CALCIUM ASCORBATE

Calcium ascorbate can be used both as a nutrient (vitamin C) and as an additive (antioxidant).
Calcium ascorbate might be beneficial over ascorbic acid because it is buffered by the calcium, making it less acidic.
Calcium ascorbate serves as a vitamin C (ascorbate) source, but with calcium — often used when a buffered / less acidic form than pure ascorbic acid is desired.

CAS Number: 5743-27-1 (anhydrous) 
5743-28-2 (dihydrate) 
EC / EINECS number: 227-261-5
E number: E302 (antioxidants, ...)
Molecular formula: typically given as Ca(C₆H₇O₆)₂ → overall formula C₁₂H₁₄CaO₁₂ (anhydrous) 
Molecular weight: ~ 426.34 g/mol (for the dihydrate form commonly used) 

SYNONYMS:
Calcium diascorbate, Calcium L‑ascorbate, Hemicalcium ascorbate, Calci‑C, Ascorbic acid calcium salt, L‑Ascorbic acid, calcium salt (2:1), Calcium ascorbate dihydrate, Calcium ascorbate USP, Calcium ascorbate (USP), Calcium diascorbate, Calcium L-ascorbate, Hemicalcium ascorbate, Calci-C, E302, Ascorbic acid calcium salt, L-Ascorbic acid calcium salt (2:1), Calcium ascorbate dihydrate, Calcium ascorbate anhydrous, Calcium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate, Calcium diascorbate, Calcium L-ascorbate, Hemicalcium ascorbate, Calci-C, E 302, CALCIUM ASCORBATE, Ascorbic acid calcium salt, Calcium diascorbate, 5743-27-1, Calcium ascorbate anhydrous, Hemicalcium ascorbate, Calci-C, L-Ascorbic acid, calcium salt (2:1), Calcium ascorbate (e 302), J96U0ZD4Y6, Ester-C, INS NO.302, E 302, INS-302, Vitamin c (as calcium ascorbate), E-302, L-Ascorbic acid, calcium salt (2:1), dihydrate, RefChem:573386, 227-261-5, 183E4W213W, Ascorbic acid calcium, Calcium L-ascorbate, Calcium L-ascorbate dihydrate, UNII-J96U0ZD4Y6, CCRIS 7671, HSDB 255, EINECS 227-261-5, CHEMBL2146095, SCHEMBL29384608, SCHEMBL29394722, DTXSID40110036, BLORRZQTHNGFTI-ZZMNMWMASA-L, CALCIUM ASCORBATE [WHO-DD], L-Ascorbic acid calcium salt (2:1), DB14483, ASCORBIC ACID CALCIUM SALT [MI], CALCIUM ASCORBATE ANHYDROUS [HSDB], DB-230070, D07575, calcium;(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-olate, Calcium L-ascorbate dihydrate, L-Ascorbic acid calcium salt dihydrate, Vitamin C calcium salt

Calcium Ascorbate is the calcium salt of ascorbic acid.
Calcium ascorbate is the calcium salt of ascorbic acid (vitamin C), belonging to the class of mineral ascorbates.
The stabilizing properties and various health benefits of calcium ascorbate make it a useful ingredient in many different products.

Calcium ascorbate is typically produced by reacting ascorbic acid with a calcium source (e.g. calcium carbonate) in aqueous solution, then drying and milling the resulting salt.
This matches the general manufacturing route for mineral ascorbates.

Calcium ascorbate supplied commercially is often a dihydrate salt (i.e. with two water molecules per formula unit) — formula often given as C₁₂H₁₄CaO₁₂·2H₂O
Calcium ascorbate is a mineral ascorbate (a salt of ascorbic acid with calcium), combining vitamin C properties with a calcium source.

Calcium ascorbate is water-soluble, crystalline, and commonly used as both a vitamin C supplement and a food additive antioxidant/preservative.
Compared to pure ascorbic acid, Calcium ascorbate is more neutral (less acidic), which can improve tolerability and stability in foods or supplements.

