CHLORHEXIDINE (DIGLUCONATE)

Chlorhexidine (Digluconate) is a water-compatible digluconate salt of the cationic bisbiguanide antimicrobial substance Chlorhexidine.

Chlorhexidine (Digluconate) provides broad antimicrobial activity through adsorption to microbial surfaces and disruption of cell-membrane integrity.

Chlorhexidine (Digluconate) is widely incorporated into regulated pharmaceutical, oral care, cosmetic, veterinary, laboratory, and specialty antimicrobial formulations.

CAS Number: 18472-51-0

EC Number: 242-354-0

Molecular Formula: C₃₄H₅₄Cl₂N₁₀O₁₄

Molecular Weight: 897.8 g/mol

SYNONYMS

Chlorhexidine (Digluconate), Chlorhexidine Digluconate, Chlorhexidine Gluconate, Chlorhexidine Di-D-Gluconate, Chlorhexidine Bis-D-Gluconate, Chlorhexidine Bisgluconate, Chlorhexidine Digluconate Salt, Chlorhexidine Gluconate Salt, Chlorhexidine D-Gluconate, Chlorhexidine Bigluconate, Chlorhexidini Digluconas, Chlorhexidini Gluconas, Chlorhexidine Gluconate Solution, Chlorhexidine Digluconate Solution, Chlorhexidine Gluconate 20% Solution, Chlorhexidine Digluconate 20% Solution, Aqueous Chlorhexidine Digluconate, CHG, CHG Solution, CHX Digluconate, Chlorhexidine Digluconate Concentrate, Chlorhexidine Gluconate Concentrate, Chlorhexidine Digluconate Antimicrobial, Chlorhexidine Digluconate Antiseptic, Chlorhexidine Digluconate Preservative, Chlorhexidine Digluconate Oral Care Active, Chlorhexidine Digluconate Dental Active, Chlorhexidine Digluconate Pharmaceutical Active, Chlorhexidine Digluconate Cosmetic Preservative, Chlorhexidine Digluconate Veterinary Active, Chlorhexidine Digluconate Laboratory Reagent, Chlorhexidine Digluconate Reference Standard, Chlorhexidine Gluconate Reference Standard, Chlorhexidine Bisbiguanide Salt, Cationic Bisbiguanide Digluconate, 1,1′-Hexamethylenebis[5-(4-chlorophenyl)biguanide] Digluconate, 1,1′-Hexamethylenebis[5-(p-chlorophenyl)biguanide] Di-D-Gluconate, 1,6-Bis[N⁵-(p-chlorophenyl)-N¹-biguanido]hexane Digluconate, 1,6-Bis(4-chlorophenylbiguanido)hexane Digluconate, N,N″-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine Digluconate, N′,N″″′-Hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)] Di-D-Gluconate, Chlorhexidine Compound with D-Gluconic Acid (1:2), CAS 18472-51-0, EC 242-354-0, EINECS 242-354-0, PubChem CID 9552081, PubChem CID 5360565, UNII MOR84MUD8E, C₃₄H₅₄Cl₂N₁₀O₁₄

APPLICATIONS

Chlorhexidine (Digluconate) serves as an antimicrobial active in topical antiseptic formulations intended for application to intact skin.
Chlorhexidine (Digluconate) helps reduce susceptible microorganisms when concentration, contact time, vehicle composition, and application procedure are properly controlled.

Chlorhexidine (Digluconate) supports surgical hand-scrub formulations used before surgery or direct patient care.
Chlorhexidine (Digluconate) provides immediate antimicrobial action together with persistent surface-associated activity after appropriately formulated use.

Chlorhexidine (Digluconate) functions in healthcare personnel hand-wash formulations designed to reduce potentially harmful bacteria.
Chlorhexidine (Digluconate) is commercially established in regulated 4% antiseptic skin-cleansing formulations for professional and general skin cleansing.

