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Carboxymethylcellulose calcium is the calcium salt of carboxymethylcellulose and is used commonly as an FDA-approved disintegrant in pharmaceutical manufacturing.
Disintegrants facilitate the breakup of a tablet in the intestinal tract after oral administration.
Without a disintegrant, tablets may not dissolve appropriately and may effect the amount of active ingredient absorbed, thereby decreasing effectiveness.
CAS: 9050-04-8
MF: C23H30ClN3O
MW: 399.9568
EINECS: 618-597-7
Synonyms
Cellulose,ethers,carboxymethyl ether,calcium salt;N4-(2-Chloro-7-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine;hylon600;CMCCalcium;CALCIUMCARBOXYLMETHYLCELLULOSE;Calciam carboxymethylceUulose;Carboxymethylcellulose calcium (nf);Carmellose calcium (jp15)
Polymers of Carboxymethylcellulose calcium are also the active ingredient in many over-the-counter dry-eye or "natural tears" products, such as Refresh Tears or TheraTears Lubricant Eye Drops.
According to the FDA Select Committee on GRAS food substances, Carboxymethylcellulose calcium salts are virtually unabsorbed.
Carboxymethylcellulose calcium is generally regarded as safe when used in normal quantities, and the same could be expected with the calcium salt.
Carboxymethylcellulose calcium is also known as sodium calcium carboxymethyl cellulose, which is an inorganic salt with the chemical formula C6H7O6COONaCa.
Carboxymethylcellulose calcium has the following properties:
1. Physical properties: Carboxymethylcellulose calcium is a white to yellowish white powder, tasteless and odorless.
2. Solubility: insoluble in water, but can be dissolved in acidic solution.
3. Viscosity: Carboxymethylcellulose calcium has high viscosity and is often used as a thickener and adhesive.
4. Stability: Carboxymethylcellulose calcium has good thermal stability and chemical stability, and can maintain its properties under high temperature and acidic conditions.
Carboxymethylcellulose calcium is a derivative of cellulose, a natural polymer, and is characterized by its ability to form a gel-like substance when mixed with water.
Carboxymethylcellulose calcium is a white to off-white powder that is soluble in water, forming a viscous solution.
The presence of calcium ions enhances its stability and thickening properties, making Carboxymethylcellulose calcium useful in various applications.
Carboxymethylcellulose calcium is widely used as a thickening agent, stabilizer, and emulsifier in food products, pharmaceuticals, and cosmetics.
Carboxymethylcellulose calcium is non-toxic and generally recognized as safe (GRAS) for consumption.
Additionally, Carboxymethylcellulose calcium exhibits excellent film-forming properties and can improve the texture and mouthfeel of food products.
Carboxymethylcellulose calcium's ability to retain moisture makes it valuable in personal care formulations.
Carboxymethylcellulose calciumis also utilized in the textile and paper industries for its binding and coating properties.
Overall, Carboxymethylcellulose calcium is a versatile compound with significant industrial and commercial applications due to its functional characteristics.
Carboxymethylcellulose calcium Chemical Properties
Solubility: Practically insoluble in acetone, chloroform, ethanol (95%), toluene, and ether. Insoluble in water, but swells to form a suspension.
InChI: InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-14-17(24)9-11-21(19)26-22-12-10-18(28-4)15-20(22)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26)
InChIKey: SVUDQUZYHLUPQN-UHFFFAOYSA-N
EPA Substance Registry System: Carboxymethylcellulose calcium (9050-04-8)
Carboxymethylcellulose calcium occurs as a white to yellowishwhite, hygroscopic, odorless powder.
White to yellowish powder or fibrous. No smell.
Carboxymethylcellulose calcium is stable to heat, light, air, microorganisms, etc.
A few are insoluble in water.
In order to improve taste, Carboxymethylcellulose calcium is often processed into fine powder below 200 mesh.
Water absorption is swollen several times.
The pH value of 1g/20ml suspension in water is 4.5~6.0, which has weak binding when acidic and strong binding when alkaline, and loses collapsibility.
Production Methods
Cellulose, obtained from wood pulp or cotton fibers, is carboxymethylated, followed by conversion to the calcium salt.
Carboxymethylcellulose calcium is then graded on the basis of its degree of carboxymethylation and pulverized.
Uses
Can be used for soup powder molding, dissolved due to water swelling characteristics, promote the collapse and dispersion.
For solid and powdered foods such as cocoa powder, instant coffee, and powder cool drinks, Carboxymethylcellulose calcium has the effect of promoting dispersion and dissolution in water.
Pharmaceutical Applications
The main use of Carboxymethylcellulose calcium is in tablet formulations, where it is used as a binder, diluent, and disintegrant.
Although carboxymethylcellulose calcium is insoluble in water, it is an effective tablet disintegrant as it swells to several times its original bulk on contact with water.
Concentrations up to 15% w/w may be used in tablet formulations; above this concentration, tablet hardness is reduced.
Carboxymethylcellulose calcium is also used in other applications similarly to Carboxymethylcellulose calcium; for example, as a suspending or viscosity-increasing agent in oral and topical pharmaceutical formulations.
Carboxymethylcellulose calcium is also used in modern wound dressings for its water absorption, retention and hemostatic properties.
