino)-3-oxapentane, Dabco BL 11, Dabco BL 19, Dabco BL 19I, N,N,N',N'-Tetramethyl-2,2'-oxybis(ethylamine), Niax A 99, NSC 109887, Texacat ZF 20, Toyocat ET, Toyocat ETS, 2,2'-oxybis[n,n-dimethyl-ethanamin,2,2'-oxybis[N,N-dimethyl-Ethanamine,A 99,A 99 (Amine),a99(amine),dabcobl11,dabcobl19,dabcobl19i, 2,2'-Oxybis[N,N-dimethylethanamine, 1,5-Bis(dimethylamino)-3-oxapentane, Bis(dimethylaminoethyl) Ether, Bis[2-(dimethylamino)ethyl] Ether,Kalpur PC, Kaolizer 12, Kaolizer 12P, Minico TMDA, N,N,N',N'-Tetramethyl-2,2'-oxybis[ethylamine], N,N,N',N'-Tetramethyl-3-oxapentane-1,5-diamine, N,N,N',N'-Tetramethylbis-aminoethyl Ether, Ethanamine, 2,2'-oxybis[N,N-dimethyl-, Ethylamine, 2,2'-oxybis[N,N-dimethyl- (6CI,7CI,8CI), 2,2'-Oxybis[N,N-dimethylethanamine], 1,5-Bis(dimethylamino)-3-oxapentane, 2,2'-Oxybis[N,N-dimethylethylamine], A 1, A 133, A 99, A 99 (amine), Addocat 108, BL 11, BL 19, Bis(dimethylaminoethyl) ether, Bis[2-(dimethylamino)ethyl] ether, DY 1, Dabco BL 11, Dabco BL 19, Dabco BL 19I, ET 33B, Jeffcat Z 20, Jeffcat ZF 20, Jeffcat ZM 20, Kalpur PC, Kaolizer 12, Kaolizer 12P, Minico TMDA, N,N,N',N'-Tetramethyl-2,2'-oxybis[ethylamine], N,N,N',N'-Tetramethyl-3-oxapentane-1,5-diamine, N,N,N',N'-Tetramethylbisaminoethyl ether, NP 99, NSC 109887, Niax A 1, Niax A 99, Niax Catalyst A 1, PC CAT NP 133, PC CAT NP 90, PC CAT NP 99, Tetramethyl bis(aminoethyl) ether, Texacat ZF 20, Texacat ZF 22, Toyocat ET, Toyocat ET 33B, Toyocat ETS, ZF 20, 2,2’-Oxybis(N,N-dimethylethanamine), Potassium Clavulanate Impurity M, bis 2-dimethylaminoethyl ether, niax catalyst al, kalpur pc, toyocat ets, niax a 1, texacat zf 20, dabco bl 19i, dabco bl 11, dabco bl 19, Ethanamine, 2,2'-oxybis[N,N-dimethyl-, 2,2′-Oxybis(N,N-dimethylethylamine), Bis(2-dimethylaminoethyl) ether, Bis[2-(dimethylamino)ethyl] ether, Ethanamine, 2,2′-oxybis[N,N-dimethyl-], N,N,N′,N′-Tetramethyl-2,2′-oxybis(ethylamine), A99, A133, BDMAEE, Dabco BL11, Dabco BL19, ET33B, Jeffcat ZM20, Kalpur PC, Niax A1, Niax A99, Texacat ZF20, Toyocat ET, Toyocat ETS, A99, A99 (amine), Bis(dimethylaminoethyl) ether, Bis[2-(dimethylamino)ethyl]ether, 2,2'-Bis(dimethylamino)diethyl ether, 1,5-Bis(dimethylamino)-3-oxapentane, Dabco BL11, Dabco BL19, Dabco BL19I, DMAEE, Ethanamine, 2,2'-oxybis(N,N-dimethyl)-, Ethylamine, 2,2'-oxybis(N,N-dimethyl)-, Kalpur PC, NIAX A99, NIAX Catalyst A-99, 2,2'-Oxybis(N,N-dimethylethylamine), 2,2'-Oxybis(N,N-dimethylethanamine), 2,2-Oxybis(N,N-dimethylethylamine), N,N,N',N'-Tetramethyl-3-oxapentane-1,5-diamine, N,N,N',N'-Tetramethyl-2,2'-oxybis(ethylamine), N,N,N',N'-Tetramethyl-2,2'-oxybis(ethylamine), Texacat ZF 20, Toyocat ET, Toyocat ETS

Bis-(2-dimethylaminoethyl)ether (CAS 3033-62-3), also known as 2,2′-oxybis(N, N-dimethylethanamine), is a colorless to light yellow clear liquid with the molecular formula C8H20N2O and a molecular weight of 160.26 g/mol.
Bis-(2-dimethylaminoethyl)ether has a boiling point of 189 °C at 760 mmHg, a density of 0.841 g/mL at 25 °C, and a refractive index of n20/D 1.430.