Its regulatory acceptance (e.g. E302) and physical–chemical properties make Calcium ascorbate a widely used and useful compound in nutrition, food processing, and pharmaceuticals.
Calcium ascorbate is a compound with the molecular formula CaC12H14O12.
Calcium ascorbate is the calcium salt of ascorbic acid, one of the mineral ascorbates.

Calcium ascorbate is approximately 10% calcium by mass.
As a food additive, Calcium ascorbate has the E number E 302.
Calcium Ascorbate is a calcium salt of Ascorbic Acid (q.v.).

USES and APPLICATIONS of CALCIUM ASCORBATE:
As food additive / antioxidant / preservative: As E302, Calcium ascorbate is used to prevent oxidation, protect color and flavor — e.g. in fruits, juices, meat products, baked goods, etc.
Vitamin C source / dietary supplement: Calcium ascorbate serves as a vitamin C (ascorbate) source, but with calcium — often used when a buffered / less acidic form than pure ascorbic acid is desired (less irritating to stomach).

Physiological functions: As for ascorbate / vitamin C broadly: antioxidant (donates electrons, neutralizes free radicals), cofactor for enzymes (e.g. in collagen synthesis), supports immune system, Calcium ascorbate helps regeneration of other antioxidants.
Calcium contribution: Because it's a calcium salt, Calcium ascorbate also gives a small amount of calcium (roughly ~ 10% by mass of the compound is calcium) in addition to vitamin C.

Form of vitamin C; other forms include ascorbic acid, L-ascorbic acid, ascorbyl palmitate and magnesium ascorbyl phosphate.
Calcium ascorbate, often referred to as Ester-C, is considered a stable form of vitamin C and an antioxidant.
Calcium ascorbate can be used both as a nutrient (vitamin C) and as an additive (antioxidant).

Calcium ascorbate might be beneficial over ascorbic acid because it is buffered by the calcium, making it less acidic.
This might be beneficial for those who suffer from gastrointestinal side effects when they take other forms of vitamin C.
Calcium ascorbate might be beneficial to use over the other commonly used buffered mineral ascorbate (sodium-ascorbate), because it does not contribute sodium.

Vitamin C is well known for its contribution to normal collagen formation and function of cartilage, normal function of the immune system and protection of cells from oxidative stress.
In some cases, supplemental vitamin C may cause slight gastric upset in those with sensitive digestions.

Our high-performance calcium ascorbate is a gentle, non-acidic form of vitamin C powder, which is an excellent choice for people with specific health problems.
It’s also ideal for those who find tablets difficult to swallow.

Outside of the skin care segment of the cosmetics industry, calcium ascorbate is a common ingredient in some makeup products, mouthwash, and whitening toothpaste.
Calcium ascorbate is primarily an additive in the food and beverage industry, but also has applications in cosmetics, skin care, pharmaceuticals, and as an ingredient in animal feed.

Food additive / preservative / antioxidant — Calcium ascorbate is used in processed foods, juices, meat products (e.g. cured meats), baked goods, etc. to prevent oxidation, maintain color/flavor.
Dietary supplement / vitamin C source — Calcium ascorbate is used in nutritional supplements, tablets, powders especially when buffered form is desired over acidic ascorbic acid.

Pharmaceutical / lab reagent — Calcium ascorbate is used by manufacturers and labs as a standard for vitamin C assays, quality control standards, etc.
Calcium ascorbate is used to treat or prevent vitamin C deficiency.
Calcium ascorbate is used to help growth and good health.

-Calcium ascorbate - food additive:
Calcium ascorbate is a common food additive with valuable antioxidant properties.
Often used as a preservative, calcium ascorbate can extend the shelf life of food and beverage products and protect against deterioration of color, flavor, and overall quality.

As a type of vitamin C, calcium ascorbate also offers health benefits, such as improving immune functioning, repairing damaged tissues, and promoting bone, teeth, and skin health.
Calcium ascorbate is a natural food additive that can produce healthy, clean-label foods and beverages to meet the growing demand of health-conscious consumers.

-Calcium ascorbate is used additive in the food and beverage industry:
In the food and beverage industry, calcium ascorbate is a common food additive for its health benefits or as a stabilizing agent.
Fortifying foods with calcium ascorbate boosts their vitamin C content, which can make up for vitamin C depletion that occurs during processing.