Chlorhexidine (Digluconate) contributes to preoperative skin-cleansing and skin-preparation systems.
Chlorhexidine (Digluconate) requires careful control of application site, drying, contact time, alcohol compatibility, and regulatory authorization.

Chlorhexidine (Digluconate) supports skin-wound and general skin-cleansing formulations where the approved label permits such use.
Chlorhexidine (Digluconate) should be used only according to the validated directions, warnings, and anatomical restrictions of the finished formulation.

Chlorhexidine (Digluconate) functions in antimicrobial wipes, swabs, applicators, and impregnated cleansing materials.
Chlorhexidine (Digluconate) can be distributed throughout compatible nonwoven substrates when adsorption and active-release behavior are properly evaluated.

Chlorhexidine (Digluconate) serves as an active ingredient in regulated oral rinses developed for gingivitis management.
Chlorhexidine (Digluconate) is commercially established in 0.12% oral-rinse formulations used as part of a professionally supervised dental program.

Chlorhexidine (Digluconate) supports dental plaque-control formulations by reducing susceptible aerobic and anaerobic oral bacteria.
Chlorhexidine (Digluconate) gains prolonged oral activity through adsorption to teeth, oral mucosa, plaque, and salivary components.

Chlorhexidine (Digluconate) contributes to dental gels developed for localized antimicrobial application around gingival tissues.
Chlorhexidine (Digluconate) enables higher local retention when viscosity, taste, mucosal compatibility, and dosing are appropriately controlled.

Chlorhexidine (Digluconate) functions in periodontal delivery systems designed to maintain antimicrobial activity within selected periodontal sites.
Chlorhexidine (Digluconate) release can be controlled through gels, films, inserts, fibers, or biodegradable matrices.

Chlorhexidine (Digluconate) supports toothpaste and dentifrice research involving cationic antimicrobial activity.
Chlorhexidine (Digluconate) requires careful compatibility testing with anionic surfactants, fluoride sources, abrasives, flavors, and thickening agents.

Chlorhexidine (Digluconate) contributes to endodontic irrigants and intracanal formulations used under professional dental control.
Chlorhexidine (Digluconate) must not be mixed indiscriminately with other endodontic chemicals because chemical incompatibility and precipitate formation may occur.

Chlorhexidine (Digluconate) supports denture cleansers and antimicrobial treatments for removable oral appliances.
Chlorhexidine (Digluconate) requires compatibility testing with acrylic resin, soft liners, metals, pigments, and appliance-cleaning ingredients.

Chlorhexidine (Digluconate) functions as an antimicrobial preservative in compatible pharmaceutical formulations.
Chlorhexidine (Digluconate) preservation performance must be demonstrated through validated antimicrobial effectiveness testing.

Chlorhexidine (Digluconate) contributes to cosmetic preservation systems where Chlorhexidine (Digluconate) is authorized by the destination-market legislation.
Chlorhexidine (Digluconate) is permitted in European Union cosmetic products at a maximum of 0.3% calculated as Chlorhexidine.

Chlorhexidine (Digluconate) supports creams, lotions, gels, and emulsions requiring antimicrobial preservation.
Chlorhexidine (Digluconate) compatibility must be confirmed because proteins, gums, surfactants, pigments, and charged polymers can reduce available activity.

Chlorhexidine (Digluconate) functions in specialized liquid cleansers containing compatible nonionic, amphoteric, or cationic surfactants.
Chlorhexidine (Digluconate) generally loses activity in the presence of conventional soaps and strongly anionic surfactants.

Chlorhexidine (Digluconate) contributes to deodorant and personal hygiene formulations intended to control odor-associated microorganisms.
Chlorhexidine (Digluconate) can complement fragrances, absorbents, antiperspirant ingredients, and additional odor-control technologies.

Chlorhexidine (Digluconate) supports specialized shampoo and scalp-cleansing formulations requiring antimicrobial activity.
Chlorhexidine (Digluconate) requires surfactant screening because many common anionic shampoo ingredients can form inactive complexes.

