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CHLORHEXIDINE DI-D-GLUCONATE

 

CAS No.:    18472-51-0
European Community (EC) Number: 242-354-0 
Chemical Name:    chlorhexidinedi-d-gluconate
Molecular Formula:    C28H42Cl2N10O7
Formula Weight:    701.61
IUPAC Name:
(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid

DESCRIPTION:
Chlorhexidine digluconate solution is a bis(biguanide) family cationic broad spectrum antibiotic that is available in a range of concentrations and has been safely used for over 40 years for a variety of health-related applications; but its specific use for umbilical cord care was uniquely tested in three clinical trials in Nepal, Bangladesh, and Pakistan, in the form of 7.1% chlorhexidine digluconate (CHX). 
Given the promising results of the trials, in 2013 the World Health Organization (WHO) added CHX to its Model List of Essential Medicines for Children; and in 2014 the WHO issued a new guideline on umbilical cord care, which included a formal recommendation on the use of chlorhexidine.
Chlorhexidine digluconate is a broad spectrum antiseptic. 
Its mechanism of action involves destabilization of the outer bacterial membrane. 
CHLORHEXIDINE DI-D-GLUCONATE is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria.
CHLORHEXIDINE DI-D-GLUCONATE has both bactericidal and bacteriostatic mechanisms of action, the mechanism of action being membrane disruption, not ATPase inactivation as previously thought.
CHLORHEXIDINE DI-D-GLUCONATE is also useful against fungi and enveloped viruses, though this has not been extensively investigated. 
Chlorhexidine is harmful in high concentrations, but is used safely in low concentrations in many products, such as mouthwash and contact lens solutions.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Chlorhexidine Gluconate is the gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. 
Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. 
Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. 
Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.
Chlorhexidine gluconate is an organochlorine compound and a D-gluconate adduct. 
Chlorhexidine gluconate has a role as an antibacterial agent. 
Chlorhexidine gluconate derives from a chlorhexidine.

Chlorhexidine (CHX) (commonly known by the salt forms chlorhexidine gluconate and chlorhexidine digluconate (CHG) or chlorhexidine acetate) is a disinfectant and antiseptic that is used for skin disinfection before surgery and to sterilize surgical instruments.
Chlorhexidine di-D-gluconate may be used both to disinfect the skin of the patient and the hands of the healthcare providers. 
Chlorhexidine di-D-gluconate is also used for cleaning wounds, preventing dental plaque, treating yeast infections of the mouth, and to keep urinary catheters from blocking. 
Chlorhexidine di-D-gluconate is used as a liquid or powder.
Side effects may include skin irritation, teeth discoloration, and allergic reactions, although the risk appears to be the same as other topical antiseptics. 
Chlorhexidine di-D-gluconate may cause eye problems if direct contact occurs. 
Use in pregnancy appears to be safe.
Chlorhexidine may come mixed in alcohol, water, or surfactant solution. 
Chlorhexidine di-D-gluconate is effective against a range of microorganisms, but does not inactivate spores.

Chlorhexidine came into medical use in the 1950s. 
Chlorhexidine is available over the counter (OTC) in the United States. 
Chlorhexidine di-D-gluconate is on the World Health Organization's List of Essential Medicines. 
In 2017, it was the 286th most commonly prescribed medication in the United States, with more than one million prescriptions.
The name "chlorhexidine" breaks down as chlor(o) + hex(ane) + id(e) + (am)ine.
Chlorhexidine di-D-gluconate is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
Chlorhexidine di-D-gluconate is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Chlorhexidine is a broad-spectrum biocide effective against Gram-positive bacteria, Gram-negative bacteria and fungi. 
CHLORHEXIDINE DI-D-GLUCONATE is used primarily as its salts (e.g., the dihydrochloride, diacetate, and digluconate). 
Chlorhexidine inactivates microorganisms with a broader spectrum than other antimicrobials (e.g. antibiotics) and has a quicker kill rate than other antimicrobials (e.g. povidone-iodine). 
CHLORHEXIDINE DI-D-GLUCONATE has both bacteriostatic (inhibits bacterial growth) and bactericidal (kills bacteria) mechanisms of action, depending on its concentration. 
Chlorhexidine kills by disrupting the cell membrane. 
The most common side effects associated with chlorhexidine gluconate oral rinses are: 
1) an increase in staining of teeth and other oral surfaces
2) an increase in calculus formation 
3) an alteration in taste perception
4) toothache
5) upper respiratory tract infection 
6) headache


0.12% Chlorhexidine gluconate (CHG) is an oral rinse containing (1, 1 1-hexamethylene bis [5-(p-chlorophenyl) biguanide] di-D-gluconate) in a base containing water, 11.6% alcohol, glycerin, PEG-40 sorbitan diisostearate, flavor, sodium saccharin, and FD&C Blue No.1. 
Chlorhexidine gluconate product is a near neutral solution (pH range 5-7). 
Chlorhexidine gluconate is a salt of Chlorhexidine and gluconic acid.