Food manufacturers often add calcium ascorbate to orange juice or other fruit juices after they pasteurize them to replenish their vitamin C content.
Calcium ascorbate can also increase the calcium content in dairy products like ice cream or yogurt.

As a stabilizer, calcium ascorbate preserves the color and freshness of food and beverage products to extend their shelf life and stability.
Because calcium ascorbate has a low pH, it helps prevent microbial growth which can lead to spoilage or cause food to become contaminated.
Calcium ascorbate is popular as a food preservative because it is a natural alternative to harsher chemical preservatives.

The Food and Drug Administration lists calcium ascorbate as a generally-recognized-as-safe substance as a food additive, preservative, or nutrient supplement.
Because it is safe for human consumption and does not harm the environment, calcium ascorbate can also be a safe additive in animal feed or water.

-Calcium ascorbate is used an antioxidant in the skin care and cosmetics industry:
In the cosmetics industry, ascorbates play an essential role as antioxidants in many skin care products, including lotions, moisturizers, creams, cleansers, and sunscreen.

Calcium ascorbate is also a skin conditioning agent that can slow the signs of aging and preserve the youthful appearance of the skin, which is why it is a common ingredient in anti-aging cosmetic lotions and eye cream.
Calcium ascorbate also has lightening properties and is common in skin lightening spot treatments that reduce the appearance of discoloration.

-Calcium ascorbate in skin care products offers many benefits to consumers, including:
*Protecting the skin against free radicals
*Slowing skin deterioration
*Reducing or healing inflammation
*Reducing the appearance of wrinkles and fine lines
*Lightening blemishes or discoloration
*Building collagen in the skin

-Nutritional supplement in the pharmaceutical industry uses of Calcium ascorbate:
In the pharmaceutical industry, calcium ascorbate is a nutritional or dietary supplement for those with low vitamin C levels.
Vitamin C is an essential vitamin for humans, and many fruits and vegetables are a natural source of it.

Some animals produce vitamin C themselves, but humans must obtain all their vitamin C from the foods they eat or through vitamin C supplements.
Most people receive sufficient vitamin C from their diet, but those who lack vitamin C can develop scurvy — a condition whose symptoms include joint pain, fatigue, muscle weakness, rash, and tooth pain.

Those who do not consume enough vitamin C in their diets can take calcium ascorbate supplements to boost their vitamin C intake and maintain healthy body functioning.
Calcium ascorbate also serves as a calcium supplement to maintain and build bone strength.

Most people who eat a normal diet consume plenty of calcium, but those who are lactose-intolerant, have a dairy allergy, or follow a vegan diet may have low calcium levels.

Those who have osteoporosis may also require additional calcium.
Compared to other forms of calcium, calcium ascorbate is easier for the body to absorb, making it an excellent choice for calcium supplementation.

BENEFITS / RATIONALE FOR USE (VS PURE ASCORBIC ACID) CALCIUM ASCORBATE:
Using Calcium ascorbate (vs pure ascorbic acid) gives some advantages:
*Less acidic: 
Because it's a salt, Calcium ascorbate's more neutral — which often makes it gentler on the stomach than pure ascorbic acid.

*Provides calcium plus vitamin C:
As a calcium salt, Calcium ascorbate delivers some calcium mineral along with ascorbate — potentially helpful for meeting both nutrient needs simultaneously.

*Antioxidant and preserving properties useful in foods:
Calcium ascorbate helps prevent oxidation, maintain color/flavor, extends shelf-life of food and beverage products.
Calcium ascorbate is used as a buffered vitamin C, may be preferred in supplements or fortified foods especially when acidity must be controlled (e.g. for sensitive stomachs or pH-sensitive formulations).

WHAT DO I NEED TO TELL MY DOCTOR BEFORE I TAKE CALCIUM ASCORBATE?
If you are allergic to calcium ascorbate; any part of calcium ascorbate; or any other drugs, foods, or substances.
Tell your doctor about the allergy and what signs you had.