Chlorhexidine (Digluconate) functions in veterinary shampoos, rinses, sprays, wipes, creams, and topical cleansing formulations.
Chlorhexidine (Digluconate) veterinary use must account for animal species, application site, licking risk, concentration, and regulatory authorization.

Chlorhexidine (Digluconate) contributes to antimicrobial wound-dressing research involving fibers, foams, films, and absorbent matrices.
Chlorhexidine (Digluconate) can be loaded into porous structures for gradual release after exposure to moisture or wound fluid.

Chlorhexidine (Digluconate) supports hydrogel systems designed for sustained local antimicrobial delivery.
Chlorhexidine (Digluconate) release depends on polymer charge, crosslink density, water uptake, ionic strength, and environmental pH.

Chlorhexidine (Digluconate) functions in antimicrobial coating research for selected medical-device surfaces.
Chlorhexidine (Digluconate) requires assessment of coating adhesion, sterilization stability, release profile, biocompatibility, and device performance.

Chlorhexidine (Digluconate) contributes to catheter, tubing, membrane, and medical-polymer research intended to reduce microbial surface colonization.
Chlorhexidine (Digluconate) cannot independently establish infection prevention without complete device evaluation and clinical validation.

Chlorhexidine (Digluconate) supports antimicrobial textile finishes for medical, hygiene, laboratory, and technical textile research.
Chlorhexidine (Digluconate) can be adsorbed, encapsulated, immobilized, or incorporated into compatible fibers and textile coatings.

Chlorhexidine (Digluconate) functions in antimicrobial polymer composites containing thermoplastics, thermosets, elastomers, and waterborne binders.
Chlorhexidine (Digluconate) performance depends on dispersion, polymer compatibility, surface availability, migration, and controlled release.

Chlorhexidine (Digluconate) serves as an analytical reference substance in pharmaceutical and chemical quality-control laboratories.
Chlorhexidine (Digluconate) supports identity testing, assay calibration, chromatographic retention confirmation, and impurity analysis.

Chlorhexidine (Digluconate) contributes to high-performance liquid chromatography method development and validation.
Chlorhexidine (Digluconate) enables evaluation of specificity, linearity, precision, accuracy, recovery, and degradation-product separation.

Chlorhexidine (Digluconate) functions as a microbiological research reagent in susceptibility and time-kill studies.
Chlorhexidine (Digluconate) can be evaluated through minimum inhibitory concentration, minimum bactericidal concentration, and microbial-reduction methods.

Chlorhexidine (Digluconate) supports membrane-interaction research involving Gram-positive and Gram-negative bacteria.
Chlorhexidine (Digluconate) allows investigation of membrane permeability, depolarization, intracellular leakage, and loss of microbial viability.

Chlorhexidine (Digluconate) contributes to biofilm studies involving oral, medical, veterinary, and environmental microorganisms.
Chlorhexidine (Digluconate) can be assessed for prevention of attachment, reduction of viable biofilm cells, and interaction with extracellular matrices.

Chlorhexidine (Digluconate) serves as a comparative material in studies involving Chlorhexidine free base, diacetate, and dihydrochloride.
Chlorhexidine (Digluconate) helps researchers determine how counterion, solubility, pH, and delivery system affect antimicrobial performance.

Chlorhexidine (Digluconate) supports preservative challenge testing during development of pharmaceutical and cosmetic formulations.
Chlorhexidine (Digluconate) can be assessed against representative bacteria, yeasts, and molds over defined storage intervals.

Chlorhexidine (Digluconate) contributes to antimicrobial surface studies involving plastics, ceramics, glass, metals, and composite materials.
Chlorhexidine (Digluconate) can be adsorbed, immobilized, encapsulated, or incorporated according to the chemistry of the selected surface.