CAS No.:    18472-51-0
European Community (EC) Number: 242-354-0 
Chemical Name:    chlorhexidinedi-d-gluconate
Molecular Formula:    C28H42Cl2N10O7
Formula Weight:    701.61


USES of CHLORHEXIDINE DI-D-GLUCONATE:
CHLORHEXIDINE DI-D-GLUCONATE is a preservative generally used in concentrations of 0.01 to 0.1 percent to protect against bacteria. 
CHLORHEXIDINE DI-D-GLUCONATE is unstable at high temperatures. 
Chlorhexidine digluconate is more widely used in europe than in the united States.
Hydrogenolysis of benzyl-nitrogen bonds. 
Chlorhexidine gluconate is an antimicrobial irrigant that is used as an antiseptic for the skin in the healthcare industry. 
CHLORHEXIDINE DI-D-GLUCONATE is used in hospitals to prevent infection of patients during surgeries and can also be found in mouthrinses.
Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.
The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. 
Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. 
Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. 
Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.
Chlorhexidine digluconate 20% solution is a broad spectrum bacteriostatis antiseptic agent, oral care agent, disinfectant, cosmetic biocide, and preservative. 
CHLORHEXIDINE DI-D-GLUCONATE is very effective against plaque, oral flora including Candida and is active against gram-positive and gram-negative organisms, facultative anaerobes, aerobes, and yeast. 
CHLORHEXIDINE DI-D-GLUCONATE can be used in antiseptic soap, mouthwash that fights plaque, disinfecting wounds and burns, vaginal flushing, hair dyes and bleaches, makeup, and other skin and hair care products.
Chlorhexidine gluconate is an antimicrobial irrigant that is used as an antiseptic for the skin in the healthcare industry. 
Chlorhexidine gluconate is used in hospitals to prevent infection of patients during surgeries and can also be found in mouthrinses.

Chlorhexidine digluconate, 20% w/v aq. Soln is used as an oral antiseptic agent and anti-microbial agent. 
CHLORHEXIDINE DI-D-GLUCONATE is an active ingredient in germicidal mouthwash, pet shampoo, surgical lubricants and wipes and hand soap. 
CHLORHEXIDINE DI-D-GLUCONATE is utilized in the study to know the role of essential oils for improving skin antisepsis. 
CHLORHEXIDINE DI-D-GLUCONATE plays a vital role as disinfectants and preservative in pharmaceutical products. 
CHLORHEXIDINE DI-D-GLUCONATE is also used as an additive in cosmetics such as creams, toothpaste and deodorants.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Clinical Use:
1,6-Di(4 -chlorophenyldiguanido)hexane gluconate (Hibiclens)is the most effective of a series of antibacterial biguanides originallydeveloped in Great Britain

Biocidal Uses:
CHLORHEXIDINE DI-D-GLUCONATE is being reviewed for use as a biocide in the EEA and/or Switzerland, for: human hygiene, disinfection, veterinary hygiene.

Consumer Uses:
CHLORHEXIDINE DI-D-GLUCONATE is used in the following products: washing & cleaning products, cosmetics and personal care products, biocides (e.g. disinfectants, pest control products), perfumes and fragrances, air care products and polishes and waxes.
Other release to the environment of this substance is likely to occur from: indoor use as processing aid, indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints) and outdoor use as processing aid.


Manufacturing Process    of CHLORHEXIDINE DI-D-GLUCONATE:
35 parts of hexamethylene bis-dicyandiamide, 35 parts of p-chloroaniline hydrochloride and 250 parts of β-etoxyethanol are stirred together at 130- 140°C for 2 hours under reflux. 
The mixture is then cooled and filtered. 
The solid is washed with water and crystallised from 50% aqueous acetic acid. 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide) is obtained as colorless plates, melting point 258-260°C. 
By addition of D-gluconic acid to aqueous solution of chlorhexidine base is prepared 1,1'-hexamethylenebis(5-(p chlorophenyl)biguanide)digluconate (1:2).