If you have high calcium levels.
This is not a list of all drugs or health problems that interact with calcium ascorbate.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems.
You must check to make sure that it is safe for you to take calcium ascorbate with all of your drugs and health problems.
Do not start, stop, or change the dose of any drug without checking with your doctor.

WHAT ARE SOME THINGS I NEED TO KNOW OR DO WHILE I TAKE CALCIUM ASCORBATE?
Tell all of your health care providers that you take calcium ascorbate.
This includes your doctors, nurses, pharmacists, and dentists.
Calcium ascorbate prevents many other drugs from getting into the body.

If you take other drugs, check with your doctor or pharmacist to see if you need to take them at some other time than calcium ascorbate.
Calcium ascorbate may affect certain lab tests.
Tell all of your health care providers and lab workers that you take calcium ascorbate.

HOW IS CALCIUM ASCORBATE BEST TAKEN?
Use calcium ascorbate as ordered by your doctor.
Read all information given to you.
Follow all instructions closely.
Take Calcium ascorbate with or without food.
Take with a full glass of water.

WHAT DO I DO IF I MISS A DOSE of CALCIUM ASCORBATE?
Take a missed dose as soon as you think about Calcium ascorbate.
If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
Do not take 2 doses at the same time or extra doses.

CALCIUM ASCORBATE:
A gentle non-acidic form of vitamin C
Calcium ascorbate is soluble fine crystals also provide a useful amount of calcium
Calcium ascorbate is ideal for those who find tablets difficult to swallow or require large amounts of this vitamin

Calcium ascorbate can be easily added to drinks or sprinkled on to foods
Each gram of Calcium ascorbate provides almost 900mg of vitamin C plus just over 100mg of calcium
Calcium ascorbate is suitable for those with intestinal problems due to its gentle action

PHYSICAL and CHEMICAL PROPERTIES of CALCIUM ASCORBATE:
Chemical name: Calcium ascorbate — calcium salt of Ascorbic acid (vitamin C)
IUPAC name: Calcium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate (bis-ascorbate salt)
Chemical formula: Ca(C₆H₇O₆)₂ (anhydrous)
Molar mass: ~ 390.31 g/mol (anhydrous form)
Dihydrate form: molecular weight ~ 426.34 g/mol (as often supplied).
EC / EINECS number: 227-261-5 (for certain forms)
CAS numbers: Common ones are 5743-27-1 (anhydrous) and 5743-28-2 (dihydrate).
E number (as food additive): E 302
Appearance: white to slightly yellow crystalline powder.

Odor: odorless (or almost odorless).
Solubility: soluble in water. According to one source, water solubility is “about 50 g/100 mL” (for anhydrous form)
Slightly soluble or practically insoluble in ethanol/alcohol (e.g. 96% ethanol) for dihydrate form.
pH (in solution): roughly near neutral / slightly acidic–neutral; for a 10% solution pH ~ 6.8–7.4.
Melting point / decomposition: for dihydrate form: melting point about 166 °C (decomposition) reported.
For anhydrous form: one source reports “melting point 192°C”.
Other physical data: density ≈ 1.21 g/cm³ (for the anhydrous salt)
LogP (octanol–water partition, est.) –2.653 (indicating hydrophilicity / water solubility)
Chemical formula: Ca(C6H7O6)2

Molar mass: 390.310 g·mol−1
Solubility in water: About 50 g/100 mL
Solubility: Slightly soluble in alcohol; insoluble in ether
Molecular Weight: 390.31 g/mol
Hydrogen Bond Donor Count: 6
Hydrogen Bond Acceptor Count: 12
Rotatable Bond Count: 4
Exact Mass: 390.0111167 Da
Monoisotopic Mass: 390.0111167 Da

Topological Polar Surface Area: 220 Ų
Heavy Atom Count: 25
Formal Charge: 0
Complexity: 232
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 4
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 3
Compound Is Canonicalized: Yes

FIRST AID MEASURES of CALCIUM ASCORBATE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of CALCIUM ASCORBATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of CALCIUM ASCORBATE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of CALCIUM ASCORBATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of CALCIUM ASCORBATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of CALCIUM ASCORBATE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available