Chlorhexidine (Digluconate) functions in nanoparticle and microparticle delivery systems designed for localized antimicrobial release.
Chlorhexidine (Digluconate) release can be adjusted through particle size, porosity, coating composition, and environmental conditions.

Chlorhexidine (Digluconate) supports formulation screening involving compatible surfactants, polymers, solvents, humectants, salts, and preservatives.
Chlorhexidine (Digluconate) compatibility studies help identify combinations that preserve antimicrobial availability and physical stability.

Chlorhexidine (Digluconate) contributes to research on adsorption and retention on negatively charged surfaces.
Chlorhexidine (Digluconate) can remain associated with biological tissues, minerals, polymers, and particulate materials after initial contact.

Chlorhexidine (Digluconate) functions in studies of antimicrobial substantivity after deposition onto oral, skin, textile, or polymer surfaces.
Chlorhexidine (Digluconate) may be released gradually from adsorptive surfaces during subsequent contact with water or biological fluids.

Chlorhexidine (Digluconate) supports research into the effects of blood, proteins, organic matter, and surface contamination on antimicrobial performance.
Chlorhexidine (Digluconate) activity can decrease when Chlorhexidine (Digluconate) becomes strongly bound or chemically inactivated.

Chlorhexidine (Digluconate) contributes to quality-control testing of concentrated aqueous antimicrobial raw materials.
Chlorhexidine (Digluconate) specifications commonly include assay, pH, relative density, color, related substances, and microbiological quality.

Chlorhexidine (Digluconate) serves as a water-compatible source of Chlorhexidine for formulations that cannot efficiently dissolve Chlorhexidine free base.
Chlorhexidine (Digluconate) enables accurate liquid dosing when Chlorhexidine (Digluconate) is supplied at a standardized active concentration.

Chlorhexidine (Digluconate) supports production-scale manufacture of oral, topical, cosmetic, veterinary, and laboratory formulations.
Chlorhexidine (Digluconate) performance must be verified through application-specific efficacy, safety, compatibility, stability, and regulatory assessment.

DESCRIPTION

Chlorhexidine (Digluconate) is the 1:2 salt or molecular association formed between Chlorhexidine and two equivalents of D-gluconic acid.
Chlorhexidine (Digluconate) is also widely described as Chlorhexidine Gluconate in pharmaceutical and regulatory terminology.

Chlorhexidine (Digluconate) has the molecular formula C₃₄H₅₄Cl₂N₁₀O₁₄ and a molecular weight of approximately 897.8 g/mol.
Chlorhexidine (Digluconate) is identified by CAS Number 18472-51-0 and EC Number 242-354-0.

Chlorhexidine (Digluconate) contains one bisbiguanide Chlorhexidine structure associated with two gluconic acid molecules.
Chlorhexidine (Digluconate) combines a cationic antimicrobial region with highly hydroxylated gluconate counterions.

Chlorhexidine (Digluconate) contains two para-chlorophenyl groups, two biguanide regions, and a central hexamethylene chain.
Chlorhexidine (Digluconate) gains strong surface affinity from the protonated biguanide groups and hydrophobic aromatic regions.

Chlorhexidine (Digluconate) is commonly supplied as an aqueous concentrate containing approximately 20% Chlorhexidine (Digluconate).
Chlorhexidine (Digluconate) aqueous concentrates are easier to meter and incorporate into water-based formulations than Chlorhexidine free base.

Chlorhexidine (Digluconate) concentrate normally appears as a clear, colorless to pale-yellow aqueous liquid.
Chlorhexidine (Digluconate) appearance can vary with active concentration, impurity profile, storage conditions, and analytical specification.

Chlorhexidine (Digluconate) has high compatibility with water because the gluconate salt form is substantially more hydrophilic than Chlorhexidine free base.
Chlorhexidine (Digluconate) solubility and clarity can still be affected by pH, electrolytes, surfactants, polymers, and other counterions.