Therapeutic Function:    Antiseptic
Biochem/physiol Actions of CHLORHEXIDINE DI-D-GLUCONATE:
Cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. 
Its mechanism of action involves destabilization of the outer bacterial membrane. 
CHLORHEXIDINE DI-D-GLUCONATE is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.

The antimicrobial properties of the biguanides were discovered as a result of earlier testing of these compounds as possible antimalarial agents. 
Although the biguanides are technically not bisquaternary ammonium compounds and, therefore, should probably be classified separately, they share many physical, chemical, and antimicrobial properties with the cationic surfactants. 
The biguanides are strongly basic, and they exist as dications at physiological pH. 
In chlorhexidine, the positive charges are counterbalanced by gluconate anions (not shown). 
Like cationic surfactants, these undergo inactivation when mixed with anionic detergents and complex anions such as phosphate,carbonate, and silicate.
Chlorhexidine has broad-spectrum antibacterial activity but is not active against acid-fast bacteria, spores, or viruses. 

CHLORHEXIDINE DI-D-GLUCONATE has been used for such topical uses as preoperative skin disinfection, wound irrigation, mouthwashes, and general sanitization. 
Chlorhexidine is not absorbed through skin or mucous membranes and does not cause systemic toxicity.

Products that may contain chlorhexidine digluconate
Cosmetics
Hand Soaps
Health Care Products
• Dental preparations for gingivitis
• Surgical lubricants
• Surgical scrubs
• Surgical wipes
Pet Care Products
• Horse scrubs
• Lubricants
• Pet shampoos
• Skin treatment solutions
• Teat dips
CLINICAL PHARMACOLOGY:
Chlorhexidine gluconate oral rinse provides antimicrobial activity during oral rinsing. 
The clinical significance of Chlorhexidine gluconate oral rinse’s antimicrobial activities is not clear. Microbiological sampling of plaque has shown a general reduction of counts of certain assayed bacteria, both aerobic and anaerobic, ranging from 54-97% through six months use. 
Use of Chlorhexidine gluconate oral rinse in a six month clinical study did not result in any significant changes in bacterial resistance, overgrowth of potentially opportunistic organisms or other adverse changes in the oral microbial ecosystem. 
Three months after Chlorhexidine gluconate oral rinse use was discontinued, the number of bacteria in plaque had returned to baseline levels and resistance of plaque bacteria to Chlorhexidine gluconate was equal to that at baseline.

Pharmacokinetics:
Pharmacokinetic studies with Chlorhexidine gluconate oral rinse indicate approximately 30% of the active ingredient, Chlorhexidine gluconate, is retained in the oral cavity following rinsing. 
This retained drug is slowly released in the oral fluids. 
Studies conducted on human subjects and animals demonstrate Chlorhexidine gluconate is poorly absorbed from the gastrointestinal tract. 
The mean plasma level of Chlorhexidine gluconate reached a peak of 0.206 mcg/g in humans 30 minutes after they ingested a 300-mg dose of the drug. 
Detectable levels of Chlorhexidine gluconate were not present in the plasma of these subjects 12 hours after the compound was administered. 
Excretion of Chlorhexidine gluconate occurred primarily through the feces (~90%). 
Less than 1% of the Chlorhexidine gluconate ingested by these subjects was excreted in the urine.


CAS No.:    18472-51-0
European Community (EC) Number: 242-354-0 
Chemical Name:    chlorhexidinedi-d-gluconate
Molecular Formula:    C28H42Cl2N10O7
Formula Weight:    701.61

