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DESCRİPTİON
CAPRYLIC/CAPRIC TRIGLYCERIDE (MASESTER E6000) is a polyethylene glycol (PEG) derivative of a mixture of mono-, di-, and triglycerides of caprylic and capric acids having an average of 6 moles of ethylene oxide.
CAPRYLIC/CAPRIC TRIGLYCERIDE (MASESTER E6000) is a water-loving, thin, and transparent liquid that is soluble in aqueous surfactant solutions can solubilize oils and oil-soluble ingredients and has a nice skin feel.
CAPRYLIC/CAPRIC TRIGLYCERIDE (MASESTER E6000) is a popular ingredient in micellar cleansing waters.
CAPRYLIC/CAPRIC TRIGLYCERIDE (MASESTER E6000) is an excellent emollient and a skin-replenishing component.
CAS: 73398-61-5/65381-09-1
SYNONYMS
Caprylic/capric triglyceride,65381-09-1,Caprylic acid, capric acid, triglyceride,Glycerol octanoate decanoate,Caprylic acid, capric acid triglyceride,EINECS 265-724-3,/decanoic acid triglyceride,Decanoic acid, ester with 1,2,3-propanetriol octanoate
Definition and Chemical Structure:
Caprylic/capric glyceride (CCG) is a mixture of the glycerides (esters of glycerol) of caprylic acid (C8) and capric acid (C10).
These fatty acids are medium-chain triglycerides (MCTs) found in natural fats and oils, primarily from coconut oil and palm kernel oil.
The molecular structure of CCG consists of a glycerol backbone bound to fatty acid chains, specifically the caprylic (C8H16O2) and capric acids (C10H20O2), forming a triglyceride structure.
Historical Context and Importance:
Historically, CCG has been used for centuries due to its beneficial properties as an emollient, emulsifier, and surfactant in various industries.
The medium-chain fatty acids in CCG have gained popularity due to their unique metabolic properties.
They are absorbed and metabolized differently from long-chain fatty acids, which gives CCG applications in both health and industry.
Applications and Industry Relevance:
CCG is used extensively in the food, pharmaceutical, and cosmetic industries.
It has garnered attention in medical applications due to its potential health benefits, including weight management and improved energy metabolism.
Additionally, it is used as an emulsifying agent in the production of topical creams, lotions, and oral formulations.
Chemical Properties
Molecular Structure:
The chemical structure of caprylic/capric glyceride is that of a triglyceride molecule where one glycerol molecule (C3H8O3) is esterified with a mixture of caprylic acid and capric acid.
The ratio of caprylic to capric acid varies depending on the source and the specific formulation.
This results in a mixture that typically contains 70-80% caprylic acid and 20-30% capric acid.
Physical Properties:
Appearance:
CCG is a clear, colorless to pale yellow liquid at room temperature.
Molecular Weight:
The molecular weight varies depending on the exact composition of the glyceride mixture but typically falls in the range of 400-600 g/mol.
Boiling Point:
The boiling point of CCG is approximately 240°C (464°F).
Solubility:
CCG is soluble in alcohol, chloroform, and other organic solvents. It is only sparingly soluble in water, which makes it an effective emulsifier in formulations that combine water and oil.
Density:
Its density is approximately 0.9–1.0 g/cm³, which is typical for medium-chain triglycerides.
Chemical Behavior and Stability:
Caprylic/capric glyceride is relatively stable under normal conditions but can hydrolyze in the presence of heat or moisture, especially under alkaline conditions, releasing free fatty acids and glycerol.
It is resistant to oxidation compared to long-chain triglycerides due to its shorter carbon chain length, making it more stable in cosmetic and pharmaceutical formulations.
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Production Methods
Natural Sources:
Caprylic/capric glyceride is most commonly derived from natural vegetable oils, particularly coconut oil and palm kernel oil.
These oils contain a high percentage of medium-chain fatty acids, making them ideal for extraction and production.
The triglycerides are typically isolated through a process of hydrolysis or through fractionation of the oils, followed by transesterification with glycerol to form CCG.
Synthetic Production:
While CCG can be derived from natural sources, it can also be synthetically produced by esterifying caprylic and capric acids with glycerol.