Chlorhexidine (Digluconate) dissociates into positively charged Chlorhexidine species and gluconate ions in aqueous environments.
Chlorhexidine (Digluconate) antimicrobial activity originates primarily from the cationic Chlorhexidine component.

Chlorhexidine (Digluconate) adsorbs electrostatically onto negatively charged microbial cell surfaces.
Chlorhexidine (Digluconate) disrupts membrane organization, increases permeability, and promotes leakage of intracellular components.

Chlorhexidine (Digluconate) can provide predominantly growth-inhibiting activity at lower available concentrations.
Chlorhexidine (Digluconate) can produce greater membrane damage and microbial killing at higher available concentrations.

Chlorhexidine (Digluconate) generally displays strong activity against many Gram-positive bacteria.
Chlorhexidine (Digluconate) also provides useful but organism-dependent activity against numerous Gram-negative bacteria, yeasts, and selected fungi.

Chlorhexidine (Digluconate) has limited activity against bacterial spores and variable activity against mycobacteria and non-enveloped viruses.
Chlorhexidine (Digluconate) should not be described as universally sporicidal, virucidal, or sterilizing without formulation-specific evidence.

Chlorhexidine (Digluconate) exhibits substantivity through adsorption onto oral tissues, skin, proteins, minerals, and polymeric surfaces.
Chlorhexidine (Digluconate) can be released gradually after adsorption and provide residual antimicrobial activity.

Chlorhexidine (Digluconate) oral-rinse studies demonstrate measurable retention of Chlorhexidine (Digluconate) within the oral cavity after rinsing.
Chlorhexidine (Digluconate) retained on oral surfaces is gradually released into oral fluids.

Chlorhexidine (Digluconate) is incompatible with many conventional soaps and strongly anionic surfactants.
Chlorhexidine (Digluconate) may form poorly soluble complexes or lose freely available antimicrobial activity in strongly anionic systems.

Chlorhexidine (Digluconate) is generally more compatible with carefully selected nonionic, amphoteric, and cationic ingredients.
Chlorhexidine (Digluconate) still requires direct compatibility testing because minor formulation components can alter activity or clarity.

Chlorhexidine (Digluconate) performance can be reduced by blood, serum, proteins, pus, cellulose, clays, and other adsorptive materials.
Chlorhexidine (Digluconate) total analytical concentration may therefore exceed the freely available antimicrobial concentration.

Chlorhexidine (Digluconate) stability is influenced by formulation pH, temperature, light exposure, oxygen, and impurity content.
Chlorhexidine (Digluconate) should be protected from prolonged excessive heat and unsuitable strongly acidic or alkaline conditions.

Chlorhexidine (Digluconate) can form degradation products during unsuitable manufacturing or storage conditions.
Chlorhexidine (Digluconate) quality-control procedures should monitor related chlorinated aromatic impurities in regulated applications.

Chlorhexidine (Digluconate) is nonvolatile under ordinary handling conditions.
Chlorhexidine (Digluconate) aqueous aerosols or droplets can nevertheless be generated during spraying, high-speed mixing, or pressurized transfer.

Chlorhexidine (Digluconate) is commercially used in regulated 0.12% oral-rinse and 4% skin-cleansing formulations.
Chlorhexidine (Digluconate) finished-product concentration, directions, warnings, and permitted uses remain category and jurisdiction dependent.

Chlorhexidine (Digluconate) is permitted as a cosmetic preservative in the European Union at a maximum concentration of 0.3% calculated as Chlorhexidine.
Chlorhexidine (Digluconate) cosmetic safety assessments and statutory maximum limits should be treated as separate regulatory frameworks.

Chlorhexidine (Digluconate) may cause serious hypersensitivity reactions in susceptible individuals.
Chlorhexidine (Digluconate) finished medicinal formulations can carry warnings concerning wheezing, breathing difficulty, shock, facial swelling, hives, and rash.

Chlorhexidine (Digluconate) is commonly classified as harmful if swallowed and capable of causing serious eye damage.
Chlorhexidine (Digluconate) is also commonly classified as very toxic to aquatic life with long-lasting effects.