Chemical Properties of CHLORHEXIDINE DI-D-GLUCONATE:
density     :1.06 g/mL at 25 °C(lit.)
storage temp. :    2-8°C
solubility :    water: soluble50% (w/v)
form :    Liquid
color :    Colorless
Sensitive :    Light Sensitive
Λmax:    257nm(H2O)(lit.)
Merck:     14,2091
Molecular Weight:    897.8    
Hydrogen Bond Donor Count:    18    
Hydrogen Bond Acceptor Count:    16    
Rotatable Bond Count:    23    
Exact Mass:    896.3198018    
Monoisotopic Mass:    896.3198018    
Topological Polar Surface Area:    455 Ų    
Heavy Atom Count:    60    
Formal Charge:    0    
Complexity:    819    
Isotope Atom Count:    0    
Defined Atom Stereocenter Count:    8    
Undefined Atom Stereocenter Count:    0    
Defined Bond Stereocenter Count:    2    
Undefined Bond Stereocenter Count:    0    
Covalently-Bonded Unit Count:    3    
Compound Is Canonicalized:    Yes
Physical Description: Crystals from methanol
Color/Form:
Crystals from methanol
Melting Point: 134 °C
MW: 578.38; crystals; decomposes 260-262 °C. 
Vapor Pressure: 1.98X10-14 mm Hg at 25 °C (est)
log Kow = 0.080 at pH 5
Henry's Law constant = 1.13X10-30 atm-cu m/mole at 25 °C (est)
Stability/Shelf Life:
Stable under ambient warehouse conditions to moisture and simulated sunlight.
Dissociation Constants:
pKa1 = 7.63; pKa2 = 9.92; pKa3 = 8.22; pKa4 = 10.52
Chemical Classes:
Other Uses -> Biocides/Disinfectants


Solubility in water at 20 °C: 0.06 g/100 mL
Appearance: Almost colorless or pale yellowish, clear liquid.
Solubility: Miscible with glacial acetic acid and with water; miscible with three times its volume of acetone and with five times its volume of dehydrated alcohol; further addition of acetone or dehydrated alcohol yields a white turbidity.

CAS No.:    18472-51-0
European Community (EC) Number: 242-354-0 
Chemical Name:    chlorhexidinedi-d-gluconate
Molecular Formula:    C28H42Cl2N10O7
Formula Weight:    701.61


SAFETY INFORMATION ABOUT CHLORHEXIDINE DI-D-GLUCONATE:
First aid measures:
Description of first-aid measures:
General advice:
Show this material safety data sheet to the doctor in attendance.
If inhaled:
After inhalation: fresh air.
In case of skin contact:
In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with water/ shower.
In case of eye contact:
After eye contact: rinse out with plenty of water. 
Immediately call in ophthalmologist.
Remove contact lenses.
If swallowed:
After swallowing: immediately make victim drink water (two glasses at most). 
Consult a physician.
Most important symptoms and effects, both acute and delayed
Firefighting measures:
Extinguishing media:
Suitable extinguishing media:
Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
Special hazards arising from the substance or mixture:
Carbon oxides
Nitrogen oxides (NOx)
Hydrogen chloride gas
Not combustible.
Ambient fire may liberate hazardous vapours.
Advice for firefighters:
In the event of fire, wear self-contained breathing apparatus.
Further information:
Suppress (knock down) gases/vapors/mists with a water spray jet. 
Prevent fire extinguishing water from contaminating surface water or the ground water system


Accidental release measures:
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: 
Do not breathe vapors, aerosols. 
Avoid substance contact. 
Ensure adequate ventilation. 
Evacuate the danger area, observe emergency procedures, consult an expert.
Environmental precautions:
Do not let product enter drains.
Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions
Take up with liquid-absorbent material (e.g. Chemizorb® ).
Dispose of properly. 
Clean up affected area.

Handling and storage:
Precautions for safe handling:
Conditions for safe storage, including any incompatibilities
Storage conditions:
Tightly closed.
Storage stability:
Recommended storage temperature: 2 - 8 °C
Light sensitive.
Exposure controls/personal protection:
Control parameters:
Ingredients with workplace control parameters
Exposure controls:
Personal protective equipment:
Eye/face protection:
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). 
Tightly fitting safety goggles
Skin protection:
Handle with gloves. 
Gloves must be inspected prior to use. 
Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. 
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. 
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M)
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. 
This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. 
It should not be construed as offering an approval for any specific use scenario.
Body Protection:
protective clothing:
Respiratory protection required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type: Filter type ABEK
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
Control of environmental exposure:
Do not let product enter drains.