Bis-(2-dimethylaminoethyl)ether exhibits a vapor pressure of 49 Pa at 20 °C, a flash point of 151 °F (66 °C), and a predicted pKa of 9.12 ± 0.28.
Bis-(2-Dimethylaminoethyl)Ether is the established blowing catalyst for all types of flexible polyurethane foam.

Bis-(2-dimethylaminoethyl)ether's strong catalytic effect on the blowing reaction can be effectively balanced by adding a strong gelling catalyst.
When used in flexible slabstock formulations, Bis-(2-dimethylaminoethyl)ether improves the processing of all grades of foam, ranging from low to high density and from filled to high-resiliency grades.

The unique performance characteristics of Bis-(2-Dimethylaminoethyl)Ether make it an effective choice for high-resiliency molded foam.
Bis-(2-dimethylaminoethyl)ether, with the CAS number 3033-62-3, is an organic compound characterized by its ether functional group and two dimethylaminoethyl substituents.

Bis-(2-dimethylaminoethyl)ether typically appears as a colorless to pale yellow liquid with a distinctive amine-like odor.
Bis-(2-dimethylaminoethyl)ether is soluble in water and various organic solvents, which enhances its utility in chemical applications.
The presence of dimethylamino groups imparts basic properties, making it a potential nucleophile in various chemical reactions.

Proper safety measures, including the use of personal protective equipment, are essential when working with this substance in laboratory or industrial settings.
Bis-(2-dimethylaminoethyl)ether appears as a clear or yellow liquid

Bis-(2-dimethylaminoethyl)ether, also known as Bis(2-(dimethylamino)ethyl) ether, is a colorless to transparent liquid that may sometimes appear brownish or yellow.
Bis-(2-dimethylaminoethyl)ether has a boiling point of 188 °C and is fully soluble in water as well as in organic solvents such as alcohol and benzene.

Bis-(2-dimethylaminoethyl)ether is a highly efficient tertiary amine catalyst widely used in the polyurethane industry for the production of nearly all types of foam products.
Bis-(2-dimethylaminoethyl)ether appears as a clear or yellow liquid.

Bis-(2-dimethylaminoethyl)ether, also known as 2,2'-oxybis(N,N-dimethylethylamine) or DMAEE, belongs to the class of organic compounds known as trialkylamines.
These are organic compounds containing a trialkylamine group, characterized by exactly three alkyl groups bonded to the amino nitrogen.

Based on a literature review very few articles have been published on Bis-(2-dimethylaminoethyl)ether.
This compound has been identified in human blood as reported.
Bis-(2-dimethylaminoethyl)ether is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives.

Technically Bis-(2-dimethylaminoethyl)ether is part of the human exposome.
The exposome can be defined as the collection of all the exposures of an individual in a lifetime and how those exposures relate to health.
An individual's exposure begins before birth and includes insults from environmental and occupational sources.

Bis-(2-dimethylaminoethyl)ether is a clear or yellow liquid;
Bis-(2-dimethylaminoethyl)ether is a component (5%) of NIAX Catalyst ESN, along with dimethylaminopropionitrile (95%); used in the past as a catalyst in the manufacture of flexible polyurethane foams

Bis-(2-dimethylaminoethyl)ether is a high-efficiency tertiary amine catalyst.
Bis-(2-dimethylaminoethyl)ether is suitable for the production of all foamed plastic products, mainly used in flexible foam products, especially high-rebound products.

The Global Bis-(2-dimethylaminoethyl)ether Market size is expected to be worth around USD 191.5 Million by 2034, from USD 92.9 Million in 2024, growing at a CAGR of 7.5% during the forecast period from 2025 to 2034.
Bis-(2-dimethylaminoethyl)ether appears as a clear or yellow liquid.

Bis-(2-dimethylaminoethyl)ether is a specialized organic chemical used primarily as a catalytic agent within polyurethane foam production, offering reactivity control, balanced cell structure, and improved flexibility in industrial foam processing.
Bis-(2-dimethylaminoethyl)ether acts as a tertiary amine catalyst supporting rigid, semi-rigid, and flexible PU formulations used in insulation, automotive padding, construction boards, and bedding materials.