Chlorhexidine (Digluconate) quality is commonly controlled through identification, assay, pH, relative density, color, and related-substance testing.
Chlorhexidine (Digluconate) acceptance limits must follow the selected pharmaceutical, cosmetic, analytical, or industrial specification.

Chlorhexidine (Digluconate) provides a practical water-compatible form of Chlorhexidine for liquid formulation and controlled dosing.
Chlorhexidine (Digluconate) requires careful management of ionic compatibility, biological potency, hypersensitivity risk, and environmental release.

PROPERTIES

Chemical Name: Chlorhexidine (Digluconate)

Preferred Standard Name: Chlorhexidine Digluconate

Common Pharmaceutical Name: Chlorhexidine Gluconate

INCI Name: Chlorhexidine Digluconate

Abbreviation: CHG

Chemical Class: Cationic Bisbiguanide Salt

Substance Type: Antimicrobial and Preservative Substance

Parent Substance: Chlorhexidine

Counterion: D-Gluconate

Salt Ratio: One Chlorhexidine Molecule to Two D-Gluconic Acid Molecules

CAS Number: 18472-51-0

EC Number: 242-354-0

PubChem CID: 9552081

Alternative PubChem CID: 5360565

UNII: MOR84MUD8E

Molecular Formula: C₃₄H₅₄Cl₂N₁₀O₁₄

Alternative Formula: C₂₂H₃₀Cl₂N₁₀·2C₆H₁₂O₇

Molecular Weight: 897.8 g/mol

Exact Mass: Approximately 896.3548 Da

InChIKey: YZIYKJHYYHPJIB-UUPCJSQJSA-N

Physical Form of Pure Salt: Solid or Highly Concentrated Salt Material

Common Commercial Form: Aqueous Solution

Typical Commercial Concentration: Approximately 20%

Typical Appearance: Clear, Colorless to Pale-Yellow Liquid

Odor: Odorless or Mild Characteristic Odor

Water Compatibility: High

Water Solubility: High Relative to Chlorhexidine Free Base

Alcohol Compatibility: Formulation Dependent

Volatility: Negligible

Ionic Character: Strongly Cationic in Aqueous Formulations

Primary Function: Antimicrobial Active

Secondary Functions: Antiseptic, Preservative, Oral Care Active, and Surface-Substantive Antimicrobial

Mechanism of Action: Adsorption to Microbial Surfaces and Disruption of Membrane Integrity

Gram-Positive Activity: Generally Strong

Gram-Negative Activity: Broad but Organism and Formulation Dependent

Yeast and Fungal Activity: Active against Selected Species

Spore Activity: Limited

Mycobacterial Activity: Limited or Formulation Dependent

Non-Enveloped Virus Activity: Generally Limited

Substantivity: High on Many Negatively Charged Surfaces

Protein Binding: Strong

Organic-Matter Sensitivity: Available Activity Can Be Reduced

Soap Compatibility: Generally Poor

Anionic Surfactant Compatibility: Generally Poor

Strongly Anionic Polymer Compatibility: Generally Poor

Nonionic Surfactant Compatibility: Often Better, Subject to Testing

Amphoteric Surfactant Compatibility: Formulation Dependent

Cationic Ingredient Compatibility: Often Better, Subject to Testing

pH Sensitivity: Solubility, Stability, and Activity Depend on Formulation pH

Electrolyte Sensitivity: Counterions and Ionic Strength Can Affect Clarity and Availability

Chlorhexidine Base Fraction: Approximately 56.3% of Anhydrous Chlorhexidine (Digluconate) by Molecular Weight

Equivalent Chlorhexidine Base in 20% Salt Solution: Approximately 11.3% by Weight on an Idealized Anhydrous Basis

Established Oral-Rinse Concentration: 0.12% Chlorhexidine Gluconate in Regulated Formulations