Stability and reactivity:
Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions:
Violent reactions possible with:
The generally known reaction partners of water.
Incompatible materials:
Strong oxidizing agents


CAS No.:    18472-51-0
European Community (EC) Number: 242-354-0 
Chemical Name:    chlorhexidinedi-d-gluconate
Molecular Formula:    C28H42Cl2N10O7
Formula Weight:    701.61

SYNONYMS OF CHLORHEXIDINE DI-D-GLUCONATE:

MeSH Entry Terms    HelpNew Window
1,1'-HBCB

avagard

Chlorhexamed

chlorhexidine bigluconate

chlorhexidine digluconate

chlorhexidine gluconate

Corsodyl ICI

Curasept ADS 220

Dyna-Hex

Eludril

Gibitan

Hexidine

Hibiclens

Hibident

Hibiscrub

Hibisol

Hibitane

Peridex

Perio Chip

Depositor-Supplied Synonyms:
CHLORHEXIDINE DIGLUCONATE

Chlorhexidine gluconate

Hibiclens

18472-51-0

Peridex

Unisept

Chlorhexidine D-digluconate

UNII-MOR84MUD8E

Chlorhexidine di-D-gluconate

Exidine

Periogard

MOR84MUD8E

Hibiscrub

Hibitane

1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide), digluconate

Dyna-hex

Bacticlens

Chlorhexamed

Kleersight

Bioscrub

Corsodyl

Disteryl

Hibident

Hibidil

Microderm

Orahexal

Periochip

Plurexid

Septeal

Abacil

Fight bac

Plac out

Prevacare R

Arlacide G

Brian Care

Steri-Stat

Cida-Stat

Hibitane 5

Chlorhexidin glukonatu

Peridex (antiseptic)

Bactoshield CHG 2%

Pharmaseal Scrub Care

CHG SCRUB

Caswell No. 481G

NSC-753971

Prevacare

PwrioChip

Chlorhexidin glukonatu [Czech]

MFCD00083599

pHiso-Med

Chlorhexidine digluconate solution

Hibitane gluconate

Hibiclens (TN)

Periogard (TN)

DRG-0091

EINECS 242-354-0

Peridex (TN)

Chlohexidine gluconate

EPA Pesticide Chemical Code 045504

C22H30Cl2N10.2C6H12O7

Chlorhexidine gluconate [USAN:USP:JAN]

55-56-1

EC 242-354-0

SCHEMBL34468

1,6-Bis(5-(p-chlorophenyl)biguandino)hexane digluconate

CHEMBL4297088

DTXSID5034519

CHEBI:28312

1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) gluconate

1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide)digluconate

Chx plus concentrate premium chlorhexidine teat dip concentrate

1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) di-D-gluconate

Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-, digluconate

Chlorhexidine gluconate (JP17/USP)

AKOS015896303

AKOS025310696

NSC 753971

D-Gluconic acid, compd. with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)

D-Gluconic acid, compd. with N1,N14-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)

D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)

M166

C08038

D00858

Chlorhexidine digluconate solution, 20% in H2O

J-011837

1,1'-Hexamethylenebis[5-(4-chlorophenyl)biguanide] Digluconate

Chlorhexidine digluconate, Pharmaceutical Secondary Standard; Certified Reference Material

1,1'-Hexamethylenebis[5-(p-chlorophenyl)biguanide] (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid(1:2)

1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane; 1,1'-Hexamethylenebis(5-[p-chlorophenyl]biguanide)

1-(4-chlorophenyl)-3-[N-[6-[[N-[N-(4-chlorophenyl)carbamimidoyl]carbamimidoyl]amino]hexyl]carbamimidoyl]guanidine; (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid

2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, di-D-gluconate

2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, digluconate

2,4,11,13-Tetraazatetradecanediimidamide, N,N'-bis(4-chlorophenyl)-3,12-diimino-, di-D-gluconate

D-Gluconic acid, compd with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)

D-Gluconic acid, compd. with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecane diimidamide (2:1)

Gluconic acid, compd. with 1,1'-hexamethylene bis(5-(p-chlorophenyl)biguanide) (2:1), D- (8CI)

N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)]--D-gluconic acid (1/2)