Bis-(2-dimethylaminoethyl)ether is a low-molecular-weight tertiary amine ether that plays a critical role in industrial catalysis, particularly in polyurethane chemistry.
Bis-(2-dimethylaminoethyl)ether's molecular architecture combines an ether linkage with two tertiary amine functionalities, which gives the molecule both polarity and strong basicity.

This dual nature is responsible for its high catalytic efficiency, miscibility with many organic systems, and rapid activity in polymer-forming reactions.
From a chemical behavior standpoint, Bis-(2-dimethylaminoethyl)ether is a strong Lewis base and proton acceptor.

The tertiary amine groups readily interact with acidic species, including isocyanates and water-derived intermediates in polyurethane systems.
In foam chemistry, Bis-(2-dimethylaminoethyl)ether preferentially accelerates the blowing reaction (the reaction between isocyanate and water that generates carbon dioxide), while still contributing to the gel reaction (polyol–isocyanate crosslinking).

This selectivity makes Bis-(2-dimethylaminoethyl)ether especially valuable in flexible and semi-flexible foam formulations where controlled cell opening, low density, and uniform foam rise are required.
One of the defining performance characteristics of Bis-(2-dimethylaminoethyl)ether is its high volatility relative to higher-molecular-weight amine catalysts.

This volatility contributes to fast reaction initiation and rapid foam rise, but Bis-(2-dimethylaminoethyl)ether also explains the strong amine odor associated with its use.
In modern formulations, Bis-(2-dimethylaminoethyl)ether is often partially or fully replaced by reactive or low-emission amine catalysts in applications where odor, emissions, or worker exposure must be minimized.

Nevertheless, Bis-(2-dimethylaminoethyl)ether remains a benchmark catalyst due to its predictable behavior and strong catalytic profile.
From a stability perspective, Bis-(2-dimethylaminoethyl)ether is chemically stable under normal storage conditions but is hygroscopic and can absorb moisture from the air.

Water uptake does not typically degrade Bis-(2-dimethylaminoethyl)ether but can influence catalytic performance by altering reaction kinetics in moisture-sensitive systems.
Like many ethers, prolonged exposure to air and light may lead to slow peroxide formation; therefore, storage under inert conditions or with stabilizers is sometimes recommended for long-term storage.

Thermally, Bis-(2-dimethylaminoethyl)ether remains stable at ambient and moderately elevated temperatures encountered during storage and processing.
However, under fire conditions or extreme heat, Bis-(2-dimethylaminoethyl)ether decomposes to release nitrogen-containing vapors and irritating amine fumes.

This behavior underlines the importance of adequate ventilation and fire-prevention measures in facilities handling the substance.
In occupational and industrial hygiene contexts, Bis-(2-dimethylaminoethyl)ether is recognized as a corrosive and toxic amine.

USES and APPLICATIONS of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
Bis-(2-dimethylaminoethyl)ether is often used as a reagent in organic synthesis, particularly in the production of polymers and as a catalyst in certain reactions.
From a regulatory and commercial standpoint, Bis-(2-dimethylaminoethyl)ether is sold under numerous trade names and catalyst blends, often as part of proprietary polyurethane catalyst packages.

These blends may combine Bis-(2-dimethylaminoethyl)ether with other tertiary amines to fine-tune foam rise profile, curing speed, and physical properties of the final polymer.
Despite newer alternatives, Bis-(2-dimethylaminoethyl)ether continues to be widely referenced in technical literature and remains an important reference material in polyurethane research and development.

In summary, Bis-(2-dimethylaminoethyl)ether is best understood not merely as a simple tertiary amine, but as a high-performance, fast-acting industrial catalyst whose chemical structure directly translates into its reactivity, volatility, and practical utility.
Its advantages in reaction speed and formulation flexibility are balanced by considerations related to toxicity, odor, and handling safety, which define how and where Bis-(2-dimethylaminoethyl)ether is used in modern chemical manufacturing.

Bis-(2-dimethylaminoethyl)ether primarly promotes the urea (water-isocyanate) reaction in flexible and rigid polyurethane foams.
Bis-(2-dimethylaminoethyl)ether has a low odour and is highly active for flexible foams, semi-flexible foams and rigid foams.