In industrial settings, the production of CCG involves the use of high temperatures and the addition of catalysts to speed up the esterification process.
This method allows for the controlled production of different ratios of caprylic to capric acid in the final product.
Industrial Scale and Process:
On an industrial scale, the production of CCG generally involves the following steps:
Extraction of caprylic and capric acids from coconut or palm kernel oil.
Transesterification of the fatty acids with glycerol to produce the triglyceride mixture.
Purification through distillation and deodorization to remove impurities and to adjust the fatty acid composition as needed.
The process is usually carried out under controlled conditions to prevent degradation and ensure a consistent final product.
Applications
Pharmaceutical and Medical Use:
Caprylic/capric glyceride has found numerous applications in pharmaceuticals, particularly as a carrier oil in oral drug formulations and as a solubilizer in various liquid medicines.
Due to the medium-chain length of the fatty acids, CCG is easily absorbed and metabolized, providing quick energy without the need for bile salts, which are typically required for the digestion of long-chain triglycerides.
It is also used in the treatment of gastrointestinal conditions, such as malabsorption syndromes, where it provides a readily digestible source of calories.
Additionally, medium-chain triglycerides like CCG have been studied for their potential role in weight loss and energy expenditure, as they are metabolized quickly to produce ketones, an alternative energy source.
Cosmetic and Personal Care Industry:
CCG is widely used in cosmetic formulations for its emollient properties.
It helps in moisturizing the skin, leaving a non-greasy, soft feel.
Due to its ability to stabilize emulsions, it is a key ingredient in lotions, creams, and hair care products.
Furthermore, its mildness and low irritation potential make it suitable for sensitive skin products.
Food Industry:
In food applications, CCG serves as a food-grade emulsifier and stabilizer.
It helps to combine water and oil in various food products, such as salad dressings, margarine, and processed foods.
It also acts as a carrier oil for flavors and vitamins, improving the stability of certain formulations.
Other Uses:
Caprylic/capric glyceride is also used in the production of biodiesel, as a feedstock for producing renewable fuels.
Furthermore, it has found uses in the production of biodegradable plastics and as a surfactant in various industrial processes.
Toxicology and Safety
General Safety Profile:
Caprylic/capric glyceride is generally considered to be safe for use in food, pharmaceuticals, and cosmetics when used as directed.
The United States Food and Drug Administration (FDA) recognizes CCG as a food-grade ingredient, and it is also classified as Generally Recognized as Safe (GRAS) when used in food products.
In cosmetics, it is commonly included in formulations for skin creams, lotions, and hair care products due to its mildness and low risk of irritation.
Chronic Exposure and Long-Term Effects:
Long-term studies on the effects of chronic exposure to CCG are limited, but available data suggests that it poses minimal risk under normal usage conditions.
However, like many other fatty acid derivatives, excessive consumption may lead to an imbalance in the body's fatty acid intake, potentially affecting lipid metabolism.
For cosmetic applications, CCG is generally regarded as non-irritating and non-sensitizing to the skin, but individuals with very sensitive skin or allergies to coconut oil or palm kernel oil (the natural sources of CCG) may experience localized irritation.
It is important for manufacturers to conduct patch testing to confirm skin compatibility in formulations intended for sensitive skin.
Environmental Impact:
Caprylic/capric glyceride is biodegradable and breaks down relatively quickly in the environment.
This property reduces its potential for environmental accumulation and toxicity.
However, large-scale discharges of CCG into aquatic systems could pose risks to aquatic life due to changes in the composition of the water, such as reduced oxygen availability or interference with microbial communities.
In general, when used in industrial applications, it is important to follow proper disposal methods to ensure that it does not contaminate water systems.
The biodegradable nature of CCG makes it less harmful than some synthetic chemicals, and its use in biodegradable formulations supports environmental sustainability.
Recent Advances and Research
Innovations in Production Techniques:
Research in the production of caprylic/capric glyceride has focused on improving the sustainability and efficiency of its extraction and synthesis.
Traditional methods for isolating caprylic and capric acids from coconut oil and palm kernel oil involve high temperatures and chemical processes, which may not be environmentally optimal.