Chlorhexidine digluconate
1,6-bis(4-Chlorophenyldiguanino)hexane digluconate
(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid - N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)] (2:1)
(2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexansäure--N,N''''-hexan-1,6-diylbis[N'-(4-chlorphenyl)(imidodicarbonimidic diamid)](2:1) [German]
1,1'-Hexamethylenebis(5-[p-chlorophenyl]biguanide)
1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane
18472-51-0 [RN]
242-354-0 [EINECS]
4-CHLORHEXIDINE DIGLUCONATE
acide (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoïque - diamide N,N''''-hexane-1,6-diylbis[N'-(4-chlorophényl)(imidodicarbonimidique)] (2:1) [French]
Betasept [Trade name]
Chlorhexamed [Trade name]
chlorhexidine bigluconate
chlorhexidine D-digluconate
chlorhexidine di-D-gluconate
Chlorhexidine digluconate solution
Chlorhexidine gluconate [JAN] [USAN]
Corsodyl [Trade name]
D-Gluconic Acid compd. with N,N''-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)
Diamide N,N''''-1,6-hexanediylbis[N'-(4-chlorophényl)(imidodicarbonimidique)] - acide D-gluconique (1:2) [French] [ACD/IUPAC Name]
Hexidine
Hibident [Trade name]
Hibidil [Trade name]
Hibiscrub [Trade name]
Hibisol [Trade name]
hibitane [Trade name]
Imidodicarbonimidic diamide, N,N''''-1,6-hexanediylbis[N'-(4-chlorophenyl)-, compd. with D-gluconic acid (1:2) [ACD/Index Name]
Manusan [Trade name]
Maskin [Trade name]
Maskin R [Trade name]
MFCD00083599 [MDL number]
MOR84MUD8E
N,N''''-1,6-Hexandiylbis[N'-(4-chlorphenyl)(imidodikohlenstoffimiddiamid)] --D-gluconsäure (1:2) [German] [ACD/IUPAC Name]
N,N''''-1,6-Hexanediylbis[N'-(4-chlorophenyl)(imidodicarbonimidic diamide)] - D-gluconic acid (1:2) [ACD/IUPAC Name]
N,N''-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide di-D-gluconate
N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)] - D-gluconic acid (1:2)
N,N''''-Hexane-1,6-diylbis[N'-(4-chlorophenyl)(imidodicarbonimidic diamide)] - D-gluconic acid (1:2)
Peridex [Trade name]
pHiso-Med [Trade name]
Plurexid [Trade name]
Rotersept [Trade name]
Septeal [Trade name]
STERILON [Trade name]
UNII-MOR84MUD8E
Unisept [Trade name]
(1E)-2-[6-[[amino-[(Z)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
[18472-51-0]
1,1?-Hexamethylenebis(5-[p-chlorophenyl]biguanide)
1,1′-Hexamethylenebis(5-[p-chlorophenyl]biguanide)
1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide), digluconate
1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) di-D-gluconate
1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide)digluconate
1,6-Bis(5-(p-chlorophenyl)biguandino)hexane digluconate
105791-72-8 [RN]
12068-31-4 [RN]
124973-71-3 [RN]
14007-07-9 [RN]
150621-85-5 [RN]
151498-43-0 [RN]
2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, di-D-gluconate
2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, digluconate
2-[amino-[6-[[amino-[[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexylimino]methyl]-1-(4-chlorophenyl)guanidine; 2,3,4,5,6-pentahydroxyhexanoic acid
20% chlorhexidine gluconate solution
200-238-7 [EINECS]
21293-24-3 [RN]
23289-58-9 [RN]
40330-16-3 [RN]
4348068 [Beilstein]
51365-13-0 [RN]
52196-45-9 [RN]
52387-19-6 [RN]
55-56-1 [RN]
60042-57-1 [RN]
60404-86-6 [RN]
82432-16-4 [RN]
Abacil
Arlacide G
Bacticlens
Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-, digluconate
CHLORAPREP
Chlorhexidin glukonatu [Czech]
Chlorhexidine (digluconate)
Chlorhexidine Di Gluconate
Chlorhexidine digluconate, 20% in water
chlorhexidine digluconate, 20% w/v aq. soln., non-sterile
Chlorhexidine digluconatemissing
chlorhexidine gluconate solution
chlorhexidinedigluconate
D-Gluconic acid, compd with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)
D-Gluconic acid, compd. with N,N'-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradeca- nediimidamide (2:1)
D-Gluconic acid, compd. with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecane diimidamide (2:1)
D-Gluconic acid, compd. with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)
D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)
Disteryl
DYNA-HEX
EXIDINE [Wiki]
Gluconic acid, compd. with 1,1'-hexamethylene bis(5-(p-chlorophenyl)biguanide) (2:1), D- (8CI)
Hibiclens [Trade name] [Wiki]
HIBISTAT
Hibitane 5
N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)]--D-gluconic acid (1/2)
Orahexal
Peridex (antiseptic)
Peridex;Periogard
PERIOGARD [Wiki]
Plac out
PwrioChip
UNII:MOR84MUD8E
 

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