Bis-(2-dimethylaminoethyl)ether is a versatile and efficient tertiary amine catalyst, primarily aimed at enhancing the production of various foam products, notably flexible polyurethane foams, including high resilience and reactive injection molding (RIM) types.
As a colorless to brown liquid, Bis-(2-dimethylaminoethyl)ether possesses excellent solubility in water, alcohol, and benzene, making it adaptable to diverse manufacturing environments.

Bis-(2-dimethylaminoethyl)ether stands out due to its high catalytic activity, promoting smooth foaming processes and providing significant formulation flexibility.
Bis-(2-dimethylaminoethyl)ether offers substantial tolerance to tin, while also improving the physical and chemical properties of the resulting foam, such as resilience and elongation, making it superior to alternative catalysts in producing high-quality foam products.

Catalyst in Polyurethane Foam Production: Bis-(2-dimethylaminoethyl)ether is widely used as a highly efficient tertiary amine catalyst, especially for flexible foam, soft foam, high-resilience foam, and RIM (Reaction Injection Molding) products.
Chemical Intermediate: Bis-(2-dimethylaminoethyl)ether is used in organic synthesis and specialty chemical manufacturing.

Research Reagent: Bis-(2-dimethylaminoethyl)ether is utilized in laboratory and industrial settings, not for medicinal or household use.
Bis-(2-dimethylaminoethyl)ether is used in the manufacturing of flexible polyurethane foams.
Bis-(2-dimethylaminoethyl)ether is widely used in flexible polyether slabstock and moulded foams using TDI or MDI formulations.

Bis-(2-dimethylaminoethyl)ether can be used alone or with other amine catalyst to balance the blowing and gelation reactions.
Bis-(2-dimethylaminoethyl)ether gives rapid cream time and is recommended for use in partially water-blow rigid spray foams.
Bis-(2-dimethylaminoethyl)ether is a power catalyst for the isocyanate-water reaction and has applications in certain moisture-cured coatings,caukls and adhesives.

Bis-(2-dimethylaminoethyl)ether is an efficient tertiary amine catalyst, which is suitable for the production of almost all foam products, mainly for the production of flexible foam products, especially for high resilience and RIM products.
Bis-(2-dimethylaminoethyl)ether is characterized by high catalytic activity, smooth foaming, large tolerance to tin, easy to adjust the formulation, and the physical and chemical properties of products produced with it, such as resilience and elongation, are better than other products.

In formulation science, Bis-(2-dimethylaminoethyl)ether demonstrates excellent solubility and compatibility with polyether polyols, polyester polyols, and common polyurethane additives.
Bis-(2-dimethylaminoethyl)ether blends easily without phase separation and maintains catalytic activity over a wide temperature range.
Bis-(2-dimethylaminoethyl)ether's low viscosity allows precise metering and rapid dispersion, which is particularly advantageous in continuous foam production and high-speed industrial processes.

ALTERNATIVE PARENTS of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
*Dialkyl ethers 
*Organopnictogen compounds 
*Hydrocarbon derivatives 

SUBSTITUENTS of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
*Tertiary aliphatic amine
*Ether
*Dialkyl ether
*Organic oxygen compound
*Organopnictogen compound
*Hydrocarbon derivative
*Organooxygen compound
*Aliphatic acyclic compound

REACTIVITY PROFILE of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
Bis-(2-dimethylaminoethyl)ether reacts as a base.
Bis-(2-dimethylaminoethyl)ether reacts exothermically with acids.

PREPARATION of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
The main methods for the synthesis of Bis-(2-dimethylaminoethyl)ether are:
(1) reaction of sodium dimethylaminoethanol and SO3 or chlorosulfonic acid;
(2) Reaction of trimethylamine with dichloroethyl ether or dimethylaminoethoxyethyl ether;
(3) One-step synthesis of dimethylamine and monoethyleneglycol under solid catalyst.

CHEMICAL PROPERTIES of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
Bis-(2-dimethylaminoethyl)ether is a colorless and transparent liquid or Brown liquid.
Bis-(2-dimethylaminoethyl)ether is soluble in water, easily soluble in alcohol, benzene, etc.