Established Skin-Cleanser Concentration: 4% Chlorhexidine Gluconate in Regulated Formulations

EU Cosmetic Preservative Maximum: 0.3% Calculated as Chlorhexidine

Referenced Cosmetic Safety Assessment Level: Up to 0.20% as Chlorhexidine Digluconate

Common Hazard Concerns: Harmful if Swallowed, Serious Eye Damage, Hypersensitivity, and Aquatic Toxicity

Aquatic Hazard: Very Toxic to Aquatic Life with Long-Lasting Effects in Common Classifications

Chemical Stability: Stable under Recommended Storage Conditions

Incompatible Materials: Strong Oxidizing Agents, Strongly Anionic Ingredients, Conventional Soaps, and Incompatible Reactive Chemicals

Storage Conditions: Cool, Tightly Closed, Protected from Excessive Heat, Light, Freezing, and Contamination

Shelf Life: Grade and Specification Dependent

FIRST AID

Inhalation: Move the person exposed to Chlorhexidine (Digluconate) mist or aerosol into fresh air and keep the person at rest.
Obtain immediate medical attention if Chlorhexidine (Digluconate) exposure causes wheezing, breathing difficulty, facial swelling, dizziness, or persistent respiratory irritation.

Skin Contact: Remove clothing contaminated with concentrated Chlorhexidine (Digluconate) and rinse the affected skin thoroughly with water.
Obtain medical attention if Chlorhexidine (Digluconate) causes persistent irritation, rash, hives, swelling, or other hypersensitivity symptoms.

Eye Contact: Immediately rinse eyes exposed to Chlorhexidine (Digluconate) with clean running water for at least 15 minutes while holding the eyelids open.
Remove contact lenses when easy to do, continue rinsing, and obtain urgent medical attention because concentrated Chlorhexidine (Digluconate) can cause serious eye damage.

Ingestion: Rinse the mouth thoroughly after accidental ingestion of Chlorhexidine (Digluconate) and do not induce vomiting unless instructed by medical personnel.
Contact a physician or poison information center promptly after significant Chlorhexidine (Digluconate) ingestion or whenever symptoms develop.

Note to Physicians: Treat Chlorhexidine (Digluconate) exposure symptomatically and provide supportive care.
Assess Chlorhexidine (Digluconate) exposure for hypersensitivity, airway involvement, eye injury, gastrointestinal effects, and the amount and route of exposure.

HANDLING AND STORAGE

Handling: Handle Chlorhexidine (Digluconate) according to good industrial hygiene and pharmaceutical or cosmetic manufacturing practices.
Avoid generating Chlorhexidine (Digluconate) mist and prevent Chlorhexidine (Digluconate) contact with the eyes, skin, clothing, and incompatible ingredients.

Ventilation: Provide effective general ventilation and local exhaust wherever Chlorhexidine (Digluconate) is transferred, sprayed, sampled, diluted, or mixed.
Use suitable respiratory protection when engineering controls cannot adequately control airborne Chlorhexidine (Digluconate) droplets or aerosol.

Storage: Store Chlorhexidine (Digluconate) in tightly closed original or chemically compatible approved containers.
Protect Chlorhexidine (Digluconate) from excessive heat, direct light, freezing, strong oxidizing agents, anionic contamination, and unauthorized access.

Spill and Leak Procedures: Contain released Chlorhexidine (Digluconate) with a suitable inert absorbent and avoid generating aerosol during cleanup.
Prevent Chlorhexidine (Digluconate) from entering drains, soil, or surface water and transfer Chlorhexidine (Digluconate) waste into labeled disposal containers.

Handling Precautions: Wear chemical-resistant gloves, protective clothing, and tightly fitting safety goggles while handling concentrated Chlorhexidine (Digluconate).
Keep emergency eyewash and safety-shower facilities accessible and consult the current grade-specific Safety Data Sheet before commercial Chlorhexidine (Digluconate) processing.