Recent advances in enzymatic processes have led to more efficient methods of producing medium-chain triglycerides (MCTs) like CCG. Enzyme-catalyzed esterification reactions offer a more selective and environmentally friendly approach to the synthesis of CCG.
These processes operate under milder conditions (lower temperatures, no harsh chemicals), thus reducing the carbon footprint of production and enhancing the purity of the final product.
Advances in Medical and Cosmetic Applications:
In the medical field, CCG and other medium-chain triglycerides have gained attention for their potential role in weight loss and metabolic health.
Recent studies have explored how CCG may help increase fat oxidation and energy expenditure, making it a useful adjunct in the management of obesity.
It is thought that CCG is metabolized in the liver to produce ketones, which provide an alternative energy source to glucose.
This has prompted its investigation in ketogenic diets and supplementation for athletes seeking quick energy.
In the cosmetic industry, ongoing research is focused on improving the stability of CCG-based formulations.
Studies are exploring the use of CCG in anti-aging skincare products, as medium-chain triglycerides are believed to have antioxidant properties and may help promote skin regeneration.
Additionally, CCG is being investigated for use in hair care products, where it may help improve hair texture and provide moisture without causing greasiness.
Research into Health Benefits:
The health benefits of medium-chain triglycerides, including CCG, have been extensively studied in recent years.
Research has suggested that CCG can improve cognitive function in patients with neurodegenerative diseases like Alzheimer's, by providing a readily available fuel source for brain cells.
Moreover, studies are exploring the potential anti-inflammatory and antimicrobial properties of CCG.
A growing body of evidence supports the idea that CCG may be useful in managing metabolic conditions such as Type 2 diabetes.
By promoting the production of ketones and enhancing fat oxidation, CCG could help improve insulin sensitivity and blood sugar control, though further studies are needed to fully establish its benefits in these areas.
Studies on Environmental and Safety Concerns:
While CCG is biodegradable and has a low toxicity profile, research continues to focus on ensuring its safe use in both industrial and consumer products.
Studies on the environmental fate of CCG are important for understanding the potential impact of large-scale use, particularly in the food and cosmetic industries, where the compound is widely used.
Regulatory agencies such as the European Medicines Agency (EMA) and the FDA continue to evaluate new safety data on CCG, particularly regarding its long-term effects and environmental impact.
The push for more environmentally sustainable production practices and the investigation of renewable sources of CCG are ongoing trends in the research community.
Summary of Key Findings:
Caprylic/capric glyceride is a versatile and safe compound widely used in the food, pharmaceutical, and cosmetic industries.
Derived from coconut oil and palm kernel oil, it offers numerous benefits due to its medium-chain triglyceride structure, which allows for quick metabolism and absorption in the body.
It is regarded as safe in consumer products, with a low toxicity profile and a mild impact on the environment due to its biodegradability.
Its applications are broad and growing, particularly in the medical field, where it is explored for its potential in weight management, energy production, and even cognitive health.
In cosmetics, CCG serves as an effective emollient, stabilizer, and solubilizer in skin and hair care formulations.
Future Trends and Areas of Study:
As demand for more sustainable and efficient production processes increases, there is likely to be a shift toward green chemistry and enzymatic methods for producing caprylic/capric glyceride.
Furthermore, the continued exploration of its health benefits, particularly in metabolic and neurological health, promises to expand its use in dietary supplements and medical therapies.
Research into CCG's environmental impact and long-term safety will be essential as its use continues to grow in various industries.
It is expected that more studies will focus on its antimicrobial properties, weight management potential, and impact on skin aging, which could lead to new applications and innovations in both healthcare and personal care.
Overall, caprylic/capric glyceride is a promising compound with multiple applications, and continued research will likely open new doors for its use in the future.
SAFETY INFORMATION ABOUT CAPRYLIC/CAPRIC TRIGLYCERIDE (MASESTER E6000)
First aid measures:
Description of first aid measures:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area:
If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.
In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.
If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment.
Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.
Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.
Handling and storage:
Precautions for safe handling:
Avoid inhalation of vapour or mist.
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials
Exposure controls/personal protection:
Control parameters:
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
It should not be construed as offering an approval for any specific use scenario.
Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Stability and reactivity:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.
Disposal considerations:
Waste treatment methods:
Product:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product