PHYSICAL and CHEMICAL PROPERTIES of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
Appearance: Clear to yellow liquid 
Odor: Amine‑like, characteristic 
Boiling Point: ~188–189 °C (≈372 °F) 
Flash Point: ~56–66 °C (closed cup)
Melting/Freezing Point: ~–20 °C
Density: ~0.84–0.85 g/mL @25 °C 
Refractive Index: ~1.43 D @20 °C 
Solubility: Soluble/miscible in water, alcohols, benzene 
Linear Formula: ((CH3)2N(CH2CH2))2O

CAS Number: 3033-62-3
Molecular Weight: 160.26
EC Number: 221-220-5
MDL number: MFCD00059199
UNSPSC Code: 12352100
PubChem Substance ID: 24884926
NACRES: NA.22
Chemical Formula: C8H20N2O
Average Molecular Weight: 160.261
Monoisotopic Molecular Weight: 160.157563272

IUPAC Name: {2-[2-(dimethylamino)ethoxy]ethyl}dimethylamine
Traditional Name: {2-[2-(dimethylamino)ethoxy]ethyl}dimethylamine
CAS Registry Number: Not Available
SMILES: CN(C)CCOCCN(C)C
InChI Identifier: InChI=1S/C8H20N2O/c1-9(2)5-7-11-8-6-10(3)4/h5-8H2,1-4H3
InChI Key: GTEXIOINCJRBIO-UHFFFAOYSA-N
Physical state: liquid

Color: Amber
Odor: Ammonia odor
Melting point/freezing point: No data available
Initial boiling point and boiling range: 189 °C at 1.013 hPa
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits:
Upper explosion limit: 5.1 % (V)

Lower explosion limit: 1 % (V)
Flash point: 66.11 °C
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity:
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available

Water solubility: Soluble
Partition coefficient: n-octanol/water: No data available
Vapor pressure: 0.37 hPa at 21 °C
Density: 0.841 g/cm³ at 25 °C
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available

Explosive properties: No data available
Oxidizing properties: No data available
Relative vapor density 5.53 (Air = 1.0)
Molecular Weight: 160.26 g/mol
Computed by PubChem 2.2 (PubChem release 2025.04.14)
XLogP3-AA: 0.2
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 3

Rotatable Bond Count: 6
Exact Mass: 160.157563266 Da
Monoisotopic Mass: 160.157563266 Da
Topological Polar Surface Area: 15.7 Ų
Heavy Atom Count: 11
Formal Charge: 0
Complexity: 74.2
Isotope Atom Count: 0

Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Molecular Formula / Molecular Weight: C8H20N2O = 160.26
Physical State (20 °C): Liquid
Storage Temperature: Room Temperature (Recommended in a cool and dark place, <15 °C)

CAS RN: 3033-62-3
Reaxys Registry Number: 1739668
PubChem Substance ID: 87564225
SDBS (AIST Spectral DB): 18646
MDL Number: MFCD00059199
CAS: 3033-62-3
IUPAC Name: {2-[2-(dimethylamino)ethoxy]ethyl}dimethylamine
Molecular Formula: C8H20N2O
InChI Key: GTEXIOINCJRBIO-UHFFFAOYSA-N

SMILES: CN(C)CCOCCN(C)C
Molecular Weight (g/mol): 160.26
Form: Liquid
Appearance (Color): Clear colorless
Refractive Index: 1.4280–1.4320 @ 20 °C
Assay (GC): ≥97.5%
CAS: 3033-62-3
MF: C8H20N2O
MW: 160.26
EINECS: 221-220-5

Preferred IUPAC Name: 2-[2-(dimethylamino)ethoxy]-N,N-dimethylethanamine
Common Name: Bis-(2-dimethylaminoethyl)ether
CAS Registry Number: 3033-62-3
EC (EINECS) Number: 221-220-5
Molecular Formula: C₈H₂₀N₂O
Molecular Weight: 160.26 g/mol
PubChem CID: 18204
RTECS Number: KR9460000
MDL Number: MFCD00059199

Appearance: Clear to light yellow liquid
Odor: Ammonia-like / amine odor
Boiling Point: ~188–190 °C at 760 mmHg
Flash Point: ~66 °C (151 °F)
Vapor Pressure: ~0.37 hPa at 21 °C
Density / Specific Gravity: ~0.841 g/cm³ at 25 °C
Refractive Index: 1.430–1.431
Water Solubility: Soluble

Viscosity: ~1.53 mm²/s
pKa (estimated): ~9.12 ± 0.28
Log P (Partition coef.): −0.34 at 20 °C
Structure: Linear dialkyl ether with two tertiary amine groups.
Functional Groups: Tertiary amine, ether.
SMILES: CN(C)CCOCCN(C)C
InChIKey: GTEXIOINCJRBIO-UHFFFAOYSA-N
Reactivity: Acts as a base and reacts exothermically with acids. Can form peroxides on prolonged exposure to air.

FIRST AID MEASURES of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of BIS-(2-DIMETHYLAMINOETHYL)ETHER:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available